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The Relationship Between Metacognitive Awareness Of Reading Strategies Use And 10th Grade Students' College And Career Readiness Achievement In English Language Arts, Davida Smith-Keita

Electronic Theses and Dissertations

This study examined the relationship between 10th grade students’ metacognitive awareness of readings strategies use and their college and career readiness achievement in English language arts as a primary focus of research and, secondarily, the relationship between metacognitive awareness of reading strategies use and Lexile® growth as a measure of reading ability. The explanatory research design for this quantitative study included a statistical analysis of scores from the Metacognitive Awareness of Reading Strategies Inventory (MARSI) (Mokhtari & Reichard, 2002), existing college and career readiness achievement scores from the 2016-2017 Georgia Milestones 9th Grade Literature and Composition summative assessment, and existing …

On The Future Of Antidepressant Treatments: Targeting Neurotrophic Factors And Plasticity, Stephen W. White

Electronic Theses and Dissertations

For 60-plus years the explanatory model for Major Depressive Disorder (MDD) has been the monoamine theory, which states that low levels of monoamine neurotransmitters or alterations in their post-synaptic receptors are responsible for depressive symptoms. Drugs designed to elevate synaptic monoamine levels have remained the first line of pharmacotherapy prescribed by clinicians for MDD patients. However, these drugs have shortcomings. Despite evidence that current antidepressants elevate synaptic monoamine levels within hours of administration, these drugs require four to six weeks of daily administration before symptom relief appears. Furthermore, approximately half of patients taking typical antidepressants never achieve full symptom relief. …

Too Intimate To Speak : Regional Cinemas And Literatures, Victor Fan

Journal of Modern Literature in Chinese 現代中文文學學報

In this essay, I look back at a moment in Chinese literature and cinema, the 1930s and 1940s, when writers, filmmakers, and critics were driven by a series of political crises to conceptualize the relationship between “mother language” and “national language” from a very different perspective than Song’s. I do so by scrutinizing film and literary criticisms from this period. A national language, literature, and cinema are not static, unified, and internally coherent entities that naturally subsume their regional counterparts under them. While Putonghua 普通話 (literally, common language) required—and still requires—an ongoing process of putong hua 普通化 (communalization), regional topolects, …

Fabrication Of Superhydrophobic Gold Film On Polymer Substrates, Siriwan Boonmeewiriya

Chulalongkorn University Theses and Dissertations (Chula ETD)

Superhydrophobic surface was fabricated by a reduction reaction between chloroauric acid (HAuCl4) and sodium formate (HCOONa) on polydimethylsiloxane (PDMS) substrate without any further surface modification. This generated gold films with superhydrophobic properties examined by water contact angle (WCA) and contact angle hysteresis measurement. Wettability of the fabricated gold film on PDMS substrate can be controlled by the deposition time which provides the WCA > 160o and it could be up to 164.41o with a contact angle hysteresis of 1.93o when the deposition time was prolonged at least 2 hours. To propose the deposition mechanism, the morphological structure and chemical characters of …

“Krue Seumangat; Kehamilan Sehat Tanpa Anemia” Booklet Effect To Anemia Among Pregnant Women At Kota Langsa Indonesia : A Quasi Experimental Study, Putri Nahrisah

Chulalongkorn University Theses and Dissertations (Chula ETD)

Purpose : To assess the effect of education interventional program by previously developing ane education material (booklet of anemia and supplement reminder) upgrade dietary and iron-folic acid te intake of anemic pregnant women in province Aceh. Patients and methods: It was quasi experimental study using a pre- and posttest design, purposively applied at two municipalities having more than 40% anemic pregnancy. The intervention group (n=70) received two home visits for individual counseling session and was given the paper-based reminder, the control group (n=70) followed the usual antenatal care. The knowledge regard anemia and nutritional anemia score, average daily iron intake …

Jorunnamycin A Induces Anoikis In Human Lung Cancer H460 Cells, Gea Abigail Uy Ecoy

Chulalongkorn University Theses and Dissertations (Chula ETD)

Metastasis is a key driving force behind the high mortality rate associated with lung cancer. Anoikis is a type of apoptosis triggered by the loss of appropriate cell attachment and its loss via several cancer cell survival strategies has been shown to promote transformation and metastasis. Jorunnamycin A, a promising renieramycin-type anti-cancer compound, is a bistetrahydroisoquinolinequinone alkaloid that has been recently isolated from the Thai blue sponge Xestospongia sp. for use in this study. Herein, we report the anti-metastasis activity of jorunnamycin A, a bistetrahydroisoquinolinequinone isolated from the Thai blue sponge Xestospongia sp. evidenced by its suppression of epithelial-to-mesenchymal-transition, sensitization …

Rod Library: Notes For The Stalled, V10n6, January 2018, University Of Northern Iowa. Rod Library.

Rod Library newsletter: Notes for the Stalled

Contents:

--Student Technology Fee
--Textbook Initiative
--Diversity Exhibits
--Upcoming Events

Reconstructing Phase Diagrams From Local Measurements Via Gaussian Processes: Mapping The Temperature-Composition Space To Confidence, Dhiren K. Pradhan, Shalini Kumari, Evgheni Strelcov, Dillip K. Pradhan, Ram S. Katiyar, Sergei V. Kalinin, Nouamane Laanait, Rama K. Vasudevan

Faculty & Staff Scholarship

We show the ability to map the phase diagram of a relaxor-ferroelectric system as a function of temperature and composition through local hysteresis curve acquisition, with the voltage spectroscopy data being used as a proxy for the (unknown) microscopic state or thermodynamic parameters of materials. Given the discrete nature of the measurement points, we use Gaussian processes to reconstruct hysteresis loops in temperature and voltage space, and compare the results with the raw data and bulk dielectric spectroscopy measurements. The results indicate that the surface transition temperature is similar for all but one composition with respect to the bulk. Through …

Matrix Effect Study And Immunoassay Detection Using Electrolyte-Gated Graphene Biosensor, Jianbo Sun, Yuxin Liu

Faculty & Staff Scholarship

Significant progress has been made on the development of electrolyte-gated graphene field effect transistor (EGGFET) biosensors over the last decade, yet they are still in the stage of proof-of-concept. In this work, we studied the electrolyte matrix effects, including its composition, pH and ionic strength, and demonstrate that variations in electrolyte matrices have a significant impact on the Fermi level of the graphene channel and the sensitivity of the EGGFET biosensors. This is attributed to the polarization-induced interaction between the electrolyte and the graphene at the interface which can lead to considerable modulation of the Fermi level of the graphene …

Biomimetic Layer-By-Layer Self-Assembly Of Nanofilms, Nanocoatings, And 3d Scaffolds For Tissue Engineering, Shichao Zhang, Malcolm Xing, Bingyun Li

Faculty & Staff Scholarship

Achieving surface design and control of biomaterial scaffolds with nanometer- or micrometer-scaled functional films is critical to mimic the unique features of native extracellular matrices, which has significant technological implications for tissue engineering including cell-seeded scaffolds, microbioreactors, cell assembly, tissue regeneration, etc. Compared with other techniques available for surface design, layer-by-layer (LbL) self-assembly technology has attracted extensive attention because of its integrated features of simplicity, versatility, and nanoscale control. Here we present a brief overview of current state-of-the-art research related to the LbL self-assembly technique and its assembled biomaterials as scaffolds for tissue engineering. An overview of the LbL self-assembly …

Enhanced Hot Electron Lifetimes In Quantum Wells With Inhibited Phonon Coupling, Hamidreza Esmaielpour, Vincent R. Whiteside, Herath P. Piyathilaka, Sangeetha Vijeyaragunathan, Bin Wang, Echo Adcock-Smith, Kenneth P. Roberts, Tetsuya D. Mishima, Michael B. Santos, Alan D. Bristow, Ian R. Sellers

Faculty & Staff Scholarship

Hot electrons established by the absorption of high-energy photons typically thermalize on a picosecond time scale in a semiconductor, dissipating energy via various phonon-mediated relaxation pathways. Here it is shown that a strong hot carrier distribution can be produced using a type-II quantum well structure. In such systems it is shown that the dominant hot carrier thermalization process is limited by the radiative recombination lifetime of electrons with reduced wavefunction overlap with holes. It is proposed that the subsequent reabsorption of acoustic and optical phonons is facilitated by a mismatch in phonon dispersions at the InAs-AlAsSb interface and serves to …

Overview Of Big Data And Its Visualization, Richard S. Segall, Gao Niu

Faculty Publications

Big Data is data sets that are so voluminous and complex that traditional data processing application software are inadequate to deal with them. This chapter discusses what Big Data is and its characteristics, and how this information revolution of Big Data is transforming our lives and the new technology and methodologies that have been developed to process data of these huge dimensionalities. This chapter discusses the components of the Big Data stack interface, categories of Big Data analytics software and platforms, descriptions of the top 20 Big Data analytics software. Big Data visualization techniques are discussed with real data from …

Massively Parallel Computational Studies Of Material Response At High Strain Rate Deformation, Jayalath Abeywardhana Mudiyanselage Madawa Abeywardhana

Open Access Theses & Dissertations

Large scale molecular dynamics (MD) simulations are now commonly utilized to study materials at extreme conditions: high pressure and/or temperatures and ultra-high strain rates of deformation. A variety of emerging architectures such as general purpose graphics processing units (GP-GPU) and many-integrated core (MIC) architecture as well as new execution models have changed the traditional approach of high-performance computing. ExMatEx, the DoE initiative for enabling exa-scale (10^18 flops) performance in scientific applications, has developed several proxy applications to facilitate co-design of novel algorithms and hardware by software developers and microchip vendors.

We have used CoMD, a proxy application for classical MD, …

At Night My Body Waits, Saul Hernandez

Open Access Theses & Dissertations

No abstract provided.

Functional Investigation Of A Brainstem Excitatory Connection Relevant To Sensorimotor Gating, Luis Enrique Martinetti

Open Access Theses & Dissertations

To focus attention, our brain has to "gate" or block irrelevant sensory information that could lead to brain overload. This is done by way of a neuronal pre-attentive mechanism termed sensorimotor gating (SG). Therefore, deficits in the SG mechanism prevent patients from focusing attention. SG deficits have been observed in patients suffering from various neurological disorders, and it is a hallmark of schizophrenia. Previous work has identified key brain areas, such as the pedunculopontine tegmental nucleus (PPTg), that send inputs to the brainstem to regulate SG. However, there is still a knowledge gap concerning what cell types are involved and …

Implementation Of Magnesium Alloy Az91d On Wire And Arc Additive Manufacturing, David Adrian Martinez Holguin

Open Access Theses & Dissertations

As progress on Additive Manufacturing (AM) techniques focusing on ceramics and polymers evolve, metals continue to be a challenging material to manipulate when fabricating products. Current methods, such as Selective Laser Sintering (SLS) and Electron Beam Melting (EBM) face many intrinsic limitations due to the nature of their processes. Material selection, elevated cost and low deposition rates are some of the barriers to consider when one of these methods is to be used for the fabrication of engineering products. The research here presented demonstrates the use of a Wire and Arc Additive Manufacturing (WAAM) system for the creation of metallic …

Indios To Vecinos: Identity And Classification In Paso Del Norte, Eric Murillo

Open Access Theses & Dissertations

Identity for Native Americans in the US-Mexico borderlands is still a challenge in many ways. Native Americans in the US-Mexico borderlands often struggle to be seen as such, and many are subjected to a fragmented identity. This research explores how Spanish colonial classification continues to affect Native Americans from the borderlands.

People Detection From Time-Of-Flight Imagery With Inpainting-Based Preprocessing, Basavarajaiah Totada

Open Access Theses & Dissertations

The Thesis describes a method of detection and tracking of people using depth images captured by a Time-of-Flight (ToF) camera, such as those obtained with a Microsoft Kinect V2. Key advantages of this approach are that the identity of people is not disclosed, and the system can operate in low-light conditions. The automated approach developed here is inspired by cell-tracking methods as implemented in the well-known biomedical imaging software called CellProfiler. Our approach involves significant preprocessing of the depth images by a combination of adaptive center weighted median filtering and iterative inpainting. The next step is detection of each person's …

Characterizing The Role Of The Cellular Protein Schlafen 11 In Flavivirus Replication, Federico Valdez

Open Access Theses & Dissertations

Schlafen 11 (Slfn11) is a ubiquitously expressed interferon stimulating gene (ISG) that controls synThesis of proteins by regulating tRNA abundance. Through this mechanism Slfn11 has previously been shown to impair human immunodeficiency virus 1 (HIV-1) infection and the expression of codon-biased open reading frames. Because replication of positive-sense single- stranded RNA [(+)ssRNA viruses] requires the immediate translation of the incoming viral genome whereas negative sense, single stranded [(-)ssRNA] viruses carry at infection an RNA replicase that makes multiple translation competent copies of the incoming viral genome, we reasoned that (+)ssRNA viruses will be more sensitive to the effect of Slfn11 …

Visually-Induced Analgesia In A Deep Tissue Experimental Pain Model: A Randomised Cross-Over Experiment, Megan Van Selm, William Gibson, Mervyn Travers, Lorimer Moseley, Dana A. Hince, Benedict Wand

Physiotherapy Papers and Journal Articles

Background: Visualizing one’s own painful body part appears to have an effect on reported pain intensity. Furthermore, it seems that manipulating the size of the viewed image can determine the direction and extent of this phenomenon. When visual distortion has been applied to clinical populations the analgesic effects have been in opposition to those observed in some experimental pain models. To help resolve this problem we explored the effect of visualisation and magnification of the visual image on reported pain using a delayed onset muscle soreness (DOMS) pain model.

Methods: We induced DOMS in the quadriceps of 20 healthy volunteers. …

Evaluation Of Older People's Knowledge, Awareness, Motivation And Perceptions About Falls And Falls Prevention In Residential Aged Care Homes: A Tale Of Two Cities, Jacqueline Francis-Coad, Tessa Watts, Christopher Etherton-Beer, Gerwyn Panes, Howard Griffiths, Michelle Anderson, Tracy Williams, Beth Griffiths, Debbie Nobre, Anne-Marie Hill

Physiotherapy Papers and Journal Articles

Falls prevention strategies can only be effective in reducing falls amongst older people if they are adopted and enacted in their daily lives. There is limited evidence identifying what older people in residential aged care (RAC) homes understand about falls and falls prevention, or what may limit or enable their adoption of strategies. This study was conducted in two countries and explored older people’s knowledge and awareness of falls and their preferences, opportunities and motivation to undertake falls prevention strategies. A cross-sectional survey was administered to participants (N = 70) aged 65 years and over, living in six RAC homes …

The Translation, Validity And Reliability Of The German Version Of The Fremantle Back Awareness Questionnaire, Katja Ehrenbrusthoff, Cormac G. Ryan, Christian Gruneberg, Benedict Wand, Denis J. Martin

Physiotherapy Papers and Journal Articles

Background: The Fremantle Back Awareness Questionnaire (FreBAQ) claims to assess disrupted self-perception of the back. The aim of this study was to develop a German version of the Fre-BAQ (FreBAQ-G) and assess its test-retest reliability, its known-groups validity and its convergent validity with another purported measure of back perception.

Methods: The FreBaQ-G was translated following international guidelines for the transcultural adaptation of questionnaires. Thirty-five patients with non-specific CLBP and 48 healthy participants were recruited. Assessor one administered the FreBAQ-G to each patient with CLBP on two separate days to quantify intra-observer reliability. Assessor two administered the FreBaQ-G to each patient …

Students With Autism Spectrum Disorder Support While Attending A Four-Year Institution Of Higher Education, Laurie J. Koehler Crawford

University of the Pacific Theses and Dissertations

The number of children being diagnosed with Autism Spectrum Disorder (ASD), an impairment that affects an individual’s social-communication abilities and behavior, is currently 1 in 68. An estimated 50,000 students who have ASD are reaching adulthood and exiting secondary education annually―a phenomenon known as the Autism Tsunami. There is a lack of services available to support this wave of young adults with ASD to be self-sustaining, contributing members of their communities. This is evidenced by the 37% of adults in their early 20s, who have ASD, and who have never worked or attended any postsecondary educational program. Due to the …

Genomic-Enabled Prediction Models Using Multi-Environment Trials To Estimate The Effect Of Genotype × Environment Interaction On Prediction Accuracy In Chickpea, Manish Roorkiwal, Diego Jarquin, Muneendra K. Singh, Pooran M. Gaur, Chellapilla Bharadwaj, Abhishek Rathore, Reka Howard, Samineni Srinivasan, Ankit Jain, Vanika Garg, Sandip Kale, Annapurna Chitikineni, Shailesh Tripathi, Elizabeth Jones, Kelly R. Robbins, José Crossa, Rajeev K. Varshney

Department of Agronomy and Horticulture: Faculty Publications

Genomic selection (GS) by selecting lines prior to field phenotyping using genotyping data has the potential to enhance the rate of genetic gains. Genotype × environment (G × E) interaction inclusion in GS models can improve prediction accuracy hence aid in selection of lines across target environments. Phenotypic data on 320 chickpea breeding lines for eight traits for three seasons at two locations were recorded. These lines were genotyped using DArTseq (1.6 K SNPs) and Genotyping-by-Sequencing (GBS; 89 K SNPs). Thirteen models were fitted including main effects of environment and lines, markers, and/or naïve and informed interactions to estimate prediction …

Gene Expression Profiling Of Iron Deficiency Chlorosis Sensitive And Tolerant Soybean Indicates Key Roles For Phenylpropanoids Under Alkalinity Stress, Brian M. Waters, Keenan Amundsen, George L. Graef

Department of Agronomy and Horticulture: Faculty Publications

Alkaline soils comprise 30% of the earth and have low plant-available iron (Fe) concentration, and can cause iron deficiency chlorosis (IDC). IDC causes soybean yield losses of $260 million annually. However, it is not known whether molecular responses to IDC are equivalent to responses to low iron supply. IDC tolerant and sensitive soybean lines provide a contrast to identify specific factors associated with IDC.We used RNA-seq to compare gene expression under combinations of normal pH (5.7) or alkaline pH (7.7, imposed by 2.5mM bicarbonate, or pH 8.2 imposed by 5mM bicarbonate) and normal (25μM) or low (1μM) iron conditions from …

Managing Grazing Lands To Improve Soils And Promote Climate Change Adaptation And Mitigation: A Global Synthesis, Marcia Delonge, Andrea D. Basche

Department of Agronomy and Horticulture: Faculty Publications

The potential to improve soils to help farmers and ranchers adapt to and mitigate climate change has generated significant enthusiasm. Within this discussion, grasslands have surfaced as being particularly important, due to their geographic range, their capacity to store substantial quantities of carbon relative to cultivated croplands and their potential role in mitigating droughts and floods. However, leveraging grasslands for climate change mitigation and adaptation will require a better understanding of how farmers and ranchers who rely on them for their livelihoods can improve management and related outcomes. To investigate opportunities for such improvements, we conducted a meta-analysis of field …

Understanding Complexities: Teacher Voices On Differentiating Literacy Practices, Kimberly K. Ilosvay Edd, Elise Pepe

Northwest Journal of Teacher Education

The fact that populations attending U.S. schools are diverse, in terms of cultural representation, SES, languages spoken, etc., means that it is imperative for teachers and teacher candidates to have knowledge of various ways students gain and use literacy. This qualitative study describes reported influences on decisions made and differentiated literacy practices present in classrooms deemed effective with diverse learners. Using a multidimensional framework (Cohen, 2006), analysis highlights social, emotional, ethical, and academic education. Findings reveal the importance of how teachers define literacy and how schools support teachers when designing literacy instruction for different learners. Differences in teacher beliefs and …

แนวทางในการออกแบบเพื่อลดผลกระทบจากการสะท้อนของเปลือกอาคาร, ทัชชา อังกนะภัทรขจร

Chulalongkorn University Theses and Dissertations (Chula ETD)

จากความนิยมในการเลือกใช้วัสดุเปลือกอาคารกระจกเพิ่มมากขึ้นในปัจจุบัน ส่งผลให้เกิดปัญหาแสงสะท้อนที่สร้างความเดือดร้อนแก่สภาพแวดล้อมโดยรอบตามมา งานวิจัยนี้มีวัตถุประสงค์เพื่อศึกษาผลกระทบของแสงสะท้อนจากเปลือกอาคาร ที่มีสาเหตุมาจากรูปทรงอาคารและทิศทางการวางอาคารต่อสภาพแวดล้อม รวมทั้งเสนอแนะแนวทางในการออกแบบอาคารเพื่อลดผลกระทบต่อสิ่งแวดล้อมจากแสงสะท้อนของเปลือกอาคาร สำหรับเป็นข้อมูลเพิ่มเติมในการสร้างมาตรฐานการออกแบบอาคารให้มีความเหมาะสมมากขึ้น ซึ่งงานวิจัยนี้ ได้ใช้ซอฟต์แวร์ทางคอมพิวเตอร์ในการคำนวณหาความส่องสว่างและทิศทางการสะท้อนของรังสีอาทิตย์ตามวันเวลาที่กำหนด โดยมีอาคารกรณีศึกษา 5 รูปทรง ประกอบด้วย อาคารรูปทรงสี่เหลี่ยมจัตุรัสเปลือกอาคารเรียบตรง อาคารรูปทรงสี่เหลี่ยมเปลือกอาคารลาดเอียงเข้าหาอาคาร อาคารรูปทรงสี่เหลี่ยมเปลือกอาคารลาดเอียงออกจากอาคาร อาคารรูปทรงโค้งเว้า และอาคารรูปทรงแตงกวา เมื่อวิเคราะห์ข้อมูลที่ได้จากการจำลอง พบว่า บนพื้นที่ขนาด 500 เมตร x 500 เมตร อาคารรูปทรงสี่เหลี่ยมที่มีเปลือกอาคารลาดเอียงออกจากอาคารในแนวตั้งในทางทิศใต้ ก่อให้เกิดแสงสะท้อนในแนวราบเป็นพื้นที่รวมมากที่สุด ในขณะที่อาคารรูปทรงแตงกวาก่อให้เกิดการกระจายตัวของแสงสะท้อนทุกทิศทางเป็นบริเวณกว้างมากที่สุด และอาคารรูปทรงโค้งเว้าก่อให้เกิดค่าความส่องสว่างของแสงสะท้อนสูงที่สุดจากการสะท้อนรวมกันไปยังจุดใดจุดหนึ่ง ซึ่งพื้นที่ที่โดนแสงสะท้อนสูงสุดมีค่าความส่องสว่างมากกว่าค่าเฉลี่ยแสงธรรมชาติในส่วนที่ไม่ถูกสะท้อนกว่า 2 เท่า และสำหรับแสงที่สะท้อนตกกระทบต่อสภาพแวดล้อมโดยรอบอาคารกรณีศึกษา หากรัศมียิ่งใกล้อาคารจะเกิดแสงสะท้อนที่มีระยะเวลายาวนานกว่า โดยจากการใช้วิธีการทางสถิติในการแบ่งระดับคะแนนของแสงสะท้อนจากเปลือกอาคารออกเป็น A B C และ D โดยระดับ A เป็นระดับที่ก่อให้เกิดค่าความส่องสว่างต่ำที่สุด ในขณะที่ระดับ D เป็นระดับที่ก่อให้เกิดค่าความส่องสว่างสูงที่สุด พบว่า อาคารรูปทรงแตงกวา เป็นรูปทรงที่แสงสะท้อนส่วนใหญ่ที่เกิดขึ้นอยู่ในระดับคะแนน D เป็นจำนวนมากที่สุดในรูปทรงทั้งหมดที่ทำการศึกษา ทั้งสภาพแวดล้อมแนวราบและแนวตั้ง จึงถือเป็นรูปแบบอาคารที่ควรระมัดระวังเป็นอย่างยิ่งในการออกแบบเพราะก่อให้เกิดผลกระทบด้านแสงสะท้อนโดยรวมมากที่สุด

Knowing When Not To Answer: Positional Peptide Sequencing With Encoder-Decoder Networks, Korrawe Karunratanakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

การถอดรหัสเปปไทด์นั้นเป็นองค์ประกอบสำคัญสำหรับการศึกษาโปรตีน โดยทั่วไปแล้วการวิเคราะห์ข้อมูล mass spectrum นั้นจะศึกษาเพียงสายของกรดอะมิโนที่ปรากฏอยู่ในฐานข้อมูลเท่านั้น ทำให้การค้นหาสายเปปไทด์แบบใหม่ที่อาจเกิดจากการกลายพันธุ์นั้นทำได้ยาก วิถีการถอดรหัสด้วยดีโนโวแก้ไขข้อจำกัดนี้ด้วยการถอดรหัสสายเปปไทด์โดยตรงจากข้อมูล mass spectrum โดยใช้ความรู้เกี่ยวกับกระบวนการแตกตัวของไอออน ทำให้ไม่จำเป็นต้องใช้ฐานข้อมูลโปรตีนช่วย อย่างไรก็ดี วิธีดังกล่าวยังมีข้อจำกัดด้านความแม่นยำและต้องการการตรวจทานโดยผู้เชี่ยวชาญ วิทยานิพนธ์ฉบับนี้นำเสนอวิธีการถอดรหัสเปปไทด์ด้วยวิธีการดีโนโวแบบใหม่ชื่อ SMSNet โดยใช้โมเดล deep learning เข้าช่วย โดยยังสามารถทำนายกรดอะมิโนได้อย่างครอบคลุมในระดับความแม่นยำของกรดอะมิโนที่ 95% งานฉบับนี้เสนอขั้นตอน ถอดรหัส ตัดออก และสืบค้น เพื่อตัดผลทำนายในตำแหน่งที่มีความกำกวมออกและใช้ข้อมูลจากฐานข้อมูลโปรตีนช่วยเพื่อให้ทำนายสายเปปไทด์ได้ถูกต้องทั้งเส้น นอกจากนี้ งานนี้ได้นำเสนอการใช้ rescorer ในการแก้ไขคะแนนความมั่นใจสำหรับผลทำนายในแต่ละตำแหน่ง ซึ่งส่งผลให้สามารถแยกกลุ่มคะแนนความมั่นใจสำหรับคำตอบที่ถูกต้องและคำตอบที่ผิดได้ดียิ่งขึ้น เมื่อประกอบทุกขั้นตอนวิธีในงานวิจัยฉบับนี้เข้าด้วยกันพบว่า SMSNet สามารถทำนายสายเปปไทด์ได้ในประสิทธิภาพที่ใกล้เคียงกับการทำนายด้วยฐานข้อมูลในการทดลองจริง

Targeting Ovarian Cancer And Endothelium With An Allosteric Ptp4a3 Phosphatase Inhibitor, Kelley E. Mcqueeney, Joseph M. Salamoun, James C. Burnett, Nektarios Barabutis, Paula Pekic, Sophie L. Lewandowski, Danielle C. Llaneza, Robert Cornelison, Yunpeng Bai, Zhong-Yin Zhang, John D. Catravas

Bioelectrics Publications

Overexpression of protein tyrosine phosphatase PTP4A oncoproteins is common in many human cancers and is associated with poor patient prognosis and survival. We observed elevated levels of PTP4A3 phosphatase in 79% of human ovarian tumor samples, with significant overexpression in tumor endothelium and pericytes. Furthermore, PTP4A phosphatases appear to regulate several key malignant processes, such as invasion, migration, and angiogenesis, suggesting a pivotal regulatory role in cancer and endothelial signaling pathways. While phosphatases are attractive therapeutic targets, they have been poorly investigated because of a lack of potent and selective chemical probes. In this study, we disclose that a potent, …