Digital Commons Network^™

Hypoxia-Mediated Mitochondria Apoptosis Inhibition Induces Temozolomide Treatment Resistance Through Mir-26a/Bad/Bax Axis., Xin Ge, Min-Hong Pan, Lin Wang, Wei Li, Chengfei Jiang, Jun He, Khaled Abouzid, Ling-Zhi Liu, Zhumei Shi, Bing-Hua Jiang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Glioblastoma multiforme (GBM) is one of the most hypoxic tumors of the central nervous system. Although temozolomide (TMZ) is an effective clinical agent in the GBM therapy, the hypoxic microenvironment remains a major barrier in glioma chemotherapy resistance, and the underlying mechanisms are poorly understood. Here, we find hypoxia can induce the protective response to mitochondrion via HIF-1α-mediated miR-26a upregulation which is associated with TMZ resistance in vitro and in vivo. Further, we demonstrated that HIF-1α/miR-26a axis strengthened the acquisition of TMZ resistance through prevention of Bax and Bad in mitochondria dysfunction in GBM. In addition, miR-26a expression levels negatively …

China Maritime Report No. 3: China’S Distant-Ocean Survey Activities: Implications For U.S. National Security, Ryan D. Martinson, Peter A. Dutton

CMSI China Maritime Reports

Today, the People’s Republic of China (PRC) is investing in marine scientific research on a massive scale. This investment supports an oceanographic research agenda that is increasingly global in scope. One key indicator of this trend is the expanding operations of China’s oceanographic research fleet. On any given day, 5-10 Chinese “scientific research vessels” (科学考查船) may be found operating beyond Chinese jurisdictional waters, in strategically-important areas of the Indo-Pacific. Overshadowed by the dramatic growth in China’s naval footprint, their presence largely goes unnoticed. Yet the activities of these ships and the scientists and engineers they embark have major implications for …

Modelling Tidally Induced Larval Dispersal Over Anton Dohrn Seamount, Nataliya Stashchuk, Vasiliy Vlasenko, Kerry L. Howell

School of Biological and Marine Sciences

Massachusetts Institute of Technology general circulation model is used for the analysis of larval dispersal over Anton Dohrn Seamount (ADS), North Atlantic. The model output validated against the in situ data collected during the 136th cruise of the RRS ‘James Cook’ in May–June 2016 allowed reconstruction of the details of the baroclinic tidal dynamics over ADS. The obtained velocities were used as input data for a Lagrangian-type passive particle tracking model to reproduce the larval dispersal of generic deep-sea water invertebrate species. It was found that the residual tidal flow over ADS has a form of a pair of dipoles …

An Assessment Of Biomarker-Based Multivariate Classification Methods Versus The Pip25index For Paleo Arctic Sea Ice Reconstruction, Denizcan Köseoğlu, Simon T. Belt, Katrine Husum, Jochen Knies

School of Geography, Earth and Environmental Sciences

© 2018 Elsevier Ltd The development of various combinative methods for Arctic sea ice reconstruction using the sympagic highly branched isoprenoid (HBI) IP25in conjunction with pelagic biomarkers has often facilitated more detailed descriptions of sea ice conditions than using IP25alone. Here, we investigated the application of the Phytoplankton-IP25index (PIP25) and a recently proposed Classification Tree (CT) model for describing temporal shifts in sea ice conditions to assess the consistency of both methods. Based on biomarker data from three downcore records from the Barents Sea spanning millennial timescales, we showcase apparent and potential limitations in both approaches, and provide recommendations for …

Novel Application Of Laboratory Instrumentation Characterizes Mass Settling Dynamics Of Oil-Mineral Aggregates (Omas) And Oil-Mineral-Microbial Interactions, L Ye, Aj Manning, T-J Hsu, S Morey, Ep Chassignet, Ta Ippolito

School of Biological and Marine Sciences

AbstractIt is reasonable to assume that microbes played an important role in determining the eventual fate of oil spilled during the 2010 Deepwater Horizon disaster, given that microbial activities in the Gulf of Mexico are significant and diverse. However, critical gaps exist in our knowledge of how microbes influence the biodegradation and accumulation of petroleum in the water column and in marine sediments of the deep ocean and the shelf. Ultimately, this limited understanding impedes the ability to forecast the fate of future oil spills, specifically the capacity of numerical models to simulate the transport and fate of petroleum under …

Genetic Variants In The Sirt6 Transcriptional Regulatory Region Affect Gene Activity And Carcass Quality Traits In Indigenous Chinese Beef Cattle (Bos Taurus), Lin-Sheng Gui, Sayed Haidar Abbas Raza, Matthew Garcia, Yong-Gang Sun, Irfan Ullah, Yin-Cang Han

Animal, Dairy, and Veterinary Science Faculty Publications

Background: The aim of this study was to analyze potential influences of polymorphisms within the regulatory region of the bovine SIRT6 gene on carcass quality traits. Expression analyses suggested that SIRT6 gene is predominately expressed in kidney, compared with other tissues. In 535 indigenous Chinese beef cattle, two novel single nucleotide polymorphisms (SNPs) were identified within the promoter region of the SIRT6 gene.

Results: Association analysis indicated that G allele of the c.-1100 A > G had a positive effect on fat deposition, and the Hap4/4 diplotype had more favourable results than other dipoltypes with respect to the evaluation of carcass …

Oprm1 Genotype Interacts With Serotonin System Dysfunction To Predict Alcohol-Heightened Aggression In Primates, Carlos A. Driscoll, Stephen G. Lindell, Melanie L. Schwandt, Stephen J. Suomi, J. Dee Higley, Markus Heilig, Christina S. Barr

Faculty Publications

Although the notion that alcohol promotes violence is widespread, not all individuals are aggressive while intoxicated. Genetic variation could be a contributing factor to individual differences in alcohol-heightened aggression. The present study examines the effects of OPRM1C77G genotype on responses to threat in rhesus macaques under normal conditions and following alcohol administration. Prior studies have shown that a low CSF level of 5-HIAA is a trait marker for individuals prone to escalated aggression. We wanted to examine whether the predictive value for this marker on aggression was moderated by OPRM1 genotype. Animals were administered alcohol (BAC 100-200 mg%), were provoked …

Kenyon Collegian - November 1, 2018

The Kenyon Collegian

No abstract provided.

Gesture Recognition With Transparent Solar Cells, Dong Ma, Guohao Lan, Mahbub Hassan, Wen Hu, B. Mushfika Upama, Ashraf Uddin, Youseef, Moustafa

Research Collection School Of Computing and Information Systems

Transparent solar cell is an emerging solar energy harvesting technology that allows us to see through these cells. This revolutionary discovery is creating unique opportunities to turn any mobile device screen into solar energy harvester. In this paper, we consider the possibility of using such energy harvesting screens as a sensor to detect hand gestures. As different gestures impact the incident light on the screen in a different way, they are expected to create unique energy generation patterns for the transparent solar cell. Our goal is to recognize gestures by detecting these solar energy patterns. A key uncertainty we face …

Emerging Roles Of The Membrane Potential: Action Beyond The Action Potential, Lina Abdul Kadir, Michael Stacey, Richard Barrett-Jolley

Bioelectrics Publications

Whilst the phenomenon of an electrical resting membrane potential (RMP) is a central tenet of biology, it is nearly always discussed as a phenomenon that facilitates the propagation of action potentials in excitable tissue, muscle, and nerve. However, as ion channel research shifts beyond these tissues, it became clear that the RMP is a feature of virtually all cells studied. The RMP is maintained by the cell's compliment of ion channels. Transcriptome sequencing is increasingly revealing that equally rich compliments of ion channels exist in both excitable and non-excitable tissue. In this review, we discuss a range of critical roles …

Beyond Maximum Grade: Modernising The Assessment And Reporting Of Adverse Events In Haematological Malignancies, G Thanarajasingam, Lm Minasian, F Baron, Et Al

Peninsula Medical School

Tremendous progress in treatment and outcomes has been achieved across the whole range of haematological malignancies in the past two decades. Although cure rates for aggressive malignancies have increased, nowhere has progress been more impactful than in the management of typically incurable forms of haematological cancer. Population-based data have shown that 5-year survival for patients with chronic myelogenous and chronic lymphocytic leukaemia, indolent B-cell lymphomas, and multiple myeloma has improved markedly. This improvement is a result of substantial changes in disease management strategies in these malignancies. Several haematological malignancies are now chronic diseases that are treated with continuously administered therapies …

Response Of Common Bean (Phaseolus Vulgaris L.) To Nitrogen, Phosphorus And Rhizobia Inoculation Across Variable Soils In Zimbabwe, Vongai Chekanai, Regis Chikowo, Bernard Vanlauwe

All Peer-Reviewed Publications

Common bean is an important crop with potential to curb malnutrition in poor Sub-Saharan African populations. Yields of common bean (Phaseolus vulgaris L.) are, however poor, limited by low soil phosphorus (P), nitrogen (N) and poor biological N2-fixation. On-farm experiments were carried out to study the effect of N, P and rhizobia inoculation on common bean yield and yield components during the 2014/2015 and 2015/2016 cropping seasons in Eastern Zimbabwe. Experiments were conducted on five farmers’ fields located in two agroecologies; three fields were considered to be degraded with soil organic carbon (SOC) < 4 g kg−1 and available P < 6 mg kg−1, while the two non–degraded sites had SOC > 7 g kg−1 and available P > 15 …

Medical University Of Graz - Summer Internship 2018, Nada Belal

Trick to the Treat of Internships and Research

Program Overview:

• Assist a transplant team at Medical University of Graz for 6 weeks
• Mainly general surgery and transplantation procedures, but can observe and assist in other types of operations, as well.
• Great opportunity to apply all that you have learned in the classroom through hands-on experience.

The University Of Texas Md Anderson Cancer Center - Biology Summer Internship, Marla Fortoul

Trick to the Treat of Internships and Research

Program Overview:

• 10 week program
• MD Anderson Cancer Center in Houston, Texas
• Students will be matched with a faculty mentor in any number of areas of biomedical research where a project will be assigned.
• Participants work alongside the mentor in a lab or clinic on projects designed by faculty to reflect current research.
• Workshops and lectures provide opportunities to connect with faculty, residents, postdoctoral and clinical fellows, and other participants.
• Through the program, students assess goals related to careers in oncology research and patient care.
• Symposium in which participants present talks and posters on their research projects to peers and …

Osteogenesis Of Dental Stem Cells, Jerry Ennolikara

Trick to the Treat of Internships and Research

Program Overview:

• This research lab is dedicated to the study of bioengineering bone tissue, an application of biology research within medicine known as "regenerative medicine," through a variety of in-vivo and in-vitro projects.
• The primary focus of our lab is to replace a lifetime of bone graft surgeries associated with cleft palate, a congenital disorder where the palatal process of the maxilla fails to fuse during development, with a noninvasive injectable treatment.
• The lab upholds the central motif of tissue engineering of "cells, scaffolds, and growth factors" with our research utilizing periodontal ligamental stem cells/human gingival mesenchymal stem cells; 3D …

Ussouthcom's Office Of The Command Surgeon - Pathway Internship Experience, Alexander Jakub Martinek

Trick to the Treat of Internships and Research

Program Overview: The Office of the Command Surgeon enables and synchronizes health engagement activities utilizing the whole of government approach to enhance regional health preparedness and increase our partner nations’ military and security forces’ medical capabilities.

Practicum In Biology I: Gastroenterology Site, Roksana Hesari

Trick to the Treat of Internships and Research

Program Overview:

• Instructor - Dr. Mark Jaffe, DPM
• Didactic and experiential learning in applied settings
• Primary research literature exposure in field of interest
• Weekly face-to-face lectures for three hours
• Practicum site shifts for minimum 5 hours weekly
• Partnerships with Alvin Sherman Library and Career Services Department

Cleveland Clinic Florida - Summer Scholar Program, Marina Handal

Trick to the Treat of Internships and Research

Program Overview:

• Cleveland Clinic Florida’s Summer Scholar Program is designed to allow students to gain shadowing experience in the medical field via the clinical and hospital settings.
• Students are assigned 3 rotations total within the 6-week span of the program; high school assignments run for a total of 3 weeks.
• Rotations include Internal Medicine, Cardiology, Neurosurgery, ICC, Emergency Medicine, and various other subspecialties.
• Students can expect to be at the Weston hospital Monday-Friday 8 am- 5 pm (varies based on rotation/clinic hours/surgery schedule).
• Attend weekly lectures that consist of discussion of the ethics of medicine, educational path to becoming a …

Cleveland Clinic Summer Scholars Program, Vanessa Cruise

Trick to the Treat of Internships and Research

Program Overview:

• Currently available to: High school juniors going into senior year and pre-med college freshmen that have completed their first year of college
• College freshman program is a 6 week program (3 rotations, 2 weeks long each). Rotations can be aligned with your preferred specialties if resources allow.

Science Alive, Allan Barraza, Ahjay Bhatia, Gwen Bui, Sophia Nguyen

Trick to the Treat of Internships and Research

Program Overview:

• Introduces STEM concepts to young students
• Encourage their pursuit of higher education
• Be role models
• Make friends

Cleveland Clinic Summer Scholar Program, Mahnoor Asif

Trick to the Treat of Internships and Research

Program Overview:

• The program lasts a total of 6 weeks, and you rotate through 3 different departments
• Dress code: Business professional attire + Cleveland Clinic white coat
• Every day will be different in terms of activity and length depending on your rotation site, if you have to do rounds, how early your first patient is coming into the clinic, etc. However, an average day will be from 8:30 a.m. - 5:30 p.m.

Protein Modeling, Alesa Chabbra

Trick to the Treat of Internships and Research

Program Overview:

• The program is designed to answer the question "How can modeling using protein visualization software and 3D printing best demonstrate links between protein structure and function?"
• Done in collaboration with CREST and Center for BioMolecular Modeling

Indigenous Knowledge And The Development Debate In Africa, Fidelis Ewane, Samson Ajagbe

International Journal of African Development

This research employs Bourdieu’s theory of habitus to explain the disposition of the donor community to integrate indigenous knowledge systems and practices into development projects. The theory’s objectivist perspective specifies the mechanism that links structural conditioning to social practice and regularities. It holds that power is culturally and symbolically created, and it is constantly re-legitimized through the interplay of agency and structure. This facilitates an analysis of the development field as social space characterized by indigenous and donor power relations. It argues that the reinforcement of indigenous knowledge as the main channel for development will generate transferable local capacities and …

Mitochondrial Dna Sequence Alignments For Phylogenetic Analysis Of The Shrimp Genus Farfantepenaeus, Laura Timm, S. Simon, Heather Bracken-Grissom Dr.

DEEPEND Datasets

This dataset includes 12S, 16S, and COI sequence data. Sequences were obtained from the eight recognized species of Farfantepenaeus: F. aztecus, F. brasiliensis, F. brevirostris, F. californiensis, F. duorarum, F. isabelae, F. notialis, and F. subtilis. Also included are several sequences from species of Litopenaeus, which serve as outgroup(s).

The Effects Of Exercise Training Intensities On Changes In Body Composition, Visceral Adipose Tissue, Adiponectin And C-Reactive Protein, Leslie E. Solis

Theses and Dissertations

Obesity is currently characterized as a worldwide health pandemic. Despite many efforts to provide the optimal exercise prescription to obese and overweight individuals for maximization of fat loss and decreasing metabolic risks, findings in the literature continue to remain ambiguous. This investigation aimed to examine the effects of low- vs. high-intensity short-term training on body composition and visceral adipose tissue (VAT) under equivalent caloric expenditure in overweight and obese Hispanic adults of Laredo, Texas. Additionally, it aimed to analyze how changes in body composition and VAT affect serum levels of adiponectin and C-reactive protein (CRP),bioactive chemicals utilized in the detection …

Clethrionomys Gapperi, Roger W. Barbour

Roger W. Barbour Slide Collection

Clethrionomys gapperi

Clethrionomys Gapperi, Roger W. Barbour

Roger W. Barbour Slide Collection

Clethrionomys gapperi

Microtus Chrotorrhinus, Roger W. Barbour

Roger W. Barbour Slide Collection

Microtus chrotorrhinus

Microtus Longicaudus, Roger W. Barbour

Roger W. Barbour Slide Collection

Microtus longicaudus

Microtus Longicaudus, Roger W. Barbour

Roger W. Barbour Slide Collection

Microtus longicaudus