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Articles 21931 - 21960 of 31410
Full-Text Articles in Entire DC Network
2018-2019 Factbook, Tennessee. General Assembly
2018-2019 Factbook, Tennessee. General Assembly
Factbook
This Fact Book provides an overview of the state's budget for the fiscal year.
Crimson Wave: Shedding Light On Menstrual Health, Margaret Flemings, Rachel Pak, Shanzay Kazmi
Crimson Wave: Shedding Light On Menstrual Health, Margaret Flemings, Rachel Pak, Shanzay Kazmi
Student Library Research Awards
300-level Award recipient for 2018. Project completed for course CS 320. Supporting faculty: Orit Shaer
Improving Models For Air-Sea Gas Exchange Using Measurements Of Noble Gas Ratios In A Wind-Wave Tank, Callan Krevanko
Improving Models For Air-Sea Gas Exchange Using Measurements Of Noble Gas Ratios In A Wind-Wave Tank, Callan Krevanko
Honors Thesis Collection
Gas flux at high wind speeds is not fully understood, and bubbles are rarely accounted for in models of air-sea gas exchange. Observing noble gas fluxes under bubble-rich and high wind conditions provides needed insight into fundamental gas exchange laws. The noble gases are ideal tracers for measuring gas exchange because they are inert and only respond to physical forcing; their range of physical properties results in unique responses to environmental changes for each gas. To quantify the effect of physical processes on gas fluxes, we took discrete and continuous measurements of noble gas ratios at the University of Miami …
"Not Just A White Woman's Disease": Radicalizing Eating Disorder Knowledge, Alexa Riobueno-Naylor
"Not Just A White Woman's Disease": Radicalizing Eating Disorder Knowledge, Alexa Riobueno-Naylor
Honors Thesis Collection
Eating disorder knowledge is dominated by a homogenous perspective largely devoid of racial or cultural diversity. Dialogues about what it means to be a woman and what it means to have an eating disorder have historically been singularly situated within the bodies of white women. These predominantly white narratives have served as the foundation for research studies on eating disorders which have shaped knowledge related to eating disorder diagnosis and treatment. By comparing the narratives of black (n=20), white (n=23), and Latina (n=15) women with eating disorders as well as incorporating perspectives from fifteen clinicians who treat eating disorders, this …
Malevolent Creativity: A Cross-Cultural Study, Michelle Zichun Wang
Malevolent Creativity: A Cross-Cultural Study, Michelle Zichun Wang
Honors Thesis Collection
Creativity is most often perceived to be a highly desirable and exclusively positive attribute, yet both history and a growing body of research remind us that creativity is not always benevolent. When creativity is deliberately used to cause harm, it is known as “malevolent creativity.” An extreme example of malevolent creativity is the development of the atomic bomb. To better understand the mechanisms underlying the production of malevolently creative products and problem solutions, this study investigated the degree to which demonstrations of benevolent creativity (commonly referred to simply as creativity), creative self-efficacy (a personal judgment of one’s own creative ability), …
Effects Of Macromolecular Crowding On Antimicrobial Peptide Activity, Hannah Schmidt
Effects Of Macromolecular Crowding On Antimicrobial Peptide Activity, Hannah Schmidt
Honors Thesis Collection
Due to the increasing public health concern of antibiotic resistant bacteria, antimicrobial peptides (AMPs) are a promising area of research for the development of new therapeutics. AMPs induce bacterial cell death in one of two ways: translocating into the cell and interfering with its nucleic acids or permeabilizing the cell membrane and inducing cell lysis. While a large amount of previous research has focused on AMPs in dilute buffers, this does not accurately reflect the physiological conditions where AMPs would be active as drugs. Blood plasma and the extracellular matrix contain large concentrations of macromolecules that can affect the AMP’s …
Investigating The Structural Determinants Of Tar Destabilization By Single Molecule Force Spectroscopy, Sarah Plachinski 2018
Investigating The Structural Determinants Of Tar Destabilization By Single Molecule Force Spectroscopy, Sarah Plachinski 2018
Honors Thesis Collection
No abstract provided.
Brothers Without A Mother: An Exploration Of Fraternity Life, Anna Ehrlich
Brothers Without A Mother: An Exploration Of Fraternity Life, Anna Ehrlich
Honors Thesis Collection
No abstract provided.
“No Idea”: Biopower And The School-To-Prison Pipeline For Students With Disabilities, Emily Boyk
“No Idea”: Biopower And The School-To-Prison Pipeline For Students With Disabilities, Emily Boyk
Honors Thesis Collection
No abstract provided.
The Forgotten Convention Ground: A Comparative Study Of Women Asylum Seekers And Gender-Based Persecution, Melissa Bruehl
The Forgotten Convention Ground: A Comparative Study Of Women Asylum Seekers And Gender-Based Persecution, Melissa Bruehl
Honors Thesis Collection
No abstract provided.
E-Boys And E-Girls: Constructing And Performing Identity In League Of Legends, Yelim Lee
E-Boys And E-Girls: Constructing And Performing Identity In League Of Legends, Yelim Lee
Honors Thesis Collection
Conducted over the course of a year and 6 months, E-boys and E-girls is an ethnography of online communities, particularly the League of Legends gaming communities. League of Legends is a highly competitive and team-work orientated game that forces people from around the world to communicate with each other. As players want to find others to game with consistently, online communities have formed out of necessity. Through interactions with the men and women, e-boys and e-girls, on one such community, I have come to observe persisting and rigid norms regarding gender performance and interaction. Even though people have the ability …
Categorization Of Inhibitory Neuronal Subpopulations In The Auditory Cortex Of Zebra Finch Songbirds, Alexa Pagliaro
Categorization Of Inhibitory Neuronal Subpopulations In The Auditory Cortex Of Zebra Finch Songbirds, Alexa Pagliaro
Honors Thesis Collection
Young zebra finch songbirds typically learn their father's (tutor) song which serves as a template for the development of their own song. Some birds imitate their tutor’s song with great success (good learners) whereas others fail to copy key components of the model song (poor learners). NCM (caudomedial Nidopallium), a secondary auditory region in the avian brain, is thought to contain (part of) the substrate for the neural representation of tutor song memory. Good learners exhibit greater left-hemispheric dominance in this region upon re-exposure to tutor song, indicating a role for the left NCM in the song learning process. It …
Strengthening The Relationship Between The Immune System And Adult Neurogenesis: I. Examining Connections Between Total Hemocyte Counts, Crayfish Body Size, And Neurogenic Niche Cell Counts Ii. Localization Of App-Homologue In Crayfish Adult Neurogenesis Pathway, Vanessa Kelley
Honors Thesis Collection
No abstract provided.
A Method For Optimizing Amino Acids In Defined Media For Pichia Pastoris Protein Expression, Angel Kuo
A Method For Optimizing Amino Acids In Defined Media For Pichia Pastoris Protein Expression, Angel Kuo
Honors Thesis Collection
In the biopharmaceutical industry, media for host organisms have been optimized with nutrients like amino acids to maximize recombinant protein production. Because amino acids serve as the building blocks of proteins, as well as intermediates in various metabolic pathways, they are posited to relieve much of the metabolic burden experienced by organisms producing heterologous proteins. Both complex amino acid mixtures and defined amino acids have shown to improve protein titers in various organisms. While there have been some studies on media optimization with amino acids for yeast, few systematic studies of amino acid supplementation have been reported for Pichia pastoris …
Unlocking The Past: Behavioral Reconstruction Using The Clavicle In Archaeological Contexts, Audrey Choi
Unlocking The Past: Behavioral Reconstruction Using The Clavicle In Archaeological Contexts, Audrey Choi
Honors Thesis Collection
Since it plays such a critical role in the movements of the upper body, the human clavicle is likely subjected to external forces, or mechanical loads, that influence its morphology. By observing the clavicle’s morphological modifications, anthropologists can potentially reconstruct the activity patterns of past populations. However, the clavicle is largely neglected by anthropological studies. To demonstrate the utility of the clavicle for behavioral reconstruction research, this study documents patterns of clavicular sexual dimorphism, directional asymmetry, and morphological variation to investigate the demographics of four medieval European populations.
3d Cell Culture Studies Of Anti-Pancreatic Cancer Agent Dcm-Mj-I-21, Elisa Wang
3d Cell Culture Studies Of Anti-Pancreatic Cancer Agent Dcm-Mj-I-21, Elisa Wang
Honors Thesis Collection
In the United States, 40% of men and women will be diagnosed with cancer at some point in their lives. Of the possible diagnoses, pancreatic ductal adenocarcinoma (PDAC) is one the most devastating. Currently, the 5-year survival rate of PDAC is below 10%, one of the lowest for common carcinomas in the United States. The lack of effective chemotherapies for this disease is acute, leading to a search for new compounds derived from natural products. The Carrico-Moniz lab has developed isoprenylated coumarin derivatives as novel chemotherapies for PDAC. Several structure-activity relationship (SAR) studies have led to our current lead compound, …
Investigating The Mechanism Of Resistance Of Adipose Derived Stem Cells To The Chemotherapeutic Agent Methotrexate, Stephanie Kim
Investigating The Mechanism Of Resistance Of Adipose Derived Stem Cells To The Chemotherapeutic Agent Methotrexate, Stephanie Kim
Honors Thesis Collection
Methotrexate (MTX) is a potent chemotherapeutic drug that inhibits cellular replication, reducing the proliferation of rapidly dividing cancer cells. Though effective, treatments using MTX have been found to be particularly detrimental for children with Acute Lymphoblastic leukemia, who have reported shorter stature, increases in bone fractures, and a higher risk of osteoporosis. It is believed that MTX harms bone marrow stem cells responsible for skeletal regeneration. Adipose derived stem cells (ASCs), multipotent cells which have the ability to differentiate into musculoskeletal tissues, have demonstrated a striking resistance to MTX. The mechanism through which ASCs are resistant to MTX is still …
Towards Understanding The Variability Between Rates Of Biological Productivity In The Beaufort Gyre Of The Arctic Ocean, Brenda Y. Ji
Towards Understanding The Variability Between Rates Of Biological Productivity In The Beaufort Gyre Of The Arctic Ocean, Brenda Y. Ji
Honors Thesis Collection
Oceans account for more than 25% of anthropogenic CO2 removal from the atmosphere. Changes in our global climate have affected the Arctic Ocean in particular, resulting in increasing rates of warming and record-low sea ice extent, which for example, in the summer of 2012, was only half of the average over the previous three decades. It is unclear how these changes in the Arctic Ocean may affect biological productivity, which is one of the main drivers of the oceanic carbon cycle as CO2is consumed through photosynthesis and released through respiration. In order to investigate how these changes …
Adapting A Field-Deployable Noble Gas Mass Spectrometer For Continuous Measurements Of Helium, Katherine Chan
Adapting A Field-Deployable Noble Gas Mass Spectrometer For Continuous Measurements Of Helium, Katherine Chan
Honors Thesis Collection
Isotopes of the five stable noble gases (He, Ne, Ar, Kr, and Xe) are useful in analyzing physical processes in the environment such as air-sea gas exchange and sea ice formation and melting. Traditional measurements of noble gases are costly and time-consuming because of the need to transport water samples to analyze in a laboratory-based mass spectrometer. Field deployable mass spectrometers were developed as a low-cost method to increase the temporal resolution of the measurements. Our system utilizes a quadrupole mass spectrometer in tandem with a gas equilibrator cartridge to continuously measure equilibrated gases from water with ambient air as …
Immune-Derived Cells As Neural Precursors: Manipulating The Attraction Of Immune Cells To The Neurogenic Niche, Anushree Dugar
Immune-Derived Cells As Neural Precursors: Manipulating The Attraction Of Immune Cells To The Neurogenic Niche, Anushree Dugar
Honors Thesis Collection
No abstract provided.
Revisiting Marginalia: A Print Congregation Of Plant And Place, Breslin Bell
Revisiting Marginalia: A Print Congregation Of Plant And Place, Breslin Bell
Honors Thesis Collection
No abstract provided.
Crispr/Cas9 Knockout Of Pi4kα Genes In Physcomitrella Patens: A Reverse Genetics Approach To Determine The Role Of Pi4p In Bryophyte Growth And Development, Tatyana Johnson
Honors Thesis Collection
Polar growth, or asymmetrical elongation of the cell, is a highly conserved developmental process that occurs in the moss, Physcomitrella patens, during protonemal and rhizoid growth. While several studies have examined the molecular underpinnings of polar growth in vascular plants, those of polar growth in the moss have yet to be fully elucidated. Current research suggests that phosphatidylinositol-4-phosphate (PI4P), a regulatory phospholipid that controls a variety of cellular processes including membrane trafficking, cytoskeleton organization, and intracellular signaling, plays a role in polar growth of plant cells. Knockout of genes that encode phosphatidylinositol-4-kinases (PI4Ks), the enzymes that synthesize PI4P, results in …
Nutrient-Dependent Specification Of Threshold Weight In Manduca Sexta, Lorrie L. He
Nutrient-Dependent Specification Of Threshold Weight In Manduca Sexta, Lorrie L. He
Honors Thesis Collection
No abstract provided.
Implementing Simultaneous Calcium Imaging And Optogenetics In Freely Moving Rodents To Investigate The Role Of Local Inhibition In Place Field Stability, Helena Yan
Honors Thesis Collection
Place cells are pyramidal neurons in CA1, 2, and 3 of the hippocampus that fire preferentially when an animal is located in a certain position in an environment. The location to which a place cell maximally responds (its place field) is randomly assigned within an environment. Place fields can be re-assigned depending on changes to local sensory cues within an environment, a phenomenon called “remapping”. Research has established that place field formation is affected by input from the local network in the hippocampus. Interneurons in CA1 are known to provide inhibitory input into place cells, but no causal link between …
Advantage -- Seeing The Universe: How Virtual Reality Can Further Augment A Three-Dimensional Model Of A Star-Planet-Satellite System For Educational Gain In Undergraduate Astronomy Education, Eliza Mcnair
Honors Thesis Collection
This thesis introduces the “adVantage – Seeing the Universe” system, a learning environment designed to augment introductory undergraduate astronomy education. The goal of the adVantage project is to show how an immersive virtual reality (VR) environment can be used effectively to model the relative sizes and distances between objects in space. To this end, adVantage leverages the benefits of three-dimensional models by letting users observe astronomical phenomena from multiple locations. The system uses pre-set vantage points to structure students’ progress through a “mission” designed to improve their understanding of scale. With this first mission, adVantage demonstrates the potential benefits of …
Multi-Label Super Learner: Multi-Label Classification And Improving Its Performance Using Heterogenous Ensemble Methods, Yujue Wu
Honors Thesis Collection
Classification is the task of predicting the label(s) of future instances by learning and inferring from the patterns of instances with known labels. Traditional classification methods focus on single-label classification; however, many real-life problems require multi-label classification that classifies each instance into multiple categories. For example, in sentiment analysis, a person may feel multiple emotions at the same time; in bioinformatics, a gene or protein may have a number of functional expressions; in text categorization, an email, medical record, or social media posting can be identified by various tags simultaneously. As a result of such wide a range of applications, …
Detection Of Spurious Deamination Caused By Crispr Base Editors, Stephanie Yeh
Detection Of Spurious Deamination Caused By Crispr Base Editors, Stephanie Yeh
Honors Thesis Collection
No abstract provided.
The Effect Of Instructor Gender On Stem Major Choice: Evidence From Wellesley College, Karen Ni
The Effect Of Instructor Gender On Stem Major Choice: Evidence From Wellesley College, Karen Ni
Honors Thesis Collection
Does the gender of a student’s initial STEM instructor have any causal effect on major choice? Using a panel of student-by-course data from Wellesley College, I measure the effects of female STEM instructors on female student major choice. The main threats to internal validity are non-random student selection in or out of class sections based on observable or unobservable characteristics, along with simultaneity. To mitigate these threats, I employ an instrumental variable that uses the exogenous variation induced by random patterns of faculty hires and leaves within a given department and semester. My analyses find that exposure to female STEM …
Experimental Proof Of Concept For Temperature Programmed Desorption (Tpd) Implementation Of Autoresonant Ion Trap Mass Spectrometry (Art Ms), Jean Huang
Honors Thesis Collection
No abstract provided.
The Effects Of Glutamate Transporter Deletions On Lifespan In Caenorhabditis Elegans, Maya Muldowney
The Effects Of Glutamate Transporter Deletions On Lifespan In Caenorhabditis Elegans, Maya Muldowney
Honors Thesis Collection
Glutamate transporters (GLTs) remove glutamate from synapses to prevent excitotoxicity and maintain conditions necessary for glutamatergic signaling. Once transported into cells adjacent to the synapse, glutamate can be metabolized into α-ketoglutarate (α-KG) or glutamine. Since GLT deletions are often lethal in mammals, C. elegans were used to investigate the role of GLTs on metabolism and aging in this thesis. The lifespans of C. elegans GLT-knockouts (GLT-1;GLT-3, GLT-4, and GLT-5) were measured and compared to wildtype worms. A well-established method involving FUdR, a chemical that prevents egg-laying in C. elegans, was used to conduct the lifespan experiments. Results indicated that GLT-4 …