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Externality In Hegel's Philosophy Of Nature, Martin Krahn

Electronic Theses and Dissertations

The topic of my dissertation is the metaphysics of laws of nature in Hegel’s philosophy of nature. I argue that Hegel differentiates laws of nature from norms of culture through a concept of “externality,” according to which the universals or laws of nature stand outside of, apart from, independent from their particulars. He contrasts this with norms of culture, where the universals are internal to the particulars, such that in culture the particular events or actions shape the norms, whereas in nature, the laws remain the same through their independence from the particular events. I then address the consequences this …

A Structural And Dynamic Model For The Assembly Of Replication Protein A On Single-Stranded Dna, Luke A. Yates, Ricardo J. Aramayo, Nilisha Pokhrel, Colleen C. Caldwell, Joshua A. Kaplan, Rajika L. Perera, Maria Spies, Edwin Antony, Xiaodong Zhang

Biological Sciences Faculty Research and Publications

Replication Protein A (RPA), the major eukaryotic single stranded DNA-binding protein, binds to exposed ssDNA to protect it from nucleases, participates in a myriad of nucleic acid transactions and coordinates the recruitment of other important players. RPA is a heterotrimer and coats long stretches of single-stranded DNA (ssDNA). The precise molecular architecture of the RPA subunits and its DNA binding domains (DBDs) during assembly is poorly understood. Using cryo electron microscopy we obtained a 3D reconstruction of the RPA trimerisation core bound with ssDNA (∼55 kDa) at ∼4.7 Å resolution and a dimeric RPA assembly on ssDNA. FRET-based solution studies …

Machine Learning Methods For Functional Near Infrared Spectroscopy, Danushka Sandaruwan Bandara

Dissertations - ALL

Identification of user state is of interest in a wide range of disciplines that fall under the umbrella of human machine interaction. Functional Near Infra-Red Spectroscopy (fNIRS) device is a relatively new device that enables inference of brain activity through non-invasively pulsing infra-red light into the brain. The fNIRS device is particularly useful as it has a better spatial resolution than the Electroencephalograph (EEG) device that is most commonly used in Human Computer Interaction studies under ecologically valid settings. But this key advantage of fNIRS device is underutilized in current literature in the fNIRS domain.

We propose machine learning methods …

Regulation Of In Vivo Excitatory/Inhibitory Balance By The Cystine/Glutamate Exchanger System Xc-, Sheila Marie Shahidzadeh Sears

Dissertations - ALL

System xc- (Sxc-) is a cellular antiporter that links the import of L-cystine with the export of L-glutamate. In the central nervous system (CNS), this export contributes to the ambient glutamate levels found in the synaptic cleft. To wit, a 50% reduction in extracellular glutamate has been demonstrated in animals null for the substrate-specific light chain, xCT. Moreover, in most tissues, including the CNS, cystine import through Sxc- is necessary for the synthesis and maintenance of glutathione (GSH) levels. Given that either a reduction in ambient glutamate levels and/or a redox imbalance involving GSH have been reported to affect synaptic …

Village Doctors And Vulnerable Bodies: Gender, Medicine, And Risk In North India, Jocelyn Killmer

Dissertations - ALL

This dissertation tracks an uncommon migration: the movement of young women doctors from urban medical colleges to rural clinics in Rajasthan, North India. The ability for young women doctors to transfer their lives to a rural clinic, even for a year or two, is vital for career advancement in Rajasthan’s government health sector. Yet I found that women, over and over, rejected this opportunity, turning this urban to rural migration into a trickle rather than a flow. Through interviews, observations, and travel in urban and rural Jaipur district, I explore the meanings of urban and rural spaces as well as …

Identifying The Genetic Mechanisms In Seizure Threshold Regulation, Yifan Gong

Dissertations - ALL

Epilepsy is a brain disease defined by having recurrent and spontaneous seizures. The susceptibility to seizure is determined by seizure threshold, which describes the balance between excitatory and inhibitory neurotransmission in the brain. Epileptogenesis, the transition from normal brain to epileptic brain, is accompanied by a progressive reduction of seizure threshold and has been shown to have genetic influences. Expression of neuronal cyclooxygenase-2 (COX-2) gene, PTGS2, a primary gene that regulates prostaglandin synthesis in the normal brain, is enhanced by excitatory neurotransmission and is under tight regulation of N-Methyl-D-Aspartate type glutamate receptor (NMDAR) activity in cortical neurons. The 3’ untranslated …

Sex Differences In Cardiovascular Adaptations To Chronic Endurance Exercise, Jacqueline A. Augustine

Dissertations - ALL

Endurance exercise typically leads to beneficial cardiac adaptations manifested as increased cardiac mass, higher cardiac function and lower central hemodynamic load (blood pressure, aortic stiffness and wave reflections). However, studies in male marathoners suggest detrimental cardiac remodeling, such that larger cardiac mass is associated with reduced cardiac function and higher central hemodynamic load. There are well-established sex differences in cardiac adaptations to endurance exercise and central hemodynamics across the lifespan. Whether there are sex differences in cardiovascular adaptations in marathoners requires further scrutiny. We examined sex differences in 1) Left ventricle (LV) structure, 2) LV function 3) 24-hour central hemodynamic …

Statement To The Board Of Trustees, Fall 2018, David Trubatch

University Senate - Board of Trustees Statements

Reports to the University Board of Trustees by the Senate President - President Trubatch's Board of Trustees Address (Fall 2018)

The Colourful Truth: The Reality Of Indigenous Overrepresentation In Juvenile Detention In Australia And The United States, Rachel Thampapillai

American Indian Law Journal

No abstract provided.

Schooling At The Intersection Of Refugee Identity And (Dis)Ability: Implications From North Korean Students With Refugee Backgrounds, Yosung Song

Dissertations - ALL

Researchers have previously found that school-age refugees and asylum-seekers are frequently characterized as experiencing physical, emotional, or psychological disabilities or disorders in schools because of the adversity that they face and a lack of adequate resources during their refugee journey. In their relocated society, many refugee students are interpreted as having disabilities or receiving special education services. While refugee experiences are often framed as causing deficits in students, the purpose of this study was to better understand the interplay of (dis)ability and refugee identity at a school that publicly proclaimed refugee experience as an asset. Grounded in a qualitative methodology, …

Winter Sports At The University Of Washington: 1934 - 1950, John W. Lundin

Works by Local Authors

An Excerpt from Early Skiing on Snoqualmie Pass Written for the Husky Winter Sports Club. Skiing at the University of Washington goes back to January 1934, when the University of Washington Ski Club formed with a membership of 100 men and women. The club developed a race course at Paradise on Mt. Rainier, rented a cabin at Paradise for the season, and formed a ski team that trained at Paradise and Snoqualmie Summit. The University Book Store ran a bus to Paradise on weekends in 1934, and in 1936, rented ski equipment and offered a bus service from Seattle to …

Tennessee Consolidated Retirement System Comprehensive Annual Financial Report For The Fiscal Year Ended June 30, 2018, Tennessee. Department Of Treasury.

TCRS Financial Reports

No abstract provided.

Tennessee Comprehensive Annual Financial Report For The Fiscal Year Ended June 30, 2018, Tennessee. Department Of Finance & Administration.

Annual Comprehensive Financial Reports

No abstract provided.

History In Motion: Seeing Cuba’S Future Through The Past And Present, Kevin Kecskes

Hatfield Graduate Journal of Public Affairs

This article is a foreword for Volume 3, Issue 1 of the Hatfield Graduate Journal of Public Affairs.

Education And The Economy: The Rising Private Sector’S Effect On University Enrollment And Post-Graduation Employment In Contemporary Cuba, Adriane Bolliger

Hatfield Graduate Journal of Public Affairs

During Cuba’s Socialist Revolution of the 1960s, the education system was restructured to train and prepare citizens as part of the subsidized state-owned universal education model. In a centrally-planned system like Cuba’s, the state determines the needs of the economy and provides corresponding funding for associated educational and vocational training programs. Students who graduate from these programs transition into government jobs with modest stipends to support the state. Fidel Castro envisioned this system as the solution to Cuba’s instability based on full employment and prosperity for the public and for the state.

Change came in 2008 when presidential power was …

Rethinking The Federal Indian Status Test: A Look At The Supreme Court's Classification Of The Freedmen Of The Five Civilized Tribe Of Oklahoma, Clint Summers

American Indian Law Journal

No abstract provided.

The Tribal Franchise: An Expression Of Tribal Sovereignty And A Potential Solution To The Problem Of Mass Disenrollment, Brent Mulvaney

American Indian Law Journal

No abstract provided.

Constructions Of Masculinity In Bollywood Promotional Content, Alyssa Grace Lobo

Theses - ALL

Following a growing public discussion on violence against women in India, some commentators have turned their eye upon Bollywood. The film industry’s role in perpetuating models of courtship based on the stalking and harassment of women has drawn criticism from several quarters. While there has been much said about the depiction of women in Bollywood film, there has been relatively less said on portrayals of masculinity. The research that does exist focuses on textual analyses of films, or looks at masculinity through the lens of global capital flows. This thesis instead, analyzes trailers, posters, promotional pictures and social media for …

Four Phases Of Subjectivity: A Rhetorical And Phenomenological Analysis Of Aimé Césaire And Cahier D’Un Retour Au Pays Natal, Chelsea Binnie

Electronic Theses and Dissertations

This dissertation project sets out to perform a rhetorical and phenomenological analysis of the subjectivity that Césaire portrays in his epic poem Cahier d’un retour au pays natal, or Notebook of a Return to My Native Land. Césaire published and republished Cahier four times in a 17-year period and the modified accounts of subjectivity presented in the lines of the poem mirrors that of Césaire’s own human subjectivity. Césaire poetically unleashes Cahier and his Négritude project in an effort to shift the geography of reason from its self-appointed European center, to create a liminal space for the totalized …

Probiotic Use In Trauma Patients: A Pathway To Determining The Standard Of Care To Improve Outcomes, Heather Vitko

Electronic Theses and Dissertations

The gut microbiome consists of normally non-pathogenic bacteria, viruses, and fungi. These friendly microbes serve to maintain GI barrier function and integrity, play a role in host nutrient and drug metabolism, immunomodulation, and prevent pathogenic bacteria from colonizing or causing disease. The importance of a healthy microbiome for the overall health of the host is just recently being appreciated within the medical and science communities. Disruption of the microbiome places one at greater risk for illness and infection. Patients who suffer a traumatic injury are among those at highest risk for complications associated with microbial imbalance, or dysbiosis. In addition …

Bullying Of Linguistically Diverse Learners: Results From The Youth Risk Behavior Survey, Jenna Woodarek

Electronic Theses and Dissertations

Bullying is a serious phenomenon yielding significant consequences for youth who are victimized, often targeted due to their perceived level of difference from their peers. This “otherness” can often be amplified in minoritized populations, especially those which have multiple, cooccurring vulnerabilities to be targets of bullying. After a period of bullying rates decreasing in the US, special interest group inquiries found bullying rates to be on the rise again and reportedly motivated by ethnicity or race, immigrant status, and proficiency in the English language. The present research study aims to expand upon the existing pertinent literature base specific to the …

Pyrrolo[2,3-D]Pyrimidine Classical Antifolates For Targeted Cancer Chemotherapy- Applications Of Bioisosteric And Regioisomeric Substitutions For Improved Tumor-Selectivity And Potency, Manasa Punaha Ravindra

Electronic Theses and Dissertations

In 2018, it is estimated that 1,735,350 new cases of cancer and 609,640 deaths from the disease will be diagnosed in the United States alone. Conventional chemotherapy is by far the most successful category of clinical oncology, having cured (complete remission (CR), without return) or provided clinical benefit to millions of people. However, since its earliest discovery, the major causes of failure of conventional cancer chemotherapy have been dose-limiting toxicities and development of resistance. There is a desperate ongoing search for new cancer therapies as tumor-targeted agents (without harming normal cells or tissues) with low propensity for the development of …

A Disability Theology Of Limits For Responding To Moral Injury, Lisa Hickman

Electronic Theses and Dissertations

The lament of Jeremiah, “they dress the wound of my people as if it were not serious,” reverberates today as veterans return home from a decade of war, ridden by PTSD and moral injury, only to discover lethargy, lack of seriousness and complacency in societal response. The seriousness of our soldiers’ wounds, to body and spirit alike, demand ethical, societal and theological responsibility. Failure to address the seriousness of these wounds results in distress, depression and even suicide for the soldier. Statistics may describe a portion of the reality, but the degree to which soldiers suffer in silence and the …

Low Temperature Thermochronologic Constraints Across The East-Central Denali Fault: Evaluating Vertical Tectonics Along A Transpressive Orogen, Thomas Stuart Warfel

Theses - ALL

The Denali Fault is an active intracontinental structure located ~500 km north of the southern Alaskan plate boundary. In 2002, a M 7.9 earthquake initiated on a previously unmapped thrust fault subsidiary to the Denali Fault (Susitna Glacier Thrust) and propagated ~227 km eastward along the east-central segment of the Denali Fault and the Totschunda Fault. The objective of this thesis is to evaluate how fault geometry and rheologic strength control spatial-temporal patterns of exhumation along large-scale transpressive structures. Apatite fission track (AFT) thermochronology and apatite (U-Th)/He (AHe) dating are used on a combination of bedrock and cobble samples to …

State V. Giltz Respondent's Brief Dckt. 45712

Not Reported

No abstract provided.

August 2017 - August 2018 Case Law On American Indians, Thomas P. Schlosser

American Indian Law Journal

No abstract provided.

Three Essays On The Management Of Local Government Cash Flows, Michelle Lynn Lofton

Dissertations - ALL

This dissertation is composed of three essays which evaluate financial strategies used to manage cash flows and the broader working capital management process in local governments. The objective of this dissertation is to address unresolved questions in the literature regarding the use of short-term financial resources to improve a government’s internal operating process and successfully navigate challenging fiscal environments. Together, the three essays contribute to our understanding of cash flow management strategies and the consequences of their implementation in United States local governments.

The first essay, in Chapter 2, evaluates the motivating factors that encourage managers to use an external …

Static Enforcement Of Termination-Sensitive Noninterference Using The C++ Template Type System, Scott Douglas Constable

Dissertations - ALL

A side channel is an observable attribute of program execution other than explicit communication, e.g., power usage, execution time, or page fault patterns. A side-channel attack occurs when a malicious adversary observes program secrets through a side channel. This dissertation introduces Covert C++, a library which uses template metaprogramming to superimpose a security-type system on top of C++’s existing type system. Covert C++ enforces an information-flow policy that prevents secret data from influencing program control flow and memory access patterns, thus obviating side-channel leaks. Formally, Covert C++ can facilitate an extended definition of the classical noninterference property, broadened to also …

Gaseous State: A Historical Geography Of Natural Gas And The Capitalist State In An Age Of Climate Change, Carlo Sica

Dissertations - ALL

In the 1930s U.S., a set of social forces and crises pushed forward state energy regulation. As states struggle to end greenhouse-gas emissions from fossil fuels, the threat of climate change demands new explanations for how energy policy emerges. In this dissertation, I explain the period of U.S. natural gas regulation between 1938 and 1978 from critical political economy and Marxist state theoretical perspectives. My main conclusion is that the capitalist state stabilizes markets for energy to serve capital with an auxiliary means of production. Based on that conclusion, I recommend that Marxist state theory be class-centered, i.e., recognize that …

Seeing And Believing: Philosophical Issues In Theory Of Mind Development, Joseph A. Hedger

Dissertations - ALL

All human beings understand the behaviors of others as causal results of their mental states. Philosophers call this ability folk psychology and developmental researchers call it theory of mind (ToM). My dissertation concerns how this reasoning works and how it is acquired.

First, I develop and expand a theory of how folk psychology develops in childhood. This is the Perceptual Access Reasoning, or PAR theory of the Fabricius lab. Contrary to the two views dominant in the field, I argue that ToM (belief reasoning or BR) is acquired around 6 years of age after undergoing two preliminary cognitive stages, reality …