Digital Commons Network^™

Anti-Correlated Cortical Networks Arise From Spontaneous Neuronal Dynamics At Slow Timescales, Nathan X. Kodama, Tianyi Feng, James J. Ullett, Hillel J. Chiel, Siddharth S. Sivakumar, Roberto F. Galán

Faculty Scholarship

In the highly interconnected architectures of the cerebral cortex, recurrent intracortical loops disproportionately outnumber thalamo-cortical inputs. These networks are also capable of generating neuronal activity without feedforward sensory drive. It is unknown, however, what spatiotemporal patterns may be solely attributed to intrinsic connections of the local cortical network. Using high-density microelectrode arrays, here we show that in the isolated, primary somatosensory cortex of mice, neuronal firing fluctuates on timescales from milliseconds to tens of seconds. Slower firing fluctuations reveal two spatially distinct neuronal ensembles, which correspond to superficial and deeper layers. These ensembles are anti-correlated: when one fires more, the …

Water Transport In The Lateral Line Canal Of The Intertidal Fish Xiphister Mucosus (Girard 1858) And Its Significance To Evaporative Water With Preliminary Observations Of The Metabolic Consequences Of Water Loss, Whitney Anne Gayer

Dissertations and Theses

The lateral line canal system is a sensory organ found in all teleost fish that has a wide range of morphological variation. Variation in morphology may often be the result of evolutionary necessity where the need for function dictates form. Xiphister mucosus is an amphibious Stichaeid fish that inhabits the rocky intertidal zone of the northeastern Pacific Ocean. The rocky intertidal is considered an extreme environment where crashing waves and ebbing tides may require the specialization of adaptations for surviving the many abiotic stressors encountered there.

The lateral line trunk canal of Xiphister is regarded as unique among teleosts with …

Biotap Selects Uab Scholars For Inaugural Cohort To Improve Teaching Professional Development, Alicia Rohan

Browse All News

No abstract provided.

Daily Eastern News: January 12, 2018, Eastern Illinois University

January

No abstract provided.

Target Engagement Imaging Of Parp Inhibitors In Small-Cell Lung Cancer, Brandon Carney, Susanne Kossatz, Benjamin H. Lok, Valentina Schneeberger, Kishore K. Gangangari, Naga Vara Kishore Pillarsetty, Wolfgang A. Weber, Charles M. Rudin, John T. Poirier, Thomas Reiner

Publications and Research

Insufficient chemotherapy response and rapid disease progression remain concerns for smallcell lung cancer (SCLC). Oncologists rely on serial CT scanning to guide treatment decisions, but this cannot assess in vivo target engagement of therapeutic agents. Biomarker assessments in biopsy material do not assess contemporaneous target expression, intratumoral drug exposure, or drug-target engagement. Here, we report the use of PARP1/2-targeted imaging to measure target engagement of PARP inhibitors in vivo. Using a panel of clinical PARP inhibitors, we show that PARP imaging can quantify target engagement of chemically diverse small molecule inhibitors in vitro and in vivo. We measure PARP1/2 inhibition …

The Impact Of Library Tutorials On The Information Literacy Skills Of Occupational Therapy And Physical Therapy Students In An Evidence-Based Practice Course: A Rubric Assessment, April Schweikhard, Toni Hoberecht, Alyssa Peterson, Ken Randall

Library System Faculty Publications

This study measures how online library instructional tutorials implemented into an evidence-based practice course have impacted the information literacy skills of occupational and physical therapy graduate students. Through a rubric assessment of final course papers, this study compares differences in students’ search strategies and cited sources pre- and post-implementation of the tutorials. The population includes 180 randomly selected graduate students from before and after the library tutorials were introduced into the course curriculum. Results indicate a statistically significant increase in components of students’ searching skills and ability to find higher levels of evidence after completing the library tutorials.

Novel Role Of Histone Deacetylase 11 (Hdac11) In Regulating Normal And Malignant Hematopoiesis, Jie Chen

USF Tampa Graduate Theses and Dissertations

During hematopoiesis, multilineage progenitor cells and the precursors are committed to individual hematopoietic lineages. In normal myelopoiesis, the immature myeloid cells (IMCs) differentiate into macrophages, neutrophils or dendritic cells. However, under tumor burden, these IMCs differentiate into myeloid derived suppressor cells (MDSCs) result in an up-regulation of immune suppressive factors and pro-tumor effect. The development of normal or malignant is tightly controlled by endogenous signals such as transcription factors and epigenetic regulations. HDAC11 is the newest identified members of the histone deacetylase (HDAC) family. Previous study in our group had identified HDAC11 as a negative regulator of interleukin 10 (IL-10) …

Teaching And Learning Science In The 21st Century: Challenging Critical Assumptions In Post-Secondary Science, Amanda L. Glaze

Middle Grades & Secondary Education: Faculty Publications

It is widely agreed upon that the goal of science education is building a scientifically literate society. Although there are a range of definitions for science literacy, most involve an ability to problem solve, make evidence-based decisions, and evaluate information in a manner that is logical. Unfortunately, science literacy appears to be an area where we struggle across levels of study, including with students who are majoring in the sciences in university settings. One reason for this problem is that we have opted to continue to approach teaching science in a way that fails to consider the critical assumptions that …

State V. George Respondent's Brief Dckt. 45196

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Beta-Catenin Cleavage Enhances Transcriptional Activation, Tatiana Goretsky, Emily M. Bradford, Qing Ye, Olivia F. Lamping, Tomas Vanagunas, Mary Pat Moyer, Patrick C. Keller, Preetika Sinh, Josep M. Llovet, Tianyan Gao, Qing-Bai She, Linheng Li, Terrence A. Barrett

Internal Medicine Faculty Publications

Nuclear activation of Wnt/β-catenin signaling is required for cell proliferation in inflammation and cancer. Studies from our group indicate that β-catenin activation in colitis and colorectal cancer (CRC) correlates with increased nuclear levels of β-catenin phosphorylated at serine 552 (pβ-Cat⁵⁵²). Biochemical analysis of nuclear extracts from cancer biopsies revealed the existence of low molecular weight (LMW) pβ-Cat⁵⁵², increased to the exclusion of full size (FS) forms of β-catenin. LMW β-catenin lacks both termini, leaving residues in the armadillo repeat intact. Further experiments showed that TCF4 predominantly binds LMW pβ-Cat⁵⁵² in the nucleus of inflamed and …

A Meta-Analysis Of Expressive Writing On Positive Psychology Variables And Traumatic Stress, Jeffrey Pavlacic, Erin Michelle Buchanan, Nicholas P. Maxwell, Tabetha Gaile Hopke, Stefan E. Schulenberg

Faculty and Student Publications (Open Access)

No abstract provided.

Recent Advances In Topical Nano Drug-Delivery Systems For The Anterior Ocular Segment, Prit Lakhani, Akash Patil, Soumyajit Majumdar

Faculty and Student Publications (Open Access)

No abstract provided.

Composition And Seasonal Abundance Of Hover Flies (Diptera: Syrphidae) At A Midelevation Site In Central Utah, Tyson J. Terry, C. Riley Nelson

Western North American Naturalist

Dipteran pollinators are important in the successful reproduction of many plants, yet are less studied than other groups. We know that these insects affect the biodiversity of natural landscapes, yet much remains unknown about the extent of their influence in pollination systems and flight seasons. In this study, we collected hover flies (Diptera: Syrphidae) with 3 Malaise traps at a midelevation site in central Utah throughout the flies’ flight season of 2015. We collected 27 genera and 48 species in our traps. We determined seasonal flight times by collecting at weekly intervals throughout the frost-free year. Abundance of all hover …

An Exploration Of The Impact Of Social Support On The Parents Of Children With Autism Disorder, Elizabeth Mcdevitt

Nursing Capstones

No abstract provided.

Search For The Pair Production Of Third-Generation Squarks With Two-Body Decays To A Bottom Or Charm Quark And A Neutralino In Proton–Proton Collisions At S=13tev, Cms Collaboration, J. G. Acosta, S. Oliveros

Faculty and Student Publications (Open Access)

No abstract provided.

Fabrication And Characterization Of Collagen-Apatite Composites For Bone Tissue Engineering, Changmin Hu

Doctoral Dissertations

Due to the high demand of scaffolds for treating bone fractures every year, biomimetic coatings and scaffolds resembling the composition and structure of natural bone are of keen interest of bone tissue engineers. In this research, a series of biomimetic coatings and scaffolds have been developed, including biomimetic apatite coatings, biomimetic collagen-apatite composite coatings, intrafibrillar calcified collagen fibrils, intrafibrillar silicified collagen fibrils, and intrafibrillar calcified collagen scaffolds.

First, a crack-free apatite coating was deposited on the surface-treated Ti6Al4V substrate using a biomimetic process, in which the surface-treated titanium substrate was immersed in a modified simulated body fluid (m-SBF). Dual-beam focused …

Enallagma Anna, A Damselfly New To The Great Lakes Region (Odonata: Coenagrionidae), Mark F. O'Brien, Paul D. Pratt

The Great Lakes Entomologist

Enallagma anna, a predominantly western North America damselfly, is now recorded from southwestern Michigan and southwestern Ontario for the first time.

Gleaning On Coreidae (Heteroptera) By Tachopteryx Thoreyi (Odonata: Petaluridae), R. D. Waltz

The Great Lakes Entomologist

(excerpt)

Tachopteryx thoreyi (Hagen in Selys) is an uncommon or rare, fen and seep dwelling dragonfly noted for its large size, restricted habitat requirements, and characteristic habit of perching on tree trunks.

Psilotreta Indecisa And Agarodes Distinctus (Trichoptera: Odontoceridae, Sericostomatidae): New State Records And Notes On The Habitat Of These Species In Michigan, Ethan Bright, Doug Bidlack

The Great Lakes Entomologist

The caddisfly species Psilotreta indecisa and Agarodes distinctus are reported for the first time in the State of Michigan. These species appear to be widely distributed in the state based upon their collection localities. Habitat information from collection localities is given.

The Sequential Relationship Of Body Oscillations In The Paper Wasp, Polistes Fuscatus (Hymenoptera: Vespidae), Bobbi J. Harding, George J. Gamboa

The Great Lakes Entomologist

Three kinds of body oscillations by foundresses of the paper wasp, Polistes fuscatus, were analyzed from 100 h of videotapes of 17 multiple- and 16 single-foundress, preworker colonies. The three kinds of oscillations were observed to be temporally proximate only after prey returns. Their sequential occurrence was always antennal drumming (AD), abdominal wagging (AW), and lateral vibration (LV). This sequence is consistent with the hypothesized communicative meanings of ADs, AWs, and LVs. In particular, ADs may signal larvae to withold salivary secretions prior to receiving a liquid meal from an adult female; oscillations AW and LV may signal larvae …

Phenology And Infestation Patterns Of The Cottonwood Twig Borer (Lepidoptera: Tortricidae) In Iowa, Joel D. Mcmillin, Michael J. Anderson, Elizabeth E. Butin, Elwood R. Hart

The Great Lakes Entomologist

Cottonwood twig borer, Gypsonoma haimbachiana (Lepidoptera: Totricidae), phenology and infestation patterns on Populus spp. were examined over a 2-year period in Iowa. Weekly sampling of infested shoots during the host growing season verified the existence of five instars. Head capsule size increased nonlinearly from the first to the fifth instar and corresponded to a concomitant geometric increase in the volume of larval feeding galleries. The sampling indicated that the cottonwood twig borer had two generations per year in Iowa. Corresponding with the two generations, two peaks of larval abundance were observed; one in the second week of June and the …

Temperature Effects On Development In Aphelinus Albipodus (Hymenoptera: Aphelinidae) From Two Geographic Regions, Jang-Hoon Lee, Norman C. Elliott

The Great Lakes Entomologist

Aphelinus albipodus Hayat & Fatima was imported to the United States for classical biological control of the Russian wheat aphid, Diuraphis noxia (Mordvilko). Temperature effects on development of A. albipodus from two geographic regions (hereafter referred to as strains) were measured using the Russian wheat aphid as host. Temperature thresholds for egg to mummy, mummy to adult, and egg to adult development were 8.9,10.9, and 9.7°C for A. albipodus collected near Pingluo, China, and were and 8.5, 10.3, and 9.6°C for A. albipodus collected near Urumqi, China. The time required to develop from egg to adult did not differ among …

The Parasitoid Complex Of First Generation Ostrinia Nubilalis (Lepidoptera: Pyralidae) Larvae In Northwest Ohio, Daniel M. Pavuk, Laura L. Hughes

The Great Lakes Entomologist

A survey of first generation European corn borer (Ostrinia nubilalis) larvae was conducted during 1997 in six cornfields located in northwestern Ohio in order to determine the larval parasitoid complex utilizing this host. Collected larvae were held under constant conditions until the larvae completed development or parasitoids emerged. The following species were recorded: Eriborus terebrans (Hymenoptera: Ichneumonidae), Macrocentrus grandii (Hymenoptera: Braconidae), Sympiesis viridula (Hymenoptera: Eulophidae), and Lixophaga sp. (Diptera: Tachinidae), Levels of parasitism in the different fields ranged from 14.3 to 83.3%. Future research will include surveys of additional fields and sampling of O. nubilalis over the entire …