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2018

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Complicated Narratives Of “Korean-Ness”: Towards Strategic Provisionality In Parental Involvement, Seungho Moon, Jeesun Jung Jan 2018

Complicated Narratives Of “Korean-Ness”: Towards Strategic Provisionality In Parental Involvement, Seungho Moon, Jeesun Jung

Education: School of Education Faculty Publications and Other Works

The purpose of this paper is to advance the discourse on parental involvement drawing from Butlerian notion of strategic provisionality. In developing a new approach to understanding cultural differences and their relation to Korean parental involvement, the authors analyze qualitative and quantitative data from five New York metropolitan elementary schools. The authors examine the ways in which ‘Korean-ness’ and Korean parental involvement are discursively constructed and embodied in sociopolitical and historical contexts in the United States. We present two themes related to Korean parental involvement: (a) the double-edged component of respect for teachers and (b) biopolitics related to English language …


Final Evaluation Report: A Randomized Controlled Trial Of The Effectiveness Of A Responsible Fatherhood Program: The Case Of Tyro Dads, Young-Il Kim, Sung Joon Jang Jan 2018

Final Evaluation Report: A Randomized Controlled Trial Of The Effectiveness Of A Responsible Fatherhood Program: The Case Of Tyro Dads, Young-Il Kim, Sung Joon Jang

Faculty Publications - Department of Sociology

Despite the growing number of responsible fatherhood programs, only a few of them have been evaluated based on a randomized controlled trial. To fill this gap in evaluation research on fatherhood programs, we conducted a single-blind, randomized, controlled trial to assess the effectiveness of an Ohio-based fatherhood program called “TYRO Dads” in improving the father-child relationship among low-income, primarily unmarried, nonresidential fathers.

We collected data from 252 fathers who participated in the study at 17 research sites in eight cities in Ohio by conducting a survey three times between February 2015 and September 2016: before the intervention (pretest), immediately after …


Crystal Structure Of (2-{[(8-Aminona­Phthalen-1-Yl)Imino]­Meth­Yl}-4,6-Di-Tert-Butyl­Phenolato-Κ3n,N′,O)Bromido­Nickel(Ii), Patrick O’Brien, Matthias Zeller, Wei-Tsung Less Jan 2018

Crystal Structure Of (2-{[(8-Aminona­Phthalen-1-Yl)Imino]­Meth­Yl}-4,6-Di-Tert-Butyl­Phenolato-Κ3n,N′,O)Bromido­Nickel(Ii), Patrick O’Brien, Matthias Zeller, Wei-Tsung Less

Chemistry: Faculty Publications and Other Works

The title compound, [NiBr(C25H29N2O)], contains an NiII atom with a slightly distorted square-planar coordination environment defined by one O and two N atoms from the 2-{[(8-aminonaphthalen-1-yl)imino]methyl}-4,6-di-tert-butylphenolate ligand and a bromide anion. The Ni—O and Ni—N bond lengths are slightly longer than those observed in the phenyl backbone counterpart, which can be attributed to the larger steric hindrance of the naphthyl group in the structure of the title compound. The molecule as a whole is substantially distorted, with both the planar naphthalene-1,8-diamine and imino–methyl– phenolate substitutents rotated against the NiN2OBr plane by 38.92 (7) and 37.22 (8), respectively, giving the molecule …


Dna Lesions Produced From The Reaction Of Diols And 5-Formylcytosine And Their Effects On Dna Replication, Brock Allen Jan 2018

Dna Lesions Produced From The Reaction Of Diols And 5-Formylcytosine And Their Effects On Dna Replication, Brock Allen

University of the Pacific Theses and Dissertations

Nucleic acids are complex macromolecules that are susceptible to both endogenous and exogenous damage. This study explored damage resulting from interactions with environmental nucleophilic toxins, such as a variety of diols and amines found in industry. These nucleophiles can react with electrophilic groups, such as 5-formylcytosine. 5-formylcytosine is an oxidation product of the epigenetic base 5-methylcytosine. It is typically removed by thymine DNA glycosylase (TDG) but is known to accumulate in the genome, making the formyl group susceptible to attack. In this study we used GC/MS and ESI-MS to show that DNA lesions from the nucleophilic addition reaction of toxins …


The Roles Of Hpa Axis Activity And Attentional Bias In The Development Of Anxiety Symptoms In Low-Income Mexican-Origin Children, Stephanie Brewer Jan 2018

The Roles Of Hpa Axis Activity And Attentional Bias In The Development Of Anxiety Symptoms In Low-Income Mexican-Origin Children, Stephanie Brewer

Dissertations

The overarching goal of this research is to increase understanding of the development of anxiety in children of low-income Mexican-origin immigrants. Mexican-origin children display disproportionately high rates of mental disorders such as anxiety, as they face many chronic stressors related to poverty and immigration. A likely mediator of this process is HPA axis activity, causing a buildup of cortisol in the body in response to chronic stress. There is a large amount of evidence indicating that HPA axis activity is a mechanism through which accumulated poverty-related stress causes mental illness, but this mediator has not been examined in relation to …


Measuring Community Violence, Trauma, And Family Functioning Among Youth Living In Low-Income, Urban Environments, Kyle Deane Jan 2018

Measuring Community Violence, Trauma, And Family Functioning Among Youth Living In Low-Income, Urban Environments, Kyle Deane

Dissertations

Exposure to community violence is a pressing public health concern that has profound effects on an adolescent’s development and psychological well-being, and is disproportionately experienced by ethnic minority youth living in economically disadvantaged urban environments. Efforts to measure violence exposure and its sequelae have centered primarily on the use of retrospective questionnaires and cross-sectional design and often fail to consider other contributory risk or resilience factors. Comprised of three related studies, the goal of this dissertation is to address the relations between of exposure to community violence, adjustment difficulties, such as posttraumatic stress, and family functioning among African American and …


In Between: What The Experiences Of Biracial, Bisexual Women Tell Us About Identity Formation, Marissa C. Floro Jan 2018

In Between: What The Experiences Of Biracial, Bisexual Women Tell Us About Identity Formation, Marissa C. Floro

Dissertations

Research on bisexual, biracial women has been scarce; identity development in particular shows not only a gap in the research for this particular population, but shows the lack of intersectional models for approaching identity as a whole. Traditional models of queer identity have used White, gay, cisgender men as the default sample and coming out as the benchmark goal for identity integration. Biracial identity research, though more holistic, rarely includes intersectionality. Through feminist, queer theory and constructivist grounded theory, this project hopes to challenge traditional models of categorical identity development, give voice and visibility to a continually underrepresented group of …


Comparison Between The Structure-Function Relationship In The Wild Type Gαi1 Protein And Its Oncogenic Mutant, Jesse Lee Goossens Jan 2018

Comparison Between The Structure-Function Relationship In The Wild Type Gαi1 Protein And Its Oncogenic Mutant, Jesse Lee Goossens

Dissertations

Many signal transduction pathways are regulated by guanine nucleotide-binding (G?) proteins, which function as molecular switches fluctuating between active and inactive conformations. Proper function depends on three flexible switch regions that are involved in the relatively slow hydrolysis of GTP. Deep sequencing studies have found mutations in the GNAS and GNAI1 genes involved in tumorigenesis, among which include a mutation corresponding to a highly conserved arginine residue in the switch II region. A mutation in GNAI1 encoding an R208Q change in G?i1 has been linked to intestinal cancers. We investigated the molecular basis of oncogenesis of this mutant by studying …


Shaping Black Boys: Exploring School Construction Of Masculinity And The Impact On Black Male Scholastic Perceptions Toward Academic Achievement And Schooling, Kisha V. Jenkins Jan 2018

Shaping Black Boys: Exploring School Construction Of Masculinity And The Impact On Black Male Scholastic Perceptions Toward Academic Achievement And Schooling, Kisha V. Jenkins

Dissertations

African American boys face unique challenges. They are more likely to be suspended or expelled from school than any other racial group (Losen, 2015). Equally disturbing, African American male students are largely suspended for more subjective and ambiguous reasons such as appearing “threatening or disrespectful” (Verdugo, 2007, p. 60). Research on teacher bias in the classroom has indicated that “African American males are generally viewed as possessing characteristics incongruent with academic success (e.g., laziness), valuing athletics over academic accomplishments, and having a propensity toward aggression and violence” (Thomas & Stevenson, 2009, p. 162). These issues experienced by African American males …


Child Maltreatment And Psychosocial Functioning In The Context Of Foster Care: Self-Concept As A Mediator And A Moderator, Grace Jhe Bai Jan 2018

Child Maltreatment And Psychosocial Functioning In The Context Of Foster Care: Self-Concept As A Mediator And A Moderator, Grace Jhe Bai

Dissertations

Youth in foster care experience high prevalence rates of emotional and behavioral problems (Burns et al., 2004; Clausen et al., 1998; Fernandez, 2009; Orton et al., 2009; see McWey et al., 2010; see Pilowsky, 1995) due to a range of risk factors they encounter. Exposure to maltreatment can generally lead to increased internalizing problems (e.g., Avery et al., 2000; Carlson et al., 1997; see McWey et al., 2010), externalizing behaviors (e.g., Prino & Peyrot, 1994; McWey et al., 2010), social problems (e.g., Bolger & Patterson, 2001; Bolger et al., 1998), and poor self-perceptions or self-worth (see Arata et al., 2005; …


An Examination Of School Psychologists’ Exposure To And Preparedness To Support Transgender Students In Schools, Natalie Meier Meier Jan 2018

An Examination Of School Psychologists’ Exposure To And Preparedness To Support Transgender Students In Schools, Natalie Meier Meier

Dissertations

The purpose of this study was to examine school psychologists’ professional practice in relation to transgender youth. The frequency with which school psychologists engage in the professional guidelines outlined by the National Association of School Psychologists (NASP) in their position statement: "Safe Schools for Transgender and Gender Diverse Students" was explored as well as school psychologists’ feelings of preparedness to complete these duties. Results indicate rural practitioners and school psychologists in elementary and middle schools feel the least prepared to implement the NASP best practices for serving transgender students. School psychologists working in non-rural and high school settings with more …


The Experience Of Mentors In A Cross-Age Peer Mentoring Program: Exploring The Helper Therapy Principle, Dakari Quimby Jan 2018

The Experience Of Mentors In A Cross-Age Peer Mentoring Program: Exploring The Helper Therapy Principle, Dakari Quimby

Dissertations

Mentoring programs are increasingly popular interventions for promoting positive development in Black youth from high risk environments. Cross-age peer mentoring refers to an older youth serving as a mentor for a younger mentee. Although not as widely studied as adult mentoring, this relationship has been found to have a beneficial effect for both the mentor and mentee. The current study seeks to better illuminate this bidirectional benefit by focusing on one half of the relationship—the experience of cross age peer mentoring by Black American mentors from low income communities. This is an important untapped area of study as peer mentoring …


Spain's Rapid Transition: A Case Study Of Late Modernization, Sydney Elizabeth Brown Jan 2018

Spain's Rapid Transition: A Case Study Of Late Modernization, Sydney Elizabeth Brown

Honors Theses

Throughout the mid-twentieth century, Spain was under the control of dictator Francisco Franco. Under Franco's rule, while the rest of the world was modernizing, Spain was a very conservative and traditional society, with many of its traditions and ideals centered on the Catholic Church. As time went on, Franco was forced to loosen his control on Spain ever so slightly, allowing Spain the freedom to begin the process of modernization. However, it was not until after the death of the dictator that the modernization process in Spain was able to fully take off. Spain is a unique case of modernization, …


Inner Surface Biofilm Inactivation By Atmospheric Pressure Helium Porous Plasma Jet, Peng Lu, Dana Ziuzina, Patrick J. Cullen, Paula Bourke Jan 2018

Inner Surface Biofilm Inactivation By Atmospheric Pressure Helium Porous Plasma Jet, Peng Lu, Dana Ziuzina, Patrick J. Cullen, Paula Bourke

Articles

We present a helium porous plasma jet based on gas diffuser, designed with the aim of decontaminating inner surfaces of contaminated structures, e.g., pipes. The porous plasma jet operates with three discharge modes in ambient air and inside a vessel. Its decontamination capacity is demonstrated by evaluating the inactivation efficacy of biofilm form of Pseudomonas aeruginosa, adherent to inner surface of a glass vial. Plasma treatments for 5 min with filament mode and double region helium discharge mode reduced bacterial numbers by 2.4 and 2.5 Log10 CFU/ml. Plasma treatment with double region air‐like discharge mode was the most …


The Effect Of Explicit Instruction Of Formulaic Language On Efl Argumentative Writing Quality, Armağan Bakili Akkoç, Jingjing Qin, Erkan Karabacak Jan 2018

The Effect Of Explicit Instruction Of Formulaic Language On Efl Argumentative Writing Quality, Armağan Bakili Akkoç, Jingjing Qin, Erkan Karabacak

All Works

© 2018, IJAL. This study investigated the effects of explicit teaching of formulaic language on the overall quality of Turkish EFL university students' argumentative writing. Forty-four freshmen and twenty-seven sophomores participated in the study, with half of them assigned to the experimental group and the other to the control group. Forty target formulaic language items were explicitly taught to the experimental group with a variety of activities for four hours in two weeks. The experimental group was found to increase the overall quality scores of their writing significantly after the intervention. They also outperformed the control group in the immediate …


Near-Complete Genome Sequence Of A Novel Single-Stranded Rna Virus Discovered In Indoor Air, Karyna Rosario, Noah Fierer, Mya Breitbart Jan 2018

Near-Complete Genome Sequence Of A Novel Single-Stranded Rna Virus Discovered In Indoor Air, Karyna Rosario, Noah Fierer, Mya Breitbart

Marine Science Faculty Publications

Viral metagenomic analysis of heating, ventilation, and air conditioning (HVAC) filters recovered the near-complete genome sequence of a novel virus, named HVAC-associated RNA virus 1 (HVAC-RV1). The HVAC-RV1 genome is most similar to those of picorna-like viruses identified in arthropods but encodes a small domain observed only in negative-sense single-stranded RNA viruses.


Genomic Evolution, Recombination, And Inter-Strain Diversity Of Chelonid Alphaherpesvirus 5 From Florida And Hawaii Green Sea Turtles With Fibropapillomatosis, Cheryl Morrison, Luke Iwanowicz, Thierry Work, Elizabeth Fahsbender, Mya Breitbart, Cynthia Adams, Deb Iwanowicz, Lakyn Sanders, Mathias Ackermann, Robert Cornman Jan 2018

Genomic Evolution, Recombination, And Inter-Strain Diversity Of Chelonid Alphaherpesvirus 5 From Florida And Hawaii Green Sea Turtles With Fibropapillomatosis, Cheryl Morrison, Luke Iwanowicz, Thierry Work, Elizabeth Fahsbender, Mya Breitbart, Cynthia Adams, Deb Iwanowicz, Lakyn Sanders, Mathias Ackermann, Robert Cornman

Marine Science Faculty Publications

Chelonid alphaherpesvirus 5 (ChHV5) is a herpesvirus associated with fibropapillomatosis (FP) in sea turtles worldwide. Single-locus typing has previously shown differentiation between Atlantic and Pacific strains of this virus, with low variation within each geographic clade. However, a lack of multi-locus genomic sequence data hinders understanding of the rate and mechanisms of ChHV5 evolutionary divergence, as well as how these genomic changes may contribute to differences in disease manifestation. To assess genomic variation in ChHV5 among five Hawaii and three Florida green sea turtles, we used high-throughput short-read sequencing of long-range PCR products amplified from tumor tissue using primers designed …


The Policy And Practice Of Inclusion Of Children With Specific Learning Difficulties In Mainstream Primary Girls’ Schools In Riyadh, Saudi Arabia: Exploring The Attitudes And Experiences Of Teachers, Amirah Alshenaifi Jan 2018

The Policy And Practice Of Inclusion Of Children With Specific Learning Difficulties In Mainstream Primary Girls’ Schools In Riyadh, Saudi Arabia: Exploring The Attitudes And Experiences Of Teachers, Amirah Alshenaifi

Plymouth Institute of Education Theses

This research project examines the implementation of the policy and practice of inclusion in girls’ primary schools of Saudi Arabia. In particular, it focuses on the work of teachers - their attitudes, beliefs, methods, and experiences - because it is they who are ultimately responsible for applying the policy by using inclusive practices in their classroom activities. Since the 1970s many countries have adopted a policy of including in mainstream schools those children with physical or cognitive impairments, or with learning difficulties. Formerly, children with special needs or learning difficulties were segregated in ‘special’ schools; this process of separation caused …


Understanding The Impact On The Wellbeing Of Students With Specific Learning Difficulties Through Teaching Interventions, Dylan K Williams Jan 2018

Understanding The Impact On The Wellbeing Of Students With Specific Learning Difficulties Through Teaching Interventions, Dylan K Williams

Plymouth Institute of Education Theses

The study set out to explore whether teaching methods can improve the wellbeing of students with SpLDs. This study addresses a gap in the literature, identifying wellbeing differences between different types of educational environment and SEN provisions. It explores whether there are benefits from inclusive education to student wellbeing, considering constructs of wellbeing relevant to the impact of SpLDs, synthesising pedagogic, psychotherapeutic and developmental perspectives. 74 student participants were recruited through the SEN departments of 4 UK schools - each with differing approaches to SEN support. Student participants completed two psychometric wellbeing questionnaires. They also engaged in photographic exercise, capturing …


Comparing Interventions And Beliefs About Autism And Links To Interpersonal Relatedness In Two Cities, In Turkey And England, Mahmut Serkan Yazici Jan 2018

Comparing Interventions And Beliefs About Autism And Links To Interpersonal Relatedness In Two Cities, In Turkey And England, Mahmut Serkan Yazici

Plymouth Institute of Education Theses

This thesis explores similarities and differences between interventions and beliefs about autism in Turkey and England. It is known that Turkish culture is interdependent and English culture is independent. It is also known that differences in interpersonal relatedness affect views about social behaviour, life goals and social priorities. This thesis, therefore, also explores whether interpersonal relatedness influences interventions and belief about autism in both countries. This research is based on case studies of special and mainstream schools in two cities, one in Turkey and one in England. The study used mixed research methods including questionnaires, interviews and observations. Participants included …


The Sorption Fate Of Active Pharmaceutical Ingredients In Soils Receiving High Wastewater Inputs And Implications For Risk Assessments, Katherine Edith Lees Jan 2018

The Sorption Fate Of Active Pharmaceutical Ingredients In Soils Receiving High Wastewater Inputs And Implications For Risk Assessments, Katherine Edith Lees

School of Geography, Earth and Environmental Sciences Theses

Population growth, increasing affluence, and greater access to medicines have led to an increase in active pharmaceutical ingredients (APIs) entering sewerage networks. Wastewater in lower and lower middle-income countries use that use wastewater for irrigation may use untreated or poorly treated wastewater resulting in the potential for greater concentrations of APIs to enter soils in this way. Wastewater re-used for irrigation is currently not included in environmental risk assessments for APIs in soils. The addition of wastewater to soils changes the organic content and can increase the pH of soils, which will have an impact on the fate of any …


Ecology And Climates Of Early Middle Pleistocene Interglacials In Britain, Francis Rowney Jan 2018

Ecology And Climates Of Early Middle Pleistocene Interglacials In Britain, Francis Rowney

School of Geography, Earth and Environmental Sciences Theses

This thesis refines and develops understanding of the ecological and climatic characteristics of early Middle Pleistocene (MIS 19-13, c. 780-430 ka) interglacial environments in Britain. This period is characterised by globally muted (i.e. low amplitude) glacial-interglacial cycles, which increased in amplitude c. 430 ka with the Mid-Brunhes Transition (MBT). However, the influence of these global climatic characteristics on climates and ecology at regional and local scales is yet to be fully understood. Local ecological processes, particularly disturbance processes, have also received limited attention in pre-Holocene interglacial settings, despite their likely importance for vegetation and habitat structure. Chapters 4, 5 and …


Organic Nitrogen Uptake By Marine Algae: Consequences For Marine Ecosystem Functioning And Biodiversity, Monica Raccagni Jan 2018

Organic Nitrogen Uptake By Marine Algae: Consequences For Marine Ecosystem Functioning And Biodiversity, Monica Raccagni

School of Geography, Earth and Environmental Sciences Theses

Dissolved organic nitrogen (DON) represents a major pool of fixed, reactive nitrogen in marine systems. It is now recognized that this pool can support primary production and the ability of some algal species to exploit DON compounds as sources of Nitrogen (N) may indicate that specific DON components can exert selective pressure on the composition of the phytoplankton community. In this study the ability of monocultures of ecologically-relevant algal species from the English Channel (Emiliania huxleyi, Micromonas pusilla, Alexandrium minutum and Chaetoceros peruvianus) to grow with DON as the only N source was examined using different artificial media. Among the …


The Separation Of The Polar Constituents Of Petroleum, William Robson Jan 2018

The Separation Of The Polar Constituents Of Petroleum, William Robson

School of Geography, Earth and Environmental Sciences Theses

Identification of the heteroatom (nitrogen, sulphur, and oxygen; NSO)-containing compounds of petroleum is of key importance when considering industrial and environmental issues associated with crude oil production. The inherent molecular complexity of petroleum is such that detailed compositional investigations must ideally be preceded by some form of pre-fractionation. However, the more commonly performed methods of crude oil fractionation are often insufficient in the extent to which they separate oils, not allowing defined “molecular” fractions to be obtained and thus hindering more detailed investigations. The following work therefore focused on the development of chromatographic methods to aid in the characterisation of …


Autonomous Biogeochemical Floats Detect Significant Carbon Dioxide Outgassing In The High-Latitude Southern Ocean, Alison R. Gray, Kenneth S. Johnson, Seth M. Bushinsky, Stephen C. Riser, Joellen L. Russell, Lynne D. Talley, Rik Wanninkhof, Nancy L. Williams, Jorge L. Sarmiento Jan 2018

Autonomous Biogeochemical Floats Detect Significant Carbon Dioxide Outgassing In The High-Latitude Southern Ocean, Alison R. Gray, Kenneth S. Johnson, Seth M. Bushinsky, Stephen C. Riser, Joellen L. Russell, Lynne D. Talley, Rik Wanninkhof, Nancy L. Williams, Jorge L. Sarmiento

Marine Science Faculty Publications

Although the Southern Ocean is thought to account for a significant portion of the contemporary oceanic uptake of carbon dioxide (CO2), flux estimates in this region are based on sparse observations that are strongly biased toward summer. Here we present new estimates of Southern Ocean air-sea CO2 fluxes calculated with measurements from biogeochemical profiling floats deployed by the Southern Ocean Carbon and Climate Observations and Modeling project during 2014–2017. Compared to ship-based CO2 flux estimates, the float-based fluxes find significantly stronger outgassing in the zone around Antarctica where carbon-rich deep waters upwell to the surface ocean. …


First World Problems, Developing World Impacts: An Assessment Of The Adequacy Of The Law On Shipbreaking, Shannen Trout Jan 2018

First World Problems, Developing World Impacts: An Assessment Of The Adequacy Of The Law On Shipbreaking, Shannen Trout

The Plymouth Law and Criminal Justice Review

Shipbreaking, or recycling, is a potentially destructive practice reflecting many dimensions to the modern sustainable development debate. It engages a suite of legal issues and has prompted discussion between professionals concerned with the environment, the economy and workplace ethics. This article seeks, first, to identify the breadth of issues that arise within the shipbreaking industry; and then proceeds to discuss the legal frameworks that regulate the trade, their effectiveness or otherwise; and concludes that the overall efforts to impose legislative or other regulatory systems, internationally and domestically, are far from what is needed in order to reform shipbreaking into a …


Carbon And Nitrogen Isoscapes In West Antarctica Reflect Oceanographic Transitions, Emily K. Brault, Paul L. Koch, Kelton W. Mcmahon, Kyle H. Broach, Aaron P. Rosenfield, Wilson Sauthoff, Valerie J. Loeb, Kevin R. Arrigo, Walker O. Smith Jr. Jan 2018

Carbon And Nitrogen Isoscapes In West Antarctica Reflect Oceanographic Transitions, Emily K. Brault, Paul L. Koch, Kelton W. Mcmahon, Kyle H. Broach, Aaron P. Rosenfield, Wilson Sauthoff, Valerie J. Loeb, Kevin R. Arrigo, Walker O. Smith Jr.

Graduate School of Oceanography Faculty Publications

Antarctic marine ecosystems are spatially and temporally dynamic. Regional climate change is significantly altering the patterns and magnitudes of this dynamism with cascading impacts on biogeochemistry, productivity, and food web architecture. Isoscapes (or isotopic maps) provide a valuable analytical framework to characterize ecosystem processes and address questions about trophic dynamics, animal movement, and elemental cycling. Applications of stable isotope methods to Antarctic ecosystems are currently limited by a paucity of information on geospatial isotope characteristics within the Southern Ocean. In response, we have created the first empirically derived zooplankton isoscapes for West Antarctica based on analysis of bulk nitrogen and …


Calibrating Amino Acid Δ13C And Δ15N Offsets Between Polyp And Protein Skeleton To Develop Proteinaceous Deep-Sea Corals As Paleoceanographic Archives., Kelton W. Mcmahon, Branwen Williams, Thomas P. Guilderson, Danielle S. Glynn, Matthew D. Mccarthy Jan 2018

Calibrating Amino Acid Δ13C And Δ15N Offsets Between Polyp And Protein Skeleton To Develop Proteinaceous Deep-Sea Corals As Paleoceanographic Archives., Kelton W. Mcmahon, Branwen Williams, Thomas P. Guilderson, Danielle S. Glynn, Matthew D. Mccarthy

Graduate School of Oceanography Faculty Publications

Compound-specific stable isotopes of amino acids (CSI-AA) from proteinaceous deep-sea coral skeletons have the potential to improve paleoreconstructions of plankton community composition, and our understanding of the trophic dynamics and biogeochemical cycling of sinking organic matter in the Ocean. However, the assumption that the molecular isotopic values preserved in protein skeletal material reflect those of the living coral polyps has never been directly investigated in proteinaceous deep-sea corals. We examined CSI-AA from three genera of proteinaceous deep-sea corals from three oceanographically distinct regions of the North Pacific: Primnoa from the Gulf of Alaska, Isidella from the Central California Margin, and …


Comparison Of Neuroprotective Efficacy Of Poly-Arginine R18 And R18d (D-Enantiomer) Peptides Following Permanent Middle Cerebral Artery Occlusion In The Wistar Rat And In Vitro Toxicity Studies, Diego Melani, Megan C. Bakeberg, Jane L. Cross, Vince W. Clark, Ryan S. Anderton, David J. Blacker, Neville W. Knuckey, Bruno P. Meloni Jan 2018

Comparison Of Neuroprotective Efficacy Of Poly-Arginine R18 And R18d (D-Enantiomer) Peptides Following Permanent Middle Cerebral Artery Occlusion In The Wistar Rat And In Vitro Toxicity Studies, Diego Melani, Megan C. Bakeberg, Jane L. Cross, Vince W. Clark, Ryan S. Anderton, David J. Blacker, Neville W. Knuckey, Bruno P. Meloni

Health Sciences Papers and Journal Articles

We have previously demonstrated that arginine-rich and poly-arginine peptides possess potent neuroprotective properties, with poly-arginine peptide R18 identified as being highly effective at reducing infarct volume following middle cerebral artery occlusion (MCAO) in the Sprague Dawley rat. Since peptides synthesised using D-isoform amino acids have greater stability than L-isoform peptides due to increased resistance to proteolytic degradation, they represent potentially more effective peptide therapeutics. Therefore we compared the neuroprotective efficacy of R18 and its D-enantiomer R18D following permanent MCAO in the Wistar rat. Furthermore, as increased peptide stability may also increase peptide toxicity, we examined the effects of R18 and …


Perinatal Hypoxic-Ischemic Encephalopathy And Neuroprotective Peptide Therapies: A Case For Cationic Arginine-Rich Peptides (Carps), Adam B. Edwards, Ryan S. Anderton, Neville W. Knuckey, Bruno P. Meloni Jan 2018

Perinatal Hypoxic-Ischemic Encephalopathy And Neuroprotective Peptide Therapies: A Case For Cationic Arginine-Rich Peptides (Carps), Adam B. Edwards, Ryan S. Anderton, Neville W. Knuckey, Bruno P. Meloni

Health Sciences Papers and Journal Articles

Perinatal hypoxic-ischemic encephalopathy (HIE) is the leading cause of mortality and morbidity in neonates, with survivors suffering significant neurological sequelae including cerebral palsy, epilepsy, intellectual disability and autism spectrum disorders. While hypothermia is used clinically to reduce neurological injury following HIE, it is only used for term infants (>36 weeks gestation) in tertiary hospitals and improves outcomes in only 30% of patients. For these reasons, a more effective and easily administrable pharmacological therapeutic agent, that can be used in combination with hypothermia or alone when hypothermia cannot be applied, is urgently needed to treat pre-term (_36 weeks gestation) and …