Digital Commons Network^™

Continuous Theta Rhythm During Spatial Working Memory Task In Rodent Models Of Streptozotocin-Induced Type 2 Diabetes, Stephanie Hernandez, Ryan A. Wirt, James M. Hyman

McNair Poster Presentations

Alzheimer’s disease is a neurodegenerative disorder altering memory loss thought to be due to neuropathological symptoms such as the buildup of beta amyloid plaques (Ab) and neurofibrillary tangles (NFT). The etiology of Alzheimer’s is still unknown; however, potential risk factors such as diabetes may lead to its development. The most common form of diabetes is type 2 diabetes known for persistent insulin resistance leading to a state of hyperglycemia. Insulin resistance has been shown to affect cognitive abilities such as learning, memory and also alters synaptic plasticity. Neural connections between the hippocampus (HC) and anterior cingulate cortex (ACC) are known …

Comparison Of Bacteriophage Annotation Methods, Alicia Salisbury, Philippos Tsourkas

McNair Poster Presentations

The rise of antibiotic-resistant bacteria has increased interest in bacteriophages (viruses that kill bacteria) in recent years. Due to the decreasing cost of genome sequencing, the number of sequenced phage genomes is growing at a geometric rate. Sequencing is followed by annotation, in which genes, start codons, and putative protein functions are identified. Most phage genomes are auto-annotated with programs designed for prokaryotes. Accuracy metrics for these programs with regard to phage genomes are not available. The genome of Escherichia coli phage Lambda was used to benchmark the accuracy of several genome annotation methods and programs. Discovered in 1951, Lambda …

Evolution Of Nuchal Glands, Unusual Defensive Organs Of Asian Natricine Snakes (Serpentes: Colubridae), Inferred From A Molecular Phylogeny, Hirohiko Takeuchi, Alan H. Savitzky, Li Ding, Anslem De Silva, Indraneil Das, Tao Thien Nguyen, Tein-Shun Tsai, Teppei Jono, Guang-Xiang Zhu, Dharshani Mahaulpatha, Yezhong Tang, Akira Mori

Biology Faculty Publications

A large body of evidence indicates that evolutionary innovations of novel organs have facilitated the subsequent diversification of species. Investigation of the evolutionary history of such organs should provide important clues for understanding the basis for species diversification. An Asian natricine snake, Rhabdophis tigrinus, possesses a series of unusual organs, called nuchal glands, which contain cardiotonic steroid toxins known as bufadienolides. Rhabdophis tigrinus sequesters bufadienolides from its toad prey and stores them in the nuchal glands as a defensive mechanism. Among more than 3,500 species of snakes, only 17 Asian natricine species are known to possess nuchal glands or …

September 21, 2018, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Modelling Offshore Wave Farms For Coastal Process Impact Assessment: Waves, Beach Morphology, And Water Users, Christopher Stokes, Daniel C. Conley

School of Biological and Marine Sciences

No abstract provided.

Magnolin Targeting Of Erk1/2 Inhibits Cell Proliferation And Colony Growth By Induction Of Cellular Senescence In Ovarian Cancer Cells, Ji‐Hong Song, Cheol‐Jung Lee, Hyun‐Jung An, Sun‐Mi Yoo, Han C. Kang, Joo Y. Lee, Kwang D. Kim, Dae Joon Kim, Hye S. Lee, Yong‐Yeon Cho

School of Medicine Publications

Ras/Raf/MEKs/ERKs and PI3 K/Akt/mTOR signaling pathways have key roles in cancer development and growth processes, as well as in cancer malignance and chemoresistance. In this study, we screened the therapeutic potential of magnolin using 15 human cancer cell lines and combined magnolin sensitivity with the CCLE mutaome analysis for relevant mutation information. The results showed that magnolin efficacy on cell proliferation inhibition were lower in TOV‐112D ovarian cancer cells than that in SKOV3 cells by G1 and G2/M cell cycle phase accumulation. Notably, magnolin suppressed colony growth of TOV‐112D cells in soft agar, whereas colony growth of SKOV3 cells in …

Sepsis Treatment: Is There A Role For Vitamins?, Jon Sevransky, Md, Mhs, Fccm

Sepsis Symposium

Presented at the 3rd Annual Sepsis Symposium

Outline

• Review treatment of patients with sepsis
• Review the benefits and limitations of single center vs multicenter clinical trials
• Discuss the evidence supporting use of Vitamin C, Thiamine and Steroids in Sepsis
• To describe the design of the VICTAS study (Vitamin C, Thiamine and Steroids in Sepsis)

Balancing Early Antibiotic Administration And Stewardship In Sepsis, Cindy Hou, Do, Ma, Mba, Facoi, Facp

Sepsis Symposium

Presented at the 3rd Annual Sepsis Symposium

Almost Anything Glows, Andrews University

Student Movement V. 103 (2018-2019)

No abstract provided.

Wavelet Methods For Cardio Signals Processing, Hakimjon Nasridinovich Zaynidinov Prof., Dilfuza Bahodirovna Zaynutdinova Dos., Umida Azimova, Muslim Adhamovich Kuchkarov

Bulletin of TUIT: Management and Communication Technologies

The article discusses the use of wavelet transforms and algorithms in the digital processing of cardiosignals in a number of medical applications due to their good adaptability to the analysis of non-stationary signals (that is, those whose statistical characteristics change with time). Since an electrocardiogram is a transient signal, wavelet methods can be used to recognize and detect key diagnostic features. In real-time systems for digital signal processing, it is important that mathematical operations are performed quickly, and the time required to execute commands must be known precisely and in advance. For this, both the program and the hardware must …

Nonlinear Mathematical Model For Monitoring And Forecasting The Process Of Distributing Aerosol Particles In The Atmosphere, Normahmad Ravshanov Prof., Tursun Shafiev, Nodira Tashtemirova

Bulletin of TUIT: Management and Communication Technologies

In this article there was developed a mathematical model for predicting, monitoring and assessing the ecological state of the atmosphere and underlying surface by passive and active impurities, where the varying velocity of particles in the atmosphere are considered. The successful solution of the tasks of monitoring and predicting the level of atmospheric pollution by harmful substances released from production facilities into the environment is based on the use of mathematical models that take into account the physical characteristics of the propagation of impurities, the relationship between the concentrations of impurities and environmental parameters: change in wind speed and direction …

The Santa Clara, 2018-09-20, Santa Clara University

The Santa Clara

No abstract provided.

Rosalie Rodriguez Interview, Jennifer Thomson

Bucknell: Occupied

Jennifer Thomson, assistant professor of History at Bucknell University, interviews Rosalie Rodriguez, Director of Multicultural Student Services. Thomson and Rodriguez discuss the issue of food insecurity on college campuses. Rodriguez discusses the factors which lead to campuses which do not support student dietary needs, as well as the cultural conceptions which contribute to food insecurity. She offered examples of policy and cultural changes that support food security for all students, and she mentioned the launch of a food pantry at Bucknell to support students. Guest Kelsey Hicks, Director of the Women's Resource Center, discussed the disproportionate impact of food insecurity …

The Setonian,September 20, 2018, Seton Hall University

2018

No abstract provided.

Relationships Between Borders, Management Agencies, And The Likelihood Of Watershed Impairment, Josh Epperly, Andrew Witt, Jeffrey Haight, Susan E. Washko, Trisha Brooke Atwood, Janice Brahney, Soren Brothers, Edd Hammill

Watershed Sciences Faculty Publications

In the United States, the Clean Water Act (CWA) establishes water quality standards important for maintaining healthy freshwater ecosystems. Within the CWA framework, states define their own water quality criteria, leading to a potential fragmentation of standards between states. This fragmentation can influence the management of shared water resources and produce spillover effects of pollutants crossing state lines and other political boundaries. We used numerical simulations to test the null prediction of no difference in impairment between watersheds that cross political boundaries (i.e. state lines, national or coastal borders, hereafter termed “transboundary”) and watersheds that cross no boundaries (hereafter “internal”). …

Prospectus, September 20, 2018, Parkland College, Paul Benson, Emma Fleming, Ashley House, Ayla Mcdonald, Savannah Weishaar

Prospectus 2018

Parkland Pride's First Year in the CU Pride Parade! Degree Completion Day: Are You on Track? Heroes Without Capes: Parkland Students for Sustainability Work to Preserve Native Species; Prospectus News Joins SPARK Online

September 20, 2018, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Greenhouse Gas Emissions And Crop Yield In No-Tillage Systems: A Meta-Analysis, Yawen Huang, Wei Ren, Lixin Wang, Dafeng Hui, John H. Grove, Xiaojuan Yang, Bo Tao, Ben Goff

Biology Faculty Research

No-tillage (NT) has been touted as one of several climate-smart agriculture (CSA) management practices that improve food security and enhance agroecosystem resilience to climate change. However, the sustainable effectiveness of NT greatly depends on trade-offs between NT-induced changes in crop yield and greenhouse gas (GHG, i.e. CH4, CO2, and N2O) emissions. Such trade-offs are regulated by climate fluctuations and heterogeneous soil conditions and have not been well addressed. Supporting CSA management decisions requires advancing our understanding of how NT affects crop yield and GHG emissions in different agroecological regions. In this study, a meta-analysis was conducted using 740 paired measurements …

Keep Calm And Carry On: Infant Carrying Practices And Motor Development, Mariah Clanton, Alyssa Crittenden

AANAPISI Poster Presentations

Increasingly, infants in the post-industrialized west are being diagnosed with conditions such as plagiocephaly or torticollis – which are postural deformities that can be corrected with positioning behavior. While a handful of studies have cursorily explored infant carrying practices, here I provide the first comprehensive cross-cultural literature review that aims to make connections between infant transport style and the timing of infant development in the emergence of sitting, crawling, and walking .Such a synthesis is important, not only in terms of contributing to cross-cultural research, but also for parents in the cultural west to aid in the better understanding of …

Curriculum Minutes 09/20/2018, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.

In Cardiac Injury, The Nsaid Carprofen Causes Dysfunction Of The Immune System, Staff

Browse All News

No abstract provided.

The Diamond, September 20, 2018, Dordt College

Dordt Diamond

• Front Page: Big Changes: Dordt to Unveil New University Logo; Putting the She in STEM; More Than Words on a Page
• News: 9/11 Perspective: May We Never Forget; A Wild Week of Welcome; On With the Show: Students Ready to Pop This Weekend; Supreme Court: A Heated Confirmation Hearing Still Boils; Beyond the Cornfields; Suicide Rates Rise; New Grinds at the Coffee Shop; Looking Back: Doon Oil Spill; Rice to Spice Up Grille Menu; Learning to Live with ADHD; A Family Affair: Dordt Welcomes New Ag Professors; Dordt Dining Serves Record Numbers at Annual Scholarship Banquet
• Opinion: The Importance of …

Minutes From The September 20, 2018 Meeting Of The University Of Montana Faculty, University Of Montana--Missoula. Faculty

University of Montana Faculty Senate Meeting Minutes

Meeting minutes from the September 20, 2018 meeting of the University of Montana faculty.

Comprehensive Evaluation Of Treatment And Outcomes Of Low-Grade Diffuse Gliomas, Catherine R. Garcia, Stacey A. Slone, Thomas A. Pittman, William H. St. Clair, Donita D. Lightner, John L. Villano

Markey Cancer Center Faculty Publications

Background

Low-grade gliomas affect younger adults and carry a favorable prognosis. They include a variety of biological features affecting clinical behavior and treatment. Having no guidelines on treatment established, we aim to describe clinical and treatment patterns of low-grade gliomas across the largest cancer database in the United States.

Methods

We analyzed the National Cancer Database from 2004 to 2015, for adult patients with a diagnosis of World Health Organization grade II diffuse glioma.

Results

We analyzed 13,621 cases with median age of 41 years. Over 56% were male, 88.4% were white, 6.1% were black, and 7.6% Hispanic. The most …

Prostaglandin D2/J2 Signaling Pathway In A Rat Model Of Neuroinflammation Displaying Progressive Parkinsonian-Like Pathology: Potential Novel Therapeutic Targets, Chuhyon Corwin, Anastasia Nikolopoulou, Allen L. Pan, Mariela Nunez-Santos, Shankar Vallabhajosula, Peter A. Serrano, John Babich, Maria E. Figueiredo-Pereira

Publications and Research

Background: Prostaglandins are products of the cyclooxygenase pathway, which is implicated in Parkinson’s disease (PD). Limited knowledge is available on mechanisms by which prostaglandins contribute to PD neurodegeneration. To address this gap, we focused on the prostaglandin PGD2/J2 signaling pathway, because PGD2 is the most abundant prostaglandin in the brain, and the one that increases the most under pathological conditions. Moreover, PGJ2 is spontaneously derived from PGD2.

Methods: In this study, we determined in rats the impact of unilateral nigral PGJ2-microinfusions on COX-2, lipocalin-type PGD2 synthase (L-PGDS), PGD2/J2 receptor 2 (DP2), and 15 hydroxyprostaglandin dehydrogenase (15-PGDH). Nigral dopaminergic (DA) and …

Facilitating And Improving Environmental Research Data Repository Interoperability, Corinna Gries, Amber Budden, Christine Laney, Margaret O’Brien, Mark Servilla, Wade Sheldon, Kristin Vanderbilt, Dave Vieglais

Copyright, Fair Use, Scholarly Communication, etc.

Environmental research data repositories provide much needed services for data preservation and data dissemination to diverse communities with domain specific or programmatic data needs and standards. Due to independent development these repositories serve their communities well, but were developed with different technologies, data models and using different ontologies. Hence, the effectiveness and efficiency of these services can be vastly improved if repositories work together adhering to a shared community platform that focuses on the implementation of agreed upon standards and best practices for curation and dissemination of data. Such a community platform drives forward the convergence of technologies and practices …

Kenyon Collegian - September 20, 2018

The Kenyon Collegian

No abstract provided.

Haptoglobin Improves Shock, Lung Injury, And Survival In Canine Pneumonia, Kenneth E. Remy, Irene Cortés-Puch, Steven B. Solomon, Junfeng Sun, Benjamin M. Pockros, Jing Feng, Juan J. Lertora, Roy R. Hantgan, Xiaohua Liu, Andreas Perlegas, H. Shaw Warren, Mark T. Gladwin, Daniel B. Kim-Shapiro, Harvey G. Klein, Charles Natanson

Open Access Publications

During the last half-century, numerous antiinflammatory agents were tested in dozens of clinical trials and have proven ineffective for treating septic shock. The observation in multiple studies that cell-free hemoglobin (CFH) levels are elevated during clinical sepsis and that the degree of increase correlates with higher mortality suggests an alternative approach. Human haptoglobin binds CFH with high affinity and, therefore, can potentially reduce iron availability and oxidative activity. CFH levels are elevated over approximately 24-48 hours in our antibiotic-treated canine model of S. aureus pneumonia that simulates the cardiovascular abnormalities of human septic shock. In this 96-hour model, resuscitative treatments, …

Innovation And Achievements Of Designer Breeding By Molecular Modules In China, Xue Yongbiao, Chong Kang, Han Bin, Gui Jianfang, Jing Haichun

Bulletin of Chinese Academy of Sciences (Chinese Version)

With over 1.3 billion people, food security is always the No. 1 issue in the governmental agenda in China, and sustainable food production requires innovation in crop breeding. This paper outlines the research effort and output of the past five years of a grand project of Chinese Academy of Sciences of the Innovation System of Designer Breeding by Molecular Modules, and provides a few examples of how to combine the cutting-edge theories and technologies of life sciences to design rice varieties and other species. The achievements demonstrate that the project has made substantial progresses in designer breeding by using molecular …

Achievements And Prospect Of Designer Breeding By Molecular Modules In Rice, Xue Yongbiao, Han Bin, Chong Kang, Wang Tai, He Zuhua, Fu Xiangdong, Chu Chengcai, Cheng Zhukuan, Xu Yunyuan, Li Ming

Bulletin of Chinese Academy of Sciences (Chinese Version)

Cultivation of cereal crops including rice, started in China over 8000 years ago, and Chinese knowledge of crop breeding has great impact on cereal production of the whole world. As of the early 1990s, scientists from Chinese Academy of Sciences(CAS), representing China as one of the sponsor countries, joined the International Rice Genome Project and were in charge of sequencing Chromosome 4 of "geng" rice and the whole genome of "xian" rice 93-11, which marked the beginning of the serial efforts from Chinese plant science community to develop rice into a model crop/plant to study genomic and molecular basis underlying …