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A Multifactorial Cytochrome P450 2d6 Genotype-Phenotype Prediction Model To Improve Precision Of Clinical Pharmacogenomic Tests, Rachel Dalton

Graduate Student Theses, Dissertations, & Professional Papers

BACKGROUND: CYP2D6 is difficult to accurately genotype due to a large number of single nucleotide variants (SNVs), indels, and structural variation such as deletions, duplications, and CYP2D6/CYP2D7 hybrid genes. CYP2D6 targeted genotyping panels are of limited utility; clinically relevant variants that are not genotyped will be missed. Sequencing solves this problem but requires additional tools to address structural variation. The goal of our study was to determine the predictive power of Stargazer, a novel allele-calling program, which combines SNV/indel calls with structural variation identification.

METHODS: In a panel of 309 human livers, CYP2D6 diplotypes and activity scores were initially assigned …

Evaluation Of A Web-Based Performance Program For Wildland Firefighters, José M. Peña Cueto

Graduate Student Theses, Dissertations, & Professional Papers

Introduction: In an effort to increase work capacity and reduce occupational injury rates and mortality rates among wildland firefighters, a web-based performance program named The Black was developed. The training program was designed to provide evidence-based training specific to wildland firefighters’ needs.

Purpose: A formative and process evaluation of the program was conducted to study the user rates, and user’s attitudes and preferences regarding the program during the pilot of its first phase.

Methodology: A sequential mixed-methods design was utilized for this evaluation. Qualitative interviews were conducted with firefighters who attended an introductory seminar. Interview data was utilized by program …

Engaging Native Americans With The Athletic Training Profession, John R. Sunchild

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

Beaches Without Sand, Connor Mcelwee

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

Examining Injury Data Reporting Practices Among Wildland Firefighters, Erin M. Boggs

Graduate Student Theses, Dissertations, & Professional Papers

Wildland Firefighter (WLFF) Crews lack an injury surveillance program to collect information on non-traumatic and traumatic injuries. Tactical athletes including: police, military and structural firefighters all have a variety of collection systems in place for injury data collection. The lack of injury data prevents WLFF crews from identifying high-risk environments, implementing injury prevention programs, and improving the overall quality of care on the job. Over the last several decades the recent rise in wildfire occurrences and wildfire suppression costs creates a need for healthy and strong individuals in the field. The cost of firefighter salaries and medical care can be …

Examining Upper Extremity Injuries In Male Baseball Players Between The Ages Of 14 To 22 Years Old, James T. Yancy

Graduate Student Theses, Dissertations, & Professional Papers

Yancy, James T. (J.T.), MAT., May 2018 AthleticTraining

Examining Upper Extremity Injuries In Male Baseball Players Between The Ages Of 14 To 22 Years Old

Chairperson: Melanie McGrath

The number of upper extremity injuries is increasing in advanced baseball (14 to 22 years old) at an alarming rate. The length of seasons, multiple leagues and the velocity of throwing in overhead sports are the most common causes of elbow and shoulder injuries. In addition, biomechanical variables also influence the risk of injury. Any alteration in range of motion (ROM) directly impacts the biomechanics of overhead activities, such as pitching or …

The Role Of Bipolar Disorder, Stigma, And Hurtful Messages In Romantic Relationships, Callie Parrish

Graduate Student Theses, Dissertations, & Professional Papers

This study explores hurtful messages received by individuals diagnosed with bipolar disorder I/II from their romantic partners. Close romantic relationships present opportunities for the utterance of hurtful messages, and the stigmatization that accompanies a mental health diagnosis could affect the attributions made surrounding hurtful messages. By applying attribution theory, the current study increases understanding of how individuals with bipolar disorder experience and attribute hurtful messages. Participants (N = 99) were adults diagnosed with bipolar disorder who had received a hurtful message from their romantic partner. Data was collected via online surveys comprised of Likert scales and short answer questions. …

Characterization Of Tetraethyl Orthosilicate-Based Dynamic Hydrogels For Use As Reversible 3-D Cell Culture Matrices, Krisitan Stipe

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

The Psychological And Physiological Effect Of Performing The Primal Reflex Release Technique On Female, Division I Collegiate Athletes, Erika K. Vichcales

Graduate Student Theses, Dissertations, & Professional Papers

Anxiety is a cognitive, behavioral, and physiological reaction to stress, and athletes have an increased risk being in a high-stress environment. One of the effects of increased stress on the body is a condition known as central sensitization (CS) where the central nervous system amplifies sensory input across many organ systems causing a pain response in normally non-painful areas or hypersensitivity to stimuli. The Primal Reflex Release Technique (PRRT) is a manual-therapy approach for evaluating and relieving musculoskeletal pain in patients, and is meant to facilitate a “neural reboot” of a hyper-aroused nervous system. The purpose of this study is …

Personality And Mental Health Support Effects On Occupational Trauma And Posttraumatic Growth In Police Officers, Jennifer Leigh Wills

Graduate Student Theses, Dissertations, & Professional Papers

Purpose: The purpose of this study is to investigate relationships between occupational trauma exposure, work environment stress, personality traits, posttraumatic stress, and posttraumatic growth in police officers.

Scope of the study: A cross sectional mixed method research study design with longitudinal component was utilized. The sample consisted of 109 police officers in approximately 13 police agencies from multiple communities ranging from small rural departments to major city and statewide agencies.

Instruments used: The California Psychological Inventory 434 (CPI-434); the Police Stress Questionnaire-Operational; the Police Stress Questionnaire-Organizational; the Critical Incident History Questionnaire; the Posttraumatic Checklist for the DSM-5; the Centrality of …

Determining Skin Temperature Differences Between Three Cold Compression Modalities, Madison S. Mccarthy

Graduate Student Theses, Dissertations, & Professional Papers

Background: Cold and compression are common therapeutic interventions used in the treatment of acute musculoskeletal injuries. Cryotherapy uses extreme cold to decrease cell metabolism and pain following injury. Compression works to decrease overall blood flow and control edema. The benefit of combining cold and compression is to increase the rate and depth of the temperature drop, while utilizing the effects of both modalities. Purpose: The objective of this study was to determine if a crushed ice pack was as effective as newer cold compression technology to decrease skin temperature. A crushed ice pack was compared to the PowerPlay and Game …

Examining The Impact Of Adding Gluteal Strengthening Exercises To The Fifa 11+ Warm-Up Program On High School Girls' Basketball Reported Injuries., Heather Bartz

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

A Risk/Benefit Analysis And Prescription Optimization For Integrating High-Intesity Interval Training Into Cardiopulmonary Rehabilitation Programs, Matt C. Chapman

Graduate Student Theses, Dissertations, & Professional Papers

Aerobic exercise is an effective solution for improving mortality rates and physical outcomes in patients with cardiovascular disease (CVD). There is a controversy, however, in the research literature over what type of training modality produces the best results. High-intensity interval training (HIIT) has emerged as a promising alternative to moderate-intensity continuous training (MCT), which is typically used to treat cardiovascular ailments. Currently, there is no consensus on the ideal HIIT prescription that would produce optimal benefits for patients, however. The goal of this review is to clarify whether HIIT provides either superior or equivalent outcomes in mortality, cardiac autonomic control, …

Exercise Program To Modify Risk Factors For Shoulder Injury In Collegiate And Professional Pitchers, Rina Kasuga

Graduate Student Theses, Dissertations, & Professional Papers

Upper extremity injuries are very common in collegiate and professional baseball pitchers. Approximately 60% of all injuries in collegiate baseball are due to throwing, and pitchers suffer over 70% of throwing-related injuries. In Major League Baseball (MLB), about 50% of players on the disabled list were pitchers, and the injury rate for pitchers is 34 % higher than position players. Therefore, there is a significant need for injury prevention programs to effectively reduce injuries in the population. Although numerous research has been devoted to the study of risk factors and treatment of baseball-related injuries in youth and adolescent players, there …

Finding Home After Fallout: The Future Of Fukushima's Forests, Katy N. Spence

Graduate Student Theses, Dissertations, & Professional Papers

This long-form journalistic piece is about radioactive forests in Yamakiya, Fukushima Prefecture, Japan, and how locals are dealing with it. Residents of Yamakiya were forced to evacuate their village in April 2011 following an explosion at the Fukushima Daiichi nuclear plant.

One Yamakiyan, Hidekatsu Ouchi, stepped into the role of community leader and is the focus of this story. He hopes Yamakiya can use the radiation, rather than condemning it. Ouchi’s devotion to his community is connected to the Japanese concept of furusato, which refers to an individual’s obligation and nostalgia for family, community and place. The story asserts …

The Introduction Of Yoga Recovery On Physiological And Psychological Stress And Performance In Ncaa Athletes, Paige D. Schober

Graduate Student Theses, Dissertations, & Professional Papers

NCAA student athletes face unique physiological and psychological stressors daily, which may contribute to overtraining, burnout, and other physical and mental health issues. However, NCAA institutions often leave recovery up to the individual athlete due to time restriction and Countable Athletic Related Activities (CARA) hour limitations on team mandated activities. Attention to methods to promote recovery from these training loads is increasing in NCAA institutions. A mind-body activity such as yoga is proposed to have physiological and psychological benefits for student athletes. The goal of this review is to identify which aspects of yoga promote the most effective recovery in …

The Battle Of The Little Bighorn Gunshot Trauma Analysis: Suicide Prevalence Among The Soldiers Of The 7th Cavalry, Genevieve M. Mielke

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

Chipping Through Time: The Evolution Of Lithic Spatial Organization At The Bridge River Pithouse Village, British Columbia, Ethan P. Ryan

Graduate Student Theses, Dissertations, & Professional Papers

Archaeological investigations at Housepit 54 within the Bridge River site have, to date, exposed 15 discreet floors primarily dating to ca. 1500-1000 cal. B.P. In this thesis, the spatial distributions of lithic artifacts from every floor are examined. Questions will be addressed specifically towards formation processes and the potential relationships between the patterning of lithic distributions as they relate to hearth-centered activity areas or domestic areas and fluctuations in estimated population. In addition, this thesis explores spatial organization as a cultural trait or concept that can be transmitted through time. Using the same methodological and theoretical approach for each floor, …

Facies Architecture And Controls On Reservoir Behavior In The Turonian Wall Creek Member Of The Frontier Formation, Powder River Basin, Wyoming, Nathan M. La Fontaine

Graduate Student Theses, Dissertations, & Professional Papers

Inter-well heterogeneities influencing fluid migration in deltaic reservoirs are controlled by lateral lithofacies changes and vertical complexities such as low permeability thin-beds. Subsurface tools often cannot predict the spatial and stratigraphic organization of these architectural elements, nor their influence on effective reservoir properties and connectivity. This study integrates sedimentological, stratigraphic, and fluid simulation data to 1) document the facies architecture and depositional evolution of the Turonian Wall Creek Member (WCM) of the Frontier Formation, and 2) quantify the role of multi-scale stratigraphic heterogeneity on reservoir behavior. Upscaled permeability properties derived from fluid simulation of nested, small-scale facies models condition the …

Lit, Tyler Brumfield

Graduate Student Theses, Dissertations, & Professional Papers

LIT investigates the power of our daily visual interactions with commercial signage. The exhibition is comprised of ten individual illuminated constructions that appropriate the aesthetic strategies and design elements from commercial signage. The work offers the viewer a new aesthetic experience by nullifying the communicative and directional agendas that would normally accompany commercial signage. The viewer is free to see and experience the captivating nature of formal elements such as shape, color and light. The work explores the intersection of appropriation, minimal aesthetics and everyday experiences.

Home Is Where The Food Is: Causes And Consequences Of Partial Migration In Elk, Kristin Jennifer Barker

Graduate Student Theses, Dissertations, & Professional Papers

Migratory and non-migratory ungulates often coexist in partially migratory populations, but the mechanisms that drive and maintain different migratory behaviors within the same herd are poorly understood. In western North America, increasing numbers of elk (Cervus canadensis) reside on low-elevation winter range year-round. These residents can cause issues associated with crop damage, potential for disease transmission to livestock, and reduced effectiveness of harvest management strategies. Because migrants transfer nutrients, alter carnivore distributions, and structure vegetative communities across seasonal ranges, reductions in migratory behavior raise ecological as well as management-related concerns. This work investigated the factors affecting migratory behavior …

Impacts Of Vegetation Growth On Reach-Scale Flood Hydraulics In A Sand-Bed River And The Implications For Vegetation-Morphology Coevolution, Samuel Box

Graduate Student Theses, Dissertations, & Professional Papers

Vegetation affects river morphology via plant effects on the flow field, sediment transport and deposition, and substrate erodibility. Changes in the flow field caused by above-ground biomass mediate geomorphic response to flooding and habitat suitability for vegetation growth. Using numerical hydraulic models that incorporate drag due to spatially heterogeneous vegetation, I quantify how changes in the antecedent characteristics of woody vegetation in the active channel lead to changes in local bed shear stress, reach-average bed shear stress, and the vegetative component of reach-average total shear stress. Flood hydraulics in turn affect channel morphology and vegetation, providing a feedback mechanism by …

A Decade Of Governing The Blackfoot Community Conservation Area (Bcca): Community Involvement And Landscape Connectivity Through Public Private Partnerships, Alexander A. Barton

Graduate Student Theses, Dissertations, & Professional Papers

In recent decades, non-governmental organizations have acquired and established community forests and conservation areas in the U.S. However, there have been few empirical studies on their governance. This study focuses on the Blackfoot Community Conservation Area (BCCA) in the Blackfoot watershed of Montana, created in 2005. The BCCA is a 41,000 acre mosaic of private, state, and federal lands, including 5,600 acres known as the “Core” located near Ovando mountain and owned by the Blackfoot Challenge, a local watershed organization and leader in grassroots conservation. This research examined the definitions, activities and lessons learned over the past decade with regard …

Matrix Of Community, Shelby A. Hanson

Graduate Student Theses, Dissertations, & Professional Papers

ma·trix noun

Origin: Latin

Matter - Matrix - Matrix

Matr- Breeding Female Womb

1. An environment or material in which something develops,

a surrounding medium or structure.

2. A mold in which something is cast or shaped.

3. A rectangular array of quantities or expressions in rows and

columns that is treated as a single entity and manipulated according to particular

rules.

Wildfire Risk Perception And Homeowner Mitigation: Evidence From Montana, Madison G. Nagle

Graduate Student Theses, Dissertations, & Professional Papers

Fire prevention managers find that homeowners often do not perform mitigation actions that could reduce the damage and spread of wildfire. There is widespread belief among these fire professionals that one of the primary reasons that homeowners do not perform mitigation actions is that homeowners misperceive the risk that wildfire poses. Thus, a significant component of fire prevention programs’ focus on increasing homeowner awareness of the risk. However, it is possible that homeowners are aware of the fire risk but choose not to mitigate because of a variety of reasons, to include the costs of mitigation, limited monetary liability that …

Differential Decomposition Rates Of Non-Human Remains With The Facilitation Of Sodium Hydroxide In Dissimilar Deposition Environments, Hayley Savage

Graduate Student Theses, Dissertations, & Professional Papers

Dissolving bodies is a contemporary method of disposing human remains and has been practiced throughout the years. In popular media, criminals attempt to dispose of their victims by using various chemicals to dissolve the corpses. There is an immense gap in the literature pertaining to this research, so this present study aims to combat the lack of information on the topic. This research investigates the effects of sodium hydroxide (NaOH), generally known as lye or caustic soda, a common household chemical, on human tissues and bone by using an animal analogue (domestic pig, Sus scrofa domesticus). Four dissimilar deposition environments …

The Biophysical And Biochemical Impacts Of Forest Disturbances Across Ecosystems, Leila Ann Cooper

Graduate Student Theses, Dissertations, & Professional Papers

Forest disturbances result in numerous impacts on ecosystem services. In the western United States, disturbances such as wildfires and bark beetle outbreaks have resulted in millions of hectares of dead trees. Despite the potential for these events to have significant climatic impacts, it remains a challenge both to effectively locate and characterize disturbance events across landscapes, and to identify the disturbance biophysical and biochemical impacts. The objective of my dissertation research was to improve the ways in which we locate and classify forest disturbances over large areas, as well as to increase our understanding of disturbance biophysical and biochemical impacts …

The Effect Of Academic Advisor Type On Undergraduate Student Retention, Brian Patrick French

Graduate Student Theses, Dissertations, & Professional Papers

This study was designed to examine the effect of academic advisor type on retention of first-year, full-time, four-year degree-seeking students at a mid-size research university in the western U.S., while controlling for several predictor variables identified in contemporary and seminal literature as having a potential impact on student retention. Predictor variables are: socioeconomic status, first generation in family to attend college, high school grade point average, first semester grade point average, and enrollment in developmental coursework.

In the study, a binary logistic regression model was employed to determine whether academic advisor type had a statistically significant effect on the probability …

The Formation Of A Citizen-Police Encounter And Its Effect On Dispositional Outcomes For Traffic Stops In A City And County Jurisdiction, Darby A. Semenza

Graduate Student Theses, Dissertations, & Professional Papers

This research extends Donald Black’s (1976) theory of law to a large, more diverse sample of traffic stops than previous research. The theory suggests that with every citizen-police encounter, there is social distance separating the two parties. This distance is based on observable characteristics of both the officer and citizen involved. Specifically, their gender, age, race, demeanor, and whether they differ across these variables or not. A large difference in “social distance” increases the likelihood that an officer will cite a motorist; while a small distance reduces this likelihood. Social distance is the amount of diversity between two parties in …

Healing Self And Community: Living Pluralism In The Anishinaabe Paradigm, Andrea A. Fitzpatrick

Graduate Student Theses, Dissertations, & Professional Papers

Abstract: Healing Self and Community: Living Pluralism in The Anishinaabe

This thesis is a study of pluralism through Anishinaabe writers Winona LaDuke, Basil Johnston, Lynn Anderson, and others, focusing on their perceptions and pedagogies and how those perceptions inform pluralistic living. Anishinaabe methodology tends to be innately interconnected, and pluralistic. As such, it can enlighten, heal self-identity structures, and perceptions of the biosphere. I will contextualize how it is necessary to investigate the stories we learn and those we tell, how it is vital to understand where they come from. Included is analysis of how pluralism shows up in mine …