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2018

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Reliability Of The Styku 3d Whole Body Scanner For The Assessment Of Body Size In College Athletes, Joseph Daniel Derouchey Jan 2018

Reliability Of The Styku 3d Whole Body Scanner For The Assessment Of Body Size In College Athletes, Joseph Daniel Derouchey

Theses and Dissertations

3-dimensional (3D) anthropometrics, such as volumes and surface area, have been shown to be important in predicting sport performance, and assessing health status, but most commercially available whole-body scanners are cost prohibitive. The main purpose of this study was to determine the test-retest reliability of a commercially available single camera 3D body scanning system to assess whole body and segmental circumferences, surface areas, and volumes of healthy collegiate athletes and students. Forty-nine male and female student-athletes active in various sports from a division I institute were scanned and measurements were analyzed. The single camera system demonstrated good within- and between-session …


A Mixed Method Study Of The Impact Of Advanced Placement, International Baccalaureate, And Dual Enrollment Courses On College Transition And Success, Kazimir Bartley Gazdzik Jan 2018

A Mixed Method Study Of The Impact Of Advanced Placement, International Baccalaureate, And Dual Enrollment Courses On College Transition And Success, Kazimir Bartley Gazdzik

Theses and Dissertations

In an educational environment that has limited resources, and greater pressures for increased academic standards, what is the best option to help prepare high school students for college academics? This research study: A Mixed Method Study of the Impact of Advanced Placement, International Baccalaureate, and Dual Enrollment Courses on College Transition and Success attempted to investigate the impact of advanced courses on college transition.

The results of this research showed no statistical difference in academic success or transition to college between students who had taken advanced classes and those who had not. There were also no statistical differences between students …


Genomic Regulation Of Abiotic Stress Response In The Soil Nematode Oscheius Tipulae, Riley Mcglynn Jan 2018

Genomic Regulation Of Abiotic Stress Response In The Soil Nematode Oscheius Tipulae, Riley Mcglynn

Theses and Dissertations

Oscheius tipulae is a species of free-living soil nematode that can be found in ecosystems worldwide. Because of this, individuals must be able to respond to heat, freezing, and desiccation stresses in order to survive. They do this by producing a suite of cellular responses, some of which are necessary to survive multiple stresses, and some are stress-specific. While these cellular responses are well known, the ways in which they are regulated in a genome-wide context are not. In this project, multiple high throughput sequencing and bioinformatics analyses were utilized to answer this question. First, the O. tipulae genome was …


The Protective Effects Of Social Support And Engagement Coping Strategy On The Relationship Between Perceived Discrimination And Psychological Distress Among Chinese Migrant Children, Jin-Liang Wang, Hsing-Fang Hsieh, Shervin Assari, James Gaskin, Detlef H. Rost Jan 2018

The Protective Effects Of Social Support And Engagement Coping Strategy On The Relationship Between Perceived Discrimination And Psychological Distress Among Chinese Migrant Children, Jin-Liang Wang, Hsing-Fang Hsieh, Shervin Assari, James Gaskin, Detlef H. Rost

Faculty Publications

This study was aimed to figure out whether perceived stress mediates the relationship between perceived discrimination and psychological distress among Chinese migrant children and whether social support and engagement coping moderate the detrimental effects of perceived discrimination on psychological distress. The sample comprised 813 middle-school students (482 migrant children, 331 non-migrant children) from three schools in Southwest China. The results indicate that migrant children’s perceived discrimination and perceived stress are associated with psychological distress, and perceived stress does not mediate the relationship between perceived discrimination and psychological distress. Both social support and engagement coping are inversely related to psychological distress …


Challenges Facing Judges Regarding Expert Evidence In Criminal Cases, Paul W. Grimm Jan 2018

Challenges Facing Judges Regarding Expert Evidence In Criminal Cases, Paul W. Grimm

Faculty Scholarship

No abstract provided.


Conservation Systematics Of The Shield-Backed Trapdoor Spiders Of The Nigrum-Group (Mygalomorphae, Idiopidae, Idiosoma): Integrative Taxonomy Reveals A Diverse And Threatened Fauna From South-Western Australia, Michael G. Rix, Joel Huey, Steven J.B. Cooper, Andrew D. Austin, Mark S. Harvey Jan 2018

Conservation Systematics Of The Shield-Backed Trapdoor Spiders Of The Nigrum-Group (Mygalomorphae, Idiopidae, Idiosoma): Integrative Taxonomy Reveals A Diverse And Threatened Fauna From South-Western Australia, Michael G. Rix, Joel Huey, Steven J.B. Cooper, Andrew D. Austin, Mark S. Harvey

Research Datasets

Supplementary material from: Rix MG, Huey JA, Cooper SJB, Austin AD, Harvey MS (2018) Conservation systematics of the shield-backed trapdoor spiders of the nigrum-group (Mygalomorphae, Idiopidae, Idiosoma): integrative taxonomy reveals a diverse and threatened fauna from south-western Australia. ZooKeys 756: 1-121. https://doi.org/10.3897/zookeys.756.24397

Supplementary material 1: Atlas of morphology : Explanation note: Atlas of morphology for shield-backed trapdoor spiders of the Idiosoma nigrum-group, illustrating a representative selection of male specimens for each species, in five standard views.

Supplementary material 2: GenBank data : Explanation note: Spreadsheet of specimens sequenced for the molecular analyses, with associated collection data and GenBank accession numbers. …


Managing Seagrass Resilience Under Cumulative Dredging Affecting Light: Predicting Risk Using Dynamic Bayesian Networks, Paul Pao-Yen Wu, Kathryn Mcmahon, Michael A. Rasheed, Gary A. Kendrick, Paul H. York, Kathryn Chartrand, M. Julian Carey, Kerrie Mengerson Jan 2018

Managing Seagrass Resilience Under Cumulative Dredging Affecting Light: Predicting Risk Using Dynamic Bayesian Networks, Paul Pao-Yen Wu, Kathryn Mcmahon, Michael A. Rasheed, Gary A. Kendrick, Paul H. York, Kathryn Chartrand, M. Julian Carey, Kerrie Mengerson

Research Datasets

Coastal development is contributing to ongoing declines of ecosystems globally. Consequently, understanding the risks posed to these systems, and how they respond to successive disturbances, is paramount for their improved management. We study the cumulative impacts of maintenance dredging on seagrass ecosystems as a canonical example. Maintenance dredging causes disturbances lasting weeks to months, often repeated at yearly intervals. We present a risk-based modelling framework for time varying complex systems centred around a dynamic Bayesian network (DBN). Our approach estimates the impact of a hazard on a system's response in terms of resistance, recovery and persistence, commonly used to characterise …


Effects Of Small-Scale, Shading-Induced Seagrass Loss On Blue Carbon Storage: Implications For Management Of Degraded Seagrass Ecosystems, Stacey M. Trevathan-Tackett, Caitlin Wessel, Just Cebrian, Peter J. Ralph, Pere Masque´, Peter I. Macreadie Jan 2018

Effects Of Small-Scale, Shading-Induced Seagrass Loss On Blue Carbon Storage: Implications For Management Of Degraded Seagrass Ecosystems, Stacey M. Trevathan-Tackett, Caitlin Wessel, Just Cebrian, Peter J. Ralph, Pere Masque´, Peter I. Macreadie

Research Datasets

1. Seagrass meadows are important global ‘blue carbon’ sinks. Despite a 30% loss of seagrasses globally during the last century, there is limited empirical research investigating the effects of disturbance and loss of seagrass on blue carbon stocks.

2. In this study, we hypothesised that seagrass loss would reduce blue carbon stocks. Using shading cloth, we simulated small-scale die-offs of two subtropical seagrass species, Halodule wrightii and Thalassia testudinum, in a dynamic northern Gulf of Mexico lagoon. The change in quantity and quality of sediment organic matter and organic carbon were compared among kill, control and bare plots before the …


Latitudinal Variation In Seagrass Herbivory: Global Patterns And Explanatory Mechanisms, Adriana Vergés, Christopher Doropoulos, Robert Czarnik, Kathryn Mcmahon, Nil Llonch, Alistair G. B. Poore Jan 2018

Latitudinal Variation In Seagrass Herbivory: Global Patterns And Explanatory Mechanisms, Adriana Vergés, Christopher Doropoulos, Robert Czarnik, Kathryn Mcmahon, Nil Llonch, Alistair G. B. Poore

Research Datasets

Aim: The aim was to quantify latitudinal patterns in seagrass–herbivore interactions in the context of a warming climate.

Location: We carried out a global meta‐analysis combined with a field experiment across 1,700 km and 12° of latitude in Western Australia.

Time period: 1984–2014. Major taxa studied: Seagrasses.

Methods: We first synthesized the global literature on herbivore exclusion experiments in seagrasses to test whether differences in herbivore impacts are related to latitude and sea surface temperature. We then quantified leaf production and consumption rates in the field at nine meadows of the seagrass Amphibolis antarctica across 1,700 km, from tropical to …


Optimal Soil Carbon Sampling Designs To Achieve Cost-Effectiveness: A Case Study In Blue Carbon Ecosystems, Mary A. Young, Peter I. Macreadie, Clare Duncan, Paul E. Carnell, Emily Nicholson, Oscar Serrano, Carlos M. Duarte, Glenn Shiell, Jeff Baldock, Daniel Ierodiaconou Jan 2018

Optimal Soil Carbon Sampling Designs To Achieve Cost-Effectiveness: A Case Study In Blue Carbon Ecosystems, Mary A. Young, Peter I. Macreadie, Clare Duncan, Paul E. Carnell, Emily Nicholson, Oscar Serrano, Carlos M. Duarte, Glenn Shiell, Jeff Baldock, Daniel Ierodiaconou

Research Datasets

Researchers are increasingly studying carbon (C) storage by natural ecosystems for climate mitigation, including coastal ‘blue carbon’ ecosystems. Unfortunately, little guidance on how to achieve robust, cost-effective estimates of blue C stocks to inform inventories exists. We use existing data (492 cores) to develop recommendations on the sampling effort required to achieve robust estimates of blue C. Using a broad-scale, spatially explicit dataset from Victoria, Australia, we applied multiple spatial methods to provide guidelines for reducing variability in estimates of soil C stocks over large areas. With a separate dataset collected across Australia, we evaluated how many samples are needed …


An Investigation Of Atomic Structures Derived From X-Ray Crystallography And Cryo-Electron Microscopy Using Distal Blocks Of Side-Chains, Lin Chen, Jing He, Salim Sazzed, Rayshawn Walker Jan 2018

An Investigation Of Atomic Structures Derived From X-Ray Crystallography And Cryo-Electron Microscopy Using Distal Blocks Of Side-Chains, Lin Chen, Jing He, Salim Sazzed, Rayshawn Walker

Computer Science Faculty Publications

Cryo-electron microscopy (cryo-EM) is a structure determination method for large molecular complexes. As more and more atomic structures are determined using this technique, it is becoming possible to perform statistical characterization of side-chain conformations. Two data sets were involved to characterize block lengths for each of the 18 types of amino acids. One set contains 9131 structures resolved using X-ray crystallography from density maps with better than or equal to 1.5 Å resolutions, and the other contains 237 protein structures derived from cryo-EM density maps with 2-4 Å resolutions. The results show that the normalized probability density function of block …


Non-Canonicaly Recruited Tcrαβcd8Αα Iels Recognize Microbial Antigens, Lukasz Wojciech, Edyta Szurek, Michal Kuczma, Anna Cebula, Wessam R. Elhefnawy, Maciej Pietrzak, Grzegorz Rempala, Leszek Ignatowicz Jan 2018

Non-Canonicaly Recruited Tcrαβcd8Αα Iels Recognize Microbial Antigens, Lukasz Wojciech, Edyta Szurek, Michal Kuczma, Anna Cebula, Wessam R. Elhefnawy, Maciej Pietrzak, Grzegorz Rempala, Leszek Ignatowicz

Computer Science Faculty Publications

In the gut, various subsets of intraepithelial T cells (IELs) respond to self or non-self-antigens derived from the body, diet, commensal and pathogenic microbiota. Dominant subset of IELs in the small intestine are TCRαβCD8αα+ cells, which are derived from immature thymocytes that express self-reactive TCRs. Although most of TCRαβCD8αα+ IELs are thymus-derived, their repertoire adapts to microbial flora. Here, using high throughput TCR sequencing we examined how clonal diversity of TCRαβCD8αα+ IELs changes upon exposure to commensal-derived antigens. We found that fraction of CD8αα+ IELs and CD4+ T cells express identical …


Quantification Of Twist From The Central Lines Of Β-Strands, Tunazzina Islam, Michael Poteat, Jing He Jan 2018

Quantification Of Twist From The Central Lines Of Β-Strands, Tunazzina Islam, Michael Poteat, Jing He

Computer Science Faculty Publications

Since the discovery of right-handed twist of a β-strand, many studies have been conducted to understand the twist. Given the atomic structure of a protein, twist angles have been defined using atomic positions of the backbone. However, limited study is available to characterize twist when the atomic positions are not available, but the central lines of β-strands are. Recent studies in cryoelectron microscopy show that it is possible to predict the central lines of β-strands from a medium-resolution density map. Accurate measurement of twist angles is important in identification of β-strands from such density maps. We propose an effective method …


Microorganisms Facilitate Uptake Of Dissolved Organic Nitrogen By Seagrass Leaves, Flavia Tarquinio, Jeremy Bourgoure, Annette Koenders, Bonnie Laverock, Christin Säwström, Glenn A. Hyndes Jan 2018

Microorganisms Facilitate Uptake Of Dissolved Organic Nitrogen By Seagrass Leaves, Flavia Tarquinio, Jeremy Bourgoure, Annette Koenders, Bonnie Laverock, Christin Säwström, Glenn A. Hyndes

Research Datasets

The database compiles data (used in Tarquinio et al. 2018, ISME Journal, accepted for publication) obtained from nitrogen stable isotope analysis (IRMS) and Nanoscale secondary ion mass spectrometry (NanoSIMS) of seagrass (Posidonia sinuosa) leaves and associated microorganisms. Row data (IRMS) are presented for bulk tissue 15N enrichment of P. sinuosa leaves at different times of incubation (plotted as bar chart in the manuscript), as well as the enrichment detected through the drawing of regions of interest (ROI) from NanoSIMS image analysis and plotted as box plots in the manuscript.


Inhibition Of Blood Coagulation Factor Xii: Evaluation Of Flavonoids As A Drug Candidate, Betsy Crosswhite Jan 2018

Inhibition Of Blood Coagulation Factor Xii: Evaluation Of Flavonoids As A Drug Candidate, Betsy Crosswhite

Honors Theses

This study investigated natural product inhibitors of blood coagulation Factor XII (FXII). FXII initiates the Kallikrein Kinin-System (KKS) within the intrinsic coagulation pathway. Increased expression of this system leads to proinflammatory and procoagulant activities. Inflammation occurs through downstream activation in the KKS. Following the activation of FXII-dependent pathway, bradykinin (BK) binds to the BK receptor 2 (B2) and produces inflammatory signaling. Abnormally increased BK can result in life threatening Hereditary Angioedema (HAE), characterized by severe reoccurring swelling. FXII is critical for pathogenic thrombosis, but is dispensable for hemostasis. This unique property of FXII makes it an attractive drug target. We …


Law's Evolving Emergent Phenomena: From Rules Of Social Intercourse To Rule Of Law Society, Brian Z. Tamanaha Jan 2018

Law's Evolving Emergent Phenomena: From Rules Of Social Intercourse To Rule Of Law Society, Brian Z. Tamanaha

Scholarship@WashULaw

Law involves institutions rooted in the history of a society that evolve in relation to surrounding social, psychological, cultural, economic, political, technological, and ecological influences. Law must be understood naturalistically, historically, and holistically. In my usage, naturalism views humans as social animals with natural traits and requirements, historicism presents law as historical manifestations that change over time, and holism sees law within social surroundings. These insights inform my perspective in A Realistic Theory of Law. While these propositions might seem obvious, few works in contemporary jurisprudence build around them.

In this essay, I draw on the notion of emergence …


The 2018 International Conference On Unmanned Aircraft Systems, R Polvara, M Patacchiola, S Sharma, J Wan, A Manning, R Sutton, A Cangelosi Jan 2018

The 2018 International Conference On Unmanned Aircraft Systems, R Polvara, M Patacchiola, S Sharma, J Wan, A Manning, R Sutton, A Cangelosi

School of Engineering, Computing and Mathematics

The autonomous landing of an unmanned aerial vehicle (UAV) is still an open problem. Previous work focused on the use of hand-crafted geometric features and sensor-data fusion for identifying a fiducial marker and guide the UAV toward it. In this article we propose a method based on deep reinforcement learning that only requires low-resolution images coming from a down looking camera in order to drive the vehicle. The proposed approach is based on a hierarchy of Deep Q-Networks (DQNs) that are used as high-end control policy for the navigation in different phases. We implemented various technical solutions, such as the …


Training Games: An Application Of Game Theory To Clinical Psychology Graduate Training, Benjamin David Cornell Jan 2018

Training Games: An Application Of Game Theory To Clinical Psychology Graduate Training, Benjamin David Cornell

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Contents

Groundwork - 4

Game Theory - 4

Game Theory and the System of Clinical Psychology Graduate Training - 6

Psychological Payouts, Reconciling Game Theory and Clinical Psychology - 8

Games in the Training of Psychotherapists - 15

Prisoners’ Dilemmas, Internship and Graduate Applicant Selection - 15

The Strategic Implications of Learning, Nash Equilibria - 21

Commitment Moves, “The Frame,” Psychotherapy, Supervision - 24

Mechanism Design, The Match - 27

Intra-systemic Conflict, Program Design - 30

Conclusion - 34

Works Cited - 36


A Qualitative Evaluation Of A Substance Abuse Treatment Program For Athletes, Megan K. Lavoy Jan 2018

A Qualitative Evaluation Of A Substance Abuse Treatment Program For Athletes, Megan K. Lavoy

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

The focus of this study was to examine the experiences of two past participants of an athlete­-specific drug and alcohol rehabilitation program. Researchers have discussed the vulnerability of an athlete population and prevalence of substance use among athletes ( e.g., Turrisi, Mastroleo, Mallett, Larimer, & Kilmer, 2007; Martens, Watson, Royland, & Beck, 2005). Some rehabilitation programs and specific approaches to treating substance abuse in athletes have started to emerge and are beginning to be discussed in the literature (Donahue et al., 2014). However, there remains a gap in the research of studies examining the experiences of these athletes who have …


Public Health Implications Of Metal Ash Concentrations From Prescribed Burns: A Study Of Open Jarrah Forests, John Edwards Jan 2018

Public Health Implications Of Metal Ash Concentrations From Prescribed Burns: A Study Of Open Jarrah Forests, John Edwards

Theses: Doctorates and Masters

Ash is not a homogenous product. It is the solid residue of combustion and contains a complex mixture of chemical products. The fire that produces ash is non-discriminatory in that it will burn anything that is combustible. The ash residue resulting from fires varies and is dependent on its source, and burn characteristics such as the temperature of the fire. Ash comprises particles of carbon, soot and trace elements. Ash presents public health risk to people and communities, through direct and indirect ingestion, inhalation and absorption. The health effects of ash exposure are not limited to symptoms affecting the eyes, …


The Distribution And Trophic Ecology Of Golden Ghost Crabs (Ocypode Convexa), Caitlin Rae Jan 2018

The Distribution And Trophic Ecology Of Golden Ghost Crabs (Ocypode Convexa), Caitlin Rae

Theses: Doctorates and Masters

Sandy beaches make up approximately three-quarters of the world’s shorelines. They are important ecosystems, hosting abundant invertebrate macrofaunal communities that provide food resource for vertebrate predators such as shorebirds, seabirds, marine mammals and fish. Although possessing a terrestrial appearance, food input on sandy beaches is derived predominantly from the sea. Such food input includes detrital matter, mostly in the form of wrack, and has the potential to support a great diversity of species, as well as stabilising energy fluxes and dynamics of consumer populations. The movement of detritus, along with other vectors such as organisms and nutrients, across ecosystem boundaries …


Within-Fire Patchiness Associated With Prescribed Burning In The Northern Jarrah Forests Of Western Australia, Zigourney Nielsen Jan 2018

Within-Fire Patchiness Associated With Prescribed Burning In The Northern Jarrah Forests Of Western Australia, Zigourney Nielsen

Theses: Doctorates and Masters

There is growing understanding of the importance of landscape mosaics and heterogeneity for biodiversity outcomes in Western Australia. However, there is limited information on the patchiness (spatial configuration of unburnt and burnt patches which occur at a range of spatial scales) within the perimeter of a single prescribed burn. Of particular concern is the idea that prescribed burning operations, carried out under very restricted weather and environmental conditions, can lead to structural and floristic homogenization of the area within a burn perimeter. This may be evident as reduced post-fire vegetation patchiness. Western Australian Jarrah (Eucalyptus marginata) forests are managed to …


Holistic Health: Shaping Women’S Experiences Of Positive Body Image, Helen Elizabeth Monks Jan 2018

Holistic Health: Shaping Women’S Experiences Of Positive Body Image, Helen Elizabeth Monks

Theses: Doctorates and Masters

This PhD thesis seeks to contribute to a nuanced understanding of positive body image and how it is expressed among a group of women participating in holistic health culture in a modern Western society. Qualitative data were collected from in-depth ethnographic interviews with 25 women in Perth, Western Australia, to illuminate an understanding of their holistic health beliefs and practices, perceptions of appearance and health ideals, as well as their understandings of positive body image. Thematic analysis of the data through Nvivo revealed several overarching themes, demonstrating how certain aspects of holistic health culture may encourage or dissuade the development …


Young People Who Fireset In Western Australia: Peer Group Influences And Impulsiveness Trump Consequences, Catherine Analise Timms Jan 2018

Young People Who Fireset In Western Australia: Peer Group Influences And Impulsiveness Trump Consequences, Catherine Analise Timms

Theses: Doctorates and Masters

The paradoxical character of fire is perfectly captured by the juxtaposition between the initial ease and excitement of lighting fires, and fire’s destructive and uncontrollable nature. Australia is fire prone with its hot, dry climate, volatile vegetation and urban sprawl surrounded by bushland. Since an estimated 50% of fires lit in Australia are deliberate (Stanley & Read, 2016) the problem of intentional firesetting cannot be overstated. This thesis argues that youth firesetting requires both macro- and microlevel approaches to appreciate the complexities of the problem, and aims to identify applicable and directed responses to minimise youth firesetting. Study one analysed …


Development, Manufacture And Application Of A Solid-State Ph Sensor Using Ruthenium Oxide, Wade Lonsdale Jan 2018

Development, Manufacture And Application Of A Solid-State Ph Sensor Using Ruthenium Oxide, Wade Lonsdale

Theses: Doctorates and Masters

The measurement of pH is undertaken frequently in numerous settings for many applications. The common glass pH probe is almost ideal for measuring pH, and as such, it is used almost ubiquitously. However, glass is not ideal for all applications due to its relatively large size, fragility, need for recalibration and wet-storage. Therefore, much research has been undertaken on the use of metal oxides as an alternative for the measurement of pH.

Here, a solid-state potentiometric pH sensor is developed using ruthenium metal oxide (RuO2). Initially, pH sensitive RuO2 electrodes were prepared by deposition with radio frequency magnetron sputtering (RFMS) …


Exploring The Preparedness Of Novice (Student) Paramedics For The Mental Health Challenges Of The Paramedic Profession: Using The Wisdom Of The Elders, Lisa Holmes Jan 2018

Exploring The Preparedness Of Novice (Student) Paramedics For The Mental Health Challenges Of The Paramedic Profession: Using The Wisdom Of The Elders, Lisa Holmes

Theses: Doctorates and Masters

This study investigates the preparedness of novice (student) paramedics for the mental health challenges of the paramedic profession and identifies the coping strategies used by veteran paramedics to successfully meet these challenges. The lived experience of veteran paramedics is utilised to provide this important assistance.

Initially, two surveys were developed and administered to 16 course coordinators and 302 students of the 16 accredited undergraduate degree paramedicine courses across Australia and New Zealand, to identify the perceived need (for preparation) within the curriculum. In addition, the anticipations, confidence and fears of novice (student) paramedics, course coordinators and veteran paramedics were also …


The Value Of Animal Behaviour As A Bio-Indicator Of Restoration Quality, Floyd Holmes Jan 2018

The Value Of Animal Behaviour As A Bio-Indicator Of Restoration Quality, Floyd Holmes

Theses: Doctorates and Masters

Woodland restoration is a complex endeavour, and restoration ecology as a scientific discipline requires constant re-assessments and adjustments if it is to improve outcomes and better provide for biodiversity. The promise of effective restoration is often used to justify destructive processes that affect many of the world’s ecosystems. It is therefore imperative that those promises can be met, which comes down to restoration ecologists’ and land managers’ capacity to predict and facilitate desirable ecological changes in a timely and socio-economically responsible manner. As perspectives have changed, and knowledge has been gained over the past few decades there have been several …


Impact Of Biobanks On Research Outcomes In Rare Diseases:A Systematic Review, Monique Garcia Jan 2018

Impact Of Biobanks On Research Outcomes In Rare Diseases:A Systematic Review, Monique Garcia

Theses: Doctorates and Masters

Rare diseases (RDs) are a global priority yet are still under researched. When combined, RDs are common, with individual diseases numbering approximately 5,000-8,000, equating to approximately 7% of the population in Europe. Extrapolating this figure for Australia suggests that about 1.2 million people are affected by RDs, with about 400,000 of those being children. The WA Rare Diseases Strategic Framework 2015-2018, the first strategy for rare diseases in Australia, recognises that in order to alleviate the significant burden of rare diseases, innovative translational tools that facilitate research into new diagnostic and therapeutic strategies should be given priority.

Registries facilitate clinical, …


Genetic Determinants Of Rates Of Cognitive Decline In Preclinical Alzheimer’S Disease, Tenielle L. S. Porter Jan 2018

Genetic Determinants Of Rates Of Cognitive Decline In Preclinical Alzheimer’S Disease, Tenielle L. S. Porter

Theses: Doctorates and Masters

In 2015 the number of people worldwide living with Dementia was 46.8 million, with approximately 50-75% of these cases being clinically defined as Alzheimer’s disease (AD). Despite extensive efforts, clinical trials have so far failed to yield a treatment that successfully addresses the underlying cause of AD. This lack of treatment has been suggested, in part, to be a result of late stage of intervention in current clinical trial design. For this reason, greater focus has been placed on preclinical trials and in turn both the identification of individuals at-risk for AD and, amongst these, those that are expected to …


Rogue: A Novel - And - Wonderlust: The Value Of Wonder For Readers, Writers, And The Vault: A Critical Essay, Amanda Betts Jan 2018

Rogue: A Novel - And - Wonderlust: The Value Of Wonder For Readers, Writers, And The Vault: A Critical Essay, Amanda Betts

Theses: Doctorates and Masters

This thesis consists of an original novel, Rogue, and an exegesis titled Wonderlust: the value of wonder for readers, writers, and The Vault.

Rogue is the second novel of the series titled The Vault, which is a speculative fiction duology for young adults (thirteen and above) with the possibility for crossover into adult readership. Rogue picks up the story of fifteen-year-old Hayley who, after choosing to leave her previous home of an underwater seed vault, finds herself washed onto the cliffs of Maria Island, off the coast of Tasmania. As Hayley ventures further into the terrestrial ‘real world’ …