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Modeling Reveals The Dependence Of Hippocampal Neurogenesis Radiosensitivity On Age And Strain Of Rats, Eliedonna Cacao, Sidath Kapukotuwa, Francis A. Cucinotta

Health Physics and Diagnostic Sciences Faculty Research

Cognitive dysfunction following radiation treatment for brain cancers in both children and adults have been correlated to impairment of neurogenesis in the hippocampal dentate gyrus. Various species and strains of rodent models have been used to study radiation-induced changes in neurogenesis and these investigations have utilized only a limited number of doses, dose-fractions, age and time after exposures conditions. In this paper, we have extended our previous mathematical model of radiation-induced hippocampal neurogenesis impairment of C57BL/6 mice to delineate the time, age, and dose dependent alterations in neurogenesis of a diverse strain of rats. To the best of our knowledge, …

Prenatal Risk For Asd: Fetal Cortisol Exposure Predicts Child Autism-Spectrum-Disorder Symptoms, Sheena Ram, Mariann A. Howland, Curt A. Sandman, Elyssia Poggi Davis, Laura M. Glynn

Psychology Faculty Articles and Research

The etiology of autism spectrum disorder (ASD) is multifactorial, complex, and likely involves interactions among genetic, epigenetic, and environmental factors. With respect to environmental influences, a growing literature implicates intrauterine experiences in the origin of this pervasive developmental disorder. In this prospective longitudinal study, we examined the hypothesis that fetal exposure to maternal cortisol may confer ASD risk. In addition, because ASD is four times more prevalent in males than in females, and because sexually dimorphic responses to intrauterine experiences are commonly observed, we examined whether or not any associations differ by fetal sex. Maternal plasma cortisol was measured at …

Prenatal Risk For Autism Spectrum Disorder (Asd): Fetal Cortisol Exposure Predicts Child Asd Symptoms, Sheena Ram, Mariann A. Howland, Curt A. Sandman, Elyssia Poggi Davis, Laura M. Glynn

Psychology Faculty Articles and Research

The etiology of autism spectrum disorder (ASD) is multifactorial, complex, and likely involves interactions among genetic, epigenetic, and environmental factors. With respect to environmental influences, a growing literature implicates intrauterine experiences in the origin of this pervasive developmental disorder. In this prospective longitudinal study, we examined the hypothesis that fetal exposure to maternal cortisol may confer ASD risk. In addition, because ASD is four times more prevalent in males than in females, and because sexually dimorphic responses to intrauterine experiences are commonly observed, we examined whether or not any associations differ by fetal sex. Maternal plasma cortisol was measured at …

Structure And Function In Petioles Of Pelargonium, Dustin M. Ray

Doctoral Dissertations

As the connection between lamina and stem, petioles are essential for plant survival. Petioles serve two major functions in service to the leaf blade. First, they hold the leaf blade away from the stem to reduce self-shading and optimize light interception, a mechanical function. Second, petioles serve as the bridge between the stem and lamina allowing water to move up the plant body and photo-assimilates to move down to the plant body from the leaf blade, a physiological function. While mechanics and physiology have been studied independently, the petiole could be a space-limited structure leading to tradeoffs between the two …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern University recognized for research focus with latest Carnegie ranking

• First-year students to represent Georgia Southern in National College Cornhole Championship

Health-Services Utilisation Amongst Older Persons During The Last Year Of Life: A Population-Based Study, Danielle Ní Chróinín, David E. Goldsbury, Alexander Beveridge, Patricia M. Davidson, Afaf Girgis, Nicholas Ingham, Jane L. Phillips, Anne M. Wilkinson, Jane M. Ingham, Dianne L. O'Connell

Research outputs 2014 to 2021

BACKGROUND: Accurate population-based data regarding hospital-based care utilisation by older persons during their last year of life are important in health services planning. We investigated patterns of acute hospital-based service use at the end of life, amongst older decedents in New South Wales (NSW), Australia.

METHODS: Data from all persons aged ≥70 years who died in the state of NSW Australia in 2007 were included. Several measures of hospital-based service utilisation during the last year of life were assessed from retrospectively linked data comprising data for all registered deaths, cause of death, hospital care during the last year of life …

Bio Buzz Newsletter, Issue 16, December 2018, Department Of Biology

Biology Buzz Newsletter

No abstract provided.

Power In Pairs: Assessing The Statistical Value Of Paired Samples In Tests For Differential Expression, John R. Stevens, Jennifer S. Herrick, Roger K. Wolff, Martha L. Slattery

Mathematics and Statistics Faculty Publications

Background: When genomics researchers design a high-throughput study to test for differential expression, some biological systems and research questions provide opportunities to use paired samples from subjects, and researchers can plan for a certain proportion of subjects to have paired samples. We consider the effect of this paired samples proportion on the statistical power of the study, using characteristics of both count (RNA-Seq) and continuous (microarray) expression data from a colorectal cancer study.

Results: We demonstrate that a higher proportion of subjects with paired samples yields higher statistical power, for various total numbers of samples, and for various strengths of …

Making Prescriptions “Talk” To Stroke And Heart Attack Survivors To Improve Adherence: Results Of A Randomized Clinical Trial (The Talking Rx Study), Ayeesha Kamran Kamal, Wardah Khalid, Abdul Muqeet,, Anum Jamil,, Kashfa Farhat, Sehar Rahim Ali Gillani, Maryam Zulfiqar, Mehreen Saif, Aliya Amin Muhammad, Fabiha Zaidi, Saleem Sayani, Salim S. Virani

Section of Neurology

Background: We developed and tested the effectiveness of a tailored health information technology driven intervention: "TalkingPrescriptions" (Talking Rx) to improve medication adherence in a resource challenged environment.
Methods: We conducted a parallel, randomized, controlled, assessor-blinded trial at the Aga Khan University (AKU), Karachi, Pakistan. Adults with diagnosis of cerebrovascular accident (CVA) or coronary artery disease (CAD) diagnosed least one month before enrollment, on anti-platelets and statins, with access to a mobile phone were enrolled. The intervention group received a) Daily Interactive Voice Response (IVR) call services regarding specific statin and antiplatelet b) Daily tailored medication reminders for statin and antiplatelet …

Mechanical Suppression Of Osteolytic Bone Metastases In Advanced Breast Cancer Patients: A Randomised Controlled Study Protocol Evaluating Safety, Feasibility And Preliminary Efficacy Of Exercise As A Targeted Medicine, Nicolas H. Hart, Daniel A. Galvão, Christobel Saunders, Dennis R. Taaffe, Kynan T. Feeney, Nigel A. Spry, Daphne Tsoi, Hilary Martin, Raphael Chee, Tim Clay, Andrew D. Redfern, Robert U. Newton

Research outputs 2014 to 2021

BACKGROUND: Skeletal metastases present a major challenge for clinicians, representing an advanced and typically incurable stage of cancer. Bone is also the most common location for metastatic breast carcinoma, with skeletal lesions identified in over 80% of patients with advanced breast cancer. Preclinical models have demonstrated the ability of mechanical stimulation to suppress tumour formation and promote skeletal preservation at bone sites with osteolytic lesions, generating modulatory interference of tumour-driven bone remodelling. Preclinical studies have also demonstrated anti-cancer effects through exercise by minimising tumour hypoxia, normalising tumour vasculature and increasing tumoural blood perfusion. This study proposes to explore the promising …

F.A.I.R. Is Fair For Research: Australian Initaitves To Improve Openness In The Scholarly Communications Environment, Jill Benn, Martin Borchert

Proceedings of the IATUL Conferences

Disruptive changes are transforming the scholarly communications environment. In an era of false reporting and fake news, quality information and verifiable data is essential. However, much of the world’s best publicly funded research remains hidden behind commercial publisher paywalls. Unlocking this research can help solve the world’s greatest research and social challenges, and result in a more informed society. This paper will explore how, within the Australian context, librarians are seeking to make research more findable, accessible, interoperable and reusable (FAIR). The Australasian Open Access Strategy Group (AOASG) and the Council of Australian University Librarians (CAUL) have worked on a …

Recent Case Decisions

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Like A Jar Of Flies? A Study Of Self-Control In An Organizational Social Dilemma With Large Stakes, Matthew W. Mccarter, Jonathan R. Clark, Darcy Fudge Kamal, Abel Winn

Business Faculty Articles and Research

We study the practice of self-control in an organizational social dilemma when the stakes are large, using 47 years of vital census data from 18^th century Sweden. From 1750 to 1800, eighty percent of Sweden lived in a simple-structure organization called a bytvång or village commons. The amount of resources a village family received was a function of their size. During this period, crop failures left the population facing starvation. Using autoregressive time-series modeling, we test whether the people of Sweden continued to take steps toward increasing the stress on the commons by marrying and birthing children or practiced …

Retinopathy Of Prematurity: A Major Review And Situation Analysis In Egypt, Ihab S. Othman

Journal of Medicine in Scientific Research

Retinopathy of prematurity (ROP) remains a major cause of childhood blindness in developing countries. As childhood and neonatal mortality in Egypt has shown tremendous improvement over the past two decades, it is expected to encounter an increasing number of cases of blindness from ROP in surviving infants unless strict guidelines and cooperation between different involved departments are explicitly set. In this review article, the author highlights the studies conducted and published risk factors, recommends protocols for early diagnosis, and describes management strategies to lessen or prevent blindness related to ROP.

Psychological Respect For Patients With Breast Cancer Using Radial Incision Which Gives Better Cosmetic Outcome After Conservative Breast Surgery, Adel K. Barsoum, Hytham R. Yassin

Journal of Medicine in Scientific Research

Background Breast cancer is considered as one of the most common cancers affecting women, and remains one of the world's biggest killers. Once diagnosed as a breast cancer patient, a woman can be exposed to psychological trauma that is manifested as stress, anxiety, and even depression. Since surgery is the most important part of breast cancer management protocol, the first time a woman looks to her body after surgery can be harmful. Despite this gloomy picture, there have been some dramatic modifications recently in the treatment of breast cancer, especially in early detected tumors. One of them is the clear …

The Role Of Urinary Hepcidin In Early Detection Of Iron Deficiency Anemia, Aisha El Sheimy, Azza Omran, Fify Helmy, Hala I. Mouhamed, Sohaila Ali, Youssof Mohamed

Journal of Medicine in Scientific Research

Iron deficiency anemia (IDA) is one of the most severe and important nutritional deficiencies, especially in children all over the world. Iron deficiency may occur because of inadequate dietary intake, increase in physiological needs of the nutrient, and/or increased losses, which may lead to anemia. IDA has been associated with cognitive, motor, and behavioral impairment in children. The most commonly used tests to determine iron status include serum iron levels, ferritin, and others. However, these test have limited role in diagnosis of IDA. For this reason, there is great interest in investigating effective method for the diagnosis of IDA. The …

Anti-Acetylcholine Receptor Antibodies As A Diagnostic Marker For Myasthenia Gravis, Aisha El-Shimy, Hala I. Mohamed, Iman Kamel, Magdy Khalaf, Youssof Abd El Motamad

Journal of Medicine in Scientific Research

Background Myasthenia gravis (MG) is a common primary disorder of neuromuscular transmission, which is characterized by fluctuating weakness of a certain voluntary muscles, particularly those innervated by motor nuclei of the brain stem, that is, ocular and mastication muscles, and caused by antibodies binding to components in the neuromuscular junction. Most MG cases demonstrate elevated serum levels of acetylcholine receptor (ACh-R) antibodies, which cause partial or complete inhibition of receptor function and complement-mediated focal lysis of the postsynaptic membrane. ACh-R antibodies are detected in the serum of more than 80–90% patients with generalized MG, in ~50% with ocular myasthenia, and …

Results Of Compression Plating Versus Locked Intramedullary Nailing Fixation In The Treatment Of Humeral Shaft Fractures In Adults, Ahmad Shawakat Rizk, Hassan Hussein Ahmad Abdallah, Mohammed Gamal El Din Al Ashahab, Said Ibrahim Said Abdelmotalb

Journal of Medicine in Scientific Research

Background Most humerus shaft fractures can be treated successfully using the conservative methods. When choosing surgical fixation, there is a debate between the use of plate and screws and intramedullary nails. Aims The aim of this study was to compare the results of the dynamic compression plate and the antegrade interlocked humeral nail in the fixation of humerus shaft fractures. Patients and methods A total of 40 patients were selected by a randomized method to be treated by either method; there were 20 patients in each group and patients were followed up for at least 6 months until union. Result …

Structured Diet And Exercise Guidance In Pregnancy To Improve Health In Women And Their Offspring: Study Protocol For The Be Healthy In Pregnancy (Bhip) Randomized Controlled Trial, Maude Perreault, Stephanie A. Atkinson, Michelle F. Mottola, Stuart M. Phillips, Keyna Bracken, Eileen K. Hutton, Feng Xie, David Meyre, Rita E. Morassut, Harry Prapavessis, Lehana Thabane

Anatomy and Cell Biology Publications

BackgroundEvidence from epidemiological and animal studies support the concept of programming fetal, neonatal, and adult health in response to in utero exposures such as maternal obesity and lifestyle variables. Excess gestational weight gain (GWG), maternal physical activity, and sub-optimal and excess nutrition during pregnancy may program the offspring's risk of obesity. Maternal intake of dairy foods rich in high-quality proteins, calcium, and vitamin D may influence later bone health status. Current clinical practice guidelines for managing GWG are not founded on randomized trials and lack specific active intervention ingredients. The Be Healthy in Pregnancy (BHIP) study is a randomized controlled …

2006 - Salinas Valley Integrated Regional Water Management Functionally Equivalent Plan Summary Document Update

Miscellaneous Monterey and San Luis Obispo County Documents and Reports

The California Department of Water Resources (DWR) and the State Water Resources Control Board (SWRCB) are encouraging local and regional water management planners to establish integrated regional water management plans through the collaboration of planning efforts and project coordination. The intent is to encourage planners to implement projects focused on meeting multiple water resources needs on a regional basis. Jointly, both agencies are soliciting grant applications for Proposition 50 Chapter 8 grant funding, which was established to provide a fiscal tool to support integrated regional water management. In order to take advantage of this funding opportunity, Monterey County Water Resources …

2010 - Excerpt From Master Response 4 - Water Supply Re Salinas Valley Water Supply (10-28-10)

Miscellaneous Monterey and San Luis Obispo County Documents and Reports

In addition to the Master Response to the Monterey County General Plan pertaining to the analysis of the Salinas Valley water supply, tables and figures referenced in the response are included at the end of the response. This document is for informational purposes only to provide a summary of information relative to the Salinas Valley water supply analysis contained in the Final EIR.

Seasonality Of Nitrogen Balances In A Mediterranean Climate Watershed, Oregon, Us, Jiajia Lin, Jana E. Compton, Scott G. Leibowitz, George Mueller-Warrant, William Matthews, Stephen H. Schoenholtz, Daniel M. Evans, Rob A. Coulombe

United States Environmental Protection Agency: Publications

We constructed a seasonal nitrogen (N) budget for the year 2008 in the Calapooia River Watershed (CRW), an agriculturally dominated tributary of the Willamette River (Oregon, U.S.) under Mediterranean climate. Synthetic fertilizer application to agricultural land (dominated by grass seed crops) was the source of 90% of total N input to the CRW. Over 70% of the stream N export occurred during the wet winter, the primary time of fertilization and precipitation, and the lowest export occurred in the dry summer. Averaging across all 58 tributary subwatersheds, 19% of annual N inputs were exported by streams, and 41% by crop …

But Are They Actually Healthier? Challenging The Health/Wellness Divide Through The Ethnography Of Embodied Ecological Heritage, Kristina Baines

Publications and Research

A holistic definition of ‘health’ remains difficult to operationalize, despite decades of attempts by medical anthropologists and the World Health Organization to do so. Anthropologists routinely reject dichotomous notions – belief vs. knowledge, wellness vs. health, mental vs. physical, environment vs. self – yet demands for physiological evidence of ‘health’ persist. In this article, I ask what evidence would sufficiently demonstrate health, and explore the possibility of measures that move beyond the physiological. Using ethnographic data collected in indigenous Maya communities in Belize and in immigrant communities in New York City, I argue that ecological heritage practices can provide a …

2018-December-19-Presidential Fellows, University Marketing And Communications, East Tennessee State University

ETSU News

JOHNSON CITY (Dec. 19, 2018) – East Tennessee State University President Brian Noland has named Dr. Joe Bidwell and Dr. Janna L. Scarborough as Presidential Fellows for the spring 2019 semester.

As fellows, the two faculty members will develop and execute a project that is aligned with one of the university’s major initiatives in teaching, learning and service. The fellows will work closely with President Noland, his leadership team and ETSU Center for Teaching Excellence staff.

Bidwell joined ETSU in 2014 and is a professor and chair of Biological Sciences. During this time, he has also served as interim chair …

Ocean Deoxygenation And Zooplankton: Very Small Oxygen Differences Matter, Karen F. Wishner, Brad A. Seibel, Christopher Roman, C. Deutsch, Dawn Outram, C. T. Shaw, M. A. Birk, K. A. S. Mislan, T. J. Adams, D. Moore, S. Riley

Graduate School of Oceanography Faculty Publications

Oxygen minimum zones (OMZs), large midwater regions of very low oxygen, are expected to expand as a result of climate change. While oxygen is known to be important in structuring midwater ecosystems, a precise and mechanistic understanding of the effects of oxygen on zooplankton is lacking. Zooplankton are important components of midwater food webs and biogeochemical cycles. Here, we show that, in the eastern tropical North Pacific OMZ, previously undescribed submesoscale oxygen variability has a direct effect on the distribution of many major zooplankton groups. Despite extraordinary hypoxia tolerance, many zooplankton live near their physiological limits and respond to slight …

Concentrations Of Multiple Phytoplankton Pigments In The Global Oceans Obtained From Satellite Ocean Color Measurements With Meris, Guoqing Wang, Zhongping Lee, Colleen B. Mouw

Graduate School of Oceanography Faculty Publications

The remote sensing of chlorophyll a concentration from ocean color satellites has been an essential variable quantifying phytoplankton in the past decades, yet estimation of accessory pigments from ocean color remote sensing data has remained largely elusive. In this study, we validated the concentrations of multiple pigments (Cpigs) retrieved from in situ and MEdium Resolution Imaging Spectrometer (MERIS) measured remote sensing reflectance (R_rs(λ)) in the global oceans. A multi-pigment inversion model (MuPI) was used to semi-analytically retrieve Cpigs from R_rs(λ). With a set of globally optimized parameters, the accuracy of the retrievals obtained with MuPI is …

Completion Of An Experiment, Michael J. Imperiale, Ira Blader, Patricia Bradford, Sarah E. F. D'Orazio, W. Paul Duprex, Craig D. Ellermeier, Ana Fernandez-Sesma, Katherine Mcmahon, Aaron Mitchell, Marcela F. Pasetti, Susannah Tringe

Microbiology, Immunology, and Molecular Genetics Faculty Publications

No abstract provided.

Modeling Of Cantú Syndrome In Zebrafish, Soma Sekhara Singareddy

McKelvey School of Engineering Graduate Student Theses & Dissertations

Although rare, Cantú syndrome (CS) is a debilitating syndrome without any specific therapy, caused by gain-of-function (GOF) mutations in KCNJ8 and ABCC9 genes that encode ATP-sensitive potassium (KATP) channels. To better understand the link between molecular dysfunction and the complex pathophysiology, animal models that can rigorously mirror human CS are essential. Using ABCC9-mutated zebrafish, which can provide significant advantages over mice as an appropriate vertebrate model, GOF has been demonstrated at a cellular level in the ventricular cardiomyocytes. This also marks the first-known characterization of KATP currents in teleost hearts. In addition, sulfonylurea sensitivities of the channels have been …

Breathing Study Shows Huge Armored Dinosaurs Battled Overheating With Nasal Air-Conditioning (December 19, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Stabilized, Hybrid Solid-State Photocatalysts For Water Purification: Preparation, Properties And Performance Under Visible Light Irradiation, Karpagavalli Ramji

Seton Hall University Dissertations and Theses (ETDs)

Stabilized heterogeneous photocatalysts that use only solar light and air have been prepared and successfully employed to decontaminate water from organic pollutants. Organic dye pollutants present, for example in textile effluents, are one of the major sources of water pollution owing to their limited biodegradability, toxicity and potential carcinogenic risks. Before certifying water for public consumption, reuse in industries or for discharge in surface water the organic pollutants must be degraded, an effort that is energy intensive and currently requires complex methodologies. We report solid-state photocatalysts that use only visible light and air to treat wastewater. Perfluoroalkyl perfluoro-substituted zinc phthalocyanine …