Digital Commons Network^™

Under-Reporting Of Adverse Drug Reactions To The Food & Drug Administration, James Alexander Lamb

Walden Dissertations and Doctoral Studies

This study examined the potential significant differences in the distribution of adverse drug reactions (ADRs) by reporter (consumer versus physician) and patient outcome at case and event level. This study also contains exploratory questions to evaluate reporting of ADRs by consumers versus physician by system organ class (SOC) and reporter demographics within the United States Food & Drug Administration Adverse Event Reporting System (FAERS). The theoretical foundation applied in this quantitative study was the social amplification of risk framework. Data from the second quarter of 2016 were obtained from FAERS, and a total of 87,807 ADR reports corresponding to 143,399 …

Nursing Students' Perceptions Of Briefing In Simulation, Beena Maret

Walden Dissertations and Doctoral Studies

Briefing for a clinical simulation in nursing school is an information session that sets the stage for a meaningful simulation activity. Improper or inadequate briefing practices can impact the quality of learning nursing students receive through clinical simulation experience. The purpose of this study, guided by the novice to expert and social cognitive theories, was to explore accelerated baccalaureate nursing (ABN) students' perceptions of their briefing experiences and how the briefing experiences influenced the acquisition of clinical skills and knowledge. Twelve ABN students from a school of nursing in one of the Northeastern states were interviewed through e-mail correspondence. Thematic …

Trini To De Bone: The Impact Of Migration On The Cultural Identities Of Trinidadian Immigrants In Philadelphia, Pennsylvania, Stephanie Zukerman

University of the Pacific Theses and Dissertations

This study examined the impact of migration and the resulting intercultural interactions on the cultural identities of first-generation immigrant Trinidadians living in the Philadelphia area of the United States. It focused on four identities: race, ethnicity, socioeconomic status, and nationality. The goal of the study was to determine how Trinidadian immigrants define and reconceptualize these four dimensions of their identities as they make new lives in American society. Another goal was to determine whether identities shift and, if so, how, for Trinidadian immigrants when they move across cultures to a society where they are no longer in the racial, ethnic, …

Evidence That A Partner-Switching Regulatory System Modulates Hormogonium Motility In The Filamentous Cyanobacterium Nostoc Punctiforme, Kelsey Wynne Riley

University of the Pacific Theses and Dissertations

Partner-switching regulatory systems (PSRSs) are utilized by many different bacteria to regulate a wide array of cellular responses, from stress response to expression of virulence factors. The filamentous cyanobacterium Nostoc punctiforme can transiently differentiate motile filaments, called hormogonia, in response to various changes in the environment. Hormogonia utilize a Type IV pilus (T4P) complex in conjunction with a secreted polysaccharide for gliding motility along solid surfaces. This study identified three genes, designated hmpU, hmpW, and hmpV, encoding the protein components of a PSRS involved in regulation of hormogonium motility in N. punctiforme. Although mutant strains with in-frame deletions in hmpU, …

Exercise Science Pre-Occupational Therapy, Ksr

Program Revisions/Additions

No abstract provided.

Recreation Administration Option, Ksr

Program Revisions/Additions

No abstract provided.

Health & Medical Humanities Minor, College Of Arts & Humanities

Program Revisions/Additions

No abstract provided.

Neuroscience Minor, Biological Sciences

Program Revisions/Additions

No abstract provided.

Association Of Mindful Parenting Dimensions, Positive Parenting, Child Reactivity, And Parent Stress, Carmen W. Dodsworth

Walden Dissertations and Doctoral Studies

The quality of caregiver-child interactions influences child, parent, and family wellness. Although the existing body of literature links mindfulness to positive outcomes within the family, little is known about how specific dimensions of mindful parenting are associated with parenting practices or child behavior reactivity. Based on a mindful parenting model and differential susceptibility model, this quantitative study used an online survey method to examine how specific dimensions of mindful parenting are associated with parenting practices and child behavior reactivity among a sample of 152 parents of elementary-age children. This study also explored how parent life stress modifies the relationship between …

Relationship Between Exposure To Phthalate And Obesity In The United States, Gladys Chidiebere Ezem

Walden Dissertations and Doctoral Studies

Obesity is a public health problem. The global obesity problem has been attributed to unhealthy diet, inactivity, and hereditary factors. However, phthalates may also contribute to the obesity epidemic. The purpose of this cross-sectional study was to examine whether there was a relationship between exposure to phthalates and obesity among adults 18 years and older in the United States. The theoretical framework was based on the socioecological model. The quantitative, cross-sectional design, and data analysis were based on the National Health and Nutrition Examination Survey, 2011-2012 database. Descriptive statistics and multiple regression analysis were used to analyze the association between …

Understanding The Perceptions And Decision-Making Behaviors Of First Responders In The Context Of Traumatic Events And Ptsd, Sunday O. Olatunji

Walden Dissertations and Doctoral Studies

Previous researchers have indicated that first responders are in an ever-changing environment, and unfortunately, the prevalence of post-traumatic stress disorder (PTSD) among first responders is increasing. This study sought to better understand first responders' perceptions of emergency preparedness protocols and training, as well as the prevalence of PTSD. This study also examined first responders' thoughts, decision making processes, and protective actions information, communications necessary during situations of emergency preparedness for traumatic events, and how PTSD impacted this process. A sample of 16 first responders of various ages was recruited for the purpose of this study. The participants were made up …

Examining Health Disparities And Childhood Obesity In Florida And Georgia, Jennifer Wesley

Walden Dissertations and Doctoral Studies

Childhood obesity is a major issue in the United States. The rates of obesity vary among racial and ethnic groups in the U.S. South. The purpose of this quantitative cross-sectional study was to investigate significant state health disparities differences in childhood obesity in the South region between Florida and Georgia. To steer this study, the social cognitive theory was used. The associations between neighborhood safety and support, physical activity, family health and activities on body mass index were examined in this study. Data was obtained from the National Survey of Children's Health 2011-2012 on 1,688 children aged 10-17 years residing …

Onchocerca Volvulus: The Road From Basic Biology To A Vaccine., Sara Lustigman, Benjamin L. Makepeace, Thomas R. Klei, Simon A. Babayan, Peter Hotez, David Abraham, Maria Elena Bottazzi

Department of Microbiology and Immunology Faculty Papers

Human onchocerciasis - commonly known as river blindness - is one of the most devastating yet neglected tropical diseases, leaving many millions in sub-Saharan Africa blind and/or with chronic disabilities. Attempts to eliminate onchocerciasis, primarily through the mass drug administration of ivermectin, remains challenging and has been heightened by the recent news that drug-resistant parasites are developing in some populations after years of drug treatment. Needed, and needed now, in the fight to eliminate onchocerciasis are new tools, such as preventive and therapeutic vaccines. This review summarizes the progress made to advance the onchocerciasis vaccine from the research laboratory into …

Educating Oncology Nurses On The Benefits Of Patient Exercise, Roberta Anderson

Walden Dissertations and Doctoral Studies

Exercise benefits patients with cancer during and after treatments. A formalized educational program is lacking at the project's site for oncology nurses on the benefits of exercise for their patients during and after treatment. The purpose of the project was to address the identified gap in practice at the project's site by providing education to oncology nurses on the benefits of exercise for their patients during and after treatment. The ARCS model of motivational design was used as a theoretical foundation to develop and guide the educational program presented to the oncology nurses. The question addressed in the project was: …

The Relationship Between Big Five Personality Traits And Burnout: A Study Among Correctional Personnel, Sharon Maylor

Walden Dissertations and Doctoral Studies

Burnout is a serious work related syndrome that is a result of exposure to chronic work stress. In addition to the consequences of burnout on the individual, the symptoms of burnout can adversely affect the organization, the clients the individual works with and the individual's close family and friends. The literature has focused on the history of burnout and the level of burnout experienced by various high stress occupations; however there has not been extensive research into the role personality traits play in burnout. The main research question of this study was to identify personality traits that are more susceptible …

The Relationships Between Older, Physically Impaired Men And Their Pets., Jennifer Hughes Williams

Walden Dissertations and Doctoral Studies

The present study examined older male adults' lived experiences with pet ownership. There is robust literature on older adults and the human-animal bond, but presently there are no qualitative phenomenological studies that focus solely on older physically impaired males who live alone and the relationships they have with their pets. With the guiding framework of biopsychosocial theory and using intensive interviews, 10 older males (65+) who suffered from some physical impairment discussed the relationships they have with their pets, and how their companion animals affect their physical, emotional, and social health. All interviews were transcribed, coded, and analyzed for themes. …

Neurodevelopmental Basis Of Autism Spectrum Disorder Based On Age And Gender, Sursatie Chetram

Walden Dissertations and Doctoral Studies

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that affects communication, socialization, and restricted/repetitive behaviors. In 2012, one out of every 55 children (1 in 42 boys and 1 in 189 girls) have been diagnosed with ASD in the United States. Only 30-40% of ASD has a known etiology (e.g., genetic predisposition) and the other 60-70% is unknown. Prior to this study, there was no known literature on age and gender differences related to neuro-developmental functioning of ASD. The purpose of this study was to examine how the differences in age and gender of people with ASD were related to …

Attitudes And Effectiveness Of Teachers In Diverse Inclusive Classrooms, Pamela Moore-Mckinley

Walden Dissertations and Doctoral Studies

Students with disabilities who participate in a fully inclusive educational program have failed to meet district or state goals for adequate yearly progress. This student population is explicitly recognized in state and federal accountability systems. The purpose for this study was to determine how certain factors affected the implementation of inclusive services at one school. This study investigated how teachers' attitudes and perceptions toward inclusion, level of education, exposure to people/students with disabilities, level of support, and knowledge of laws governing the education of students with disabilities affected inclusive classrooms. Gardner's theory of multiple intelligences was used as the theoretical …

Examining Two Structural Equation Models To Determine The Effect Of Parental Practices And Familial Cultural Values On Mexican Adolescents’ Sexual Health, Efren A. Velazquez

Theses and Dissertations

Sexual behavior is a normative part of adolescence and it is important to understand how familial factors influence Latina/o adolescents’ sexual health. The current study examined two structural equation models (SEM) and the associations between familial cultural values (i.e., familismo and filial piety), maternal and paternal monitoring (i.e., disclosure and solicitation) and Latina/o adolescent’s sexual behavior (i.e., intentions to have sex, sexual behavior, sexual responsibility). A hypothesized SEM examined whether paternal/maternal monitoring mediated the relation between familial cultural values and adolescents’ sexual health, while an alternative SEM examined whether familial cultural values mediated the association between paternal/maternal monitoring and adolescents’ …

Gender Beyond Binary, Sidra Zubairi

Theses and Dissertations

Transgender individuals challenge the binary definition of gender accepted in Pakistani society and as a result, Pakistan’s transgender community is highly marginalized. Pakistani society regards transgender individuals as “abnormal,” because their physical appearance and behavior fail to conform with conventional expectations. Based on contextual research and interviews conducted with transgender individuals in Pakistan, my thesis explores the obstacles transgender individuals face in the course of everyday survival. My research responds to the physical realities of being transgender in Pakistani society and analyzes cultural norms associated with gender, which trigger harassment. By designing transformable apparel for these individuals, informed by primary …

Anxious?: Re-Designing Women’S Jewelry To Help Manage Symptoms Of Anxiety Disorders, Nourbanu Feras Hijazi

Theses and Dissertations

Anxiety is a common and often stigmatized condition. Destigmatizing mental disorders can positively impact people’s interaction and communication with others and can prompt conversations in which people share their experiences with mental health, leading to improved societal understanding and perception.

My design solution tackles behavioral symptoms of anxiety, specifically two conditions that fall under obsessive-compulsive behavior: Dermatillomania and Trichotillomania. By redesigning women’s jewelry to specialized accessories, my intention is for these objects to help destigmatize these conditions and relieve symptoms of maladaptive behaviors and hurtful impulses. By redirecting these irresistible urges to an external artifact, the objects are designed to …

Impaired Cardiorespiratory Fitness Following Thoracic Radiotherapy, Justin M. Canada

Theses and Dissertations

Cancer (CA) is the second leading cause of death in the United States preceded only by cardiovascular disease (CVD). Over the past 30 years, the 5-year survival rate for all cancers combined has increased by more than 20%. This improved survival rate is due to early diagnosis and advances in treatment involving a multimodality treatment approach that includes radiotherapy [RT] with about half of all CA patients receiving some type of RT sometime during the course of their treatment. Cardiotoxicity is one of the most important adverse reactions of RT and leads to a meaningful risk of CVD-related morbidity and …

Utilizing Voltage-Gated Calcium Channels To Assess The Activity Of Cathinone Derivatives At Human Monoamine Transporters, Brian A. Ruiz

Theses and Dissertations

Cathinones are psychostimulant compounds heavily implicated as drugs of abuse. They exert their physiological actions at the monoamine transporters, which are responsible for maintaining synaptic neurotransmitter homeostasis. Monoamine transporters produce currents during transport and have been shown to depolarize cell membranes and activate voltage-gated calcium channels in mammalian expression systems. This phenomenon is harnessed in an assay which measures these induced calcium transients, allowing for quantification of pharmacodynamic effects of compounds at monoamine transporters. It is unknown if this electrical coupling occurs in neurons, but the implications if it does are significant. In the current work, fluorescent resonance energy transfer …

Impact Of Phosphoinositides On Regulation Of K-Atp By Atp And Hydrogen Sulfide, Tyler Hendon

Theses and Dissertations

Hydrogen sulfide (H2S) reduces ischemia reperfusion (IR) injury by stimulating adenosine triphosphate (ATP) sensitive potassium channels (KATP) [1-5]. Demonstrating H2S stimulation is unique to KATP, as other inwardly rectifying potassium (Kir) channels demonstrate inhibition or are unaffected [6]. We recently showed that H2S inhibits Kir2 and Kir3 by decreasing channel sensitivity to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 or PIP2) [6]. Here, we test the hypothesis that H2S regulation of Kir6.2, a pore-forming subunit of the KATP channel, is also dependent on PIP2. Using whole-cell patch-clamp we show that H2S increases the activity of Kir6.2 channels expressed in HEK-293 cells. To study the …

Aerobic Exercise Exposure Targeting Anxiety Sensitivity: Effects On Associated Health Behaviors In Young Adults, Autumn Lanoye

Theses and Dissertations

Anxiety sensitivity (AS) is associated with health behaviors such as low rates of physical activity, overeating, alcohol use, and poor sleep; however, interventions targeting AS via exercise-based interoceptive exposure have not assessed these as outcomes. In addition, previous studies are limited by brief follow-up periods. This study aimed to replicate previous aerobic exercise interoceptive exposures with an extended (6-week) follow-up and measurement of health behaviors.

Participants were 44 sedentary young adults with elevated AS randomized to intervention (6 20-minute sessions of moderate-intensity treadmill walking) or assessment-only control. Assessments took place at baseline, week 2 (post-treatment), week 4, and week 8 …

Counseling And Referral Experiences Of Southern Baptist Clergy, Charles Profit

Walden Dissertations and Doctoral Studies

Pastors are often called upon to counsel people troubled by what may be a diagnosable and treatable condition. Current research suggests that pastoral counselors (PC) are reluctant to provide a referral to a mental health professional (MHP) citing that only 10% of help seekers are referred, leaving millions of Americans to suffer with undiagnosed and untreated mental illness. The current literature indicates that PCs feel inadequately trained to counsel those with mental illnesses and the reluctance to refer is due to a distrust of MHPs. Currently, there is little qualitative research on pastors' counseling and referral experiences. In this study, …

An Unconventional Collaboration At The College Level To Improve Stem Student Success, Amy N. Scott, Eileen Kogl Camfield, Alex Miller, Kirkwood M. Land

College of the Pacific Faculty Articles

The purpose of this article is to illustrate the work that has resulted from a collaboration between a biology professor, a school psychology professor, a researcher in higher education access, and the writing programs director. The essential school psychologist role, as classroom observer and data analyzer, is discussed through an example of work done as part of a larger project focusing on student success and retention for at-risk populations in introductory college biology courses. Best practices for consulting at the college level are discussed and include: collaborate to cultivate the willing, collect and analyze data to sustain instructor involvement, and …

Levels Of Income And Quality Of Care For Adults With Type 2 Diabetes, Lorna Bowen

Walden Dissertations and Doctoral Studies

Type 2 diabetes impacts the lives of adults in the low-income, middle-income, and high-income brackets in the United States and globally. More research was needed on how adults 45 years and older in Marion County managed their diabetes and the care they received based on their income. This case study involved investigating how adults 45 years and older in Marion County self-managed their diabetes and the quality of care they received based on their income. The health belief model supported the conceptual framework for the study. Data were collected through face-to-face and telephone interviews with 15 purposefully selected participants. Data …

Second-Grade Teachers' Brain-Based Teaching Strategies For Struggling Readers, Tong Ba Nguyenguyen

Walden Dissertations and Doctoral Studies

In the era of this 21st Century, there are numerous known and unknown causes of reading impairments which have destructively affected elementary school students. Some causes are linguistic, and others are nonlinguistic. Lack of research on how previous teaching methods and experiences in implementing brain-based teaching (BBT) strategies became critically important, and were the concerns for this study. Developed by Hart's brain-based learning (BBL) theory together with other BBL theorists such as Jensen and Caine, the purpose of this qualitative study was to observe and explore the implementation of BBT strategies from 4 distinct second-grade participant teachers/subjects, located at the …

The Predictability Of Facebook Memorial Page Participation On Grief, Colleen Grote

Walden Dissertations and Doctoral Studies

As the world's largest social networking site, Facebook, continues to grow in popularity, it is imperative for counselors and counselor educators to better understand how online environments impact all facets of life, including death. Grief behaviors on Facebook have been a focus of scholars since the launch of the social networking site in 2004. Researchers have demonstrated that Facebook memorial pages have a significant impact on the social and cultural practices related to death and memorialization for Facebook users. However, despite a rapid rise in research related to online mourning, researchers have yet been able to establish the potential risk …