Digital Commons Network^™

Archaeological Survey Of The Ex‑Uss Independence (Cvl22), James P. Delgado, Michael L. Brennan, Kelley Elliott, Russell E. Matthews, Megan Lickliter‑Mundon, John G. Lambert, Frank Cantelas, Robert V. Schwemmer

United States Department of Commerce: Staff Publications

In August 2016, a multidisciplinary team conducted the first archaeological survey of the deep-water (829 m) wreck of the ex-USS Independence (CVL22) using the remotely operated vehicles Argus and Hercules. The survey provided 34 h of direct observation with video and still camera documentation of the wreck, which the previous year had been initially identified with a limited three-dimensional sonar survey of the site. The 2016 assessment added considerably to an understanding of changes to Independence after its use as a target vessel for the 1946 atomic bomb tests at Bikini Atoll, as a radiological laboratory, training facility, and …

Course In Gerontology And Palliative Care Developed With $150,000 Grant, Rachel Mccarthy

News and Events (Discontinued Series)

No abstract provided.

Conflict Sensitivity And Conservation: Evaluating Design, Implementation & Practice, Amanda S. Woomer

Doctor of International Conflict Management Dissertations

This dissertation investigates the use of a conflict sensitivity framework in supporting environmental conservation work. Employing an action research methodology, it consists of a multi-phase evaluation of the design and implementation of Conservation International’s (CI) Environmental Peacebuilding Training Manual. Through needs assessment, formative evaluation, and outcome evaluation phases, the dissertation explores questions related to what conflicts conservation practitioners face; what form a relevant, accessible, and effective conflict sensitivity framework might take; and what effect such a framework might have on the knowledge, attitudes, capacities, and actions of conservation practitioners. The findings indicate that conservation practitioners face a variety of conflicts …

Alaska Justice Forum ; Vol. 35, No. 1 (Summer 2018), Pamela Cravez, Paula Williams

Vols 31-36 (2014-2019)

The Summer 2018 print edition of the Alaska Justice Forum focuses on environmental justice, exploring the ongoing challenges of cleaning up contaminated sites in Alaska in terms of the costs of cleanup and long-term impacts upon people and the environment. Alaska is ranked third in the U.S. for Formerly Used Defense Sites (FUDS) properties. Most of these properties are in remote locations, placing a disproportionate impact on Alaska Native communities that depend upon environmental resources for their livelihood. This issue also looks at expanded eligibility and increased limits on Brownfields Program funds, which provide monies for assessment and cleanup of …

Phytochemical Screening Of Quaking Aspen (Populus Tremuloides) Extracts By Uplc-Qtof-Ms And Evaluation Of Their Antimicrobial Activity, Annabelle St-Pierre, Dorian Blondeau, André Lajeunesse, Julien Bley, Nathalie Bourdeau, Isabel Desgagné-Penix

Aspen Bibliography

The continual emergence of pathogen resistance is a recurring challenge and pushes for the development of antimicrobial compounds. Here, we investigated compounds from quaking aspen trees (Populus tremuloides) as potential antimicrobial agents. Several extractions using different solvents were realized, and corresponding antimicrobial activity was tested against eight microorganisms. Results revealed that polar extraction solvents including water, ethanol and methanol gave the best extraction yields (>15.07%). Minimal inhibition concentration (MIC) and minimal bactericidal/fungicidal concentration (MBC/MFC) demonstrated that water extracts had the best antimicrobial activity by a weak to moderate inhibition of growth of all eight tested microorganisms in addition to …

Evaluation Of Effectiveness Of Streambank Stabilization Practices And Flood Impact On Cedar River, Nebraska, Naisargi N. Dave

Department of Environmental Engineering: Theses and Other Student Research

Stream restoration has been a major environmental objective for preserving biodiversity, reducing loss of valuable cropland and improving water quality. The impact and efficiency of streambank stabilization practices has been simulated using erosion-prediction models; however, evaluation of the erosion-control practices to measure their efficiency is often neglected. This project monitored changes in fluvial geomorphology on the Cedar River in Nebraska and quantified the effectiveness of 18 sites with streambank stabilization practices. A flood event in 2010 due to dam failure acted as a major parameter in measuring the efficiency of the erosion control practices. The methodology included aerial imagery to …

Environmental Justice: Challenges Of Contaminated Site Cleanup In Rural Ak, Paula Williams, Pamela Cravez

Vols 31-36 (2014-2019)

Efforts to clean up contaminated sites from military installations and other sources have been ongoing in Alaska since the 1980s, and new sites continue to be identified. Most Formerly Used Defense Sites (FUDS) properties are in remote locations, placing a disproportionate impact on Alaska Native communities that depend upon environmental resources for their livelihood. Cleanup projects that are begun may take many years to complete due to the complicated nature of each site. Since 1990, over 5,300 sites have been cleanup up; more than 2,200 sites remain open, including military installations (both abandoned and active), bulk fuel storage and gas …

Cancerin: A Computational Pipeline To Infer Cancer-Associated Cerna Interaction Networks, Duc Do, Serdar Bozdag

Mathematics, Statistics and Computer Science Faculty Research and Publications

MicroRNAs (miRNAs) inhibit expression of target genes by binding to their RNA transcripts. It has been recently shown that RNA transcripts targeted by the same miRNA could “compete” for the miRNA molecules and thereby indirectly regulate each other. Experimental evidence has suggested that the aberration of such miRNA-mediated interaction between RNAs—called competing endogenous RNA (ceRNA) interaction—can play important roles in tumorigenesis. Given the difficulty of deciphering context-specific miRNA binding, and the existence of various gene regulatory factors such as DNA methylation and copy number alteration, inferring context-specific ceRNA interactions accurately is a computationally challenging task. Here we propose a computational …

St. Norbert College Graduate Receives National Science Foundation Fellowship, St. Norbert College

Press Releases 2018

No abstract provided.

Hyperthermia Induces Therapeutic Effectiveness And Potentiates Adjuvant Therapy With Nontargeted And Targeted Drugs In An In Vitro Model Of Human Malignant Melanoma, T. Mantso, S. Vasileiadis, I. Anestopoulos, G. P. Voulgaridou, E. Lampri, S. Botaitis, E. N. Kontomanolis, C. Simopoulos, G. Goussetis, R. Franco, K. Chlichlia, A. Pappa, M. I. Panayiotidis

School of Veterinary and Biomedical Sciences: Faculty Publications

In the present study, we have aimed to characterize the intrinsic, extrinsic and ER-mediated apoptotic induction by hyperthermia in an in vitro model of human malignant melanoma and furthermore, to evaluate its therapeutic effectiveness in an adjuvant therapeutic setting characterized by combinational treatments with non-targeted (Dacarbazine & Temozolomide) and targeted (Dabrafenib & Vemurafenib) drugs. Overall, our data showed that both low (43 °C) and high (45 °C) hyperthermic exposures were capable of inducing cell death by activating all apoptotic pathways but in a rather distinct manner. More specifically, low hyperthermia induced extrinsic and intrinsic apoptotic pathways both of which activated …

Formulasi Dan Karakteristik Bihun Tinggi Protein Dan Kalsium Dengan Penambahan Tepung Tulang Ikan Patin (Pangasius Hypopthalmus) Untuk Balita Stunting, Nur Afrinis, Verawati Besti, Harahap Dewi Anggraini

Media Kesehatan Masyarakat Indonesia

Stunting is the nutritional problems in Indonesia. The direct cause of stunting was infectious disease and
inadequate food intake such as protein and calcium deficiency. Patin fishbone powder contain high in protein, calcium
and phosphor needed for growth children under five years. Utilization of patin fishbone powder is processed
into flour and made rice noodle for children under five years stunting. The aims of the research were to determine
the best formula and characteristics of rice noodles high protein and calcium with addition of patin fishbone powder
(Pangasius hypopthalmus) for children under five years stunting. A complete randomized design was …

Pengaruh Kebiasaan Konsumsi Sayur, Buah Dan Perokok Pasif Terhadap Kapasitas Antioksidan Total Ibu Hamil, Nadimin Nadimin

Media Kesehatan Masyarakat Indonesia

The availability of antioxidants during pregnancy were decreases with increasing of gestational age
and influenced by environmental factors such as exposure to cigarette smoke and consumption habits of vegetables
and fruits. A cross sectional study with pregnant mothers (20-26 months pregnant) non-anemia as many as
70 people selected by purposive sampling. Total Antioxidant Capacity (KAT) was measured using Elisa method
(enzyme-liked immunosorbent assay), vegetable and fruit consumption habits collected with Food Frequency
Questionaire (FFQ) and smoking habits using interviews. The results showed around 37,1% of pregnant women
were passive smokers and rarely consume vegetables and fruits (>60,0%). The mean …

Fasudil In Combination With Bone Marrow Stromal Cells (Bmscs) Attenuates Alzheimer's Disease-Related Changes Through The Regulation Of The Peripheral Immune System., Jiezhong Yu, Yuqing Yan, Qingfang Gu, Gajendra Kumar, Hongqiang Yu, Yijin Zhao, Chunyun Liu, Ye Gao, Zhi Chai, Jasleen Chumber, Bao-Guo Xiao, Guang-Xian Zhang, Han-Ting Zhang, Yuqiang Jiang, Cun-Gen Ma

Department of Neurology Faculty Papers

Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease. Its mechanism is still not clear. Majority of research focused on the central nervous system (CNS) changes, while few studies emphasize on peripheral immune system modulation. Our study aimed to investigate the regulation of the peripheral immune system and its relationship to the severity of the disease after treatment in an AD model of APPswe/PSEN1dE9 transgenic (APP/PS1 Tg) mice. APP/PS1 Tg mice (8 months old) were treated with the ROCK-II inhibitor 1-(5-isoquinolinesulfonyl)-homo-piperazine (Fasudil) (intraperitoneal (i.p.) injections, 25 mg/kg/day), bone marrow stromal cells (BMSCs; caudal vein injections, 1 × 10

Autophagy Is Stimulated By Acute High Intensity Interval Exercise In Human Skeletal Muscle And Electrical Pulse Stimulation In C2c12 Myotubes In Vitro, Kurt A. Escobar

Health, Exercise, and Sports Sciences ETDs

Purpose: 1) To compare the effects of an acute bout of HIIT exercise (treadmill running) on autophagy to MICT exercise in human skeletal muscle 3 hours post exercise, and 2) to test an in vitro model of muscle contraction-induced autophagy using electrical pulse stimulation in C2C12 myotubes. Methods: Study 1: Ten recreationally active males and females completed a bout of high intensity interval training (HIIT) exercise and moderate intensity continuous exercise (MICT) exercise in a fasted state. Muscle biopsies from the vastus lateralis were taken pre and 3 hours post-exercise. Muscle tissue was analyzed for protein expression of markers of …

Revealing Silences: The Representation Of Black Identities In Hispanic Afro-Caribbean Autobiographical And Biographical Writing, Bryn Campbell

Spanish and Portuguese ETDs

This project explores how the historical contexts of the Hispanic Caribbean, including the regions of the Circum-Caribbean and the Caribbean Diasporas in the United States, have sustained dominant racial and nationalist ideologies that continue to silence or negate the identity of Afro-Caribbean subjects in national letters. My research focuses on the autobiographical and biographical writing of four Hispanic Afro-Caribbean men: Autobiografía de un esclavo (1840) by Juan Francisco Manzano¾originally published and translated to English in 1840 by Richard R. Madden¾ Klabel (2002) by Víctor Virgilio López García, Down These Mean Streets (1967) by Piri Thomas, and Las criadas de la …

A V-To-F Substitution In Sk2 Channels Causes Ca2+ Hypersensitivity And Improves Locomotion In A C. Elegans Als Model, Young-Woo Nam, Sabia N. Baskoylu, Dimitris Gazgalis, Razan Orfali, Meng Cui, Anne C. Hart, Miao Zhang

Pharmacy Faculty Articles and Research

Small-conductance Ca2+-activated K+ (SK) channels mediate medium afterhyperpolarization in the neurons and play a key role in the regulation of neuronal excitability. SK channels are potential drug targets for ataxia and Amyotrophic Lateral Sclerosis (ALS). SK channels are activated exclusively by the Ca2+-bound calmodulin. Previously, we identified an intrinsically disordered fragment that is essential for the mechanical coupling between Ca2+/calmodulin binding and channel opening. Here, we report that substitution of a valine to phenylalanine (V407F) in the intrinsically disordered fragment caused a ~6 fold increase in the Ca2+ sensitivity of SK2-a channels. This substitution resulted in a novel interaction between …

Emulating Balance Control Observed In Human Test Subjects With A Neural Network, Wade William Hilts

Dissertations and Theses

Human balance control is a complex feedback system that must be adaptable and robust in an infinitely varying external environment. It is probable that there are many concurrent control loops occurring in the central nervous system that achieve stability for a variety of postural perturbations. Though many engineering models of human balance control have been tested, no models of how these controllers might operate within the nervous system have yet been developed. We have focused on building a model of a proprioceptive feedback loop with simulated neurons. The proprioceptive referenced portion of human balance control has been successfully modeled by …

Conceptual Structures Of Vietnamese Emotions, Hien T. Tran

Linguistics ETDs

ABSTRACT

This dissertation presents a comparative study of the metaphoric and metonymic systems underlying the conceptualizations of two emotions, anger and sadness, in Vietnamese, American English, and Chinese. The analytic and theoretical approach is based on previous studies by Lakoff and Kövecses (1987), Kövecses (1988), Barcelona (1986), King (1989) and Yu (1995). The research presented here on emotion concepts reveals cultural variation and potential universals in the conceptualization of emotions. These results support the “Cultural Embodied Prototype” view proposed by Kövecses (2004:14) which proposes that conceptualizations of human emotions is motivated by both physiological embodied experiences (physiological embodiment) and the …

Pharmacologic Approaches To Targeting Malignant Activation Of Cap-Dependent Protein Translation In Aggressive B-Cell Lymphomas, Tara Lenore Peters

Open Access Dissertations

Despite decades of research identifying molecular drivers of cancer, targeted therapies fail to provide long-term survival benefits for cancer patients much of the time, primarily due to tumor heterogeneity and redundancies of signaling pathways. In the most common lymphoma, diffuse large B-cell lymphoma (DLBCL), malignant activation of B-cell receptor (BCR) signaling drives cancer cell growth. Expression of the PIM kinases downstream of this signaling is a common feature of the Activated B-cell like (ABC) subtype of DLBCL, and a target of interest for therapy. We found the sensitivity of ABC DLBCL to pan-PIM kinase inhibition by the clinical compound PIM447 …

2017-2018 Common Data Set, Southwestern Oklahoma State University

Common Data Sets

This document contains data compiled by the SWOSU Office of Institutional Research for the 2017-2018 academic year.

Cons, Constructions And Misconceptions Of Computer Related Crime: From A Digital Syntax To A Social Semantics, M. R. Mcguire

Qualitative Criminology (QC)

"Has the framing of computer crime been a process which has, in effect, left us all framed? What is it that we think that we understand when we use terms like “internet crime,” “cybercrime,” or “technocrime,” and in what sense does this understanding constitute knowledge? In particular, the kind of knowledge which can be defined as “social scientific?” In this paper, I apply one of the key distinctions used to define computational processes – that made between a syntax and a semantics – to illustrate some of the problems that have affected our thinking about cybercrime and undermined our responses …

Completions 2017-18, Southwestern Oklahoma State University

IPEDS

IPEDS Report created by the SWOSU Office of Institutional Research

2018-July-15-Dr. Sharon Mcgee, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Neurobehavioral Signatures In Children-Victim Of Bullying, Isabel Solis

Psychology ETDs

Experiencing bullying victimization can lead to detrimental damage to a child’s life potential, reduced long-term contributions to society, and in severe cases, to suicide or desperate acts of defensive aggression, such as school shootings. The current study aimed to examine risk factors that may increase the vulnerability of a child to become a target of bullying victimization and the related consequences of victimization, using rigorous neuropsychological and EEG measures. The end-goal is to translate these findings into a program of preventive intervention increasing the child’s resilience and improving social culture among youth in the academic environment. We propose a two-component …

Future Research Directions In Pneumonia, Charles S. Dela Cruz, Richard G. Wunderink, David C. Christiani, Stephania A. Cormier, Kristina Crothers, Claire M. Doerschuk, Scott E. Evans, Daniel R. Goldstein, Purvesh Khatri, Lester Kobzik, Jay K. Kolls, Bruce D. Levy, Mark L. Metersky, Michael S. Niederman, Roomi Nusrat, Carlos J. Orihuela, Paula Peyrani, Alice S. Prince, Julio A. Ramírez, Karen M. Ridge, Sanjay Sethi, Benjamin T. Suratt, Jacob I. Sznajder, Ephraim L. Tsalik, Allan J. Walkey, Sachin Yende, Neil R. Aggarwal, Elisabet V. Caler, Joseph P. Mizgerd

Faculty Publications

Copyright © 2018 by the American Thoracic Society. Pneumonia is a complex pulmonary disease in need of new clinical approaches. Although triggered by a pathogen, pneumonia often results from dysregulations of host defense that likely precede infection. The coordinated activities of immune resistance and tissue resilience then dictate whether and how pneumonia progresses or resolves. Inadequate or inappropriate host responses lead to more severe outcomes such as acute respiratory distress syndrome and to organ dysfunction beyond the lungs and over extended time frames after pathogen clearance, some of which increase the risk for subsequent pneumonia. Improved understanding of such host …

Polycyclic Aromatic Hydrocarbon Exposure In Seaside Sparrows (Ammodramus Maritimus) Following The 2010 Deepwater Horizon Oil Spill, Anna A. Perez-Umphrey, Christine M. Bergeon Burns, Philip C. Stouffer, Stefan Woltmann, Sabrina S. Taylor

Faculty Publications

The seaside sparrow (Ammodramus maritimus) is an abundant and permanent resident of coastal salt marshes impacted by the 2010 BP Deepwater Horizon oil spill. Such terrestrial species are often overlooked in the aftermath of marine spills, despite the potential for long-term oil exposure. We sampled the livers of seaside sparrows residing in oiled and unoiled sites from 2011 to 2014 and quantified expression of cytochrome p450 1A (CYP1A), a gene involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). In August 2011, CYP1A expression was markedly higher in birds from an oiled site compared to an unoiled site, but differences …

The Great Season Of The Majestics, Mileva Anastasiadou

The Mythic Circle

No abstract provided.

Contributors, Gwenyth E. Hood

The Mythic Circle

No abstract provided.

Novel Management Strategies For Medically-Refractory Vasospasm Following Aneurysmal Subarachnoid Hemorrhage, Fawaz Al-Mufti, Krishna Amuluru, Nitesh Damodara, Mohammad El-Ghanem, Rolla Nuoman, Naveed Kamal, Sarmad Al-Marsoummi, Nicholas A. Morris, Neha S. Dangayach, Stephan A. Mayer

Neurology Articles

Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) is an important cause of further morbidity and mortality after an already devastating condition. Though traditionally attributed to vasospasm of large capacitance arteries and the resulting down-stream disruption of cerebral blood flow, the pathogenesis of DCI has proven to be more complex with early brain injury, blood-brain barrier disruption, microthrombosis, cortical spreading depolarizations, and the failure of cerebral autoregulation as newly elucidated factors. Vasospasm is a known consequence of SAH. The standard of care includes close monitoring for neurological deterioration, most often with serial clinical examinations, transcranial Doppler ultrasonography, and vascular …

Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization In The Prelimbic Cortex, Jayme R. Mcreynolds, Elizabeth M. Doncheck, Yan Li, Oliver Vranjkovic, Evan N. Graf, Daisuke Ogasawara, Benjamin F. Cravatt, David A. Baker, Qing-Song Liu, Cecilia J. Hillard, John R. Mantsch

Biological Sciences Faculty Research and Publications

Background

Clinical reports suggest that rather than directly driving cocaine use, stress may create a biological context within which other triggers for drug use become more potent. We hypothesize that stress-induced increases in corticosterone “set the stage” for relapse by promoting endocannabinoid-induced attenuation of inhibitory transmission in the prelimbic cortex (PL).

Methods

We have established a rat model for these stage-setting effects of stress. In this model, neither a stressor (electric footshock) nor stress-level corticosterone treatment alone reinstates cocaine seeking following self-administration and extinction, but each treatment potentiates reinstatement in response to an otherwise subthreshold cocaine priming dose (2.5 mg/kg, …