Digital Commons Network^™

Skin-Tone And Academic Achievement Among 5-Year-Old Mexican Children, Selamawit Hailu

Theses and Dissertations

Skin-tone based social stratification has been characterized as an enduring part of the U.S. racial landscape (Hunter, 2002). Despite the plethora of research that examines the racial disparities in education (e.g., Reardon & Portilla, 2015), and an emerging literature finding that lighter skin-tones are associated with higher educational attainment among adults (Hunter, 2002) few studies have examined whether similar processes emerge during early childhood. Thus, grounded in Garcia Coll and colleagues’ (1996) integrative model, we tested whether skin-tone predicted children’s academic achievement, and whether these relations were modified by children’s ethnic-racial identification (i.e., positive ethnic-racial attitudes and centrality). Consistent with …

Stat3 In The Regulation Of Brown Adipocyte Differentiation, Marc Cantwell

Theses and Dissertations

Thermogenic fat is a promising target for new therapies in diabetes and obesity. Understanding how thermogenic fat develops is important to develop rational strategies to treat obesity. Previously, we have shown that Tyk2 and STAT3, part of the JAK-STAT pathway, are necessary for proper development of classical brown fat. Using primary preadipocytes isolated from newborn mice we demonstrate that STAT3 is required for differentiation and robust expression of Uncoupling Protein 1. We also confirm that STAT3 is necessary during the early induction stage of differentiation and is dispensable during the later terminal differentiation stage. Without STAT3, the brown preadipocytes have …

High-Throughput Prediction And Analysis Of Drug-Protein Interactions In The Druggable Human Proteome, Chen Wang

Theses and Dissertations

Drugs exert their (therapeutic) effects via molecular-level interactions with proteins and other biomolecules. Computational prediction of drug-protein interactions plays a significant role in the effort to improve our current and limited knowledge of these interactions. The use of the putative drug-protein interactions could facilitate the discovery of novel applications of drugs, assist in cataloging their targets, and help to explain the details of medicinal efficacy and side-effects of drugs. We investigate current studies related to the computational prediction of drug-protein interactions and categorize them into protein structure-based and similarity-based methods. We evaluate three representative structure-based predictors and develop a Protein-Drug …

Understanding The Role Of Phosphoinositide 3-Kinase And Its Function As A Driving Force Behind The Er Stress Response In Fibrostenotic Crohn’S Disease-Affected Ileal Smooth Muscle Cells, Prashant Yadav

Theses and Dissertations

Crohn’s disease (CD) affects about 780,000 people in the United States alone, and it is estimated that 6-15 per 100,000 persons will receive a diagnosis of this disease each year. There currently is no cure for Crohn’s disease, and available medical therapies simply serve to alleviate the inflammation. This does not help treat fibrostenosis that Crohn’s disease patients may develop, which can only be treated surgically. Finding alternatives to treat CD requires an understanding of mechanisms at the biochemical level. In this thesis, we attempted to gain a better understanding of certain pathways found to be active in Crohn’s disease-affected …

Evaluating The Effects Of A Flipped Classroom Compared To A Traditional Classroom On Retention Of Information And Course Engagement In A Radiation Safety Course, Stephanie A. Mchugh

Theses and Dissertations

The purpose of this study was to compare the flipped and traditional classroom pedagogies in relation to retention, critical thinking skills, and student engagement as measured by the multiple choice and short answer questions on the final exams, course evaluations, and CUCEI scores. Radiologic technologists, nuclear medicine technologists, and radiation therapists play vital roles in both diagnostic and therapeutic applications in patient care. Employers today are seeking graduates who know more, are better able to apply this knowledge, and solve more challenging problems (McLean, et al., 2016). This quasi-experimental study aimed to compare the flipped and traditional classroom pedagogies at …

Big Networks: Analysis And Optimal Control, Hung The Nguyen

Theses and Dissertations

The study of networks has seen a tremendous breed of researches due to the explosive spectrum of practical problems that involve networks as the access point. Those problems widely range from detecting functionally correlated proteins in biology to finding people to give discounts and gain maximum popularity of a product in economics. Thus, understanding and further being able to manipulate/control the development and evolution of the networks become critical tasks for network scientists. Despite the vast research effort putting towards these studies, the present state-of-the-arts largely either lack of high quality solutions or require excessive amount of time in real-world …

Advanced Imaging Analysis For Predicting Tumor Response And Improving Contour Delineation Uncertainty, Rebecca N. Mahon

Theses and Dissertations

ADVANCED IMAGING ANALYSIS FOR PREDICTING TUMOR RESPONSE AND IMPROVING CONTOUR DELINEATION UNCERTAINTY

By Rebecca Nichole Mahon, MS

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.

Virginia Commonwealth University, 2018

Major Director: Dr. Elisabeth Weiss,

Professor,

Department of Radiation Oncology

Radiomics, an advanced form of imaging analysis, is a growing field of interest in medicine. Radiomics seeks to extract quantitative information from images through use of computer vision techniques to assist in improving treatment. Early prediction of treatment response is one way of improving overall patient care. This work …

8917: Athletic Training Student Application Of Quality Improvement During Clinical Education: A Report From The Athletic Training Clinical Education Network, B. C. Jones, C. E. Welch Bacon, J. M. Cavallario, S. E. Walker, R. C. Bay, B. L. Van Lunen

Rehabilitation Sciences Faculty Publications

Context: A component of quality improvement (QI) is the ability to reflect on the effectiveness of one's practice. Past research has demonstrated that QI is more frequently implemented in patient encounters (PEs) in which athletic training students (ATSs) are assisting the preceptor. As one of the core competencies, QI will be a required curricular content component in all professional athletic training programs in 2020.

Objective: To assess whether ATSs are integrating concepts of QI during PEs as a part of their clinical experiences.

Design: Multisite, panel design.

Setting: Three Commission on Accreditation of Athletic Training Education-accredited professional athletic training programs …

2018-00-00 Water Quality Report, Morehead State University. Water System Office.

Staff Congress Records

Water quality report for Morehead State University for 2018.

2018 Msu Benefits Guide, Morehead State University. Office Of Human Resources.

Staff Congress Records

2018 Morehead State University Benefits Guide.

Dicarbon­Yl{[(E,E)-(2,3,4,5-Η)-6-Meth­­Oxy-6-Oxo-2,4-Hexa­Dien­Yl]Tri­Phenyl­Phospho­Nium}(Tri­Phenyl­Phosphane-ΚP)Iron(1+) Hexa­Fluorido­Phosphate, Yuzhi Ma, Sergey V. Lindeman, William A. Donaldson

Chemistry Faculty Research and Publications

In the title compound, [Fe(C₂₅H₂₄O₂P)(C₁₈H₁₅P)(CO)₂]PF₆, the Fe atom adopts a square-based pyramidal coordination geometry with the carbonyl groups and the two C=C bonds of the diene defining the basal sites and the phosphane ligand the apical position. The diene ligand has an E,E geometry, with the phospho­nium fragment pointed away from the Fe atom. The crystal structure displays C—H⋯F and C—H⋯O hydrogen bonding. The PF₆⁻ anion is rotationally disordered over four orientations.

Recent Progress In The Synthesis Of Six-Membered Aminocyclitols (2008-2017), William A. Donaldson

Chemistry Faculty Research and Publications

Aminocyclitols are of interest as glucosidase inhibitors, as probes for the study of pseudoglycosyltransferases, and as potential therapeutics for the treatment of Gaucher’s disease. The synthesis of these targets was reviewed in early 2008, and the aim of this review is to cover material relevant to the synthesis of aminocyclitols since that time. While not a focus of this review, biological evaluation of compounds will be presented where it is recorded in the literature.

Mazanet's 1693 "Report To The Viceroy:" The Role Of Alterity, Bare Life, And Agency In The Attitude Of A Spanish Friar Against Texas Amerindians, Pedro Cebollero

The Coastal Review

This study evaluates Spanish missionary Damián Mazanet’s beliefs and attitudes about the Texas Indians expressed in a 1693 letter. In order to control the Amerindians, Mazanet represents them as beings with bare life, which gives him permission to implement biopolitical tactics such as the reorganization of Indian populations around the mission, their removal from their own lands, and their conversion by force. In spite of this, the examination of textual silences in the letter shows such Amerindians as agents who actually refuse to be subjected by the Spanish friars and soldiers.

La Instantánea De Un Desastre "Histórico:" El Reclamo Por La Justicia Y La Reválida De La Identidad En "Cabo Trafalgar" De Arturo-Pérez Reverte, Agustín Martínez-Samos

The Coastal Review

In Cabo Trafalgar (2004) by Arturo Pérez-Reverte, I examine the turbulent historical fabric of the Battle of Trafalgar as a “harmful organic entity,” capable of altering the distinct circumstances of the peripheral subject. I observe how the narrative voice denotes social anxiety and loneliness on those whose meaning in the geopolitical context of that era is a mere anecdote, while presenting the emerging tensions between individual identity and collective uncertainty. I present how the actions of professional seamen and pressmen create a rectifier methodology that challenges the historical oblivion experienced by the participants in this tragic battle. Finally, I note …

Memory, Metatheater, And Intertextuality In "La Madrugada" By Juan Tovar, Brian T. Chandler

The Coastal Review

This work explores the concepts of temporality, memory and history in the play La madrugada by Juan Tovar presented through the use of metatheatricality and intertextuality with works such as Pedro Páramo and various historical corridos. The processes through which official history is constructed are shown in contrast with collective memory that endures in the corrido, the “authentic” voice of the people, suggesting that the only possibility for redemption is found in memory, a space where one can learn from history to rectify the mistakes of the past whose impact in politics and society is felt to this …

The Unselfishness Of God And How I Discovered It, Hannah Whitall Smith

Heritage Material

No abstract provided.

The Power And Work Of The Holy Spirit, Joanna P. Moore

Heritage Material

No abstract provided.

John Wesley And Premillennialism, Nathaniel West

Heritage Material

No abstract provided.

The Christian's Secret Of A Happy Life, Hannah Whitall Smith

Heritage Material

No abstract provided.

El Secreto De La Vida Cristiana Feliz, Hannah Whitall Smith

Heritage Material

No abstract provided.

Special Issue: Protestantism In The Balkans (Macedonia, Serbia, And Albania), Ruzhica Cacanoska

Occasional Papers on Religion in Eastern Europe

This issue of Occasional Papers on Religion in Eastern Europe is published as part of the celebration of the 500-years of the Protestant Reformation. In fact, this issue contains the works presented by its authors at the scientific gathering organized within the anniversary by the Institute for Sociological, Political and Juridical Research, a branch of “St. Cyril and Methodius University” in Skopje, Macedonia). The program, Scientific Wednesday, was held on November 1 , 2017. The scholarly gathering was titled Protestantism in the Balkans. Prof. Ruzica Cacanoska, as a member of the advisory editorial board of this journal, and also as …

Protestantism In Macedonia Today, Ruzhica Cacanoska

Occasional Papers on Religion in Eastern Europe

Protestantism arrived in Macedonia in the second half of the nineteenth century. Since then, a number of Protestant communities were established and their current membership is relatively small. The United Methodist Church in the Republic of Macedonia is considered to be traditional and is listed as such in the Constitution of the Republic of Macedonia. The contemporary Protestant structure is composed of 12 Evangelical-Protestant churches. The subject matter of this paper is a sociological research on the Protestant communities in Macedonia and it will focus on key issues related to the structure and functioning of their communities, their mutual cooperation, …

Protestantization Of The Roma From Southeastern Serbia, Dragan Todorović

Occasional Papers on Religion in Eastern Europe

The Protestantization of the Roma refers to the recent process of mass involvement of Serbian Roma in small religious communities of Protestant provenance.

The research was conducted using the deep interview method on the basis of a structured questionnaire with baptized believers of Roma nationality belonging to the Christian Baptist Church, Jehovah’s Witnesses, Christian Adventist Church, and Evangelical Pentecostal Church in the territory of Southeastern Serbia. The sample included both Roma and non-Roma high clergy of the abovementioned religious communities, as well as religious leaders of major religions of the region (Serbian Orthodox Church and Islamic Community).

This paper describes …

Congretional/Methodist Church In Macedonia, Paul Mojzes

Occasional Papers on Religion in Eastern Europe

Prior to the end of the Balkan Wars of 1912-1913 and during portions of World War I, the territory of Macedonia was served by the American Board of Commissioners for Foreign Missions (hereafter ABCFM) with headquarters in Boston, Massachusetts. The form of Protestantism promoted by ABCFM was Congregationalism but in the Balkans, they called their churches Evangelical, which is often used as a synonym for Protestants. After the end of World War I, the ABCFM was unable to continue to financially support and staff this mission field outside of Bulgaria as proper and turned their work in Macedonia (which had …

Medieval Heresis And Protestantism, Maja Angelovska-Panova

Occasional Papers on Religion in Eastern Europe

In addition to the current social and political circumstances, the appearance of heresies and reform movements during the Middle Ages. was largely determined by the educational tendencies and movement of humanism, which concentrated on the matter of the human being. Thisarticle offers a digressive analysis that examines the appearance, essence, and significance of Bogomilism, Catharism, Waldensians and their implications for later reform movements—more specifically Protestantism. It should be emphasized that in this context, such ideas, characteristic of medieval heresies, impacted Protestantism, as seen in the works of John Wycliffe (1328-1384) and Jan Hus (1369-1415). In fact, they were qualified to …

In Silico Cd4+, Cd8+ & Humoral Immunity Associated Antigenic Epitope Prediction And Hla Distribution Analysis Of Htlv-I, Tasneem Bano, Essam Mohammed Janahi, Anupam Dhasmana, Mohtashim Lohani, Shafiul Haque, Raju K. Mandel, Sajad A. Dar, Arshad Jawed, Mohd Wahid, Naseem Akhter, Mohammaed Y. Areeshi

School of Medicine Publications

Purpose: The linkage of human T-cell leukemia virus type 1 (HTLV-1) to fatal diseases is a well known fact for many years. However, there has been no significant progress in the field of the treatment that can lead to the development of a successful vaccine. Furthermore, there are no means of assessing the risk of disease and its prognosis in the infected people.

Methods:The current study has taken the cognizance of the importance of host’s immune response in reducing the risk of infectious diseases to carry out immunoinformatics driven epitope screening strategy of vaccine candidates against HTLV-1. In this …

Kaposi Sarcoma Incidence In Females Is Nearly Four-Fold Higher In The Lower Rio Grande Valley Compared To The Texas Average, Wendy Innis-Whitehouse, Xiaohui Wang, Nicolas Restrepo, Carlos Salas, Katia Moreno, Alvaro Restrepo, Megan Keniry

School of Medicine Publications

The Lower Rio Grande Valley (LRGV) is located on U.S.-Mexican border with a population that is 90% Hispanic[1]. Comprised of Hidalgo, Cameron, Starr and Willacy counties, this region has the highest poverty rate and one of the highest incidences of Type 2 diabetes in the United States[2],[3],[4]. Previous studies demonstrated a high prevalence of Human Herpes Virus 8 (HHV8) in the LRGV[5],[6],[7]. HHV8 infection has been causally linked to Kaposi Sarcoma (KS)[8]. Here, we retrospectively examine the incidence of KS in the LRGV in a set of HIV-negative Hispanic patients. Strikingly, the incidence of KS was higher in LRGV women …

Non-Congenital Severe Ocular Complications Of Zika Virus Infection, Mussaret B. Zaidi, C Gustavo De Moraes, Michele Petitto, Juan B. Yepez, Anavaj Sakuntabhai, Etienne Simon-Loriere, Matthieu Prot, Claude Ruffie, Susan S. Kim, Gladys E. Maestre

School of Medicine Publications

In 2016, during a major Zika virus (ZIKV) outbreak in Maracaibo, Venezuela, a 49-year-old woman and an unrelated 4-year-old boy developed bilateral optic neuritis 2–3 weeks after presenting an acute febrile illness characterized by low-grade fever, rash and myalgia [1]. Both patients presented sudden, painless bilateral loss of vision with no corneal or uveal abnormalities. Fundoscopic examination revealed oedema of the optic nerve and optic disc pallor. Optical coherence tomography confirmed bilateral optic nerve head swelling in the case of the adult, but it was not carried out in the child. Automated perimetry performed in the adult revealed bilateral diffuse …

Creating Space For Belonging Within The West Virginia Progressive Movement, Roger A. Jennette

Graduate Theses, Dissertations, and Problem Reports (ETD)

With the 2016 Presidential election come and gone, political activism within the United States has garnered more attention as political actors on the Progressive Left oppose the actions of the new administration. The West Virginia progressive movement is used as a case study of the national push towards progressive politics. Using participant diaries and a series of longitudinal interviews, this thesis explores the creation of spaces belonging within an activist organization to foster sustained involvement. The analysis points to the importance of creating a sense of belonging and the desire to ‘strive for better’ in a state that is often …

Spatial And Temporal Analysis Of Surface Water Quality In Relation To Marcellus Shale Gas Development In The Northern Panhandle Of West Virginia, Rachel Yesenchak

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pre-existing water chemistry data available from the West Virginia Department of Environmental Protection were used to examine temporal changes in surface water quality related to the onset of Marcellus Shale gas drilling activity in the state of West Virginia. Drilling is concentrated in the northwestern portion of the state. Watersheds were delineated for twelve discrete stream sampling locations in the Upper Ohio-Wheeling HUC-8 sub-basin, where shale gas drilling is prevalent. Kruskal-Wallis tests were deployed to compare pre- and post-drilling concentrations of conductivity, chloride, and total suspended solids for each location. Increased concentrations of these parameters are associated with surface water …