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2018

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Rapid Sample Processing Of Foodborne Pathogens Using Cross-Flow Microfiltration, Casey Bomrad, Michael R. Ladisch, Linda Liu, Jessica Lynn Zuponcic, Eduardo Ximenes Aug 2018

Rapid Sample Processing Of Foodborne Pathogens Using Cross-Flow Microfiltration, Casey Bomrad, Michael R. Ladisch, Linda Liu, Jessica Lynn Zuponcic, Eduardo Ximenes

The Summer Undergraduate Research Fellowship (SURF) Symposium

Foodborne illnesses are a prominent issue, causing 48 million illnesses annually. The Escherichia coli O157:H7 outbreak in romaine lettuce is a recent example. The source of the pathogen was contaminated irrigation water. The most common methods for detecting foodborne pathogens involve cultivation and enrichment of food samples. The enrichment steps are time-consuming, taking 24 to 72 hours to complete. Our study aims to accelerate irrigation water sample preparation for pathogenic microorganism fast detection through cross-flow microfiltration. This is accomplished by a device called a continuous cell concentration and recovery device (C3D). The C3D uses cross-flow microfiltration in a hollow fiber …

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Targeting Pro-Inflammatory Function Of Microglia Using Small Molecules To Combat Neurodegeneration, Gabrielle C. Williams, Priya Prakash, Gaurav Chopra Aug 2018

Targeting Pro-Inflammatory Function Of Microglia Using Small Molecules To Combat Neurodegeneration, Gabrielle C. Williams, Priya Prakash, Gaurav Chopra

The Summer Undergraduate Research Fellowship (SURF) Symposium

Microglia are the brain’s resident immune cells that are responsible for maintaining homeostasis in healthy conditions. During injury or infection, resting microglia get activated and produce pro-inflammatory cytokines such as IL-1b, IL-1a, IL-6, etc. along with reactive oxygen species like nitric oxide (NO) to combat neuroinflammatory diseases such as Alzheimer’s disease (AD). Inflammation is characterized by the activation of resident-immune cells in the brain called microglia that respond to the eat-me signals released by the toxic amyloid beta peptides as well as the dying neurons in the microenvironment. Recent studies have shown that activated microglia induce neuronal death by secreting …

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Spatial And Temporal Storm Generation From A Stochastic View, Jiaxiang Ding, Josept D. Revuelta-Acosta, Engel Bernard Aug 2018

Spatial And Temporal Storm Generation From A Stochastic View, Jiaxiang Ding, Josept D. Revuelta-Acosta, Engel Bernard

The Summer Undergraduate Research Fellowship (SURF) Symposium

Precipitation is one of the most important parameters in the study of hydrology and most of the research has been done on daily storm generation. Current weather generation models are used to replicate daily or monthly time resolution, which is not able to show the variability within one day or one month. This project deals with sub-daily storm generation with finer resolution and more accurate estimation, which also requires an independent storm separation method. And the Monte Carlo correlated multivariate simulation is applied to compute the variables. The description is essential for soil erosion and water quality research. Another reason …

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Effect Of Carbohydrates On The Gut Microbiome, Maciej Filar, Mohit S. Verma Aug 2018

Effect Of Carbohydrates On The Gut Microbiome, Maciej Filar, Mohit S. Verma

The Summer Undergraduate Research Fellowship (SURF) Symposium

The microbiome within the gut is directly linked to biological processes within a person, influencing factors such as metabolism, signaling pathways, and available nutrients. Long term dieting is known to alter ecological conditions within the gut, allowing certain types of microbes to flourish. Therefore, the overall health of an individual is ultimately influenced by shifts in the microbial community state caused by persistent dieting. This study investigates the connection between diet and the microbiome and draws an understanding of how common carbohydrates in food can affect bacterial composition. Using KBase software, anaerobic bacterial growth was investigated for bacteria subject to …

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Image Analysis Of A Vesicle To Calculate The Bending Modulus, Pheobe Appel, Charlie Lin, Vivek Narsimhan Aug 2018

Image Analysis Of A Vesicle To Calculate The Bending Modulus, Pheobe Appel, Charlie Lin, Vivek Narsimhan

The Summer Undergraduate Research Fellowship (SURF) Symposium

The cell membrane is an essential component of living cells and the dynamics of the membrane will provide insight into how a biological cell reacts to mechanical strain. Membrane mechanics are important in a variety of cellular processes like secretion, trafficking, signaling, and storage. Giant unilamellar vesicles are a model system for cellular membranes since the major component of all membranes is a phospholipid bilayer. Giant unilamellar vesicles allow one to examine physicochemical processes that occur in all cellular membranes, such as fusion, budding, and fission in a more controlled fashion. Contour fluctuations of the vesicles are analyzed to calculate …

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Predict The Failure Of Hydraulic Pumps By Different Machine Learning Algorithms, Yifei Zhou, Monika Ivantysynova, Nathan Keller Aug 2018

Predict The Failure Of Hydraulic Pumps By Different Machine Learning Algorithms, Yifei Zhou, Monika Ivantysynova, Nathan Keller

The Summer Undergraduate Research Fellowship (SURF) Symposium

Pump failure is a general concerned problem in the hydraulic field. Once happening, it will cause a huge property loss and even the life loss. The common methods to prevent the occurrence of pump failure is by preventative maintenance and breakdown maintenance, however, both of them have significant drawbacks. This research focuses on the axial piston pump and provides a new solution by the prognostic of pump failure using the classification of machine learning. Different kinds of sensors (temperature, acceleration and etc.) were installed into a good condition pump and three different kinds of damaged pumps to measure 10 of …

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Developing Strategies To Toughen Bio-Inspired Adhesives, Narelli P. Narciso, Samuel Lee Huntington, Jonathan J. Wilker Aug 2018

Developing Strategies To Toughen Bio-Inspired Adhesives, Narelli P. Narciso, Samuel Lee Huntington, Jonathan J. Wilker

The Summer Undergraduate Research Fellowship (SURF) Symposium

Mussels and other marine creatures adhere very well in underwater environments, having the ability to withstand the force of the sea. These animals have inspired synthetic biomimetic adhesives for wet systems, presenting potential for biomedical applications. However, most current commercial adhesives tend to be brittle, not resisting repetitive movements. This study assesses toughening strategies to improve the mussel-inspired adhesives’ ductility while maintaining its strength. The strategies included altering the polymer’s chemical structure by changing the percentage of polyethylene glycol (PEG) in the molecule and by adding fillers, such as calcium carbonate, silica and nacre - a calcium carbonate compound found …

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Cost-Effective Paper-Based Diagnostic Using Split Proteins To Detect Yeast Infections, Zachary R. Berglund, Kevin V. Solomon, Mohit S. Verma, Moiz Rasheed, Zachary Hartley, Kevin Fitzgerald, Kok Zhi Lee, Janice Chan, Julianne Dejoie, Makayla Schacht, Alex Zavala Aug 2018

Cost-Effective Paper-Based Diagnostic Using Split Proteins To Detect Yeast Infections, Zachary R. Berglund, Kevin V. Solomon, Mohit S. Verma, Moiz Rasheed, Zachary Hartley, Kevin Fitzgerald, Kok Zhi Lee, Janice Chan, Julianne Dejoie, Makayla Schacht, Alex Zavala

The Summer Undergraduate Research Fellowship (SURF) Symposium

The common yeast infection, vulvovaginal candidiasis, affects three out of four women throughout their lifetime and can be spread to their child in the form of oral candidiasis (thrush). This disease is caused by the fungal pathogen Candida albicans, which is also a major cause of systemic candidiasis, a rarer but deadly disease with up to a 49% lethality rate. Current widely-used diagnostic methods include cell cultures, pH tests, and antibody detection, to assist effective treatment. Despite availability of various diagnostic methods, there is no inexpensive, rapid, and accurate way to detect C. albicans infection. This project aims to …

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Effect Of Salts On The Deadly Amphibian Chytrid Fungus Batrachochytrium Dendrobatidis, Mariah J. Burgmeier, Spencer R. Siddons, Catherine L. Searle Aug 2018

Effect Of Salts On The Deadly Amphibian Chytrid Fungus Batrachochytrium Dendrobatidis, Mariah J. Burgmeier, Spencer R. Siddons, Catherine L. Searle

The Summer Undergraduate Research Fellowship (SURF) Symposium

The amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd) is a parasitic fungus that infects and kills amphibians worldwide. Bd causes electrolyte imbalance by destroying the keratin in the skin and causes cardiac arrest. Past studies have shown that Bd growth and motility can be inhibited by increased NaCl concentrations. In most studies, NaCl is the only type of salt used but Bd is exposed to other types of salts. In North American wetlands, runoff from road salts during winter and spring when Bd hosts (amphibians) often experience high levels of infection prevalence. This study investigated how different road salts at various …

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Structural Characterization Of The Dep Domains Of P-Rex1, Samantha R. Allgood, John J.G. Tesmer, Sandeep K. Ravala Aug 2018

Structural Characterization Of The Dep Domains Of P-Rex1, Samantha R. Allgood, John J.G. Tesmer, Sandeep K. Ravala

The Summer Undergraduate Research Fellowship (SURF) Symposium

P-Rex1 is a guanine nucleotide exchange factor for Rho-GTPases, which is indirectly involved in the regulation of cell migration and proliferation. It contains a tandem DH/PH domain archetypal of the Dbl family of GEFs, two DEP and two PDZ domains, and a C-terminal end with weak homology to inositol polyphosphate 4-phosphatase. P-Rex1 is regulated by both intra-domain interactions and interactions with other proteins such as G-protein beta gamma, PKA and phosphatidylinositol (3,4,5)-trisphosphate. Upregulation of P-Rex1 has been found in multiple human cancers, making it a potential target for anti-cancer drug therapies. Therefore, structural characterization of P-Rex1 is critical. Currently, only …

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Improving Biomanufacturing Production With Novel Elp-Based Transcriptional Regulators, Juya Jeon, Logan R. Readnour, Kevin V. Solomon Aug 2018

Improving Biomanufacturing Production With Novel Elp-Based Transcriptional Regulators, Juya Jeon, Logan R. Readnour, Kevin V. Solomon

The Summer Undergraduate Research Fellowship (SURF) Symposium

Microbes can be used to produce valuable drugs, chemicals, and biofuels, but their potential has not been fully realized due to low production yields. To improve biomanufacturing processes and yield, we are developing novel, transcriptional regulators using biosynthesis technology in order to improve cellular health and overall production. Our regulator contains elastin-like polypeptides (ELPs), which make ideal sensors since they exhibit a sharp, inverse phase transition to indicators of cell health such as intracellular pH and ionic strength, and external stimuli such as temperature. We hypothesize that ELP can be fused to transcription factors to control expression of target genes. …

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Engineering Bioluminescent Sensors Of Cyclic Amp To Study Opioid Signaling, Alexander L. Tesmer, Alexander R. French, Mathew Tantama Aug 2018

Engineering Bioluminescent Sensors Of Cyclic Amp To Study Opioid Signaling, Alexander L. Tesmer, Alexander R. French, Mathew Tantama

The Summer Undergraduate Research Fellowship (SURF) Symposium

Opioids are small signaling molecules which bind to opioid receptors on the surface of cells. The kappa opioid receptor (KOR) is one of three major types of opioid receptors found in human neurons. When an opioid binds to a KOR, a variety of biochemical signaling pathways are activated inside the cell. Each of these pathways are associated with different physiological effects of KOR activation. The production of a small signaling molecule, cyclic adenosine monophosphate (cAMP), is known to be inhibited during KOR activation of the analgesic (pain-killing) signaling pathway. The ability to interrogate the individual responses of KOR signaling pathways …

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Structural Analysis Of The Bama-B Complex In Acinetobacter Baumannii, Abigael Gichaba, Nicholas Noinaj, Robert E. Stephenson Aug 2018

Structural Analysis Of The Bama-B Complex In Acinetobacter Baumannii, Abigael Gichaba, Nicholas Noinaj, Robert E. Stephenson

The Summer Undergraduate Research Fellowship (SURF) Symposium

There are 2 types of bacteria, gram-negative and gram-positive bacteria. Gram-negative bacteria have both a plasma membrane and an outer membrane, while gram-positive only have a plasma membrane. The outer membranes of gram-negative bacteria have outer membrane proteins which are essential for the bacteria’s survival. Also located within the outer membrane is a multicomponent protein complex named the beta-barrel assembly machinery (BAM) complex. BAM is responsible for folding and inserting outer membrane proteins into the outer membrane. This protein complex serves an essential role but not much is understood about its function. In this study, two subunits of the BAM …

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Genome Analysis Of Multiple Mycobacteriophage, Emily Kerstiens, Kari Clase, Yi Li, Gillian Smith, Sarah Bell Aug 2018

Genome Analysis Of Multiple Mycobacteriophage, Emily Kerstiens, Kari Clase, Yi Li, Gillian Smith, Sarah Bell

The Summer Undergraduate Research Fellowship (SURF) Symposium

Bacteriophage are viruses that infect and kill bacteria. They can be used as treatments for antibiotic resistant bacterial infections, but more knowledge is needed about phage and how they interact with bacteria in order to develop safe and effective phage therapy treatments. This study examines the genomes of eighteen mycobacteriophage that were isolated from the environment on and surrounding Purdue University. Phage genomes were annotated using several bioinformatics software, including DNA Master, GeneMark, and PECAAN. Evidence was examined to determine the correct location within the genome and the potential function. Approximately two thousand genes were annotated in this study. A …

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Polyrotaxane Variants And Their Effects On The Cholesterol Efflux In Patients Suffering From Niemann Pick Type C, Sydney Smith, Zach Struzik, David Thompson Aug 2018

Polyrotaxane Variants And Their Effects On The Cholesterol Efflux In Patients Suffering From Niemann Pick Type C, Sydney Smith, Zach Struzik, David Thompson

The Summer Undergraduate Research Fellowship (SURF) Symposium

Niemann Pick type C disease (NPC) is a rare lysosomal storage disorder characterized by a progressive accumulation of cholesterol in the late endosomal/lysosomes compartment leading to cellular dysfunction and organ failure. Symptoms include ataxia, dysarthria, cognitive dysfunction, and seizures. Although average life expectancy is below 20, there are no FDA approved treatment available making it a serious unmet medical need. Clinical trials with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) has shown promise in cholesterol normalization within NPC cells. However, HP-beta-CD treatment has been shown to cause ototoxicity in NPC patients at high dosages. Supramolecular complexes known as polyrotaxanes have been synthesized in hopes of …

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Dna And Depletant Based Control Of The Collective Motion Of Gliding Microtubules, Caleb A. Conlisk, Feiran Li, Jong Hyun Choi Aug 2018

Dna And Depletant Based Control Of The Collective Motion Of Gliding Microtubules, Caleb A. Conlisk, Feiran Li, Jong Hyun Choi

The Summer Undergraduate Research Fellowship (SURF) Symposium

Motor proteins, like kinesin, transport cargo within biological cells by transforming chemical energy into mechanical energy through the hydrolysis of adenosine triphosphate (ATP). Kinesins walk across small tracks called microtubules. Recent studies have found that these concepts can be applied in vitro by attaching the motors to a glass substrate, on which microtubules can then glide across. These systems could be useful for many applications, such as targeted drug delivery and efficient, easy medical diagnosis. However, the motion of traveling microtubules is randomly ordered, and methods for controlling it are often hard to implement and recreate. One promising approach is …

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Water Temperature And Harmful Algal Bloom Rate, Geoff Bright, Greg Michalski, Benjamin P. Wilkins Aug 2018

Water Temperature And Harmful Algal Bloom Rate, Geoff Bright, Greg Michalski, Benjamin P. Wilkins

The Summer Undergraduate Research Fellowship (SURF) Symposium

Harmful algal blooms, made up of cyanobacteria, is an increasing problem in Midwestern lakes. Nitrogen and phosphorus fertilizers used in crops such as corn and soybeans run off into streams and eventually lakes. Nitrogen and phosphorus in the form of nitrate and phosphate respectively is then used by cyanobacteria as a food source, allowing them to bloom at an alarming rate. Massive bloom events can be hazardous to both human health and the natural environment because of the release of neurotoxins, hepatotoxins and others into the air and drinking water. We set out to find if different water temperature can …

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Mutational Analysis Of The Putative Dimer Interface Of Dna Methyltransferase 3b, Amie R. Michie, Allison B. Norvil, Nicole E. Forstoffer, Humaria Gowher Aug 2018

Mutational Analysis Of The Putative Dimer Interface Of Dna Methyltransferase 3b, Amie R. Michie, Allison B. Norvil, Nicole E. Forstoffer, Humaria Gowher

The Summer Undergraduate Research Fellowship (SURF) Symposium

DNA methylation is an epigenetic process involved in gene regulation that is key for cell differentiation and viability. DNA methyltransferase 3a and 3b (Dnmt3a andDnmt3b) are two enzymes that establish this epigenetic modification during early cell development. These two proteins have been linked to many cancers such as worsening the prognosis of patients with acute myeloid leukemia (AML), due to mutation of Dnmt3a. Over-expression of Dnmt3b has been shown to be involved in Immunodeficiency Centromere instability and Facial abnormalities syndrome (ICF). The crystal structure of Dnmt3a catalytic domain shows that it forms a tetramer and it was shown to methylate …

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Targeted Epigenetic Editing Using Optogenetic Tools, Joshua Hahn, Chongli Yuan Aug 2018

Targeted Epigenetic Editing Using Optogenetic Tools, Joshua Hahn, Chongli Yuan

The Summer Undergraduate Research Fellowship (SURF) Symposium

Epigenetics markers, such as DNA methylation and histone post-translational modifications, are modifications to the structure of DNA that impact gene expression without altering the genetic code. Among them, DNA methylation plays a critical role in various biological processes including the differentiation of stem cells, regulation of gene expression, and adaptation to environmental signals. The ability to modify DNA methylation at particular genes in various cell types is thus desirable for engineering specific cell phenotypes. Although technologies exist that can alter DNA methylation at target genes, these techniques lack spatial and temporal resolution and are not able to selectively edit individual …

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Expression Of Carbohydrates Biosynthetic Genes In Developing Soybean Seeds, Jayden Rosen, Karen A. Hudson Aug 2018

Expression Of Carbohydrates Biosynthetic Genes In Developing Soybean Seeds, Jayden Rosen, Karen A. Hudson

The Summer Undergraduate Research Fellowship (SURF) Symposium

An essential part of livestock diets is soybean meal, which is a major source of protein, but which also consists of antinutritional carbohydrates. Antinutritional carbohydrates such as raffinose and stachyose lead to irritation to the gut for monogastric livestock as well as unhealthy weight gain. A major objective of soybean genetics is to reduce these antinutritional carbohydrates within the seed and increase the levels of good carbohydrates. This will lead to healthier livestock and better meat quality. To select genes potentially responsible for variation in carbohydrate levels in seeds, the expression of genes encoding several biosynthetic enzymes was measured during …

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High-Throughput Nanoliter Dispensing Device For Biological Applications, Cole Reynolds, Euiwon Bae Dr., J Paul Robinson Dr. Aug 2018

High-Throughput Nanoliter Dispensing Device For Biological Applications, Cole Reynolds, Euiwon Bae Dr., J Paul Robinson Dr.

The Summer Undergraduate Research Fellowship (SURF) Symposium

Pathogen identification is a field that can contribute largely to the prevention of the spreading of illness and disease. In the past, pathogen identification has been a long and arduous process due to the time-consuming processes and steps that requires technician’s time and effort. With new technologies emerging however, screening of bacteria colonies can be done in a quick and high-throughput way. The problem is that using the current methods, bacteria cannot be transferred to petri dishes fast enough to keep up with the new screening methods. The current study focuses on exploring different methods to create an ergonomic device …

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Engineering Dub-Deficient Viral Proteases From Fipv And Pedv Coronaviruses, Daniel T. Wesenberg, Jozlyn R. Clasman, Andrew D. Mesecar Aug 2018

Engineering Dub-Deficient Viral Proteases From Fipv And Pedv Coronaviruses, Daniel T. Wesenberg, Jozlyn R. Clasman, Andrew D. Mesecar

The Summer Undergraduate Research Fellowship (SURF) Symposium

Coronaviruses form a class of viral pathogens lethal to humans and livestock. This issue is compounded by a lack of commercially available treatments or vaccines. In 2014, porcine epidemic diarrhea virus (PEDV) emerged in the United States and accounted for an estimated 7 million porcine deaths. Deaths of humans, companion animals, and livestock caused by coronaviruses highlight the need for therapeutic strategies to combat this devastating disease. One strategy involves engineering papain-like protease 2 (PLP2), an enzyme conserved among coronavirus species that is critical for virus replication and pathogenesis. PLP2’s de-ubiquitinating (DUB) activity aids in the suppression of the host’s …

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Satellite-Based Monitoring Of Spatiotemporal Changes In Batudulang Forest In Sumbawa, Indonesia, Mohammad Muslim, Arief Budhi Witarto, Wahyu Indrajaya Aug 2018

Satellite-Based Monitoring Of Spatiotemporal Changes In Batudulang Forest In Sumbawa, Indonesia, Mohammad Muslim, Arief Budhi Witarto, Wahyu Indrajaya

Makara Journal of Technology

Space-based earth observation technology applicable to forest inventory and monitoring is well known in the scientific community. High-resolution satellite images form an important data source for forest mapping and change detection at regional and national scales. The value of forest change information derived from remote sensing data is significantly enhanced if this information is integrated into a spatially explicit geographic information system. Satellite-based rapid assessment was conducted to measure spatiotemporal changes in Batudulang forest over the years. The general approach to quantify change in the spatial aspect of the forest involved change detection using moderate-resolution imaging spectro-radiometer satellite-based normalized difference …

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Poultry And Beef Meat As Potential Seedbeds For Antimicrobial Resistant Enterotoxigenic Bacillus Species: A Materializing Epidemiological And Potential Severe Health Hazard, Kamelia M. Osman, Ahmed Orabi, Anthony D. Kappell, Khalid S. Al-Maary, Ayman S. Mubarak, Turki M. Dawoud, Ihab M.I. Moussa, Hassan A. Hemeg, Ashgan M. Hessain, Hend M.Y. Yousef, Krassimira R. Hristova Aug 2018

Poultry And Beef Meat As Potential Seedbeds For Antimicrobial Resistant Enterotoxigenic Bacillus Species: A Materializing Epidemiological And Potential Severe Health Hazard, Kamelia M. Osman, Ahmed Orabi, Anthony D. Kappell, Khalid S. Al-Maary, Ayman S. Mubarak, Turki M. Dawoud, Ihab M.I. Moussa, Hassan A. Hemeg, Ashgan M. Hessain, Hend M.Y. Yousef, Krassimira R. Hristova

Biological Sciences Faculty Research and Publications

Although Bacillus cereus is of particular concern in food safety and public health, the role of other Bacillus species was overlooked. Therefore, we investigated the presence of eight enterotoxigenic genes, a hemolytic gene and phenotypic antibiotic resistance profiles of Bacillusspecies in retail meat samples. From 255 samples, 124 Bacillus isolates were recovered, 27 belonged to B. cereusand 97 were non-B. cereus species. Interestingly, the non-B. cereus isolates carried the virulence genes and exhibited phenotypic virulence characteristics as the B. cereus. However, correlation matrix analysis revealed the B. cereus group positively …

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Immunogenicity And Protection After Vaccination With A Modified Vaccinia Virus Ankara-Vectored Yellow Fever Vaccine In The Hamster Model, Justin G. Julander, Marco Testori, Cédric Cheminay, Ariane Volkmann Aug 2018

Immunogenicity And Protection After Vaccination With A Modified Vaccinia Virus Ankara-Vectored Yellow Fever Vaccine In The Hamster Model, Justin G. Julander, Marco Testori, Cédric Cheminay, Ariane Volkmann

Animal, Dairy, and Veterinary Science Faculty Publications

The highly efficacious live-attenuated 17D yellow fever (YF) vaccine is occasionally associated with rare life-threatening adverse events. Modified vaccinia virus Ankara (MVA), a non-replicating poxvirus, has been used as a vaccine platform to safely deliver various antigens. A MVA-based YF vaccine (MVA-BN-YF) was tested with and without a non-mineral oil adjuvant in a hamster model of lethal YF disease and protective efficacy of this vaccine was compared with the 17D vaccine. The vaccine candidate MVA-BN-YF generated a protective response in hamsters infected with YFV that was comparable to protection by the live 17D vaccine. Similar levels of neutralizing antibody were …

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Maternal Programming: Application Of A Developmental Psychopathology Perspective, Laura M. Glynn, Mariann A. Howland, Molly Fox Aug 2018

Maternal Programming: Application Of A Developmental Psychopathology Perspective, Laura M. Glynn, Mariann A. Howland, Molly Fox

Psychology Faculty Articles and Research

The fetal phase of life has long been recognized as a sensitive period of development. Here we posit that pregnancy represents a simultaneous sensitive period for the adult female with broad and persisting consequences for her health and development, including risk for psychopathology. In this review, we examine the transition to motherhood through the lens of developmental psychopathology. Specifically, we summarize the typical and atypical changes in brain and behavior that characterize the perinatal period. We highlight how the exceptional neuroplasticity exhibited by women during this life phase may account for increased vulnerability for psychopathology. Further, we discuss several modes …

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Becoming Nicole, Ivana Valencia, Veer Gulia, Robin Williams Aug 2018

Becoming Nicole, Ivana Valencia, Veer Gulia, Robin Williams

Summer Enrichment Program

No abstract provided.

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Measuring Time Perception: A Psychometric Analysis, Patrick Joseph Mcnicholas Aug 2018

Measuring Time Perception: A Psychometric Analysis, Patrick Joseph Mcnicholas

Electronic Theses and Dissertations Archive

In the literature, many methods have been used to assess the perception of time in individuals. The purpose of this study was to examine the psychometric properties of time estimation, production, reproduction, and discrimination tasks. Using psychometric terminology consistent with the Standards for Educational and Psychological Testing, this study utilized classical test theory (CTT) and item response theory (IRT) to assess the accuracy, consistency, stability, difficulty, and discrimination of the four aforementioned methods of estimating time perception in college students (N = 136). At present, the tasks were able to demonstrate both validity and reliability through the analyses conducted and …

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Using Wetlands To Prevent The Surface Accumulation Of Aphanizomenon Flos-Aquae From Upper Klamath Lake, Arick Christopher Rouhe Aug 2018

Using Wetlands To Prevent The Surface Accumulation Of Aphanizomenon Flos-Aquae From Upper Klamath Lake, Arick Christopher Rouhe

Dissertations and Theses

The ability to regulate buoyancy (sinking and floating) using cellular gas vesicles is a unique characteristic that allows many common bloom-forming cyanobacteria to accumulate at water surfaces and dominate systems. Typical control and management strategies include nutrient manipulation and phosphorus reduction, which are effective but do not reduce the advantage of buoyancy control. Since buoyancy control is based upon a mechanism that is driven by photosynthesis along with environmental conditions that trigger vesicle formation and ion exchange, buoyancy regulation can be influenced by manipulating extracellular conditions. In this study I manipulated extracellular conditions using wetland water and additions of potassium, …

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An Eqtl Landscape Of Kidney Tissue In Human Nephrotic Syndrome., Christopher E. Gillies, Rosemary Putler, Rajasree Menon, Edgar Otto, Kalyn Yasutake, Viji Nair, Paul Hoover, David Lieb, Shuqiang Li, Sean Eddy, Damian Fermin, Michelle T. Mcnulty, Nephrotic Syndrome Study Network (Neptune), Nir Hacohen, Krzysztof Kiryluk, Matthias Kretzler, Xiaoquan Wen, Matthew G. Sampson, Tarak Srivastava Aug 2018

An Eqtl Landscape Of Kidney Tissue In Human Nephrotic Syndrome., Christopher E. Gillies, Rosemary Putler, Rajasree Menon, Edgar Otto, Kalyn Yasutake, Viji Nair, Paul Hoover, David Lieb, Shuqiang Li, Sean Eddy, Damian Fermin, Michelle T. Mcnulty, Nephrotic Syndrome Study Network (Neptune), Nir Hacohen, Krzysztof Kiryluk, Matthias Kretzler, Xiaoquan Wen, Matthew G. Sampson, Tarak Srivastava

Manuscripts, Articles, Book Chapters and Other Papers

Expression quantitative trait loci (eQTL) studies illuminate the genetics of gene expression and, in disease research, can be particularly illuminating when using the tissues directly impacted by the condition. In nephrology, there is a paucity of eQTL studies of human kidney. Here, we used whole-genome sequencing (WGS) and microdissected glomerular (GLOM) and tubulointerstitial (TI) transcriptomes from 187 individuals with nephrotic syndrome (NS) to describe the eQTL landscape in these functionally distinct kidney structures. Using MatrixEQTL, we performed cis-eQTL analysis on GLOM (n = 136) and TI (n = 166). We used the Bayesian "Deterministic Approximation of Posteriors" (DAP) to fine-map …

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