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Dose Analysis Of Gadolinium Neutron Capture Therapy (Gdnct) On Cancer Using Shield-Hit12a, Fasni Bagus Novrianto, Sardjono Yohannes, Lapanporo Boni Pahlanop

ASEAN Journal on Science and Technology for Development

This research aimed to determine the dose of radiation received in cancer therapy for each decay of Gadolinium atomic nuclei with isotope 157 (157Gd) in Gadolinium Neutron Capture Therapy using the SHIELD-HIT12A program. Knowing the amount of dose given to cancer tissue should aid in minimizing the damage that could occur in the healthy tissue around the cancer tissue, effectively killing only the cancer cells. The simulation employed in this research used the SHIELD-HIT12A program by providing input on beam.dat, mat.dat, detect.dat, and geo.dat files. The output data from the program comprised the value of recoil energy lost (energy absorbed …

Analysis Of Radiation Interactions And Biological Effects For Boron Neutron Capture Therapy, Chiang Ren-Tai

ASEAN Journal on Science and Technology for Development

The direct and indirect ionizing radiation sources for boron neutron capture therapy (BNCT)are identi?ed. The mechanisms of physical, chemical and biological radiation interactions for BNCT are systematically described and analyzed. The relationship between the effect of biological radiation and radiation dose are illustrated and analyzed for BNCT. If the DNAs in chromosomes are damaged by ion- izing radiations, the instructions that control the cell function and reproduction are also damaged. This radiation damage may be reparable, irreparable, or incorrectly repaired. The irreparable damage can result in cell death at next mitosis while incorrectly repaired damage can result in mutation. Cell …

Dose Analysis Of In Vitro And In Vivo Test For Boron Neutron Capture Therapy (Bnct), Faqqiyyah Hamidatul, Sunarno Sunarno, Akhlis Isa, Sardjono Yohannes

ASEAN Journal on Science and Technology for Development

The purpose of this study was to determine the in vitro and in vivo doses of boron neutron capture cancer therapy (BNCT) using the SHIELD-HIT12A program. To be able to determine the recoil energy, the research was conducted using the Monte Carlo method. Running data obtained the value of ionization activity and recoil lost. The results showed that in vitro and in vivo doses of BNCT for soft tissue irradiation had a value of 0.312 × 10-2 Sv, which is safe and does not harm healthy body tissue around the cancer cells because it is below the threshold of 1.5 …

Beam Shaping Assembly Optimization For Boron Neutron Capture Therapy Facility Based On Cyclotron 30 Mev As Neutron Source, Fauzi Arief, Tsurayya Afifah Hana, Harish Ahmad Faisal, Wijaya Gede Sutresna

ASEAN Journal on Science and Technology for Development

A design of beam shaping assembly (BSA) installed on cyclotron 30 MeV model neutron source for boron neutron capture therapy (BNCT) has been optimized using simulator software of Monte Carlo N-Particle Extended (MCNPX). The Beryllium target with thickness of 0.55 cm is simulated to be bombarded with 30 MeV of proton beam. In this design, the parameter regarding beam characteristics for BNCT treatment has been improved, which is ratio of fast neutron dose and epithermal neutron flux. TiF3 is replaced to 30 cm of 27Al as moderator, and 1.5 cm of 32S is combined with 28 cm of 60Ni as …

Ne Stem 4u Afterschool Intervention Leads To Gains In Stem Content Knowledge For Middle School Youth, Christine E. Cutucache, Taylor Boham, Jamie Luhr, Amie Sommers, Nikolaus Stevenson, Erkko Sointu, Kati Mäkitalo‐Siegl, Sirpa Kärkkäinen, Teemu Valtonen, Neal Grandgenett, William Tapprich

Biology Faculty Publications

Afterschool interventions in STEM are linked to learning gains during the school day. These opportunities engage and excite students about STEM concepts since they observe a more hands-on, project-oriented approach. Often these opportunities for afterschool interventions are infrequent in nature and leave gaps for students in their maturation and understanding. Herein we describe the first report of an afterschool intervention, named NE STEM 4U, targeting socioeconomically disadvantaged middle school youth via a twice weekly, year-long intervention, studied across two years. We assessed the impact of this program on i.) short-term, individual student gains in STEM content knowledge and ii.) delivery …

Zombies And Immune Discourses In Hazael González’S “Luna De Sangre Sobre Lepanto”, Kiersty Lemon-Rogers

Alambique. Revista académica de ciencia ficción y fantasía / Jornal acadêmico de ficção científica e fantasía

Using immune discourse to examine zombies in González’s “Luna de sangre,” I argue that his zombies function as embodied manifestations of physical, spiritual, and cultural contagion. The ideas of Roberto Esposito, Priscilla Wald, Mabel Moraña, Sarah J. Lauro and Karen Embry, put into conversation with González’s tale, help illuminate how the author uses monstrosity to demarcate the Other and define it as those who exist outside of the human, the normative, and more generally outside of the Western social order. The historical and contemporary context of “Luna de sangre” is one of nationalism, bigotry, walls, and anti-Islamic and anti-Semitic sentiment. …

Investigating Diversity In Social Work Doctoral Education In The United States, Matthew Chin, Jaclynn Hawkins, Amy Krings, Carolyn Peguero-Spencer, Lorraine Gutiérrez

Social Work: School of Social Work Faculty Publications and Other Works

Despite its emphasis on social justice, social work in the United States has not always attended to issues of diversity in doctoral education. This article examines the state of the discipline’s research on traditionally underrepresented students in U.S. doctoral social work programs. An analysis of relevant peer-reviewed articles from social work journals revealed that this research has focused on demographic trends, degree motivation, student barriers, existing supports, and career navigation. Diversity in U.S. doctoral social work education is vastly understudied with the majority of scholarship focusing on ethnoracial difference. The limitations of this study are discussed, and future research directions …

Preseason Y Balance Test Scores Are Not Associated With Noncontact Time-Loss Lower Quadrant Injury In Male Collegiate Basketball Players, Jason Brumitt, Kyle Nelson, Duane Duey, Matthew Jeppson, Luke Hammer

Faculty Publications - College of Physical Therapy

The Y-Balance Test-Lower Quarter has shown promise as a screening tool for identifying athletes at risk of injury. Subsequent studies, utilizing heterogeneous populations or different operational definitions of injury, have presented equivocal findings. Therefore, studies evaluating the efficacy of the Y-Balance Test to discriminate injury risk in a homogeneous population is warranted. One-hundred sixty-nine male (mean age 19.9 + 1.5 y) collegiate basketball players were recruited during 2 consecutive seasons (2016–2017/2017–2018). Athletes completed the Y-Balance testing protocol at the start of each preseason. Athletic trainers tracked noncontact time-loss lower quadrant injuries over the course of the season. Receiver operator characteristic …

Advent Love: The Advent Of #Metoo, Aaron Baart

Faculty Work Comprehensive List

"It is the season of our soul’s groaning for 'thy kingdom come, thy will be done, on earth as it is in heaven.'"

Posting about ­­­­­­­­Christ's light overcoming our world of darkness from In All Things - an online journal for critical reflection on faith, culture, art, and every ordinary-yet-graced square inch of God’s creation.

https://inallthings.org/advent-love-the-advent-of-metoo/

Come Together: Interdepartmental Collaboration To Connect The Ir And Library Catalog, Amanda Makula

Copley Library: Faculty Scholarship

While institutional repositories (IRs) often include a built-in search tool and/or are indexed by Web search engines, some patrons go directly to the online library catalog with their information need. Rather than hope that users will stumble upon the IR from the library website or assume that they will start their research with a Google search, librarians can enhance IR discoverability and usage by integrating its content into the library catalog. With strong teamwork, good communication, and a shared vision, this endeavor transforms the IR and library catalog from separate, siloed platforms into a more cohesive collections package. At the …

Comparative Transcriptome Analysis Reveals An Efficient Mechanism For Α-Linolenic Acid Synthesis In Tree Peony Seeds, Qingyu Zhang, Rui Yu, Daoyang Sun, Mahbubur Rahman, Lihang Xie, Jiayuan Hu, Lixia He, Aruna Kilaru, Lixin Niu, Yanlong Zhang

ETSU Faculty Works

Tree peony (Paeonia section Moutan DC.) species are woody oil crops with high unsaturated fatty acid content, including α-linolenic acid (ALA/18:3; >40% of the total fatty acid). Comparative transcriptome analyses were carried out to uncover the underlying mechanisms responsible for high and low ALA content in the developing seeds of P. rockii and P. lutea, respectively. Expression analysis of acyl lipid metabolism genes revealed upregulation of select genes involved in plastidial fatty acid synthesis, acyl editing, desaturation, and triacylglycerol assembly in seeds of P. rockiirelative to P. lutea. Also, in association with ALA content in seeds, …

Differential Expression Of Genes Related To Innate Immune Responses In Ex Vivo Spinal Cord And Cerebellar Slice Cultures Infected With West Nile Virus, Amber M. Paul, Parminder J.S. Vig, Deyin Lu, Ram Kuwar, Maria Lopez, Dobrivoje S. Stokic, A. Arturo Leis, Michael R. Garrett, Fengwei Bai

Publications

West Nile virus (WNV) infection results in a spectrum of neurological symptoms, ranging from a benign fever to severe WNV neuroinvasive disease with high mortality. Many who recover from WNV neuroinvasive infection present with long-term deficits, including weakness, fatigue, and cognitive problems. While neurons are a main target of WNV, other cell types, especially astrocytes, play an important role in promoting WNV-mediated central nervous system (CNS) damage. Conversely, it has been shown that cultured primary astrocytes secrete high levels of interferons (IFNs) immediately after WNV exposure to protect neighboring astrocytes, as well as neurons. However, how intrinsic responses to WNV …

Many Labs 2: Investigating Variation In Replicability Across Samples And Settings, Richard A. Klein, Michelangelo Vianello, Susan L. O'Donnell, Et Al

Faculty Publications - Psychology Department

We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance (p < .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion (p < .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely highpowered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small (< 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.

Determining The Amsr-E Sst Footprint From Co-Located Modis Ssts, Brahim Boussidi, Peter Cornillon, Gavino Puggioni, Chelle Gentemann

Graduate School of Oceanography Faculty Publications

This study was undertaken to derive and analyze the Advanced Microwave Scanning Radiometer - EOS (AMSR-E) sea surface temperature (SST) footprint associated with the Remote Sensing Systems (RSS) Level-2 (L2) product. The footprint, in this case, is characterized by the weight attributed to each 4x4 km square contributing to the SST value of a given AMSR-E pixel. High-resolution L2 SST fields obtained from the MODerate-resolution Imaging Spectroradiometer (MODIS), carried on the same spacecraft as AMSR-E, are used as the sub-resolution “ground truth“ from which the AMSR-E footprint is determined. Mathematically, the approach is equivalent to a linear inversion problem, and …

Week Of December 24, 2018, New York Medical College

InTouch

• Department of Surgery Hosts 15th Annual Louis R.M. DelGuercio Distinguished Visiting Professorship and Research Day
• SHSP Hosts Winter Meet and Greet
• GSA Sponsors Third Annual Snowman Project

Testing Of Lotka’S Law And Its Suitability To Research Productivity Of Annamalai University, A Higher Education Institution, South India, Sadik Batcha M

Library Philosophy and Practice (e-journal)

Lotka’s Law describes the frequency of publications by authors in a given subject/discipline. In the present study, an attempt has been made to study the suitability of the Lotka’s Law to the publications of a Higher Educational institution of a region consisting of academic authors and researchers in various disciplines. Annamalai University has been ranked 20^th in the state level and 56^th at National level by MHRD. Annamalai University is renowned for its research output performance and has been funded for many major, minor and DST research projects. It has a large network and linkages to academia, R&D …

Differential Expression Of Genes Related To Innate Immune Responses In Ex Vivo Spinal Cord And Cerebellar Slice Cultures Infected With West Nile Virus, Parminder J.S. Vig, Deyin Lu, Amber M. Paul, Ram Kuwar, Maria Lopez, Dobrivoje S. Stokic, A. Arturo Leis, Michael R. Garrett, Fengwei Bai

Faculty Publications

West Nile virus (WNV) infection results in a spectrum of neurological symptoms, ranging from a benign fever to severe WNV neuroinvasive disease with high mortality. Many who recover from WNV neuroinvasive infection present with long-term deficits, including weakness, fatigue, and cognitive problems. While neurons are a main target of WNV, other cell types, especially astrocytes, play an important role in promoting WNV-mediated central nervous system (CNS) damage. Conversely, it has been shown that cultured primary astrocytes secrete high levels of interferons (IFNs) immediately after WNV exposure to protect neighboring astrocytes, as well as neurons. However, how intrinsic responses to WNV …

A Durable, Realistic, Low-Cost Training Model For Percutaneous Renal Access Using Ballistic Gelatin, Jonathan Ewald, Julie Cheng, Shawn Engelhart, Michael Wilkinson, Mohammad Hajiha, Hillary Wagner, Duane D. Baldwin

Loma Linda University Student Journal

The purpose of this study was to design and implement a durable, realistic, and low-cost phantom kidney model for percutaneous renal access that could improve a novice surgeon’s technical skills without compromising patient safety.

Healthcare Disparities In Lupus Nephritis: Findings From The Southern California Lupus Registry, Arezoo Haghshenas, Phildrich The, Karina Torralba, Vaneet K. Sandhu

Loma Linda University Student Journal

Lupus nephritis (LN) is a major cause of among systemic lupus erythematosus (SLE) patients. Despite therapeutic advancements, LN patients continue to have a poor prognosis related to socioeconomic status (SES). We sought to establish the correlation between SES and LN prevalence in San Bernardino and Riverside counties of Southern California.

Male And Female Mice Exhibit Divergent Responses Of The Cortical Vasculature To Traumatic Brain Injury, Amandine Jullienne, Arjang Salehi, Bethann M. Affeldt, Mohsen Baghchechi, Elizabeth Haddad, Angela Avitua, Mark Walsworth, Isabelle Enhalric, Mary Hamer, Sonali Bhakta, Jiping Tang, John Zhang, William Pearce, Andrea Obenaus

Loma Linda University Student Journal

Traumatic brain injuries (TBI) occur in 1.7 million people each year in the USA. Little is known about how the cerebrovasculature is altered after TBI. We previously reported that TBI elicits acute decrements in cerebral vessels near the injury site in rats followed by revascularization over the subsequent 2 weeks. Sexual dimorphism of the brain is well documented and different hormonal levels in males and females differentially modify the recovery process after injury. However, the effects of biological sex on the temporal evolution of revascularization following TBI are understudied. Using a model of controlled cortical impact in male and female …

The Effect Of High-Impact Exercise On Stress Urinary Incontinence In Physically Active Women, Jean Yang, Hillary Wagner Md, Julie Cheng Md, Gene Austin Krishingner, Kristin Chung, Andrea Staack

Loma Linda University Student Journal

Stress urinary incontinence (SUI) is a condition in which increased abdominal pressure with coughing, laughing, sneezing, or exercise can cause unintentional leakage of urine in the female population. CrossFit and other high impact aerobic exercises, are popular forms of exercise amongst women all age groups. The purpose of this study was to examine specific high impact exercises that can affect SUI in women.

Incorporation Of Multiple Coulomb Scattering In The Prediction Of Optimal Focal Lengths In Magnetically Focused Proton Radiosurgery, Steven Martinez, Grant Mcauley, Jerry D. Slater, Andrew Wroe

Loma Linda University Student Journal

Magnetic focusing of protons is a promising approach to improve patient radiation dose distribution in proton radiosurgery. The paths of individual protons are affected by multiple atomic deflections (multiple Coulomb scattering [MCS]) and affect overall beam characteristics in the patient. The purpose of this project is to account for the effects of MCS in the optimization of focal lengths in magnetically focused proton radiosurgery.

A Case Of Pituitary Apoplexy Complicating The Management Of Sepsis, Victor R. Laluz Md, Kevin Codorniz

Loma Linda University Student Journal

Pituitary apoplexy is a condition of sudden hemorrhage into the pituitary gland, usually at the site of a pituitary adenoma, occurring in 8% of pituitary macroadenomas. The clinical presentation of pituitary apoplexy varies based upon the timing and mechanism of pituitary mass expansion towards the optic nerve or hypothalamus, as well as the hormonal function of the neoplasm and remaining pituitary gland tissue. Nearly all patients present with headache (97%), and fewer patients present with visual field impairment (71%). Pituitary apoplexy acutely disrupts the hypothalamic-pituitary-adrenal (HPA) axis, and may lead to relative adrenal insufficiency in septic shock, with a high …

Assessing Chronic Opioid Management At An Internal Medicine-Pediatrics Clinic, Tiffany Vu, Jeremiah Cheng

Loma Linda University Student Journal

The number of deaths attributed to synthetic opioids has nearly tripled in the US from 1999 to 2014. Although there is limited evidence regarding the effectiveness of long-term opioid therapy for chronic pain, a condition estimated to affect 11.2% of the US adult population; opioids are often prescribed for this reason in the outpatient setting. The CDC has produced guidelines regarding safe opioid prescribing methods, however changes are also necessary within clinic systems to improve the safety and management of opioid prescriptions This is particularly important in resident led clinics where multiple providers often see patients over the course of …

Kwashiorkor In The United States Secondary To A Rice Milk Diet, Donovan Kearns, Karen Kagha

Loma Linda University Student Journal

Kwashiorkor is a Ghanaian word that literally translates into the phrase “the disease of the disposed child.” It is a disease that is classical seen is an infant who was weaned form the breast milk when a new child is born. Kwashiorkor is characterized by symmetric pitting edema that begins in the lower extremities and spreads to the rest of the body as the disease progressively worsens. Other symptoms include hepatomegaly, thin peeling skin with hyperkeratosis, hyperpigmentation and bradycardia with hypotension. The major pathological insult sustained in Kwashiorkor is believed to be a dietary lack of protein. Lack of dietary …

Improvement Of Cardiac Function In A Patient With Heart Failure And Lvad Placement With Treatment Of Undiagnosed Acromegaly, Navya Reddy, Xin Zheng, Kevin Codorniz, Antoine E. Sakr, Liset Stoletniy

Loma Linda University Student Journal

This case report explores the improved cardiac function of treating non- ischemic dilated cardiomyopathy with a left ventricular assist device. The importance of this case study underscores that possible early treatment of acromegalic cardiomyopathy could slow the progression of the cardiomyopathy and prevent invasive cardiac procedures.

Factors Associated With Access To Immunotherapy And Its Impact On Survival In Mucosal Melanoma, Joanne Jee Yeon Lee, Donovan Kearns, Medora Rodrigues, Blake Babcock, Naveenraj L. Solomon Md, Maheswari Senthil Md, Mark E. Reeves Md, Phd, Carlos A. Garberoglio Md, Jukes P. Namm Md

Loma Linda University Student Journal

Mucosal melanoma is rare, comprising only 1.4% of all melanomas in the United States. Yet it is associated with a worse prognosis compared to cutaneous melanoma due to aggressive biology and advanced stage at diagnosis with a reported 5-year survival rate of less than 30%. Although there are no established guidelines for the treatment of mucosal melanoma, immunotherapy has been increasingly used for the management of advanced mucosal melanoma.

Single Lower Border Plate Fixation In Anterior Mandibular Fractures, Ted Park, Kathleen Lopez, D Nguyen, Mark Martin

Loma Linda University Student Journal

Repair of symphyseal and parasymphyseal mandibular fractures is traditionally performed with a lower border plate and either an upper border microplate or arch bars as a tension band. Complications of microplates include wound dehiscence, plate exposure, and tooth root injury. Issues with arch bars include increased operative time, a second procedure for removal, risk of TMJ ankylosis, and risk of injury to the operative team. We propose that one lower border plate is adequate for simple fractures of the anterior mandible and will serve to minimize complications.

Contact Dermatitis Awareness And Education Through The Use Of Online Platforms, Brittanya Limone, Chandler Rundle, Sharon Jacob-Soo Md

Loma Linda University Student Journal

Social media has become a popular means for raising awareness and providing education. Over the last several years, these modalities have been used more than ever by healthcare providers to increase networking opportunities, promote healthcare organizations, and engage with patients, caregivers, and students.

Evaluating Estradiol As A Novel Therapy For Dry Age-Related Macular Degeneration/Geographic Atrophy, Daniel Lee, Paula Fukuhara, Mc Kenney

Loma Linda University Student Journal

Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in the elderly population in the United States and is more prevalent in post-menopausal females than age-matched males. There are no current FDA-approved therapies for dry AMD, which composes 80- 90% of all AMD cases. Late stage dry AMD (geographic atrophy) is characterized by extensive loss of the retinal pigment epithelium (RPE) along with degeneration of the photoreceptors, which cause significant central vision loss. AMD is characterized by drusen, which are extracellular deposits located beneath the retina. Drusen contain proteins associated with the process of inflammation such …