Digital Commons Network^™

The Power Of Words: The Ramifications Of Stigmatizing Language In Medical Records, Jayla Johnson

The Synapse: Intercollegiate science magazine

No abstract provided.

Analyzing Stakeholders’ Workshop Dialogue For Evidence Of Social Learning, Amanda L. Bentley Brymer, J. D. Wulfhorst, Mark W. Brunson

Environment and Society Faculty Publications

After much debate and synthesis, social learning scholarship is entering an era of empirical research. Given the range across individual-, network-, and systems-level perspectives and scales, clear documentation of social learning processes is critical for making claims about social learning outcomes and their impacts. Past studies have relied on participant recall and concept maps to document perceptions of social learning process and outcome. Using an individual-centric perspective and importing ideas from communication and psychology on question-answer learning through conversational agents, we contribute an expanded conceptual framework and qualitative analytical strategy for assessing stakeholder dialogue for evidence of social learning. We …

The Implications Of Group Norms For Adaptation In Collectively Managed Agricultural Systems: Evidence From Sri Lankan Paddy Farmers, Arielle Tozier De La Poterie, Emily Burchfield, Amanda R. Carrico

Environment and Society Faculty Publications

A growing literature seeks to explore the factors shaping adaptation to climate change. In collectively managed common pool resource systems, there is often a tension between behavior that benefits the individual and actions that benefit a larger group. Resource users in sustainable systems must therefore work together to ensure outcomes that are beneficial to the group as a whole. However, in the face of changing social, political, and environmental conditions, community norms may change, leading to the emerging of new behavioral patterns. Understanding when and why people decide to act in ways that benefit the group as a whole can …

Catalog Denison University 2018-2019

Denison University Catalogs

Denison University Courses 2018-2019

Investigating The Causes And Cures For Unclear Scholarly Writing, Marlene Ingrid Mahony

Doctoral Dissertations

This qualitative dissertation investigated possible causes and cures for unclear scholarly writing. For this study, a stipulative definition of unclear scholarly writing, or “academese,” is that the language tends to be vague and verbose. The problem, according to the included literature, is that people who use or accept vague language have less academic, social, professional, and civic power. Academese, some say, can detach readers and that can accordingly diminish collective exchange. Because higher education is meant to share knowledge, promote agency, and prepare students to communicate powerfully within and beyond the university, this study researched the causes and cures of …

Hydnora Arabica (Aristolochiaceae), A New Species From The Arabian Peninsula And A Key To Hydnora, Jay F. Bolin, Darach Lupton, Lytton John Musselman

Biological Sciences Faculty Publications

The plant parasite Hydnora arabica (Aristolochiaceae) is described from the Arabian Peninsula. This species was previously identified as Hydnora africana in Oman. It can be separated from other Hydnora taxa primarily by its terete rhizome, red to orange inner perianth tube color, and tepal lobe margins entirely covered with dense strigose setae. In Oman, Hydnora arabica is known to parasitize two leguminous trees: Acacia tortilis and the introduced Pithocellobium dulce, but may parasitize additional Fabaceae. At least eleven synonyms or subspecific varieties of H. abyssinica are described in the literature, all from east or southern Africa. These synonyms are …

Tribute To Professor Paul Giannelli, Erin Murphy

Case Western Reserve Law Review

No abstract provided.

Who Speaks For Neuroscience? Neuroimaging Evidence And Courtroom Expertise, Jane Campbell Moriarty, Daniel D. Langleben

Case Western Reserve Law Review

No abstract provided.

Using An In Vitro System For Maintaining Varroa Destructor Mites On Apis Mellifera Pupae As Hosts: Studies Of Mite Longevity And Feeding Behavior, Noble I. Egekwu, Francisco Posada, Daniel E. Sonenshine, Steven Cook

Biological Sciences Faculty Publications

Varroa destructor mites (varroa) are ectoparasites of Apis mellifera honey bees, and the damage they inflict on hosts is likely a causative factor of recent poor honey bee colony performance. Research has produced an arsenal of control agents against varroa mites, which have become resistant to many chemical means of their control, and other means have uncertain efficacy. Novel means of control will result from a thorough understanding of varroa physiology and behavior. However, robust knowledge of varroa biology is lacking; mites have very low survivability and reproduction away from their natural environment and host, and few tested protocols of …

High Frequency Temperature Variability Reduces The Risk Of Coral Bleaching, Aryan Safaie, Nyssa J. Silbiger, Timothy R. Mcclanahan, Geno Pawlak, Daniel J. Barshis, James L. Hench, Gareth J. Williams, Kristen A. Davis

Biological Sciences Faculty Publications

Coral bleaching is the detrimental expulsion of algal symbionts from their cnidarian hosts, and predominantly occurs when corals are exposed to thermal stress. The incidence and severity of bleaching is often spatially heterogeneous within reef-scales (km), and is therefore not predictable using conventional remote sensing products. Here, we systematically assess the relationship between in situ measurements of 20 environmental variables, along with seven remotely sensed SST thermal stress metrics, and 81 observed bleaching events at coral reef locations spanning five major reef regions globally. We find that high-frequency temperature variability (i.e., daily temperature range) was the most influential factor in …

Sea Turtles And Survivability In Demersal Trawl Fisheries: Do Comatose Olive Ridley Sea Turtles Survive Post-Release?, Sara M. Maxwell, Matthew J. Witt, Gaspard Abitsi, Marie Pierre Aboro, Pierre Didier Agamboue, Georges Mba Asseko, Francois Boussamba, Emmanuel Chartain, Micheline Schummer Gnandji, Brice Didier Koumba Mabert

Biological Sciences Faculty Publications

Incidental capture of air‑breathing species in fishing gear is a major source of mortality for many threatened populations. Even when individuals are discarded alive, they may not survive due to direct injury, or due to more cryptic internal physiological injury such as decompression sickness. Post‑release mortality, however, can be difficult to determine. In this pilot study, we deployed survivorship pop‑up archival tags (sPAT) (n = 3) for an air‑breathing species, the olive ridley sea turtle (Lepidochelys olivacea), one of the first studies to do so. We found that at least two of the three turtles survived after being …

Integrating Dynamic Subsurface Habitat Metrics Into Species Distribution Models, Stephanie Brodie, Michael G. Jacox, Steven J. Bograd, Heather Welch, Heidi Dewar, Kylie L. Scales, Sara M. Maxwell, Dana M. Briscoe, Christopher A. Edwards, Larry B. Crowder, Rebecca L. Lewison, Elliott L. Hazen

Biological Sciences Faculty Publications

Species distribution models (SDMs) have become key tools for describing and predicting species habitats. In the marine domain, environmental data used in modeling species distributions are often remotely sensed, and as such have limited capacity for interpreting the vertical structure of the water column, or are sampled in situ, offering minimal spatial and temporal coverage. Advances in ocean models have improved our capacity to explore subsurface ocean features, yet there has been limited integration of such features in SDMs. Using output from a data-assimilative configuration of the Regional Ocean Modeling System, we examine the effect of including dynamic subsurface …

Energy-Rich Mesopelagic Fishes Revealed As A Critical Prey Resource For A Deep-Diving Predator Using Quantitative Fatty Acid Signature Analysis, Chandra Goetsch, Melinda G. Conners, Suzanne M. Budge, Yoko Mitani, William A. Walker, Jeffrey F. Bromaghin, Samantha E. Simmons, Colleen Reichmuth, Daniel P. Costa

Biological Sciences Faculty Publications

Understanding the diet of deep-diving predators can provide essential insight to the trophic structure of the mesopelagic ecosystem. Comprehensive population-level diet estimates are exceptionally difficult to obtain for elusive marine predators due to the logistical challenges involved in observing their feeding behavior and collecting samples for traditional stomach content or fecal analyses. We used quantitative fatty acid signature analysis (QFASA) to estimate the diet composition of a wide-ranging mesopelagic predator, the northern elephant seal (Mirounga angustirostris), across five years. To implement QFASA, we first compiled a library of prey fatty acid (FA) profiles from the mesopelagic eastern North Pacific. Given …

Racism, Resistance, Resilience: Chronically Ill African American Women’S Experiences Navigating A Changing Healthcare System, Elizabeth New

Theses and Dissertations--Anthropology

This medical anthropology dissertation is an intersectional study of the illness experiences of African-American women living with the chronic autoimmune syndrome systemic lupus erythematosus (SLE), commonly known as lupus. Research was conducted in Memphis, Tennessee from 2013 to 2015, with the aim of examining the healthcare resources available to working poor and working class women using public sector healthcare programs to meet their primary care needs. This project focuses on resources available through Tennessee’s privatized public sector healthcare system, TennCare, during the first phases of the Patient Protection and Affordable Care Act (ACA). A critical medical anthropological analysis is used …

Variation Of Native American Ceramics In The Big Bend Region Of The Lower Ocmulgee River Valley, Georgia, Ad 1540 To Ad 1715, Rachel Paige Hensler

Theses and Dissertations--Anthropology

Studies of European colonialism in the Western Hemisphere have shifted focus from areas of direct European/Native American contact, to investigate Native American groups outside of direct European contact. During Spanish colonization of the Southeastern United States (AD 1520 to AD 1715), the Big Bend region of the Ocmulgee River Valley, in Georgia, located about 160 kilometers from Spanish occupied coast, was inhabited by a Native American polity from the Late Prehistoric into the Mission period. This location is ideal for studying indirect contact.

Changes in ceramic production can be used to identify changes in Native American interaction through time. Attributes …

“We’Re Being Left To Blight”: Green Urban Development And Racialized Space In Kansas City, Chhaya Kolavalli

Theses and Dissertations--Anthropology

In this dissertation, I explore ‘green’ urban development and urban agriculture projects from the perspective of residents of an African American majority neighborhood in Kansas City—who reside in an area referred to as a ‘blighted food desert’ by local policy makers. In Kansas City, extensive city government support exists for urban agricultural projects, which are touted not just as a solution to poverty associated issues such food insecurity and obesity, but also as a remedy for ‘blight,’ violence and crime, and vacant urban land. Specific narratives of Kansas City’s past are used to prop up and legitimate these future visions …

Living In Two Worlds: Evolutionary Mechanisms Act Differently In The Native And Introduced Ranges Of An Invasive Plant, Wen-Yong Guo, Carla Lambertini, Petr Pyšek, Laura A. Meyerson, Hans Brix

Natural Resources Science Faculty Publications

Identifying the factors that influence spatial genetic structure among populations can provide insights into the evolution of invasive plants. In this study, we used the common reed (Phragmites australis), a grass native in Europe and invading North America, to examine the relative importance of geographic, environmental (represented by climate here), and human effects on population genetic structure and its changes during invasion. We collected samples of P. australis from both the invaded North American and native European ranges and used molecular markers to investigate the population genetic structure within and between ranges. We used path analysis to identify …

Complete Measurement System For Measuring High Voltage And Electrical Field Using Slab-Coupled Optical Fiber Sensors, Nikola Stan

Theses and Dissertations

A slab-coupled optical fiber sensor (SCOS) falls into a narrow class of all-dielectric optical fiber electric field sensors, which makes it a perfect candidate for measurements of high electric fields in environments where presence of conductors is highly perturbing to the system under test. Its nonlinear response to high fields requires a new nonlinear calibration technique. A nonlinear calibration method is explained and demonstrated to successfully measure high electric fields, as well as high voltages with dynamic range up to 50 dB. Furthermore, a SCOS can be fitted into narrow spaces and make highly localized measurements due to its small …

ชาตินิยมกับความเป็นอื่นที่พบในการแปลบทละครเรื่อง The Merchant Of Venice ของ William Shakespeare กรณีศึกษา : บทพระราชนิพนธ์แปลในพระบาทสมเด็จพระมงกุฎเกล้าเจ้าอยู่หัว เรื่อง เวนิสวาณิช, ดอม ขุนพินิจ

Chulalongkorn University Theses and Dissertations (Chula ETD)

การศึกษาเรื่อง ชาตินิยมกับความเป็นอื่นที่พบในการแปลบทละครเรื่อง ‘The Merchant of Venice’ ของ William Shakespeare กรณีศึกษา: บทพระราชนิพนธ์แปลในพระบาทสมเด็จพระมงกุฎเกล้าเจ้าอยู่หัวเรื่อง ‘เวนิสวาณิช’ นี้เป็นการศึกษาเชิงคุณภาพตามแนวทางวัฒนธรรมศึกษาในศาสตร์การแปล โดยมุ่งศึกษาบทบาทของการแปลในการประกอบสร้างอัตลักษณ์ความเป็นอื่นและความเป็นไทยในฐานะส่วนหนึ่งของแนวคิดชาตินิยมที่ปรากฏในบทแปล เพื่อหาความสัมพันธ์ระหว่างบทบาทของการแปลกับบริบททางประวัติศาสตร์ในรัชสมัยพระบาทสมเด็จพระมงกุฎเกล้าเจ้าอยู่หัวในประเด็นดังกล่าว ในการศึกษา ผู้วิจัยได้ทบทวนทฤษฎีและงานวิจัยที่เกี่ยวข้อง โดยเฉพาะในกรอบของศาสตร์การแปล ได้แก่ แนวคิดเรื่องอุดมการณ์ วาทกรรม และทฤษฎีวาทกรรมวิเคราะห์เชิงวิพากษ์ ตลอดจนแนวคิดเรื่องความเป็นอื่นและความเป็นไทย แล้วจึงได้ศึกษาแง่มุมที่เกี่ยวข้องที่ปรากฏในตัวบทต้นฉบับและบริบททางประวัติศาสตร์ของฉบับแปล ก่อนจะทำการวิเคราะห์บทแปลที่มีการสอดแทรกวาทกรรมที่เกี่ยวข้องกับเรื่องความเป็นอื่นจากตัวบทต้นฉบับ The Merchant of Venice ของวิลเลียม เชกสเปียร์ ในบทพระราชนิพนธ์แปล เวนิสวาณิช ของพระบาทสมเด็จพระมงกุฎเกล้าเจ้าอยู่หัวด้วยแนวทางวาทกรรมวิเคราะห์เชิงวิพากษ์ ผลการศึกษาพบว่า ใน เวนิสวาณิช ปรากฏการปรับบทแปลที่มีส่วนในการกำหนดสร้างและขับเน้นอัตลักษณ์ความเป็นอื่นของตัวละครในเรื่อง และสอดแทรกอัตลักษณ์ความเป็นไทยอันพึงประสงค์ในสายตาของฝ่ายอำนาจนำ ได้แก่การเชิดชูสถาบันกษัตริย์ระบอบสมบูรณาญาสิทธิราชย์ในฐานะสัญลักษณ์ของชาติ การปรับบทแปลเช่นนี้เป็นผลจากความกังวลที่มีต่อสถานะความเป็นชาติของสยามท่ามกลางกระแสการไหลบ่าของอิทธิพลจากต่างชาติ ทั้งจากชาติตะวันตกที่เข้ามาล่าอาณานิคมในเอเชียตะวันออกเฉียงใต้ และจากชาวจีนโพ้นทะเลที่เข้ามาอาศัยอยู่ในสยาม และเผยให้เห็นบทบาทของการแปลในการเป็นเครื่องมือขับเคลื่อนอุดมการณ์ โดยสอดคล้องกับบริบททางสังคมและการเมืองในสมัยดังกล่าว

Identification Of Genes And Metabolites Involved In Durian Durio Zibethinus Fruit Ripening, Pinnapat Pinsorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Durian (Durio zibethinus M.), a major economic fruit, actively produces infamous sulfur-containing compounds during ripening. However, sulfur metabolism which is important in this fruit is rarely investigated. In this study, the integration of metabolomics using CE-TOF/MS and transcriptomics using de novo RNA-seq assembly was performed to reveal metabolic changes involved in sulfur metabolism and chemical composition related to fruit quality. During ripening, the expression level of genes involved in sulfur metabolism is concurred with the reduced sulfate ion content in placenta and the up-accumulation of sulfur metabolism-related metabolites in pulps. It is noteworthy that durian pulps highly accumulate γ-glutamylcysteine (γ-EC) …

Characterization Of Recombinant Glycogen Debranching Enzyme From Corynebacterium Glutamicum And Application For Resistant Starch Production, Chay Sirirattanachatchawan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Glycogen debranching enzyme (EC 2.4.1.25/EC 3.2.1.33) catalyzes a hydrolysis of α-1,6 glycosidic bond and a transfer α-1,4 glucan from donor molecules to acceptor molecules. The objectives of this research are to characterize a glycogen debranching enzyme from Corynebacterium glutamicum (CgGDE) and optimize resistant starch (RS) type 3 production using recombinant CgGDE. Recombinant CgGDE was expressed in Escherichia coli BL21 (DE3) and successfully purified by DEAE FFTM column. The calculated molecular weight of CgGDE was approximately 95 kDa and the protein existed as a trimer as analyzed by size exclusion chromatography. CgGDE showed the highest activity on amylopectin followed by glycogen, …

Reduced Graphene Oxide-Modified Screen-Printed Carbon Electrode For Determination Of Homocysteine Using Catechol, Suchapa Naranaruemol

Chulalongkorn University Theses and Dissertations (Chula ETD)

Homocysteine (Hcy), also known as 2-amino-4-mercaptobutyric acid, is a biomarker that is directly associated with an increased risk of cardiovascular diseases (CVDs). In this work, catechol (CA), which is redox active, had been used as an electron transfer mediator to facilitate the oxidation of Hcy. Typically, CA was first electrochemically immobilized onto the surface of screen-printed carbon electrode; however, the obtained CA-functionalized electrode did not show the electrocatalytic activity towards the detection of Hcy. Therefore, the deter– mination of Hcy was investigated in the solution containing CA using differential pulse voltammetry (DPV) at the reduced graphene oxide-modified screen-printed carbon electrode …

Image Super-Resolution Technique Using Deep Inception Based Residual Networks, Wazir Muhammad

Chulalongkorn University Theses and Dissertations (Chula ETD)

Recently, deep Convolutional Neural Networks (CNN) have achieved exceptional performance over the past few years, in the area of image processing and computer vision task, especially on single image super-resolution (SISR). It is an immensely challenging task and has multiple practical applications, such as medical image processing, satellite imaging, facial image enhancement, and compressed image improvement. However, the majority of the existing image super-resolution CNN-based methods have been developed by stacking an innumerable number of layers and blindly increasing the size of the network architecture. Conversely, this leads to an increase in the model sizes and higher computational complexities. Furthermore, …

Modification Of Screen-Printed Carbon Electrode With Mxene/Conductive Polymer Composites For Hydrogen Peroxide Detection, Supawat Neampet

Chulalongkorn University Theses and Dissertations (Chula ETD)

MXene (Ti3C2), a two-dimensional material consisting of transition metal carbides, nitrides or carbonitrides was prepared by etching method for modification electrode of a novel nanocomposites consisting of platinum nanoparticles (PtNPs) and polyaniline (PANI) via electrodeposition and electropolymerization, respectively. The fabricated MXene/PANI/PtNPs nanocomposite modified on surface screen-printed carbon electrode (SPCE) were characterized by scanning electron microscopy SEM) with energy dispersive X-rays spectroscopy (EDX), X-ray powder diffraction (XRD), and transmission electron microscopy (TEM) to verify the presence of nanocomposite materials and indicate their morphologies. This electrode was applied for the detection of hydrogen peroxide (H2O2), which is a common electroactive product from …

Synthesis And Biological Activities Of Halogenated Chalcone-Based Pyra, Dinh Phuoc Nguyen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Twenty new 1,3,5-trisubstituted pyrazoline derivatives have been synthesized from chalcones and acylhydrazides in two steps. In the first step, chalcones were prepared by treatment of various acetophenones with different substituted benzaldehydes by Claisen-Schmidt condensation. In the second step, pyrazoline derivatives were synthesized by conducting the reaction of chalcones with acylhydrazides in acetonitrile at 67 °C in the presence of triazabicyclodecene as a catalyst. The synthesized compounds were identified by 1H, 13C NMR and HRMS spectral data and were evaluated for their antibacterial, anticancer and tyrosinase inhibitory activities. In antibacterial and tyrosinase inhibitory activities, most of pyrazoline derivatives showed inactive properties. …

ฤดูสืบพันธุ์และนิเวศวิทยาการกินอาหารของปลาคางคก Allenbatrachus Grunniens (Linnaeus, 1758) บริเวณปากแม่น้ำปราณบุรี จังหวัดประจวบคีรีขันธ์, ทัพประดิษฐ์ มิตรเปรียญ

Chulalongkorn University Theses and Dissertations (Chula ETD)

ปลาคางคกชนิด Allenbatrachus grunniens (Linnaeus, 1758) เป็นปลาน้ำกร่อยชนิดสำคัญและมีความสำคัญต่อระบบนิเวศ ปากแม่น้ำปราณบุรี จังหวัดประจวบคีรีขันธ์ ในอดีตยังไม่มีรายงานทางด้านวิชาการถึงบทบาทและการใช้ประโยชน์ของปลาชนิดนี้ จากบริเวณปากแม่น้ำ การศึกษาครั้งนี้ จึงทำการศึกษาฤดูสืบพันธุ์และนิเวศวิทยาการกินอาหารของปลาคางคกชนิด A. grunniens บริเวณปากแม่น้ำปราณบุรี โดยทำการเก็บตัวอย่างปลาชนิดนี้ (จำนวน 111 ตัว) จาก 5 สถานี (St1-St5) ระหว่างเดือนพฤศจิกายน พ.ศ. 2559 ถึง เดือนตุลาคม พ.ศ. 2560 ผลการศึกษาพบว่าการกระจายตัวของปลา A. grunniens สามารถพบได้แค่ 2 สถานี (St4 และ St5) เท่านั น ขณะที่ปลา A. grunniens ความยาวเหยียดเฉลี่ย 17.46±3.53 เซนติเมตร ข้อมูลทางด้านสัณฐานวิทยาและมิญชวิทยาแสดงให้เห็นว่าโครงสร้างของรังไข่จัดเป็นแบบไข่สุก ไม่พร้อมกัน (asynchronous development ovary) เนื่องจากประกอบด้วยเซลล์ไข่หลากหลายระยะ ที่สามารถแบ่งออกเป็น 4 ระยะ คือ โอ โอโกเนีย ระยะการเจริญของการพัฒนาเซลล์ไข่ขั้นปฐมภูมิ ระยะการเจริญของการพัฒนาเซลล์ไข่ขั้นทุติยภูมิ และระยะปล่อยเซลล์ไข่ ในขณะที่โครงสร้างอัณฑะในปลาเพศผู้จัดเป็น unrestricted spermatogonial testis ที่สามารถพบการกระจายของระยะสเปอร์มาโทโกเนียมตลอด ความยาวของท่อสร้างอสุจิ ทั้งนี้ ระยะสเปอร์มาโทไซต์ระยะแรก ระยะสเปอร์มาโทไซต์ระยะที่สอง ระยะสเปอร์มาทิดและระยะสเปอร์มาโทซัวก็ ยังสามารถพบได้ภายในท่อสร้างอสุจิ (สำหรับสัดส่วนเพศของปลา A. grunniens เป็น 1:1) จากค่าดัชนีความสมบูรณ์เพศ (GSI), ค่าดัชนีความ สมบูรณ์ของตับ (HSI) และการเปลี่ยนแปลงร้อยละของการเจริญของอวัยวะสร้างเซลล์สืบพันธุ์ พบว่าค่าดัชนีความสมบูรณ์เพศสอดคล้องกับการ เจริญของอวัยวะสืบพันธุ์ของปลาคางคกทั้งสองเพศ พบช่วงสืบพันธุ์สองช่วง [ช่วงแรกคือ ช่วงเดือนมกราคม พ.ศ.2560 ถึงเดือนกุมภาพันธ์ พ.ศ.2560 และช่วงที่สอง คือ ช่วงเดือนกรกฏาคม พ.ศ.2560 ถึงเดือนตุลาคม พ.ศ.2560] A. grunniens …

Academic Information On Twitter: A User Survey, Ehsan Mohammadi, Mike Thelwall, Mary Kwasny, Kristi L. Holmes

Faculty Publications

Although counts of tweets citing academic papers are used as an informal indicator of interest, little is known about who tweets academic papers and who uses Twitter to find scholarly information. Without knowing this, it is difficult to draw useful conclusions from a publication being frequently tweeted. This study surveyed 1,912 users that have tweeted journal articles to ask about their scholarly-related Twitter uses. Almost half of the respondents (45%) did not work in academia, despite the sample probably being biased towards academics. Twitter was used most by people with a social science or humanities background. People tend to leverage …

Development Of Simple Devices For Point-Of-Care Screening Of Bacterial Infection And Inflammatory Markers, Julaluk Noiphung

Chulalongkorn University Theses and Dissertations (Chula ETD)

A paper-based analytical devices (PADs) provides a great benefit in medical diagnostics, especially in the developing world. The first part of this dissertation describes the effect of sample viscosity on PADs for the measurement of pH and nitrite concentration in human saliva. Preliminary study found that viscosity had a significant effect on the calibration curve of nitrite and a consistent curve could be generated after added washing buffer. Nitrite measurement in artificial saliva with viscosity 1.87-5.10 mPa-s was tested on the proposed device and also showed a good correlation with the standard spectrophotometry method (p=0.8484, paired sample t-test, n=20). Moreover, …

Mechanistic Study Of Potential Herbal Extracts For Development Into Hair Growth-Promoting Product, Woraanong Prugsakij

Chulalongkorn University Theses and Dissertations (Chula ETD)

Androgenic alopecia (AGA) is a major type of hair loss found in both males and females, caused by the overproduction of 5 alpha-dihydrotestosterone (DHT) which is formed from testosterone (T) by the enzymes 5 alpha-reductase (5α-R). In this study, the main focus was on cytokine factors evaluation of Avicennia marina (AM extract) in primary dermal papilla cells (DPCs) from AGA patients and the efficacy in vivo. The present study has revealed that AM extract and its active constituent, avicequinone C (AC) significantly inhibit the enzyme activity of 5α-R on cell-based assay combined with a non-radioactive thin layer chromatography (TLC) using …

Chemosensitizing Effect Of Peptides From Lentinus Squarrosulus On Cisplatin-Induced Apoptosis In Human Lung Cancer Cells, Hnin Ei Ei Khine -

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cisplatin, platinum-based chemotherapy, is one of the standard chemotherapies for the treatment of lung cancer. However, its usefulness is limited due to the adverse effects and susceptibility to chemoresistance which lead to therapeutic failure. Nowadays, natural chemosensitizers, which can enhance the efficacy and decrease the effective dose of chemo-drugs, have been found to be interested in novel therapeutic. Recently, the anticancer activity of peptides extracted from Lentinus squarrosulus Mont. in human lung cancer cells has been reported. The novel potential of L. squarrosulus peptides as a chemotherapeutic adjuvant to increase cisplatin-induced apoptosis was uncovered in this study. Crude peptides extracted …