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Case Review: Food Pattern Effects On Milk Lipid Profiles, Darby Dickton, Jimi Francis

Health & Kinesiology Faculty Publications and Presentations

It has been shown that maternal food intake determines the levels of unsaturated fatty acids that are present in human milk. This case study compares the human milk lipid profiles the first two weeks of lactation from women consuming three food patterns: vegan, standard American diet, and Asian. Participants were matched for demographics. The milk samples were analyzed using gas chromatography to determine the lipid profile for each participant. The lipid profiles differed by food pattern (p<0.007). Linoleic acid and alpha-linolenic acid levels were highest for the vegan food pattern. The ratios of omega-6 to omega-3 fatty acids were well above the suggested ratio considered to be optimal with the vegan pattern had the lowest omega-6 to omega-3 ratio and the highest level of docosahexaenoic acid, possibly indicating conversion of alpha-linoleic acid to docosahexaenoic acid. Further research is needed to determine the impact this may have on long-term infant health.

The Gut Microbiome And Aquatic Toxicology: An Emerging Concept For Environmental Health, Ondrej Adamovsky, Amanda Buerger, Alexis M. Wormington, Naomi Ector, Robert J. Griffitt, Joseph H. Bisesi Jr., Christopher J. Martyniuk

Faculty Publications

The microbiome plays an essential role in the health and onset of diseases in all animals, including humans. The microbiome has emerged as a central theme in environmental toxicology, as microbes interact with the host immune system in addition to its role in chemical detoxification. Pathophysiological changes in the gastrointestinal tissue caused by ingested chemicals, and metabolites generated from microbial biodegradation, can lead to systemic adverse effects. This critical review dissects what we know about the impacts of environmental contaminants on the microbiome of aquatic species, with special emphasis on the gut microbiome. We highlight some of the known major …

Temporal Dynamics Of Lipid And Fatty Acid Characteristics Of Gulf Menhaden, Brevoortia Patronus In The Northern Gulf Of Mexico, Robert R. Leaf, Jesse Trushenski, Nancy Brown-Peterson, Michael J. Andres

Faculty Publications

Gulf Menhaden, Brevoortia patronus, in the northern Gulf of Mexico support a large commercial fishery and are thought to play an important trophic role in the coastal ecosystem. The temporal dynamics of both fatty acid and oil content have a direct impact on the value of Gulf Menhaden to predators and to the fishery. In this work, we describe how oil content of Gulf Menhaden varies with season, sex, age, condition, and tissue and investigate how fatty acid composition of mature (137.5 mm FL) female tissues varies with season, month, and tissue type. We found pronounced temporal (January to …

Gene Expression Changes By Neuroprotectant Novel Antidotes To Organophosphates, Meghan L. Brino

Honors Theses

Recent assassinations and terrorist attacks demonstrate the need for a more effective antidote against nerve agents and other organophosphate (OP) compounds which inhibit the nervous system enzyme acetylcholinesterase (AChE). This study explored the changes in gene expression induced by novel phenoxyalkyl pyridinium oximes (U.S. patent 9,277,937) that have demonstrated the ability to cross the blood-brain barrier and attenuate brain damage in a rat model. More specifically, this study determined whether rats treated with high levels of a surrogate for the nerve agent sarin (nitrophenyl isopropyl methylphosphonate; NIMP) and rats treated with NIMP followed by a novel oxime displayed significant differences …

The Right Hammer For The Right Nail: Public Health Tools In The Struggle Between Pain And Addiction, Melissa Mcpheeters, Mary K. Bratton

University of Memphis Law Review

No abstract provided.

The Grizzly, November 1, 2018, Courtney A. Duchene, Madison Rodak, Skylar Haas, Kim Corona, Sophia Dibattista, Thomas Bantley, Shelsea Deravil, David Mendelsohn

Ursinus College Grizzly Newspaper, 1978 to Present

Midterm Elections November 6 • IDC Opening Honors Past President Fong, Celebrates Campus Milestone • Deadline for "The Lantern" is Here • Board of Trustees Comes to Campus • Geology Professors go Under the IDC • Meet the Charles Rice Post-Graduate Research Fellows • Opinions: Kavanaugh and the Powers of the Supreme Court; Is the New UC Tour Guide Dress Code Sexist? • Women's Swimming Begins Title Defense with Back-to-Back Dual Meet Wins • Senior Bridget Sherry Nominated for NFHCA Senior Game as Field Hockey Preps for Post-Season

Physiological Response Of The Giant Acorn Barnacle, Balanus Nubilus, To Air Exposure, Emily Jane Resner

Master's Theses

The giant acorn barnacle, Balanus nubilus, is a resident of the subtidal and low intertidal rocky shoreline on the Pacific Coast of North America (Alaska to Baja California). B. nubilusis notable for having the largest muscle fibers in the animal kingdom; fiber diameters that can exceed 3mm in adults! At such extreme sizes these muscle cells may be at risk for insufficient oxygen delivery to mitochondria owing to low SA:V ratios and long intracellular diffusion distances. Oxygen limitation to these muscles may be further exacerbated during low tide air exposure (emersion) or environmental hypoxia events, which are increasing …

Patriarchal Ecocide: An Ecofeminist Reading Of Rahul Varma's Bhopal And Henrik Ibsen's An Enemy Of The People, Rania M Rafik Khalil

English Language and Literature

Ecofeminism is a movement that sees a connection between the exploitation of the natural world and the subordination of women. This concept of ecology and feminism conceptualized by Simone de Beauvoir (1952) and later refined by Francoise d’Eaubonne in 1974 has greened artistic values across disciplines, it is however perceived to be found only sparsely in drama. Una Chaudhuri (1994) and Theresa J. May (2005) argue that theatre is both “immediate and communal” (May 85) with a wealth of productions that “awaken ecological sensibilities” (85) and contest “industrialisation’s animus against nature” (24). Within this context, Henrik Ibsen’s An Enemy of …

Environmental Monitoring Report For Work Performed July 1, 2017 Through June 30, 2018, Tennessee. Department Of Environment And Conservation.

Environmental Monitoring Report

No abstract provided.

Legal Influences On Shellfish Aquaculture Nursery Facility Siting In Rhode Island, Marine Affairs Institute, Roger Williams University School Of Law, Jordan Viana, Joseph Bingaman, Read Porter

Sea Grant Law Fellow Publications

No abstract provided.

On The Verge Of Diagnosis: Detection, Reporting, And Investigation Of De Novo Variants In Novel Genes Identified By Clinical Sequencing., Isabelle Thiffault, Maxime Cadieux-Dion, Emily G. Farrow, Raymond Caylor, Neil A. Miller, Sarah E. Soden, Carol J. Saunders

Manuscripts, Articles, Book Chapters and Other Papers

The variable evidence supporting gene-disease associations contributes to the difficulty of accurate variant reporting in a clinical setting. An evidence-based scoring system for evaluating the clinical validity of gene-disease associations, proposed by ClinGen, considers experimental as well as genetic evidence. De novo variants are heavily weighted, given the overall rarity in the genome and their contribution to human disease, however they are reported as "genes of unknown significance" in our center when there is insufficient evidence for the gene-disease assertion. We report a collection of 21 de novo variants in genes of unknown clinical significance ascertained via clinical testing, of …

Clinical Characteristics And Treatment Patterns Of Children And Adults With Iga Nephropathy Or Iga Vasculitis: Findings From The Curegn Study., David T. Selewski, Josephine M. Ambruzs, Gerald B. Appel, Andrew S. Bomback, Raed Bou Matar, Yi Cai, Daniel C. Cattran, Aftab S. Chishti, Vivette D. D'Agati, Cynthia J. D'Alessandri-Silva, Rasheed A. Gbadegesin, Jonathan J. Hogan, Sandra Iragorri, J Charles Jennette, Bruce A. Julian, Myda Khalid, Richard A. Lafayette, Helen Liapis, Francesca Lugani, Sarah A. Mansfield, Sherene Mason, Patrick H. Nachman, Cynthia C. Nast, Carla M. Nester, Damien G. Noone, Jan Novak, Michelle M. O'Shaughnessy, Heather N. Reich, Michelle N. Rheault, Dana V. Rizk, Manish K. Saha, Neil S. Sanghani, C John Sperati, Rajasree Sreedharan, Tarak Srivastava, Agnieszka Swiatecka-Urban, Katherine Twombley, Tetyana L. Vasylyeva, Donald J. Weaver, Hong Yin, Jarcy Zee, Ronald J. Falk, Ali G. Gharavi, Brenda W. Gillespie, Debbie S. Gipson, Larry A. Greenbaum, Lawrence B. Holzman, Matthias Kretzler, Bruce M. Robinson, William E. Smoyer, Michael Flessner, Lisa M. Guay-Woodford, Krzysztof Kiryluk, Curegn Consortium

Manuscripts, Articles, Book Chapters and Other Papers

Introduction: The Cure Glomerulonephropathy Network (CureGN) is a 66-center longitudinal observational study of patients with biopsy-confirmed minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (IgAN), including IgA vasculitis (IgAV). This study describes the clinical characteristics and treatment patterns in the IgA cohort, including comparisons between IgAN versus IgAV and adult versus pediatric patients.

Methods: Patients with a diagnostic kidney biopsy within 5 years of screening were eligible to join CureGN. This is a descriptive analysis of clinical and treatment data collected at the time of enrollment.

Results: A total of 667 patients (506 IgAN, 161 IgAV) constitute …

Molecular Level Interactions And Transformations Of Natural Organic Matter Within The Environment, Benjamin J. Haywood

LSU Doctoral Dissertations

This work was done in order to deepen the understanding of interactions occurring during sorption of anthropogenic organic compounds and dissolved organic matter (DOM) onto soil. As well as the transformation DOM undergoes during the sorption process and the overall transformation OM undergoes in the environment. This was achieved through the use of a “bottom-up” synthetic investigation, “top-down” natural system study, and a combination of these approaches.

The “bottom-up” approach, discussed in Chapter 2, involved the synthesis of a modular multi-tiered engineered soil surrogate (ESS) designed to mimic OM and general trends identified in the literature that impacts sorption behavior. …

Nrh:Quinone Oxidoreductase 2 (Nqo2) And Glutaminase (Gls) Both Play A Role In Large Extracellular Vesicles (Lev) Formation In Preclinical Lncap-C4-2b Prostate Cancer Model Of Progressive Metastasis, Thambi Dorai, Ankeeta Shah, Faith Summers, Rajamma Mathew, Jing Huang, Tze-Chen Hsieh, Joseph M. Wu

NYMC Faculty Publications

In the course of studies aimed at the role of oxidative stress in the development of metastatic potential in the LNCaP-C4-2B prostate cancer progression model system, we found a relative decrease in the level of expression of the cytoplasmic nicotinamide riboside: quinone oxidoreductase (NQO2) and an increase in the oxidative stress in C4-2B cells compared to that in LNCaP or its derivatives C4 and C4-2. It was also found that C4-2B cells specifically shed large extracellular vesicles (LEVs) suggesting that these LEVs and their cargo could participate in the establishment of the osseous metastases. The level of expression of caveolin-1 …

Multistate Infestation With The Exotic Disease-Vector Tick Haemaphysalis Longicornis - United States, August 2017-September 2018, C. B. Beard, James Occi, Denise L. Bonilla, Andrea M. Egizi, Dina M. Fonseca, Gary P. Wormser, William Halperin

NYMC Faculty Publications

Haemaphysalis longicornis is a tick indigenous to eastern Asia and an important vector of human and animal disease agents, resulting in such outcomes as human hemorrhagic fever and reduction of production in dairy cattle by 25%. H. longicornis was discovered on a sheep in New Jersey in August 2017 (1). This was the first detection in the United States outside of quarantine. In the spring of 2018, the tick was again detected at the index site, and later, in other counties in New Jersey, in seven other states in the eastern United States, and in Arkansas. The hosts included six …

Dissociation Between Cervical Mucus And Urinary Hormones During The Postpartum Return Of Fertility In Breastfeeding Women, Thomas Bouchard, Len Blackwell, Simon Brown, Richard J. Fehring, Suzanne Parenteau-Carreau

College of Nursing Faculty Research and Publications

Identifying the return of fertility with cervical mucus observations is challenging during the postpartum period. Use of urinary measurements of estrogen and progesterone can assist in understanding the return to fertility during this period. The purposes of this study were to describe the postpartum return of fertility by an analysis of total estrogen (TE) and pregnanediol glucuronide (PDG) profiles and to correlate these profiles with cervical mucus observations. Twenty-six participants collected urine samples during the postpartum period and recorded mucus scores. TE and PDG hormones were analyzed and compared with mucus scores. During amenorrhea, mucus reflected TE changes in only …

Zinc Enhances Hippocampal Long-Term Potentiation At Ca1 Synapses Through Nr2b Containing Nmda Receptors, John Sullivan, Xiao-Lei Zhang, Arthur P. Sullivan, Linnea R. Vose, Alexander A. Moghadam, Victor A. Fried, Patric K. Stanton

NYMC Faculty Publications

The role of zinc (Zn2+), a modulator of N-methyl-D-aspartate (NMDA) receptors, in regulating long-term synaptic plasticity at hippocampal CA1 synapses is poorly understood. The effects of exogenous application of Zn2+ and of chelation of endogenous Zn2+ were examined on long-term potentiation (LTP) of stimulus-evoked synaptic transmission at Schaffer collateral (SCH) synapses in field CA1 of mouse hippocampal slices using whole-cell patch clamp and field recordings. Low micromolar concentrations of exogenous Zn2+ enhanced the induction of LTP, and this effect required activation of NMDA receptors containing NR2B subunits. Zn2+ elicited a selective increase in NMDA/NR2B fEPSPs, and removal of endogenous Zn2+ …

Prenatal Tobacco And Marijuana Co-Use: Impact On Newborn Neurobehavior., Laura R. Stroud, George D. Papandonatos, Meaghan Mccallum, Tessa Kehoe, Amy L. Salisbury, Marilyn A. Huestis

Institute of Emerging Health Professions Faculty Papers

Tobacco and marijuana are some of the most common prenatal substance exposures worldwide. The social acceptability and political landscape of marijuana and its potency have changed dramatically in the last two decades leading to increased use by pregnant women. Despite evidence for increasing marijuana use and high rates of co-use of tobacco (TOB) and marijuana (MJ) during pregnancy, the impact of prenatal exposure to each substance is typically studied in isolation. We investigated the influence of co-exposure to TOB and MJ on infant neurobehavioral development over the first postnatal month. Participants were 111 mother-infant pairs from a low-income, diverse sample …

Virginia Ranks Forty-Ninth Of Fifty: The Need For Stronger Laws Supporting Foster Youth, Nadine Marsh-Carter, Bruin S. Richardson Iii, Laura Ash-Brackley, Cassie Baudeán Cunningham

University of Richmond Law Review

No abstract provided.

Wolfe Creek Crater: A Continuous Sediment Fill In The Australian Arid Zone Records Changes In Monsoon Strength Through The Late Quaternary, Gifford H. Miller, John W. Magee, Marilyn L. Fogel, Matthew J. Wooller, Paul P. Hesse, Nigel A. Spooner, Beverly J. Johnson, Lynley Wallis

All Faculty Scholarship

A bolide that impacted NW Australia during the Late Quaternary left a circular depression more than 100 m deep and nearly a kilometer in diameter, with a crater rim ∼30 m above the regional terrain. The resultant crater is a window into the regional water table. The surface of the contemporary central pan is 25 m below the adjacent terrain, coincident with the late Holocene regional water table modified by local evaporative processes. Shielded from aeolian deflation by the crater rim, the central depression has slowly filled with dust, sand, and chemical precipitates, estimated to be 20–100 m thick based …

Effects Of Tumor Metabolic Microenvironment On Regulatory T Cells, Yi-An Wang, Xiao-Ling Li, Yong-Zhen Mo, Chun-Mei Fan, Le Tang, Fang Xiong, Can Guo, Bo Xiang, Ming Zhou, Jian Ma, Xi Huang, Xu Wu, Yong Li, Gui-Yuan Li, Zhao-Yang Zeng, Wei Xiong

Chemistry Faculty Publications

Recent studies have shown that on one hand, tumors need to obtain a sufficient energy supply, and on the other hand they must evade the body’s immune surveillance. Because of their metabolic reprogramming characteristics, tumors can modify the physicochemical properties of the microenvironment, which in turn affects the biological characteristics of the cells infiltrating them. Regulatory T cells (Tregs) are a subset of T cells that regulate immune responses in the body. They exist in large quantities in the tumor microenvironment and exert immunosuppressive effects. The main effect of tumor microenvironment on Tregs is to promote their differentiation, proliferation, secretion …

The Right Hammer For The Right Nail: Public Health Tools In The Struggle Between Pain And Addiction, Melissa Mcpheeters, Mary K. Bratton

University of Memphis Law Review

No abstract provided.

California Coastal Commission Sea Level Rise Policy Guidance: Interpretive Guidelines For Addressing Sea Level Rise In Local Coastal Programs And Coastal Development Permits, California Coastal Commission

State & Federal Reports and Publications

It provides an overview of the best available science on sea level rise for California and recommended methodology for addressing sea level rise in Coastal Commission planning and regulatory actions. It is a guidance document intended to serve as a multi-purpose resource for a variety of audiences. It does not include regulations and is not specific to a particular geographic location or development intensity.

Why Women Want To Play Sports: Identity, Culture, And Motivation, Linda M. Johnston, Karen Weatherington

Peace and Conflict Studies

This paper is part of a series of research dedicated to specific issues uncovered in sports-for-peace programs. Other research has focused on cross-cultural issues, for example. In this research project, the authors were interested in how to encourage the inclusion and promotion of women in all sports around the world. The authors sought to discover who encouraged the women to play competitive sports, how long they had been playing sports, the barriers they encountered when playing competitive sports, and how they felt about identifying as sportswomen at the higher levels of competition. The authors used an on-line anonymous survey instrument …

Plant-Pathogen Interactions And Their Control: Conventional Vs. Modern Approach, Dhirendra Kumar

ETSU Faculty Works

No abstract provided.

Population Genetics Of The Eastern Subterranean Termite, Reticulitermes Flavipes, In The Southern Appalachian Mountains, Lee Ann Passarella

Honors Theses

As an area rich in biodiversity, the Appalachian Mountains are an ideal place for biological research. The pronounced impacts of Pleistocene climatic cycles on forest distributions over time have shaped the evolutionary history of animals that depend on these habitats, underpinning the research that is presented here. The present study on the eastern subterranean termite, Reticulitermes flavipes, was conducted to better understand the spatial distribution of genetic diversity within and among populations of this species in the context of the aforementioned historical climatic changes in the southern Appalachian Mountain region. I hypothesized that there would be geographically localized, distinct genetic …

Using Carbon Isotope Fractionation To Constrain The Extent Of Methane Dissolution Into The Water Column Surrounding A Natural Hydrocarbon Gas Seep In The Northern Gulf Of Mexico, M. Leonte, B. Wang, Scott A. Socolofsky, John A. Breier, John D. Kessler

School of Earth, Environmental, & Marine Sciences Faculty Publications

A gas bubble seep located in the northern Gulf of Mexico was investigated over several days to determine whether changes in the stable carbon isotopic ratio of methane can be used as a tracer for methane dissolution through the water column. Gas bubble and water samples were collected at the seafloor and throughout the water column for isotopic ratio analysis of methane. Our results show that changes in methane isotopic ratios are consistent with laboratory experiments that measured the isotopic fractionation from methane dissolution. A Rayleigh isotope model was applied to the isotope data to determine the fraction of methane …

The Quarterly Interview: Clarence Maybee, Clarence Maybee

LOEX Quarterly

No abstract provided.

20181101_Journal Subscription Cancellations For 2019, Karen R. Mcelfresh

HSLIC Blog Post

No abstract provided.

Developing Serious Games In Engineering Education: Innovation At The Nexus Of Food, Energy, And Water Systems, Nathan Rice

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

At a time when food, energy, and water (FEW) are of the utmost concern to the security and health of the world, an initiative has begun to understand the interactions between these systems. The goal of Innovation at the Nexus of Food, Energy, and Water Systems (INFEWS) is to bring together research fields that typically work in their own silos to solve complex problems increasing the resiliency and sustainability of the FEW system. Stemming from this initiative was a project to produce an educational immersive simulation game to teach youth about how their food is produced, systems thinking, and sustainable …