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2018

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Molecular Simulations Of Voltage-Gated Proton-Selective Channel, Panisak Boonamnaj Jan 2018

Molecular Simulations Of Voltage-Gated Proton-Selective Channel, Panisak Boonamnaj

Chulalongkorn University Theses and Dissertations (Chula ETD)

Voltage-gated proton-selective channels (Hv1) are a membrane protein that permeates proton across cell membranes. They play an important role in various physiological processes. Hv1 was found as a dimer in membranes. Molecular mechanisms underlying the proton conduction of Hv1 have been a subject of intense research but is still remained unclear. In this study, molecular dynamics (MD) simulations of Hv1 were carried out to gain better understanding of the structure-function relationship. The first part of this thesis involved with an investigation of the role of the C-terminal domain (CTD) in stabilizing the dimer structure of Hv1. MD data showed the …

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Fluorescent Sensors From Salicylaldimine Derivatives For Metal Ions, Phoom Sangsuwan Jan 2018

Fluorescent Sensors From Salicylaldimine Derivatives For Metal Ions, Phoom Sangsuwan

Chulalongkorn University Theses and Dissertations (Chula ETD)

An in-situ forming and sensing was developed as a high-throughput screening of fluorescent chemosensors for metal ions. The 45 salicylaldimines, formed in-situ from the condensation between 5 salicylaldehydes and 9 amines, in 96 well-plates were photographed under black light along with the 5 salicylaldehydes in the absence and presence of 18 metal ions. The library of fluorescence response images of these 50 chemosensors were processed into RGB values. The PCA of theΔRGB, the differences between those of images with and without the metal ions, showed 9 sensors with normalized loading value over 70%. The sensor array constructed from these 9 …

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Hybrid Materials From Covalent Organic Frameworks And Ionic Liquids, Ranida Maliyaem Jan 2018

Hybrid Materials From Covalent Organic Frameworks And Ionic Liquids, Ranida Maliyaem

Chulalongkorn University Theses and Dissertations (Chula ETD)

Covalent organic frameworks (COFs) are new type material, whereby their wide range of properties derived from the chemistry of frameworks and their regular porosity. Here in, we reported the successful syntheses of the novel hybrid materials between porous COF material and ionic liquids (ILs). The crystalline porous powder of boroxine‑based COF, so called COF‑5, is reproducible via a condensation reaction between hexahydroxyltriphenylene and phenyldiboronic acid under a mild condition using a conventional heating method. The as‑synthesized COF-5 was characterized with PXRD, FT-IR, TGA and BET techniques, showing that the material contained 1D regular channels caused by π-π stacking of the …

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Detection Of Sulfonamide Residues By Paper Spray Mass Spectrometry, Surased Suraritdechachai Jan 2018

Detection Of Sulfonamide Residues By Paper Spray Mass Spectrometry, Surased Suraritdechachai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Sulfonamide antibiotics are commonly used veterinary drugs in livestock to prevent or treat infectious diseases. Their residues in food are of concern since they can cause adverse health effects and development of bacterial resistance. In this work, a practical method for detection and quantification of sulfamethazine, one of sulfonamide antibiotics, in pig body fluid samples is developed via the combination of simple extraction and paper spray mass spectrometry. The method required minimal sample preparation and low analysis time while providing high sensitivity and accuracies in pig whole blood (LOD = 10.1 ng/mL, %recovery = 95.4-104.1%), pig serum (LOD = 4.6 …

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Fabrication And Mechanical Properties Of Hyaluronic Acid Microneedle Arrays For Transdermal Drug Delivery, Teeranut Rutwaree Jan 2018

Fabrication And Mechanical Properties Of Hyaluronic Acid Microneedle Arrays For Transdermal Drug Delivery, Teeranut Rutwaree

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dissolvable microneedles have been widely investigated as an alternative of hypodermic injection or other drug delivery methods. Various polymers have been used to fabricate microneedles. Type of polymers affects mechanical properties and dissolution rate of microneedles. In this study, five formulations of hyaluronic acid (HA)/ polyvinylpyrrolidone (PVP) composite microneedle patches (HA/PVP at 100/0, 75/25, 50/50, 25/50, 0/100) were fabricated. The crosslinked HA microneedles were also fabricated. Mechanical properties of the obtained microneedles were determined by universal testing machine and durometer. The skin-penetration ability and dissolution rate of HA/PVP microneedles were also investigated using porcine skin. The results show that microneedle …

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Synthesis Of Halogenated Flavonoids As Anti-Dengue Agents, Thao Huynh Nguyen Thanh Jan 2018

Synthesis Of Halogenated Flavonoids As Anti-Dengue Agents, Thao Huynh Nguyen Thanh

Chulalongkorn University Theses and Dissertations (Chula ETD)

Flavonoids have been recognized as promising compounds with various bioactivities. Certain flavonoid derivatives exhibited more potent activities than their parent compounds. Recently, halogenated flavonoids have been addressed for their anti-dengue activity. In this research, a series of twenty-two brominated and iodinated flavonoid derivatives were synthesized and explored for dengue infection inhibition. Seventeen derivatives have been investigated for the first time. 8-Bromobaicalein, 6,8-dibromopinocembrin, 6,8-dibromopinostrobin, 6,8-diiodopinostrobin were disclosed as effective and non-toxic anti-dengue agents. These compounds displayed remarkably low EC50 as well as high CC50, which could be considered as potent therapeutic agents. Moreover, the preliminary screening on brominated O7-ether chrysins discovered …

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Benzimidazole Derivatives Of Perylene Diimide For Organic Field-Effect Transistor, Tianchai Chooppawa Jan 2018

Benzimidazole Derivatives Of Perylene Diimide For Organic Field-Effect Transistor, Tianchai Chooppawa

Chulalongkorn University Theses and Dissertations (Chula ETD)

The poor solubility of perylene derivatives has been a key factor that prohibits the application of these thermally stable compounds in organic field-effect transistors (OFET) devices. In this research, the effort to enhance the solubility and exploring FET property of benzimidazole derivatives of perylene diimide were investigated. The perylene diimide core structure was functionalized by aryloxy moieties. Unfortunately, the isomeric products were still poorly soluble in common organic solvents, which made them impossible to separate and purify. Thus, the synthetic plan and goal were completely revised to the benzotriazatruxene derivatives, which were highly soluble in organic solvents such as dichloromethane …

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Green Synthesis Of Gold Nanoparticles Using Natal Lily Crinum Moorei Extract And Biological Activities, Warinda Marujiwat Jan 2018

Green Synthesis Of Gold Nanoparticles Using Natal Lily Crinum Moorei Extract And Biological Activities, Warinda Marujiwat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Crinum moorei as medical herb has different pharmacological activities such as anti-cancer and anti-inflammatory properties. Gold nanoparticle (AuNP) is an interesting anti-cancer drug carrier which can solve anti-cancer drug's problems with good biocompatibility, non-toxicity and suitable size for the intracellular uptake to treat to the target cells. From the beginning, other reducing agents were used to synthesize AuNPs. However, they lead to the contamination of chemicals on AuNP's surfaces which limits the medical application or long process and time consuming. Therefore, plant extracts were studied to make a remarkable dual function: the synthesized AuNPs agent and drug agent. In this …

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Development Of Headspace-Solid Phase Microextraction And Gas Chromatography-Mass Spectrometry/Olfactometry For Analysis Of Volatile Compounds From Chicken Products, Wongkanok Yoosong Jan 2018

Development Of Headspace-Solid Phase Microextraction And Gas Chromatography-Mass Spectrometry/Olfactometry For Analysis Of Volatile Compounds From Chicken Products, Wongkanok Yoosong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Gas chromatography-mass spectrometry/olfactometry coupled headspace solid phase microextraction (HS-SPME-GC-MS/O) was applied to analysis of volatile compounds from raw chickens and boiled chickens. The HS-SPME was 50/30 mm DVB/CAR/PDMS. The extraction temperature of boiled chicken was 50 °C for 30 min and raw chicken were extracted at room temperature. The SPME Probes were analyzed by GC-MS with a HP-5MS capillary column. 16 volatile compounds were identified in the boiled chickens in four chemical classes including aldehydes, aromatic hydrocarbon, alcohols and ketones and 20 volatile compounds were identified in raw chickens in three chemical classes including aldehydes, alcohols and esters. The identification …

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Synthesis And Antidiabetic Activity Of Furofuran Lignans Containing Multiphenolic Groups, Titiruetai Doungwichitrkul Jan 2018

Synthesis And Antidiabetic Activity Of Furofuran Lignans Containing Multiphenolic Groups, Titiruetai Doungwichitrkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Synthesis of furofuran lignans containing multiphenolic groups (6-12) was carried out. The starting material samin (5) was obtained by acid hydrolysis of sesamin (2), which was isolated from sesame seed oil. A series of target lignans were synthesized from samin (5) and a varity of phenolics through Friedel-Crafts reaction, yielding desired products (6). To increase number of hydroxy moieties on the synthesized lignans, oxidative reaction using lead (IV) tetraacetate was performed. Removal of methylenedioxy of furofuran lignans containing a phenolic moiety produced unexpected products which contains para-quinone together with ortho-dihydroxy moieties on furofuran core structures (8-9). Consequently, to avoid oxidation …

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Analysis Of Cracked Body Repaired By Adhesively Bonded Patches By Bem-Fem Coupling, Binh Viet Pham Jan 2018

Analysis Of Cracked Body Repaired By Adhesively Bonded Patches By Bem-Fem Coupling, Binh Viet Pham

Chulalongkorn University Theses and Dissertations (Chula ETD)

This thesis presents an efficient numerical technique capable of handling the stress analysis of three-dimensional cracked bodies strengthened or repaired by adhesively bonded patches. The proposed technique is implemented within the framework of the coupling of the weakly singular boundary integral equation method and the standard finite element procedure. The former is applied to efficiently treat the elastic body containing cracks whereas the latter is adopted to handle both the adhesive layers and the patches. The approximation of the near-front relative crack-face displacement is enhanced by using local interpolation functions that can capture the right asymptotic behaviour. This also offers …

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The Relationship Of Influential Factors On Material Management Effectiveness In Building Construction Projects: Case Study In Vietnam, Bao Van Pham Jan 2018

The Relationship Of Influential Factors On Material Management Effectiveness In Building Construction Projects: Case Study In Vietnam, Bao Van Pham

Chulalongkorn University Theses and Dissertations (Chula ETD)

The improvement of management processes in construction could be seen as one of the important keys to project success in which material management should be appropriately taken into consideration. Although many previous research studies have examined the components of construction material management, the relationship of factors influencing material management effectiveness has not been explored. This study was carried out to identify influential factors on material management effectiveness and develop a model to explain the relationships between these factors and the effectiveness of material management based on practical projects. The research method included the collection of contractors' opinions in building projects …

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Sbfe Analysis Of Layered Elastic Media With Consideration Of Surface Energy Effect, Chantha Chhuon Jan 2018

Sbfe Analysis Of Layered Elastic Media With Consideration Of Surface Energy Effect, Chantha Chhuon

Chulalongkorn University Theses and Dissertations (Chula ETD)

This thesis presents an efficient and accurate numerical technique for determining mechanical response of a two-dimensional, infinite, elastic, layered medium under arbitrary surface loading and surface stress effects. Governing equations of a generic bulk layer are formulated from the classical linear elasticity theory via a SBFE technique whereas those of the generic material surface are obtained from a full version of Gurtin-Murdoch surface elasticity theory. The formulation is established sufficiently general allowing both homogenous and functionally graded bulk materials to be treated for each layer. By enforcing the continuity at the interface of the material surface and the bulk, it …

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Compression Behavior Of Fire-Damaged Concrete-Filled Steel Tubular Columns Confined With Fiber-Reinforced Polymer Sheets, Dat Thanh Vu Jan 2018

Compression Behavior Of Fire-Damaged Concrete-Filled Steel Tubular Columns Confined With Fiber-Reinforced Polymer Sheets, Dat Thanh Vu

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research investigates the axial compression behavior of fire-damaged circular concrete-filled steel tube (CFST) stub columns externally confined with fiber-reinforced polymer (FRP) sheets. A total of 38 CFST specimens were tested under axial compression to investigate the load capacity, ductility, stiffness and failure mode of fire-damaged CFST columns before and after strengthening with FRP sheets. The test variables include the level of fire damage (no damage and 2-hour ISO standard fire), compressive strength of infill concrete (24MPa and 55MPa), type of FRP sheets (carbon and glass), and the number of FRP layers (0, 1, and 2 layers). The test results …

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A Bim-Database-Integrated System For Evaluating Building Life-Cycle Costs Using A Multi-Parametric Model, Hang Thi Thu Le Jan 2018

A Bim-Database-Integrated System For Evaluating Building Life-Cycle Costs Using A Multi-Parametric Model, Hang Thi Thu Le

Chulalongkorn University Theses and Dissertations (Chula ETD)

Life-cycle cost analysis (LCCA) has become an essential requirement of the sustainable procurement for many construction projects. Conventional building LCCA methods are extremely complex and time-consuming due to repetitive works, numerous required data, scattered data inputs, and various regulatory requirements, which subsequently lead to inaccurate building life-cycle costs (LCC). Building information modeling (BIM) offers a revolutionary information technology, which can overcome the asperities of the conventional building LCCA. This research develops the BIM-database-integrated system for evaluating building life-cycle costs using a multi-parametric model (BIM-BLCC). The BIM-BLCC consists of four interrelated modules. The relational database management module collects and organizes the …

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Improved Response Spectrum Analysis Procedure For Design Of Reinforced Concrete Tall Buildings, Kimleng Khy Jan 2018

Improved Response Spectrum Analysis Procedure For Design Of Reinforced Concrete Tall Buildings, Kimleng Khy

Chulalongkorn University Theses and Dissertations (Chula ETD)

Response spectrum analysis (RSA) procedure commonly used in design practice has been found to underestimate design forces in tall buildings. Failure and damage of reinforced concrete (RC) shear walls in mid-rise and high-rise buildings have been observed in recent earthquakes. In this dissertation, a modified RSA (MRSA) procedure to compute shear forces and strains in RC walls and columns to identify locations requiring ductile detailing was proposed. Six tall RC shear-wall buildings of 15 to 39 stories and four RC moment-frame buildings of 3 to 15 stories subjected to earthquake ground motions expected in Bangkok and Chiang Mai were first …

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Development Of Causal Relationship Model Of Knowledge Sharing In Construction Projects, Lambada Roeun Jan 2018

Development Of Causal Relationship Model Of Knowledge Sharing In Construction Projects, Lambada Roeun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Knowledge sharing among construction project members is very crucial for improving project success and project performance. It can also reduce mistakes in the construction process. Project management has been growing more complicated, and project members need to learn best practice from others. Currently, knowledge sharing is not well performed yet; especially, few research studies have been focused on the relationship evaluation of supporting factors that affect knowledge sharing from different contexts in construction projects. Therefore, this study aims to develop the causal relationship model of supporting factors from psychological, individual, organizational, and technological factors that affect mediators - knowledge sharing …

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The Influences Of Granite Particle As A Mixing Material Of High-Strength Concrete, May Thazin Khine Jan 2018

The Influences Of Granite Particle As A Mixing Material Of High-Strength Concrete, May Thazin Khine

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aim of this study is to investigate the effect of granite particle on the properties of high strength concrete by the partial substitution as fine aggregate. By grouping two categories as concrete with and without admixture is also performed in this experiment. The granite particle substitution percentage for concrete with admixture is set with 0%, 20%, 30%, 40% and 50% by weight of fine aggregate and 0%, 10%, 15% and 20% by weight of fine aggregate for concrete without admixture. The testing of concrete strength is conducted with compressive, split tensile, flexural, water permeability, and microstructure. The result shows …

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Geophysical Site Investigation And Ground Response Analysis Of Bangkok Subsoil Due To Earthquake, Muhammad Fatih Qodri Jan 2018

Geophysical Site Investigation And Ground Response Analysis Of Bangkok Subsoil Due To Earthquake, Muhammad Fatih Qodri

Chulalongkorn University Theses and Dissertations (Chula ETD)

The potential damages on building and infrastructure could be affected by long-distance earthquakes since the vibrations can appear ground motion amplification during the wave propagation. Bangkok urban area is located a hundred kilometers away from the potential area of the earthquake epicenter. However, some people in Bangkok could feel the shaking during the earthquake. It indicates that the long-period shaking could happen during the earthquake. In line with this phenomenon, this study aims to interpret the amplification effect and spectral acceleration in the local site of Bangkok due to remoted earthquakes. The microtremor measurement was conducted at four locations in …

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Nonlinear Finite Element Analysis Of Steel Pipe With Stiffener Plate, Rut Su Jan 2018

Nonlinear Finite Element Analysis Of Steel Pipe With Stiffener Plate, Rut Su

Chulalongkorn University Theses and Dissertations (Chula ETD)

This thesis presents the numerical studies of steel hollow section columns connected to corbels under industry crane loads, and the stiffening design using steel plates to enhance the maximum loading capacity against premature local buckling failures. The influences of inelastic material properties and geometry nonlinearity on the overall load carrying capacity of the columns were considered. Square hollow section columns were modelled in 3D using standard eight-node solid finite elements using an ANSYS software. The plate stiffener design algorithm involving variation of plate thicknesses was coded in MATLAB with a direct application programming interface to ANSYS. The full history of …

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Mechanical Performances Of Concrete Beams With Hybrid Usage Of Steel And Frp Reinforcement, Linh Van Hong Bui Jan 2018

Mechanical Performances Of Concrete Beams With Hybrid Usage Of Steel And Frp Reinforcement, Linh Van Hong Bui

Chulalongkorn University Theses and Dissertations (Chula ETD)

Fiber-reinforced polymer (FRP) bars have been recently employed to reinforce concrete members due to their high tensile strength and especially in corrosive environments to improve the durability of concrete structures. However, FRP composites have a low modulus of elasticity and a linear elastic behavior up to rupture, thus reinforced concrete (RC) components with such materials would express a lack of ductility. In order to increase the mechanical performances of RC beams, the hybrid usage (also called combined usage) of FRP and steel reinforcements in shear and flexure is proposed. At first, an experimental investigation of concrete beams strengthened in shear …

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Strengthening Of Shear Critical Reinforced Concrete Columns By Steel-Rod Collars, Phawe Suit Theint Jan 2018

Strengthening Of Shear Critical Reinforced Concrete Columns By Steel-Rod Collars, Phawe Suit Theint

Chulalongkorn University Theses and Dissertations (Chula ETD)

The inadequate shear strength of the existing old reinforced concrete columns located in the seismically active areas can lead the catastrophic shear failure. In this study, strengthening of shear-critical reinforced concrete columns by the steel-rod collar method is investigated. This proposed method is less intrusive to the existing building components. The steel-rod collar comprises the four sets of welded steel angles connected by steel-rods threaded at the ends. The three specimens were divided into one unstrengthened column, and the two strengthened columns. All the specimens were tested under the constant axial load and the reversed cyclic loadings. In addition, the …

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Habal-Habal: Characteristics Of Motorcycle Taxi Users In Metropolitan Manila, Sebastian Mapili Cano Jan 2018

Habal-Habal: Characteristics Of Motorcycle Taxi Users In Metropolitan Manila, Sebastian Mapili Cano

Chulalongkorn University Theses and Dissertations (Chula ETD)

Motorcycle taxi services in the Philippines (locally referred to as habal-habal) has been deemed to be operating only in rural areas wherein public transportation is inadequate or is utterly absent. It is also perceived as illegal and unsafe for urban operations, especially in a conurbation like Metro Manila wherein more than 30% of recorded fatal road accidents come from motorcycles. However, the worsening traffic congestion in the metropolis has spurred its growing urban presence and has led the attention of commuters to alternative modes of transport that are fast, reliable, and affordable. Inadequate understanding of habal-habal's role in the urban …

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Risk Management Of Public-Private Partnership (Ppp) Infrastructure Projects In Laos, Siamphone Maneevong Jan 2018

Risk Management Of Public-Private Partnership (Ppp) Infrastructure Projects In Laos, Siamphone Maneevong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Public-private partnership (PPP) is a popular option of project delivery and contractual scheme between the public and private sectors public infrastructure projects. Many factors contribute to the success of PPP projects, most of which are country-specific. Since Laos has recently adopted PPP for several infrastructure projects, all stakeholders must understand the critical risks that influence the performance of PPP projects. In this research, we identify, evaluate and rank the critical risk factors and risk categories that affect the PPP project development of in Laos. The questionnaire survey and In-depth interviews were used to gather information from nine respondents, who represent …

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A Study Of Applying Para Rubber Sheets In Railway Track By Using Ballast Box Test, Somkith Dethvongsone Jan 2018

A Study Of Applying Para Rubber Sheets In Railway Track By Using Ballast Box Test, Somkith Dethvongsone

Chulalongkorn University Theses and Dissertations (Chula ETD)

Recently, attempts to reduce ballast degradation have been a major topic for many railways and researchers. Nowadays, a successfully proven alternative is applied elastic under-sleeper pads in between sleeper and ballast particles, and also as the ballast mat placed under the ballast layer. The using of synthetic material as the elastic element is able to decrease the deterioration of ballast and vibrations. Para rubber is a natural elastic material and it is abundant in South East Asia countries. Therefore, this study is aimed to investigate using para rubber as an alternative element of reducing ballast breakage in ballasted track. Experiments …

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Poroelastodynamic Solutions Of Transversely Isotropic Multi-Layered Media, Suraparb Keawsawasvong Jan 2018

Poroelastodynamic Solutions Of Transversely Isotropic Multi-Layered Media, Suraparb Keawsawasvong

Chulalongkorn University Theses and Dissertations (Chula ETD)

This dissertation presents poroelastodynamic fundamental solutions of transversely isotropic poroelastic materials. Analytical general solutions for transversely isotropic poroelastic media under time-harmonic loading are derived for plane strain and axisymmetric problems by applying Fourier and Hankel integral transforms respectively. The fundamental solutions for a homogeneous half-space are then explicitly obtained by solving relevant boundary value-problems based on the derived general solutions. An exact stiffness matrix method is also employed based on the present general solutions to determine the fundamental solutions corresponding to multi-layered transversely isotropic poroelastic media. The obtained fundamental solutions are then employed in the analysis of dynamic interaction problems …

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Analysis And Optimum Design Of Cold-Formed Steel Arch Structures, Thu Huynh Van Jan 2018

Analysis And Optimum Design Of Cold-Formed Steel Arch Structures, Thu Huynh Van

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research presents the development of a unified framework for cold-formed steel warehouse design at variations of clear roof spans. The work involves the advanced finite element analyses of nonlinear arch-shape warehouse structures, namely one that considers 2nd-order nonlinear geometry effects-sufficiently accurate approximation of large deformation responses. An optimum design procedure of 3D arch steel warehouse structures is conducted with the help of a novel algorithm, called mixed ESO-PSO approach. The generic idea is based on the implementation of a well-known evolutionary structural optimization algorithm (ESO), and further integrates a mapping, underpinning particle swarm optimization (PSO), technique of design variables …

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The Effect Of Nac And Carnosine On Alzheimer’S Disease-Related In Vitro Model Through Rage-Age Signaling Pathway, Suphasarang Sirirattanakul Jan 2018

The Effect Of Nac And Carnosine On Alzheimer’S Disease-Related In Vitro Model Through Rage-Age Signaling Pathway, Suphasarang Sirirattanakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Alzheimer’s disease (AD) is the most common dementia which found increasing with age. It involves neurodegeneration which leads to various abnormalities especially memory loss, inability to learn new things, lack of creativity, lack of decision making ability, lack of critical thinking, calculation inability, inability to live normal daily life, inability to recognize person, time and place, emotional disturbance, and difficulty to use language. Since AD has severe impact in various aspects on both the patients and their families, so we are interested to study the neurodegenerative mechanism when neuronal cells are under oxidative stress which will induce neuroinflammation through the …

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Effect Of Ercc1, Xrcc1 And Gstp1 Polymorphisms On Clinical Response And Adverse Events Of Platinum-Based Chemotherapy In Epithelial Ovarian Cancer Patients, Salisa Liblab Jan 2018

Effect Of Ercc1, Xrcc1 And Gstp1 Polymorphisms On Clinical Response And Adverse Events Of Platinum-Based Chemotherapy In Epithelial Ovarian Cancer Patients, Salisa Liblab

Chulalongkorn University Theses and Dissertations (Chula ETD)

Platinum-based chemotherapy is the first line chemotherapy regimen for epithelial ovarian cancer (EOC). Pharmacogenomics is one factor that might affect its efficacy and toxicity. This cohort study was aimed to investigate the association between ERCC1, XRCC1 and GSTP1 polymorphisms on clinical responses and adverse events related to platinum-based chemotherapy in Thai EOC patients. Fifty-two patients with advanced EOC were enrolled in this cohort study. The mean age was 55.7 years old. Genotyping analysis of ERCC1 (C>A, rs3212986), XRCC1 (A>G, rs25487) and GSTP (A>G, rs1695) were performed which allele frequencies were found at 35.6%, 28.9% and 10.6%, respectively. …

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Adverse Events Of Antiretroviral Prophylaxis Regimen For Elimination And Prevention Of Mother-To-Child Transmission Among Hiv-Exposed Infants, Suvaporn Anugulruengkitt Jan 2018

Adverse Events Of Antiretroviral Prophylaxis Regimen For Elimination And Prevention Of Mother-To-Child Transmission Among Hiv-Exposed Infants, Suvaporn Anugulruengkitt

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Triple-drug antiretroviral prophylaxis of zidovudine (ZDV)/lamivudine (3TC)/nevirapine (NVP) for high risk HIV-exposed neonates is recommended within the Thai national program. However, there are limited data about the safety and drug concentration achieved with this regimen initiated at birth.
Objectives: This study aims to evaluate the safety of this triple drug neonatal prophylaxis regimen and to describe nevirapine concentration levels during the first 4 weeks of life.
Methods: A prospective cohort of HIV-exposed infants was conducted at 5 clinical sites in Thailand. We enrolled 100 high-risk HIV-exposed neonates (maternal HIV RNA >50 copies/mL prior to delivery or received antiretroviral therapy …

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