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University Of Nebraska- Lincoln: Fact Book 2017-2018

University of Nebraska-Lincoln Administration: Reports, Papers, Publications, and Presentations

Table of Contents

Front Cover.................................................................................................. 1

Introduction ....................................................................................................... 2

Table of Contents ............................................................................................. 3

General Information

University of Nebraska-Lincoln Core Values (LEADERS) ................................ 6

University of Nebraska-Lincoln Mission ......................................................... 7

The Missions of the University of Nebraska-Lincoln .......................................... 7

Teaching.................................................................................................... 8

Research.......................................................................................................... 8

Service ............................................................................................................. 9

Institutional and Professional Accreditations.........................................................10

University of Nebraska-Lincoln Administrative Organization Chart ..................14

Student Credit Hours (SCH)

Total SCH: Fall Semester Since 1979 ............................................................15

Total SCH: Spring Semester Since 1993 ......................................................16

SCH by College and Course Level, Fall and Spring Semester, 5 Year Trend .......17

SCH by College and Course Level, Fall Semester, 5 Year Trend …

Effects Of Lipid Activating Chemical Compounds On The Growth And Production Of Fatty Acids And Metabolites In Green Algae, David Nguyen, Nishikant Wase, Concetta Dirusso

UCARE: Research Products

This study examines the effects of small molecule lipid activating chemical compound, discovered from the high throughput screening (HTS) (2) methods of previous FATTT Lab studies on the growth and production of lipids and metabolites in microalgae. For this study, the effects of two lipid inducing chemical compounds from the HTS method were implemented with the microalgae strain Chlamydomonas reinhardtii CC-125. This experiment focused on scaling up to large amounts of culture, approximately 1L. These cultures were grown in specially designed large bioreactors that were able to accommodate for such large volume of algal culture. Algal cells were treated with …

Characterization Of Metabolic Network In T-Helper 2 Cells, Bailee Lichter

UCARE: Research Products

T-helper 2 (Th2) cells function in the adaptive immune system to coordinate responses to large extracellular pathogens (Luckheerham, 2012). Th2 cells are one of the differentiated subtypes cells of CD4+ T cells. CD4+ T cells recognize foreign pathogens and differenitated in specialized subtypes to affectively destroy the pathogen (Luckheerham, 2012). Upon CD4+ T cell activation, the cells undergo metabolic reprogaming, resulting in a shift in metabolism (Almedia, 2016).

We have successfully created a Th2 metabolic network model. The Th2 metabolic network model contains 1151 genes, 2601 metabolites, and 4654 reactions.

The Future Of Textiles: Disruption And Collaboration, Susan Brown, Matilda Mcquaid, David Breslauer, Suzanne Lee, Anais Missakian, Abby-George Erikson, Salem Van Der Swaagh

Textile Society of America: Symposium Proceedings

The textile field, while not “local” in the geographic sense, is a community: a group of people with a shared language, history, and practices that date back thousands of years. As deeply-rooted as those materials and practices are, textiles is also an area that has historically experienced enormous disruptions due to changing technology and globalization. In the 21^st century, we are undergoing something like a second Industrial Revolution. Advances in digital and robotic technologies and shifting labor markets are driving a revolution in where and how things are made. Global climate change, lack of food security for much of …

Methylation-Based Enrichment Facilitates Low-Cost, Noninvasive Genomic Scale Sequencing Of Populations From Feces, Kenneth L. Chiou, Christina M. Bergey

United States Public Health Resources

Obtaining high-quality samples from wild animals is a major obstacle for genomic studies of many taxa, particularly at the population level, as collection methods for such samples are typically invasive. DNA from feces is easy to obtain noninvasively, but is dominated by bacterial and other non-host DNA. The high proportion of non-host DNA drastically reduces the efficiency of high-throughput sequencing for host animal genomics. To address this issue, we developed an inexpensive capture method for enriching host DNA from noninvasive fecal samples. Our method exploits natural differences in CpG-methylation density between vertebrate and bacterial genomes to preferentially bind and isolate …

Therapeutic And Immunological Interventions In Primary Biliary Cholangitis: From Mouse Models To Humans, Atsushi Tanaka, Patrick S.C. Leung, Howard A. Young, M. Eric Gershwin

United States Public Health Resources

Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease that predominantly affects women in their fifth and sixth decades. The diagnostic hallmarks of PBC are detection of anti-mitochondrial antibodies (AMAs) and chronic non-suppurative destructive cholangitis (CNSDC) of small- and medium-sized intrahepatic bile ducts in liver histological examination [1, 2]. A significant amount of data suggests that immunological activity against small biliary epithelial cells (BECs), found histologically as portal inflammation, leads to clinical disease. In PBC, as with other autoimmune diseases, both genetic and environmental factors contribute to the development of pathology [3–8]. The first-line therapy of PBC is ursodeoxycholic …

Copd National Action Plan

United States Natonal Institutes of Health: Materials

The COPD National Action Plan is the first-ever blueprint for a multi-faceted, unified fight against the disease. Developed at the request of Congress.

Genomic Differences Between Nasal Staphylococcus Aureus From Hog Slaughterhouse Workers And Their Communities., Yaqi You, Li Song, Bareng A S Nonyane, Lance B Price, Ellen K Silbergeld

Environmental and Occupational Health Faculty Publications

New human pathogens can emerge from the livestock-human interface and spread into human populations through many pathways including livestock products. Occupational contact with livestock is a risk factor for exposure to those pathogens and may cause further spreading of those pathogens in the community. The current study used whole genome sequencing to explore nasal Staphylococcus aureus obtained from hog slaughterhouse workers and their community members, all of whom resided in a livestock-dense region in rural North Carolina. Sequence data were analyzed for lineage distribution, pathogenicity-related genomic features, and mobile genetic elements. We observed evidence of nasal S. aureus differences between …

Gender-Transformative Bandebereho Couples' Intervention To Promote Male Engagement In Reproductive And Maternal Health And Violence Prevention In Rwanda: Findings From A Randomized Controlled Trial., Kate Doyle, Ruti G Levtov, Gary Barker, Gautam G Bastian, Jeffrey B Bingenheimer, Shamsi Kazimbaya, Anicet Nzabonimpa, Julie Pulerwitz, Felix Sayinzoga, Vandana Sharma, Dominick Shattuck

Prevention and Community Health Faculty Publications

BACKGROUND: Rigorous evidence of the effectiveness of male engagement interventions, particularly on how these interventions impact relationship power dynamics and women's decision-making, remains limited. This study assessed the impact of the Bandebereho gender-transformative couples' intervention on impact on multiple behavioral and health-related outcomes influenced by gender norms and power relations.

METHODS: We conducted a multi-site randomised controlled trial in four Rwandan districts with expectant/current fathers and their partners, who were randomised to the intervention (n = 575 couples) or control group (n = 624 couples). Primary outcomes include women's experience of physical and sexual IPV, women's attendance and men's accompaniment …

Among Patients With Endometriosis, Does The Use Of Serum Biomarkers, Versus Laparoscopic Surgery For Diagnosis And Staging Of The Disease Decrease The Incidence Of Disease Related Negative Outcomes, Ellyn C. Hexum

Theses and Graduate Projects

Objective: To determine the ability and efficacy of non-invasive serum biomarker testing as a replacement for laparoscopic surgery in the diagnosis and staging of endometriosis to decrease the incidence of negative disease outcomes, leading to improvement in the accuracy of diagnoses and patient tailored treatment protocols.

Background: Endometriosis is a debilitating inflammatory disease of the reproductive tract. Currently, the gold standard for the diagnosis and staging of endometriosis is exploratory laparoscopic surgery. The use of surgery as the source of achieving a definitive diagnosis holds the potential to increase the incidence of negative disease outcomes. Because of this, the use …

Are Platelet Rich Plasma Injections A Better Choice Compared To Glucocorticoid Injections For The Treatment Of Rotator Cuff Tendinopathy In Adult Patients?, Sawyer Lange

Theses and Graduate Projects

An estimated 16 to 34 percent of the general population will experience shoulder pain at some point in their life. Rotator cuff tendinopathy makes up a large portion of that percentage. Platelet rich plasma (PRP) is an autologous blood product that has supraphsyiologic levels of growth factors and cytokines that have the potential to expedite the tendon healing process. This literature review will look at the current science surrounding PRP and look at studies comparing its efficacy to the commonly used corticosteroid injection.

Analysis Of Intrauterine Device Implementation And Review Of Prevention Strategies To Reduce Adolescent Pregnancy In Nicaragua, Haley Johnson

Theses and Graduate Projects

Adolescent pregnancy is one of the main healthcare issues facing Nicaragua. Prevention strategies are needed to avoid the maternal and fetal outcomes associated with young pregnancies. Extensive literature analysis and face-to-face discussions in Nicaragua were conducted to determine the current incidence of adolescent pregnancy and contraception use, barriers to reproductive health for adolescents, maternal outcomes of adolescent pregnancy, and if intrauterine devices have the potential to be a culturally effective method of contraception. Specific barriers to reproductive health for adolescents were identified to be machismo, societal criticism, lack of reproductive education, fear of infection from IUDs, and underutilization of healthcare …

Climate Change: Human Health, The Developing World And The Global Response, Cole James Kriett

Theses and Graduate Projects

Changes to the Earth’s biophysical system will extend and exacerbate the rates of vector-borne infectious disease, non-communicable diseases such as cardiovascular disease and lung disease, and mental health disorders. Developing nations face the greatest burden of climate sensitive human health impacts while also having the lowest capacity to adapt to these changes. Addressing these global ethical challenges cannot be accomplished without supporting organizations like UNEP or the IPCC. However, these organizations cannot achieve global sustainability alone. Human beings collectively taking responsibility for climate change will be vital to this process.

Exploring The Lives Of Retired Nurses Using The Lens Of Legacy, Verliss L. Keller-Miller

Theses and Graduate Projects

Legacy can be viewed as a summary of life. Legacy develops over a lifetime and changes and grows as one ages. How do retired nurses view their legacy? This paper looks at a select group of five female retired nurses and how each views her legacy at this time in life. Each was a professional nurse, and each is fully retired. Imogene King’s Goal Attainment Theory discusses the concepts of self and role. Through individual conversations, each retired nurse shares her life story of self and the roles she held during her working years. Literature yields little information about this …

Smallpox Bioterrorism Preparedness: The Importance Of Technology And Education For Early Detection And Response, D Taylor Jorgenson-Rathke

Theses and Graduate Projects

The use of biological agents as weapons has been prevalent throughout history. Only when the US experienced a bioterrorist attack in 2001 did additional funding begin to invest in preparing for other potential attacks. These initial investments, along with others, have funded preventative measures such as mass surveillance through biosensor technology and the development of preparedness programs such as the Laboratory Response Network and Hospital Preparedness Program. Based on learnings from previous outbreak events, in the event of a bioterrorist attack involving smallpox early detection will be the key to initiating a rapid and effective response. Additionally, further measures need …

The Future Of 5-Fluorouracil Treatment Of Colorectal Cancer: Translating A Better Understanding Into Improved Patient Care, Nathan Smits

Theses and Graduate Projects

5-fluorouracil (5-FU) is a pyrimidine analog that has been successfully employed in anticancer therapy for over forty years. Over the past several decades, researchers have characterized its cellular and clinical pharmacology and uncovered multiple mechanisms of action, which include the inhibition of thymidylate synthase (TS) and incorporation of its metabolites into DNA and RNA. The purpose of this quantitative systemic review was to summarize and evaluate what is known of these mechanisms to determine which are of most significance in the anticancer effects of 5-FU in metastatic colorectal cancer (mCRC) patients. A literature search of peer-reviewed articles dating back to …

Increased Antibiotic Resistance Of Escherichia Coli In Nicaragua: Potential Causes And Future Implications, Ryan S. Paukert

Theses and Graduate Projects

Since 1987, no new structural class of antibiotic has been introduced into human medicine. Aside from the absence of a new structural class of antibiotics, there has been a startlingly low number of new antibiotics approved since 1987. With the lack of new antibiotics, finding current antibiotics that are effective is becoming an alarming challenge due to the worldwide emergence of antibiotic resistance. Antibiotic-resistant bacteria presents a major threat to public health because they reduce the effectiveness of antibiotic treatment leading to increased morbidity, mortality, and healthcare expenditure. Without treatment for common infections, like uropathogenic Escherichia coli (UPEC), resistant infections …

Washington University Magazine, Fall/Winter 2018-2019

Washington University Magazine

No abstract provided.

Washington University Magazine, Spring 2018

Washington University Magazine

No abstract provided.

The Role Of Piay In Elementary School: The Perceptions Of Students, Aaron Skjerseth

Theses and Graduate Projects

This study is a look into students' views surrounding play and its place in the elementary classroom. The study was qualitative in nature and focused wholly on student interviews and their viewpoints and opinions on the subject. From these interviews, four broad themes were established. These themes revealed that students found play to be crucial in developing and maintaining friendships, destressing throughout the day, keeping up focus during lessons, and finally, there needs to be more play in schools. These themes suggest play should be taken more seriously in the classroom, as students view it to be crucial in several …

From The Editors, Anna M. Klobucka, Jeannette E. Riley, Catherine Villanueva Gardner

Journal of Feminist Scholarship

No abstract provided.

2018 Intersession Catalog, Illinois Mathematics And Science Academy

Intersession Catalogs

No abstract provided.

Tinctorial Cartographies: Plant, Dye & Place, Anna Heywood-Jones

Textile Society of America: Symposium Proceedings

We live in a plant-dominated biosphere, and yet the relevance and meaning of vegetal life, beyond its contribution to human existence, is rarely considered. This way of thinking has led us to see nature as external to ourselves, as “other,” as that mysterious realm beyond the human sphere of being. As in visual culture, plant life possesses signifiers and coded meanings in its contextual configurations. Botanical literacy offers insight into environmental, sociocultural, and historical narratives of place, as the forests and herbaceous margins of our communities speak of complex past, a parallel history of survival and adaptation. Plants and textiles, …

Radical Access: Textiles And Museums, Michele Hardy, Joanne Schmidt

Textile Society of America: Symposium Proceedings

This presentation discusses recent initiatives at Glenbow and Nickle Galleries that endeavor to provide new, radical levels of access to textile collections as a means to build community and affect creativity. While locking textiles away in environmentally controlled rooms and minimizing handling are useful methods for preservation, they are less effective in building vibrant communities or creating future relevance form museum collections. This paper, building on Hemming’s post-colonial textile theory, as well as Onciul’s theories on decolonizing engagement, challenge the apparent dichotomy between access and preservation. It argues that preservation without radical access, without shared community meaning making, without respecting …

Local Wear: A Chat About Textiles & The Body, Emily J. Pascoe

Textile Society of America: Symposium Proceedings

In this presentation, I propose that worn-in garments are a shared aspect of the relationship between humans and textiles, while also being unique to the user. The relationship between natural, cultural, and material forms, resulting in wear on textiles, begins with the human body. The human body is the most universal local. It is the essential qualifier to be a part of the human species. Although it is a biological form, how the body behaves, and the shapes it is molded into, are influenced by culture. The textiles that enclose the body accrue signs of the interactions. Even if the …

Getting Located: Queer Semiotics In Dress, C. Zimmerman

Textile Society of America: Symposium Proceedings

From the effeminate Macarconis of the 18^th century to the “future is female” shirts of 2017, the fashioned body has conveyed desire, signaled safety, and helped build affinity for queer people. This project will take the shape of a deep excavation and careful consideration of the historical precedence of queers encoding the nuances of dress with a multitude of identity affirming and identity challenging practices. Predominant research on unearthing how queer culture was (and is) expressed through dress had focused on the discernible gestures of normative gay male bodies; from ‘flagging’ (i.e. adorning the body with objects such as …

Polarized Localization Microscopy (Plm) Detects Nanoscale Membrane Curvature And Induced Budding By Cholera Toxin Subunit B (Ctxb), Abir Kabbani

Wayne State University Dissertations

The curvature of biological membranes at the nanometer scale is critically important for vesicle trafficking, organelle morphology, and disease propagation. Many proteins and lipids interact with diverse curvature sensing and curvature generating mechanisms. Deciphering the molecular mechanisms of toxin-membrane interactions has been limited by the resolution and drawbacks of conventional experimental techniques. This study reveals the inherent membrane bending capability of cholera toxin subunit B (CTxB) through the development and implementation of Polarized Localization Microscopy (PLM). PLM is a pointillist optical imaging technique for the detection of nanoscale membrane curvature in correlation with single-molecule dynamics and molecular sorting.

PLM combines …

Tandem Mass Spectrometry And Computational Approaches To Elucidate Conformations And N-Glycosidic Bond Stabilities Of Dna And Rna Nucleosides And Mononucleotides, Yanlong Zhu

Wayne State University Dissertations

ABSTRACT

TANDEM MASS SPECTROMETRY AND COMPUTATIONAL APPROACHES TO ELUCIDATE CONFORMATIONS AND N-GLYCOSIDIC BOND STABILITIES OF DNA AND RNA NUCLEOSIDES AND MONONUCLEOTIDES

by

YANLONG ZHU

May 2018

Advisor: Dr. Mary T. Rodgers

Major: Analytical Chemistry

Degree: Doctor of Philosophy

The influence of noncovalent interactions with sodium cations on the conformations and energetics of ten DNA and RNA nucleosides as well as two adenine mononucleotides were elucidated via infrared multiple photon dissociation (IRMPD) action spectroscopy experiments and complementary electronic structure calculations. Energy-resolved collision-induced dissociation (ER-CID) experiments of protonated and metal cationized DNA and RNA nucleosides were performed using a Bruker amaZon ETD …

Investigation Of The In Vivo Activity Of Ribosome-Targeting Peptides And Aminoglycosides In Escherichia Coli, Nisansala Sarangi Thilakarathne Muthunayake

Wayne State University Dissertations

The development of short peptides that specifically bind to higher-order structures of ribosomal RNA is one promising way to address the problem of antibiotic resistance. However, the poor correlation between in vitro and in vivo activities of these peptides is one of the major questions in antibiotic peptide research. Therefore, one of the main objectives of this dissertation work was to utilize a plasmid-based system to in vivo express ribosome-targeting peptides and study their direct inhibitory effects on bacteria. A specific plasmid system was optimized to in vivo express oncocin, a prolin-rich antimicrobial peptide and its variants in bacteria. Our …

Design Of Ruthenium(Ii) Polypyridyl Complexes For Effectively Caging Nitriles And Aromatic Heterocycles, Ao Li

Wayne State University Dissertations

ABSTRACT

DESIGN OF RUTHENIUM(II) POLYPYRIDYL COMPLEXES FOR EFFECTIVELY CAGING NITRILES

AND AROMATIC HETEROCYCLES

by

AO LI

May 2018

Advisor: Dr. Jeremy Kodanko

Major: Chemistry

Degree: Doctor of Philosophy

Ru(II) polypyridyl complexes have been frequently employed in the caging and photorelease of biologically active compounds. Traditional photocaging groups derived from Ru(II) have been largely based on bi- or tridentate ancillary ligands, and those bearing ancillary ligands with high-denticities are yet to be developed. Exploring Ru(II) polypyridyl complexes possessing ancillary ligands with high-denticities provides insight into the photophysical and photochemical properties of ruthenium complexes, which creates novel prospects in the design of …