Digital Commons Network^™

Characterization Of Early Acute Inflammation In A Mouse Calvarial Critical-Sized Defect: Augmentation Via Rhbmp-2 And Pglcnac Administration, Zachary James Grey

MUSC Theses and Dissertations

Background: Currently, the gold standard intervention for substantially large bone wounds is autologous bone grafting. While effective, this therapy is complicated by creation of an invasive second surgical site and limited material available for harvest. INFUSE® Bone Graft (rhBMP-2 delivered via an absorbable collagen sponge or ACS) has been widely used as a graft substitute, resulting in robust bone formation, but at the cost of increased inflammation and often poor healing outcomes. A better understanding of the mechanisms by which rhBMP-2 influences inflammatory processes and how these processes can be modulated through other therapies will inform future novel pharmacological avenues …

Bi-Objective Optimization Of Kidney Exchanges, Siyao Xu

Theses and Dissertations--Computer Science

Matching people to their preferences is an algorithmic topic with real world applications. One such application is the kidney exchange. The best "cure" for patients whose kidneys are failing is to replace it with a healthy one. Unfortunately, biological factors (e.g., blood type) constrain the number of possible replacements. Kidney exchanges seek to alleviate some of this pressure by allowing donors to give their kidney to a patient besides the one they most care about and in turn the donor for that patient gives her kidney to the patient that this first donor most cares about. Roth et al.~first discussed …

Leveraging Overhead Imagery For Localization, Mapping, And Understanding, Scott Workman

Theses and Dissertations--Computer Science

Ground-level and overhead images provide complementary viewpoints of the world. This thesis proposes methods which leverage dense overhead imagery, in addition to sparsely distributed ground-level imagery, to advance traditional computer vision problems, such as ground-level image localization and fine-grained urban mapping. Our work focuses on three primary research areas: learning a joint feature representation between ground-level and overhead imagery to enable direct comparison for the task of image geolocalization, incorporating unlabeled overhead images by inferring labels from nearby ground-level images to improve image-driven mapping, and fusing ground-level imagery with overhead imagery to enhance understanding. The ultimate contribution of this thesis …

Novel Computational Methods For Sequencing Data Analysis: Mapping, Query, And Classification, Xinan Liu

Theses and Dissertations--Computer Science

Over the past decade, the evolution of next-generation sequencing technology has considerably advanced the genomics research. As a consequence, fast and accurate computational methods are needed for analyzing the large data in different applications. The research presented in this dissertation focuses on three areas: RNA-seq read mapping, large-scale data query, and metagenomics sequence classification.

A critical step of RNA-seq data analysis is to map the RNA-seq reads onto a reference genome. This dissertation presents a novel splice alignment tool, MapSplice3. It achieves high read alignment and base mapping yields and is able to detect splice junctions, gene fusions, and circular …

Retail Data Analytics Using Graph Database, Rashmi Priya

Theses and Dissertations--Computer Science

Big data is an area focused on storing, processing and visualizing huge amount of data. Today data is growing faster than ever before. We need to find the right tools and applications and build an environment that can help us to obtain valuable insights from the data. Retail is one of the domains that collects huge amount of transaction data everyday. Retailers need to understand their customer’s purchasing pattern and behavior in order to take better business decisions.

Market basket analysis is a field in data mining, that is focused on discovering patterns in retail’s transaction data. Our goal is …

Scalable Feature Selection And Extraction With Applications In Kinase Polypharmacology, Derek Jones

Theses and Dissertations--Computer Science

In order to reduce the time associated with and the costs of drug discovery, machine learning is being used to automate much of the work in this process. However the size and complex nature of molecular data makes the application of machine learning especially challenging. Much work must go into the process of engineering features that are then used to train machine learning models, costing considerable amounts of time and requiring the knowledge of domain experts to be most effective. The purpose of this work is to demonstrate data driven approaches to perform the feature selection and extraction steps in …

Ultra-Fast And Memory-Efficient Lookups For Cloud, Networked Systems, And Massive Data Management, Ye Yu

Theses and Dissertations--Computer Science

Systems that process big data (e.g., high-traffic networks and large-scale storage) prefer data structures and algorithms with small memory and fast processing speed. Efficient and fast algorithms play an essential role in system design, despite the improvement of hardware. This dissertation is organized around a novel algorithm called Othello Hashing. Othello Hashing supports ultra-fast and memory-efficient key-value lookup, and it fits the requirements of the core algorithms of many large-scale systems and big data applications. Using Othello hashing, combined with domain expertise in cloud, computer networks, big data, and bioinformatics, I developed the following applications that resolve several major …

Interactive Clinical Event Pattern Mining And Visualization Using Insurance Claims Data, Zhenhui Piao

Theses and Dissertations--Computer Science

With exponential growth on a daily basis, there is potentially valuable information hidden in complex electronic medical records (EMR) systems. In this thesis, several efficient data mining algorithms were explored to discover hidden knowledge in insurance claims data. The first aim was to cluster three levels of information overload(IO) groups among chronic rheumatic disease (CRD) patient groups based on their clinical events extracted from insurance claims data. The second aim was to discover hidden patterns using three renowned pattern mining algorithms: Apriori, frequent pattern growth(FP-Growth), and sequential pattern discovery using equivalence classes(SPADE). The SPADE algorithm was found to be the …

Deep Neural Networks For Multi-Label Text Classification: Application To Coding Electronic Medical Records, Anthony Rios

Theses and Dissertations--Computer Science

Coding Electronic Medical Records (EMRs) with diagnosis and procedure codes is an essential task for billing, secondary data analyses, and monitoring health trends. Both speed and accuracy of coding are critical. While coding errors could lead to more patient-side financial burden and misinterpretation of a patient’s well-being, timely coding is also needed to avoid backlogs and additional costs for the healthcare facility. Therefore, it is necessary to develop automated diagnosis and procedure code recommendation methods that can be used by professional medical coders.

The main difficulty with developing automated EMR coding methods is the nature of the label space. The …

Emulating Perceptual Experience Of Color Vision Deficiency With Virtual Reality, Krzysztof Szczurowski, Matt Smith

Papers

Abstract. One of the major goals of Universal Design is to create experiences that are inclusive to all users, including those affected by Color Vision Deficiency. Color Vision Deficiency might have a significant impact on a users’ perception of the content or the environment. There is a range of tools already available, that can be used to either aid or automate the process of readability testing for digital interfaces and content in respect to Color Vision Deficiency. Two different approaches to addressing this issue can be found. A brief review of such methodologies is provided in this paper. The first …

“Woodlands” - A Virtual Reality Serious Game Supporting Learning Of Practical Road Safety Skills., Krzysztof Szczurowski, Matt Smith

Conference Papers

In developed societies road safety skills are taught early and often practiced under the supervision of a parent, providing children with a combination of theoretical and practical knowledge. At some point children will attempt to cross a road unsupervised, at that point in time their safety depends on the effectiveness of their road safety education. To date, various attempts to supplement road safety education with technology were made. Most common approach focus on addressing declarative knowledge, by delivering road safety theory in an engaging fashion. Apart from expanding on text based resources to include instructional videos and animations, some stakeholders …

Fp-18-12 Men's Birth Expectations, Colette A. Allred, Karen Benjamin Guzzo

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Block-Copolymer Assisted Fabrication Of Anisotropic Plasmonic Nanostructures, Calbi J. Gunder

Graduate Theses/Dissertations

The anisotropic nanostructures of noble metals are of great interest for plasmonic applications due to the possibility of tuning the localized surface plasmon resonance (LSPR) across the UV-VIS-NIR without sacrificing the linewidth as well as to achieve larger local field enhancement. Here, we report a simple and promising fabrication method of anisotropic gold nanostructures film using polystyrene-b-2vinylpyridine (PS-b-P2VP) block copolymers (BCP) as a template. In this approach, PS-b-P2VP spherical micelles were first synthesized as a template followed by selective deposition of Au precursor inside P2VP core of the micelles using ethanol solution of Au salt. Subsequently, heat treatment of the …

A Comparison Of On-Line And Off-Line Bioaerosol Measurements At A Biowaste Site, Patrick Feeney, Santiago Fernández Rodríguez, Rafael Molina, Eoin Mcgillicuddy, Stig Hellebust, Michael Quirke, Shane Daly, David O'Connor, John Sodeau

Articles

An air measurement campaign was carried out at a green-waste composting site in the South of Ireland during Spring 2016. The aim was to quantify and identify the levels of Primary Biological Aerosol Particles (PBAP) that were present using the traditional off-line, impaction/optical microscopy method alongside an on-line, spectroscopic approach termed WIBS (Wideband Integrated Bioaerosol Sensor), which can provide number concentrations, sizes and “shapes” of airborne PBAP in real-time by use of Light Induced Fluorescence (LIF). The results from the two techniques were compared in order to validate the use of the spectroscopic method for determining the releases of the …

Environmental Impact Assessment Of Pinaceae Airborne Pollen And Green Infrastructure Using Bim, Santiago Fernández-Rodríguez, Juan Pedro Cortés-Pérez, Paloma Prieto Muriel, Rafael Tormo-Molina, J. M. Maya-Manzano

Articles

Urban air quality is a parameter that plays a major role in human health at the local scale. Consequently, in urban planning, the behavior and potential risk of allergenicity for some pollen grains coming from ornamental trees and green spaces surrounding newly built buildings, should be considered. This paper aims to study how pollen exposure, influenced by weather parameters, can be assessed and integrated in the designing and building of constructions as other component of air quality assessment beforehand, by using BIM. Based on a comparative aerobiological study at the height over a building (sampled by two traps at ground …

Stories Of Strength: Chicago Latin@S' Navigation Of Health, Well-Being, And Chronic Disease, Lilian L. Milanés

Theses and Dissertations--Anthropology

Health inequalities take many forms related to race, gender, socioeconomic status, ethnic, language and many other axes throughout communities around the world. Type two diabetes, high blood pressure, and high cholesterol are examples of conditions (among many others) that disproportionately affect Latino@s in the U.S.. The research of this dissertation is based on fieldwork conducted throughout several predominantly Latin@ neighborhoods in Chicago, IL. This dissertation examines how Latin@s in Chicago navigate health and well-being, and how they engage in agentive strategies in the face of chronic disease. I recorded individual life histories and semi-structured interviews, focus groups, and participant observation …

Parent Rated Importance Of Active Play And Organised Physical Activity For Young Children, Casey Murphy

Theses

Background: Children participate in less daily physical activity, both organised and informal, often referred to as active play (AP), than in the past. For young children, parents are primarily responsible for planning their child’s day including their engagement in physical activity.

Purpose: As there has been little research in this area, the purpose of this study was to examine how parents rated the importance of their child’s level of AP and organised physical activity (OPA), how this affected the amount of time their child participated in these activities, and whether their child’s physical activity (PA) related to their own level …

Different But Same: A Call For A Joint Pro-Active Regulation Of Cross-Border Egg And Surrogacy Markets, Sharon Bassan

Health Matrix: The Journal of Law-Medicine

The article examines the need of a pro-active regulation of cross-border egg and surrogacy markets. Topics discussed include ways to regulate surrogacy market failures; conduct of both cross-border markets and the main failures that raise the need for regulation in each market; and minimalistic and a pro-active approach to regulate the markets.

Examining Nontherapeutic Circumcision, Stephen R. Munzer

Health Matrix: The Journal of Law-Medicine

The article argues that male minors have a moral anticipatory right-in-trust not to be circumcised without a medical indication. Topics discussed include ethical, political, and intellectual persuasions of children's rights, parental rights, religious freedom; moral implications to circumcise male minors without a medical indication; and moral rights of male minors

Shining City On A Hill At The Edge Of Tomorrow: Crispr-Cas9, Dickey-Wicker, And The Inner Space Race, Zachary A. Zalewski

Health Matrix: The Journal of Law-Medicine

The article highlights federal government funding of Targeted Genomic Editing (TGE) experimentation on human embryos, and recommends additional funding to accelerate scientific development and inquiry. Topics discussed include background of TGE, emphasizing CRISPR-Cas9 technology; risk of an emerging knowledge gap in this field; and legitimate concerns about what kinds of research are in the public and national interest.

Repositioning Of Omarigliptin As A Once-Weekly Intranasal Anti-Parkinsonian Agent, Bassam M. Ayoub, Shereen Mowaka, Marwa M. Safar, Nermeen Ashoush, Mona Arafa, Haidy E. Michel, Mariam M. Tadros, Mohamed M. Elmazar, Shaker A. Mousa

Pharmacy

© 2018 The Author(s). Drug repositioning is a revolution breakthrough of drug discovery that presents outstanding privilege with already safer agents by scanning the existing candidates as therapeutic switching or repurposing for marketed drugs. Sitagliptin, vildagliptin, saxagliptin & linagliptin showed antioxidant and neurorestorative effects in previous studies linked to DPP-4 inhibition. Literature showed that gliptins did not cross the blood brain barrier (BBB) while omarigliptin was the first gliptin that crossed it successfully in the present work. LC-MS/MS determination of once-weekly anti-diabetic DPP-4 inhibitors; omarigliptin & trelagliptin in plasma and brain tissue was employed after 2 h of oral administration …

Marriage Equality Comes To The Fourth Circuit, Carl Tobias

Law Faculty Publications

Marriage equality has come to America. Throughout 2014, several federal appellate courts and numerous district court judges across the United States invalidated state constitutional or statutory proscriptions on same-sex marriage. Therefore, it was not surprising that Eastern District of Virginia Judge Arenda Wright Allen held that Virginia’s bans were unconstitutional in February. The United States Court of Appeals for the Fourth Circuit affirmed her opinion that July. North Carolina, South Carolina, and West Virginia District Judges rejected these jurisdictions’ prohibitions during autumn, and the Supreme Court approved marriage equality the next year. Because marriage equality in the Fourth Circuit presents …

Living Well In The Lives Of African American Women With Chronic Illness, Gabrilla Ballard

Theses, Dissertations, and Projects

Finding support for African American women with chronic illnesses is challenging. It often requires these women to identify, cultivate, and nurture practice structures that go beyond medical structures already in place to aid in the maintenance of their health conditions. Outside of these structures, the resources needed to support the women are limited. They do not include the scope of modalities necessary to address their unique health presentations and holistic need for medical, emotional and spiritual health. Additionally, intersecting systems of oppression pose challenges to African American women when trying to access resources that could support their overall well-being. This …

Caregiver Experiences Of A Therapeutic Nursery Program : An Exploratory Study, Jaimie Tyler

Theses, Dissertations, and Projects

The purpose of this qualitative exploratory study was to increase our understanding of caregiver experiences whose children use the services of early-intervention programs. The primary value of this study is a better understanding of caregiver perceptions of program aims (how they understand the program), program impact (what they feel or believe it has done/ is doing for them), and program relationships (how they view their family’s relationships with staff). The goal was to add to the limited body of literature on the therapeutic nursery programs by seeking to better understand overall caregiver perceptions and experiences of one such program located …

Program Evaluation Of A Transitional Age Youth Program : A Project Based Upon An Investigation At Servicenet, Northampton, Massachusetts, Andrea Carnegie Chester

Theses, Dissertations, and Projects

This study was designed to survey participants of ServiceNet’s Transitional Age Youth (TAY) program to solicit feedback regarding program effectiveness in meeting their needs. Surveys were designed with ServiceNet staff to solicit participant perspectives on the importance of program goals, and satisfaction with program services in meeting those goals. Surveys included quantitative and qualitative questions, and were distributed to all active TAY program participants. Respondents placed the greatest emphasis on TAY program goals regarding living independently and housing. Subjects were somewhat less satisfied with program services geared towards employment services. Overall, subjects were very positive about TAY staff, particularly regarding …

Veterans' Stories Of Substance Use, Recovery, And Moral Injury : An Exploratory Study, Chelsea Faria

Theses, Dissertations, and Projects

This explorative/descriptive study investigates veterans’ stories of substance use/misuse, recovery, and moral injury. 12 male veterans participated in semi-structured interviews and answered questions about how their motivations for substance use/misuse and recovery changed prior to, during, and after their military service. Participants were also asked if they experienced moral injury while in the military, and if this precipitated or motivated substance use/misuse. The purpose of this study was to determine how the military impacts a veteran’s substance use/misuse and recovery. Qualitative research on moral injury is minimal, and this study aimed to address that gap in the literature. The study …

Group Rights, Group Intentions, And The Value Of Groups, David Luban

Georgetown Law Faculty Publications and Other Works

This paper is part of a symposium on Berel Lang’s 2016 book Genocide: The Act as Idea (University of Pennsylvania Press). While agreeing with much of Lang’s important argument about the moral significance of criminalizing genocide as a crime against groups, I raise several objections and questions. Lang ties the crime of genocide to group rights, specifically the right of groups to exist in the future; I argue that the concept of group rights obscures rather than clarifies the crime of genocide. What matters is not the rights of groups but the value of groups, both to their members and …

Developmental Stage Influences Chromosome Segregation Patterns And Arrangement In The Extremely Polyploid, Giant Bacterium Epulopiscium Sp. Type B, Elizabeth Hutchison

Biology

Few studies have described chromosomal dynamics in bacterial cells with more than two complete chromosome copies or described changes with respect to development in polyploid cells. We examined the arrangement of chromosomal loci in the very large, highly polyploid, uncultivated intestinal symbiont Epulopiscium sp. type B using fluorescent in situ hybridization. We found that in new offspring, chromosome replication origins (oriCs) are arranged in a three-dimensional array throughout the cytoplasm. As development progresses, most oriCs become peripherally located. Siblings within a mother cell have similar numbers of oriCs. When chromosome orientation was assessed in situ by …

A New Colombian Pest Species Of The Genus Poecilocloeus Bruner (Orthoptera: Acrididae: Proctolabinae) On Coffee, With A Key To The Neotropical Species, Luis Miguel Constantino, Oscar J. Cadena-Castañeda, Juan Manuel Cardona Granda, Pablo Benavides M., Carmenza Góngora B.

Insecta Mundi

A remarkable new species of Poecilocloeus (Orthoptera: Acrididae: Proctolabinae) found damaging coffee plantations in the Western Andes of Colombia is described and named P. coffeaphilus n. sp. This new species is part of a distinct and colorful group of Proctolabinae grasshoppers, with most species found at low altitudes in the rainforest of the Amazon basin. In contrast, the new species is found at elevations of 1600 to 1800 m in the canopy of dense cloud forests, in the southwestern part of the department of Antioquia (Western Cordillera, Colombian Andes). Information about the natural history, behavior, natural enemies and control strategies …

Seven New Taxa From The Butterfly Subtribe Euptychiina (Lepidoptera: Nymphalidae: Satyrinae) With Revisional Notes On Harjesia Forster, 1964 And Pseudeuptychia Forster, 1964, Shinichi Nakahara, Keith R. Willmott, Olaf H. H. Mielke, Johanna Schwartz, Thamara Zacca, Marianne Espeland, Gerardo Lamas

Insecta Mundi

Seven new euptychiine (Lepidoptera: Nymphalidae: Satyrinae) taxa are described and named herein, namely Harjesia argentata Nakahara, Zacca and Lamas, n. sp., Orotaygetis Nakahara and Zacca, n. gen., O. surui Nakahara, Zacca and Lamas, n. sp., Euptychoides sanmarcos Nakahara and Lamas, n. sp., Pseudeuptychia cuzquenya Nakahara and Lamas, n. sp., P. languida austrina Nakahara and Lamas, n. ssp., and Godartiana astronesthes Lamas and Nakahara, n. sp. A revisional note is provided for Harjesia Forster, 1964 and Pseudeuptychia Forster, 1964, and as a result, Taygetis vrazi Kheil, 1896 is removed from Harjesia and a new …