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A Scale Space Local Binary Pattern (Sslbp) – Based Feature Extraction Framework To Detect Bones From Knee Mri Scans, Jinyeong Mun

Electronic Theses and Dissertations

The medical industry is currently working on a fully autonomous surgical system, which is considered a novel modality to go beyond technical limitations of conventional surgery. In order to apply an autonomous surgical system to knees, one of the primarily responsible areas for supporting the total weight of human body, accurate segmentation of bones from knee Magnetic Resonance Imaging (MRI) scans plays a crucial role. In this paper, we propose employing the Scale Space Local Binary Pattern (SSLBP) feature extraction, a variant of local binary pattern extractions, for detecting bones from knee images. The proposed methods consist of two phases. …

Development Of Biclustering Techniques For Gene Expression Data Modeling And Mining, Juan Xie

Electronic Theses and Dissertations

The next-generation sequencing technologies can generate large-scale biological data with higher resolution, better accuracy, and lower technical variation than the arraybased counterparts. RNA sequencing (RNA-Seq) can generate genome-scale gene expression data in biological samples at a given moment, facilitating a better understanding of cell functions at genetic and cellular levels. The abundance of gene expression datasets provides an opportunity to identify genes with similar expression patterns across multiple conditions, i.e., co-expression gene modules (CEMs). Genomescale identification of CEMs can be modeled and solved by biclustering, a twodimensional data mining technique that allows clustering of rows and columns in a gene …

Ca2+/Calmodulin-Dependent Protein Kinase Ii Activity And Expression In The Aged Mouse Hippocampus, James Mitchum

Honors Theses

CaM Kinase II (Ca2+/calmodulin-dependent protein kinase II) is a serine/threonine-specific protein kinase enzyme that acts as a critical regulator of learning and memory. It has previously been shown that the inability of CaMKII to maintain activation is connected to memory deficits within the aging brain. While the connection between CaMKII dysfunction and learning and memory impairments is well established, little is known about the changes that cause CaMKII dysfunction. Our research set out to investigate if CaMKII is altered during the process of aging. Specifically, we looked at activity, regulation, and stability by conducting experiments to quantify CaMKII levels of …

Evolution Of The Modern Baboon (Papio Hamadryas): A Reassessment Of The African Plio-Pleistocene Record, Christopher C. Gilbert, Stephen R. Frost, Kelsey D. Pugh, Monya Anderson, Eric Delson

Publications and Research

Baboons ( Papio hamadryas) are among the most successful extant primates, with a minimum of six distinctive forms throughout Sub-Saharan Africa. However, their presence in the fossil record is unclear. Three early fossil taxa are generally recognized, all from South Africa: Papio izodi , Papio robinsoni and Papio angusticeps. Because of their derived appearance, P. angusticeps and P. robinsoni have sometimes been considered subspecies of P. hamadryas and have been used as biochronological markers for the Plio- Pleistocene hominin sites where they are found.

We reexamined fossil Papio forms from across Africa with an emphasis on their distinguishing features and …

Immigration As A Social Determinant Of Health: Proceedings Of A Workshop, Tiffiany O. Howard, National Academies Of Sciences, Engineering, And Medicine, Numerous Authors, See Full List Below

Political Science Faculty Research

Since 1965 the foreign-born population of the United States has swelled from 9.6 million or 5 percent of the population to 45 million or 14 percent in 2015. Today, about one-quarter of the U.S. population consists of immigrants or the children of immigrants. Given the sizable representation of immigrants in the U.S. population, their health is a major influence on the health of the population as a whole. On average, immigrants are healthier than native-born Americans. Yet, immigrants also are subject to the systematic marginalization and discrimination that often lead to the creation of health disparities. To explore the link …

Billy The Kid Among The Novelists, Richard W. Etulain

New Mexico Historical Review

No abstract provided.

Full Issue, New Mexico Historical Review

New Mexico Historical Review

No abstract provided.

Why The Religious Right Can't Have Its (Straight Wedding) Cake And Eat It Too: Breaking The Preservation-Through-Transformation Dynamic In Masterpiece Cakeshop V. Colorado Civil Rights Commission, Kyle C. Velte

Minnesota Journal of Law & Inequality

No abstract provided.

The Curious Case Of Wendell V. Glaxosmithkline Llc, David L. Faigman, Jennifer Mnookin

Seton Hall Law Review

No abstract provided.

The Five Functions Of Forensic Science And The Validation Issues They Raise: A Piece To Incite Discussion On Validation, D. Michael Risinger

Seton Hall Law Review

No abstract provided.

How Should Forensic Scientists Present Source Conclusions?, William C. Thompson

Seton Hall Law Review

No abstract provided.

Review Of Emerging Approaches In Non- Or Minimally Invasive Glucose Monitoring And Their Application To Physiological Human Body Fluids, Sunghoon Jang, Chen Xu

Publications and Research

The frequent blood glucose monitoring by the diabetics and physicians is a very essential step in the management of the diabetes because this devastating disease can lead the patients to blindness, kidney disease, nervous & circulatory system disease, limb amputations, stroke and cardiovascular disease (CVD). There have been numerous attempts to develop viable painless non- or minimally invasive blood glucose monitoring techniques over the last five decades in order to replace all existing methods of home blood glucose monitoring require drawing a blood sample by piercing the skin. This review describes the principles of two main emerging general technologies such …

Rock Paper Scissors And Evolutionary Game Theory, Christian Cordova, Rudolf Jovero, Evan Thomas

Math 365 Class Projects

In Rock Paper Scissors (RPS), three different "species" compete, but no single species has a dominating strategy. In evolutionary game theory, replicator equations model population densities over time. When a mutation is introduced, they are called "replicator-mutator" equations. Using the replicator-mutator equation in [1] we have shown how population density of three species change.

Quantifying The Differences In Binding Affinity Of Reduced Glutathione For Glutathione S-Transferase At Ph 6.5 And 8.5 Using Isothermal Titration Calorimetry, Clay P. Renshaw Jr., Ronald K. Gary

McNair Poster Presentations

The binding affinity between an enzyme and its substrate is often dependent on the pH of the local environment. Knowing the pH at which reduced glutathione (GSH) binds with the highest affinity to the enzyme glutathione S-transferase (GST) is useful for determining the optimal pH for purification of GST-fusion proteins during GST-affinity chromatography. In this study, GST of the species Schistosoma japonicum was purified, quantified, and utilized to study its binding interaction with GSH at pH 6.5 and 8.5 via isothermal titration calorimetry (ITC). After protein expression, extraction, and purification, the GST concentration was quantified using Qubit^TM fluorometry. …

Climate Change And Eutrophication: A Short Review, Mohammad Nazari-Sharabian, Sajjad Ahmad, Moses Karakouzian

Civil and Environmental Engineering and Construction Faculty Research

Water resources are vital not only for human beings but essentially all ecosystems. Human health is at risk if clean drinking water becomes contaminated. Water is also essential for agriculture, manufacturing, energy production and other diverse uses. Therefore, a changing climate and its potential effects put more pressure on water resources. Climate change may cause increased water demand as a result of rising temperatures and evaporation while decreasing water availability. On the other hand, extreme events as a result of climate change can increase surface runoff and flooding, deteriorating water quality as well. One effect is water eutrophication, which occurs …

Using Cluster Analysis To Identify Subgroups Of College Students At Increased Risk For Cardiovascular Disease, Dieu-My Tran, Kevin A. Kupzyk, Lani M. Zimmerman

Nursing Faculty Research

Background and Purpose: To examine the co-occurrence of cardiovascular risk factors and cluster subgroups of college students for cardiovascular risks. Methods: A cross sectional descriptive study was conducted using co-occurrence patterns and hierarchical clustering analysis in 158 college students. Results: The top co-occurring cardiovascular risk factors were overweight/obese and hypertension (10.8%, n = 17). Of the total 34 risk factors that co-occurred, 30 of them involved being overweight/obese. A six-cluster-solution was obtained, two clusters displayed elevated levels of lifetime and 30-year cardiovascular disease risks. Conclusions: The hierarchical cluster analysis identified that single White males with a family history of heart …

Proof-Of-Concept Testing Of A Real-Time Mhealth Measure To Estimate Postural Control During Walking: A Potential Application For Mild Traumatic Brain Injuries, Hyunhwa Lee, Sunchul Lee, Laura Salado, Jonica Estrada, Jacob White, Venkatesan Muthukumar, Szu-Ping Lee, Sambit Mohapatra

Nursing Faculty Research

Background: Most individuals with mild traumatic brain injury (mTBI) experience post-injury deficits in postural control. Currently available measures of postural control are lab-based or supervised, which may hinder timely symptom assessment for individuals with mTBI, including Asian populations, who do not seek initial screening post-injury. In this proof-of-concept testing study, we introduce a real-time mobile health (mHealth) system to measure postural control during walking. The proposed mHealth system can be used for home-based symptom assessment and management of mTBI. Methods: In our proposed mHealth system, a smartwatch, a smartphone, and a cloud server communicate to measure, collect, and store body …

Eating Disorder Quality Of Life Scale (Edqls) In Ethnically Diverse College Women: An Exploratory Factor Analysis, Liya M. Akoury, Vincent Rozalski, Kimberly A. Barchard, Cortney S. Warren

Psychology Faculty Research

Background: Extant research suggests that disordered eating is common in college women and is associated with decreased quality of life. The Eating Disorder Quality of Life Scale (EDQLS) examines impairment to disordered eating-related quality of life, but has not been validated in college women. Accordingly, the purpose of this study was to examine the reliability, validity, and factor structure of the EDQLS in a diverse sample of 971 college women. Method: Students from a large United States university completed questionnaires examining disordered eating and the EDQLS online. Results: The EDQLS demonstrated excellent internal consistency and good convergent validity with the …

Neuroendocrine Tumors Detected In Appendectomy Specimens: Ten-Year Single-Center Experience, Fatma Şenel, Hati̇ce Karaman, Hacer Demi̇r

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate neuroendocrine tumors (NETs) detected in appendectomy specimens and the incidence and clinicopathologic characteristics of these tumors in our center. Materials and methods: A total of 13,863 patients were evaluated retrospectively. All underwent appendectomy operation in the Kayseri Training and Research Hospital and had a histopathological examination at the Pathology Clinic between January 2007 and March 2017. Age, sex, preoperative clinical findings, operation procedure, and histopathological examination results of the cases reported to be NET are presented. Results: NET was detected in 29 cases (0.2%) in the histopathological examination of 13,863 appendectomy …

Relationship Of Serum Hla-B Alleles And Tnf-? With Rheumatic Heart Disease, Mustafa Azmi̇ Eyi̇ol, Çağri Yayla, Serkan Ünlü, Abdurrahman Tufan, Mustafa Cemri̇, Mehmet Ridvan Yalçin, Nuri̇ Bülent Boyaci

Turkish Journal of Medical Sciences

Background/aim: Acute rheumatic fever and rheumatic heart disease are major causes of morbidity and mortality in developing countries. Genetic studies have determined that the immune response in rheumatic heart disease is genetically controlled and that there is a close relationship between the gene of concern and the class II human leukocyte antigen (HLA) gene. The aim of this study was to evaluate the relationship of serum HLA-B alleles and tumor necrosis factor alpha (TNF-∝) with rheumatic heart disease. Materials and methods: A total of 50 consecutive patients with rheumatic heart disease and 50 controls were enrolled in the study. HLA …

Effect Of Intravitreal Bevacizumab On Macular Thickness: Exploring Serum And Vitreousproangiogenic Biomarkers In Patients With Diabetic Macular Edema, Tayyaba Gul Malik, Syed Shoaib Ahmed, Roquyya Gul, Muhammad Khalil, Abrar Ahmed Malik, Masoom Khan

Turkish Journal of Medical Sciences

Background/aim: This study evaluates diabetic macular-edema (DME) patients for the effect of intravitreal bevacizumab (IVB) injection on macular thickness and proangiogenic biomarkers in serum and vitreous. Materials and methods: Forty DME patients were analyzed for macular thickness (MT). Twelve proangiogenic biomarkers in serum and vitreous were analyzed before and after IVB. Results: Significant decrease in MT with vitreal vascular endothelial growth factor-A (VEGF-A) was observed as expected after IVB, while serum VEGF-A did not follow a decreasing trend in contrast to VEGF-C, which decreased both in serum and vitreous. Other vitreal factors like bone morphogenetic protein-9 (BMP9) and fibroblast growth …

Parvovirus B19 Seroprevalence In Turkish Blood Donors, Şeni̇z Göral, İdi̇l Yeni̇cesu, Gülendam Bozdayi, Aysu Duyan Çamurdan, Ayli̇n Altay Koçak

Turkish Journal of Medical Sciences

Background/aim: Parvovirus risk in blood transfusion has become a popular research topic since there are limited data on parvovirus seroprevalence in blood donors in Turkey. The aim of this study was to investigate parvovirus seroprevalence in blood donors in Turkey. Materials and methods: Blood samples of 988 blood donors admitted to a university blood bank were obtained for parvovirus B19 IgM and IgG detection. The samples were analyzed using the ELISA method. Results: IgM positivity of 3.92% and IgG positivity of 58.9% was detected in the blood samples. Parvovirus IgM positivity was found to be the highest in the age …

The Role Of Melatonin In Preventing Ovarian Tissue Damage In Rats Exposed To Magnetic Fields, Zahi̇de Küçük, Uğurkan Erkayiran, Muzaffer Çaydere, Damla Kayalp, Deni̇z Karçaaltincaba

Turkish Journal of Medical Sciences

Objectives: We observed the efficacy of melatonin in preventing ovarian tissue damage in rats exposed to magnetic fields. Materials and methods: Forty rats were divided into four treatment groups: Group 1, control group (n = 10); Group 2, melatonin administration only (n = 10); Group 3, magnetic field exposure only (n = 10); Group 4, magnetic field exposure with melatonin administration (n = 10). The magnetic field was applied at a dose of 20 μT for 30 min/day for 10 days. Melatonin was orally administered at a dose of 10 mg/kg. We evaluated follicle count, degree of fibrosis, amount of …

Paricalcitol Inhibits The Wnt/Beta-Catenin Signaling Pathway And Amelioratesexperimentally Induced Arthritis, Servet Yolbaş, Ahmet Yildirim, Ahmet Tektemur, Zulfi̇naz Betül Çeli̇k, Ebru Önalan, İbrahi̇m Hani̇fi̇ Özercan, Mehmet Mustafa Akin, Süleyman Serdar Koca

Turkish Journal of Medical Sciences

Background/aim: The Wnt/ß-catenin pathway has important biological activities, including the differentiation of cells and joint formations. The aim of our study was to determine the effect of paricalcitol on experimentally induced arthritis. Materials and methods: Type II collagen combined with Freund's adjuvant was applied to induce arthritis in Wistar albino female rats. Paricalcitol (0.3 μg/kg daily) was subcutaneously injected starting 1 day after collagen applications (prophylactic group) or 1 day after the onset of arthritis (therapeutic group), until day 29. Results: The 29th day arthritis scores were lower compared to the 13th day scores in the paricalcitol groups (P < 0.05), while they were higher in the arthritis group (P < 0.05). Marked cartilage-bone destruction and extensive perisynovial inflammation were detected in the arthritis group. Decreased cartilage-bone destruction and perisynovial inflammation in the paws were observed in the paricalcitol groups. The tissue mRNA levels of DKK1, Wnt5a, and axin-2 were higher in the arthritis group than in the control group. In the paricalcitol groups, mRNA expressions were lower than in the arthritis group. Conclusion: The present study shows that the Wnt/ß-catenin signaling pathway is active in arthritis. Moreover, paricalcitol ameliorates arthritis via inhibiting the Wnt/ß-catenin pathway. Paricalcitol and the Wnt/ß-catenin pathway are candidates for research in human rheumatoid arthritis.

The Histopathological Effects Of Calcium Triglyceride Bone Cement Andchitosan On The Healing Of Experimental Bone Defects, Levent Uslucan, Berkem Atalay, Cüneyt Korhan Oral, Mustafa Sami̇ Yildirim, Abdulkadi̇r Burak Çankaya

Turkish Journal of Medical Sciences

Background/aim: This study evaluated the histopathological effects of two different bone grafts, calcium triglyceride bone cement (CTBC) and chitosan, on the healing of experimental bone defects. Materials and methods: Ninety-two Sprague Dawley male rats, with a weight of 240 ± 20 g, were used. Two experimental groups that consisted of 64 rats were divided into four subgroups due to the sacrification days, which were 7, 14, 30, and 60. After creating an 8-mm- long and 1-mm-wide cortico-cancellous bone defect in the right tibia of each rat, CTBC and chitosan were applied to the bone defects. In the main group, after …

A Novel Quantitative Electrochemical Method To Monitor Dna Double-Strand Breaks Caused By A Dna Cleavage Agent At A Dna Sensor, Anna Banasiak, John Cassidy, John Colleran

Articles

Biosensors and Bioelectronics, Vol. 117

Synthesis, Characterisation And Dna Intercalation Studies Of Regioisomers Of Ruthenium (Ii) Polypyridyl Complexes, Laura Perdisatt, Samar Moqadasi, Luke O'Neill, Gary Hessman, Alessandra Ghion, Muhammad Qasim Mushtaq Warraich, Alan Casey, Christine O'Connor

Articles

Regioisomers of the functional group of the main ligand (L) on a series of [Ru(phen)2L]2+and [Ru(bpy)2L]2+ complexes, where phen is 1,10 phenanthroline and bpy is 2,2′-bipyridine, were synthesised to investigate the interaction with deoxyribonucleic acid (DNA) as potential therapeutics. UV–Vis binding titrations, thermal denaturation and circular dichroism were used to evaluate their interaction with DNA. The conclusions indicated the significance of the auxiliary ligand; especially 1,10-phenanthroline has on the binding constants (Kb). The systematic variation of auxiliary ligand(phen or bpy), and polypyridyl ligand (4-(1H-Imidazo[4,5-f][1,10]phenanthrolin-2-yl)benzonitrile (CPIP), 2-(4-formylphenyl)imidazo[4,5-f] [1,10] phenanthroline (FPIP), 2-(4-bromophenyl)imidazo[4,5-f][1,10]phenanthroline (BPIP) and 2-(4-nitrophenyl)imidazo[4,5-f] [1,10] phenanthroline (NPIP), split in terms of …

Examination Of The Relationship Between Classism And Career Agency, Lucy Charlene Parker

Graduate Research Theses & Dissertations

Classism is a recently studied, but historically existent form of oppression. Classism may involve students feeling that they cannot pursue a degree or career due to discrimination related to their social class status. This study explored the relationship between classism, gender, age, race, socioeconomic status, and career agency through survey design research. Career agency is the primary dependent variable in this study. Career agency includes career choice, career forethought, and career related actions related. Psychometrically established instruments including The Experiences With Perceived Classism Scale-Short Form and The Career Futures Inventory-Revised were used to assess classism and career agency. Using this …

The Doctor Of Change: A Ideological Criticism Of Doctor Who, Noah Zepponi

University of the Pacific Theses and Dissertations

This thesis has used the methodology of an ideological criticism on the long-running science-fiction television series, Doctor Who. Argued within, is that an ideological paradigm shift occurred during the fifty years of scripted storylines. To discern evidence supporting the shift, multiple episodes were viewed from each of the first eleven Doctors. During the viewing process all aspects presented within the show, such as dialogue, movements, tactics, and traits, were explored for ideological agency. Once found, the discourse was further analyzed to understand how these ideologies were enforced. From the findings, proof was examined in order to show by the end …

Neuromuscular Control Of The Calling Apparatus In The Túngara Frog (Engystomops Pustulosus), Kiran Kaur Grewal

University of the Pacific Theses and Dissertations

Male túngara frogs can add a distinctive note ("chuck”) to their mating call. Production of the chuck involves vibrating a pair of laryngeal fibrous masses that is attached to the vocal cords. The muscular control of this mechanism remains unknown. Recent studies revealed a split in the laryngeal dilator muscle, which unveiled the deep dilator as a novel laryngeal muscle with unique attachments, innervation, and (likely) function. The deep dilator may position the fibrous masses for chuck production. The goals of this study were 1) to confirm the innervation of the novel muscle through electrophysiology; and 2) to determine the …