Digital Commons Network^™

Trametinib Prevents Mesothelial-Mesenchymal Transition And Ameliorates Abdominal Adhesion Formation, Edward J. Macarak, Christine Lotto, Deepika Koganti, Xiaoling Jin, Pete J. Wermuth, Anna-Karin Olsson, Matthew Montgomery, Joel Rosenbloom

Department of Dermatology and Cutaneous Biology Faculty Papers

Background

Intra-abdominal adhesions are a major cause of morbidity after abdominal or gynecologic surgery. However, knowledge about the pathogenic mechanism(s) is limited, and there are no effective treatments. Here, we investigated a mouse model of bowel adhesion formation and the effect(s) of an Federal Drug Administration-approved drug (trametinib) in preventing adhesion formation.

Materials and methods

C57BL/6 mice were used to develop a consistent model of intra-abdominal adhesion formation by gentle cecal abrasion with mortality rates ofEDA) which arises from alternative splicing of the fibronectin messenger RNA resulting in different protein isoforms. Trichrome staining assessed collagen deposition. Quantitative polymerase chain reaction …

Exploring Procrastination And Self-Regulated Learning Through Motivational Beliefs, Betsy Ng

Journal of Research Initiatives

This study investigated the relations among procrastination, motivational beliefs, and self-regulated learning with a sample of 8th and 9th grade Singaporean students (N = 442). It examined the role of procrastination on self-regulated learning through motivational beliefs in science using structural equation modelling. The results showed positive relations of procrastination with task value, self-efficacy and test anxiety, as well as use of learning strategies. In addition, t- test analyses revealed significant gender and grade level differences in motivational beliefs. Procrastination accounted for enough variation in motivational beliefs to emerge as a significant predictor, suggesting that procrastination could influence …

Improving The Social And Emotional Education Curriculum In A Middle School, School Within A School Gifted And Talented Program, Natalie Polaschek

School of Education and Leadership Student Capstone Projects

The research question addressed in this capstone project was, how can staff address the social and emotional needs of gifted and talented students in a middle school, school within a school gifted and talented program? It documents a gifted and talented middle school teacher’s development of a social and emotional curriculum for 6th-8th grade students in a homogeneous gifted and talented program. The program includes lessons on social-emotional learning that is beneficial to all middle school students, as well as topics that are directed towards the specific needs of gifted learners. The author shares her research and the successes and …

Are Kindergarten Teachers Aware Of Their Unconscious Bias Of Gender In Stem (Science, Technology, Engineering And Math) Education?, Jodie Bray

School of Education and Leadership Student Capstone Projects

With a demand and a need for STEM (science, technology, engineering, and math) professionals in our work society, it is paramount that public education institutions become a positive interaction with STEM content. The unconscious bias that some female kindergarten teachers hold must be part of the courageous conversations to address The Cycle of Socialization in order to deconstruct gender normative behaviors. The purpose of this capstone project was to create a workshop so that female kindergarten teachers can recognize their own unconscious bias in STEM education and how they have been part of a systematic cycle of oppression. The research …

Framework For Purposeful Technology Integration In Environmental Education Using Inquiry Based Learning, Jonathan Massung

School of Education and Leadership Student Capstone Projects

The research question addressed in this project was, how do you incorporate technology to facilitate raw exploration of the natural world that reinforces inquiry-based learning in Environmental Education? The concept of the project was to create a framing guide to allow traditional and non-traditional educators to purposefully incorporate technology into a program with emphasis on environmental education standards. The primary focus of the format of the program is intended for K-12 lessons. The idea behind creating the program is to not simply add technology to a program, but to include the technology tool as a central piece with standards that …

Water Conservation Unit Plan, Richa Dolia

School of Education and Leadership Student Capstone Projects

The research question addressed in this capstone project was to provide lesson plans for teachers to integrate within their science curriculum to involve middle-school students in water conservation. The author has provided rationale for pursuing the topic of water conservation and high need to promote awareness. The water conservation curriculum project produced under this research is aligned with MN Science standards and will provide middle school science teachers with ready-to-go lessons to teach their students to bring awareness around the importance of water. (83 words)

An Environmental Education, Science Based, Curriculum On Raptors, To Help Bring A Focus And Awareness To The Raptors Found In Minnesota, Kayla Damiano

School of Education and Leadership Student Capstone Projects

The area of focus addressed in this capstone project was a curriculum on raptors, specifically raptors found in Minnesota. It documents one naturalist’s creation of a science-based unit that implements different aspects of students’ learning styles. Pedagogical concepts used in the development of this curriculum included the North American Association of Environmental Education’s (NAAEE) guidelines (NAAEE, 1996) as well as Understanding by Design – the second part of the framework: “backwards design” (Wiggins & McTighe, 2011). The author uses related literature to construct meaning and justification to the study to help support the details of the unit. She focused on …

Being Mila: Creating An Lgbtq Curriculum That Is Authentic, Follows Policies And Ethics, And Teaches Acceptance, Tam Friestad

School of Education and Leadership Student Capstone Projects

The literature and curriculum used in the classroom needs to change to reflect the students that are being taught. With the number of students and families being impacted by LGBTQ issues, one teacher decided to create a project addressing the research question of: How can I create an LGBTQ curriculum that is authentic, follows policies and ethics, and teaches acceptance? It will document the creation of a children’s book about a transgender child, as well as an accompanying Teacher Resource Guide. The author uses related literature reviews to create a book and resource guide that is authentic and developmentally appropriate. …

An Examination Of Best Practices For Teachers To Promote Empathy And Decrease Bullying Based On Ethnicity, Shannon Foster Borchardt

School of Education and Leadership Student Capstone Projects

This project examines intervention and prevention education to interrupt bullying behaviors among elementary age school children. It explores specifically how students based on culture, ethnicity, immigration status, and/or identification as an English language learner are targeted in a suburban metro district in the upper Midwest. In the context of this project, a connection is drawn between a rise in bullying behaviors based on bias in today’s political climate. It is noted that while the research on traditional bullying is vast, there is a gap in the research on bullying based on the aforementioned profile. This project provides strategies for understanding …

Clinicopathological Prognostic Factors Of Oral Squamous Cell Carcinoma: An Experience Of A Tertiary Care Hospital, Muhammad Usman Shaikh, Ahmed Raheem Baksh, Sayed Akbar Abbas, Javeria Saeed, Salman Hashmi

Department of Pathology and Laboratory Medicine

Locoregional recurrence accounts for majority of the treatment failures in oral cancer patients. Current study aimed to determine the predictors of recurrence and survival in patients with biopsy proven Squamous Cell Carcinoma (SCC) of the oral cavity. This study included 88 patients of squamous cell carcinoma treated at our institution from 2007 till 2013. Primary intervention was surgery in all patients with radiation and chemotherapy in selected patients. Primary end point was locoregional recurrence, distant metastasis and death. Out of 88 patients, 23 (26.1%) patients developed locoregional recurrence and 6 (6.8%) patients developed distant metastasis. Overall survival rate was 77.3%. …

Produktivitas Dan Efisiensi Teknis Usaha Perkebunan Kopi Di Sumatera Selatan Dan Lampung, Fauziah Zen, Budiasih Budiasih

Jurnal Ekonomi dan Pembangunan Indonesia

Coffee is the result of Indonesian plantations that have high competitiveness in the international market. However, coffee plantations in Indonesia have low productivity compared to other major coffee producing countries. This study aims to conduct a study of the productivity and technical efficiency of households coffee plantation business in the coffee producing center in Indonesia. The results of this study indicate that more than 50% of coffee plantation businesses in each of provinces have low productivity and medium technical efficiency. Education level is a variable that can increase productivity and technical efficiency significantly.

Cosmoses, Gina Keicher

Yalobusha Review

No abstract provided.

An Info To Cherish, Kirsten Ihns

Yalobusha Review

No abstract provided.

The Contributors, Marites Tiongco

DLSU Business & Economics Review

No abstract provided.

A Parametric Electrostatic Resonator Using Repulsive Force, Mark Pallay, Shahrzad Towfighian

Mechanical Engineering Faculty Scholarship

In this paper, parametric excitation of a repulsive force electrostatic resonator is studied. A theoretical model is developed and validated by experimental data. A correspondence of the model to Mathieu's Equation is made to prove the existence and location of parametric resonance. The repulsive force creates a combined response that shows parametric and subharmonic resonance when driven at twice its natural frequency. The resonator can achieve large amplitudes of almost 24 μm and can remain dynamically stable while tapping on the electrode. Because the pull-in instability is eliminated, the beam bounces off after impact instead of sticking to the electrode. …

Universal Design For Learning: Is Training Making A Difference In Teacher Pedagogy, Michelle D. Sizemore

Theses and Dissertations

David H. Rose and his colleagues at the Center for Applied Specialized Technology (CAST), a non-profit organization specializing in educational research and development, worked for over one quarter of a century to improve learning opportunities for all individuals (Rose, 2012). In the late 1990s this work led to a set of principles known as Universal Design for Learning (UDL), a research-based instructional framework grounded in neuroscience and educational research that allowed teachers to proactively identify barriers that might exist between students and learning and account for those barriers during lesson development and implementation (CAST, 2015). One school district in southwest …

2018/2019 University Of The Pacific Stockton Graduate Catalog, University Of The Pacific

Catalogue, Bulletin, Catalog

No abstract provided.

1.7 Committee Structure, Saint Mary's College Of California

Faculty Handbook

No abstract provided.

Characterizing The Recognition Motif And Novel Substrates Of Carm1, Sitaram Gayatri

Dissertations and Theses (Open Access)

A limited pool of proteins attains vast functional repertoire due to posttranslational modifications (PTMs). Arginine methylation is a common posttranslational modification, which is catalyzed by a family of nine protein arginine methyltransferases or PRMTs. These enzymes deposit one or two methyl groups to the nitrogen atoms of arginine side-chains. Elucidating the substrate specificity of each PRMT will promote a better understanding of which signaling networks these enzymes contribute to. Although many PRMT substrates have been identified, and their methylation sites mapped, the optimal target motif for each of the nine PRMTs has not been systematically addressed. Here we describe the …

Characterization Of Metronidazole- And Vancomycin-Resistant Clinical Isolates Of Clostridium Difficile, Chioma Odo

Dissertations and Theses (Open Access)

Characterization of Metronidazole- and Vancomycin-Resistant Clinical Isolates of Clostridium difficile

Chioma Odo, MS.

Supervisory Professor: Charles Darkoh, Ph.D.

ABSTRACT

The incidence of C. difficile infections (CDI) has been increasing at an alarming rate. This was precipitated by the emergence of strains with increased virulence, disease severity, and high recurrence rates. These strains also exhibit high propensity for resistance to antibiotics such as fluoroquinolones and beta lactams, which has made the treatment of CDI very challenging. Currently, metronidazole and vancomycin are the most commonly used drugs for the treatment of primary CDI. Metronidazole is used for the treatment of mild to …

Ecomorph Convergence In Stick Insects (Phasmatodea) With Emphasis On The Lonchodinae Of Papua New Guinea, Yelena Marlese Pacheco

Theses and Dissertations

Phasmatodea exhibit a variety of cryptic ecomorphs associated with various microhabitats. Multiple ecomorphs are present in the stick insect fauna from Papua New Guinea, including the tree lobster, spiny, and long slender forms. While ecomorphs have long been recognized in phasmids, there has yet to be an attempt to objectively define and study the evolution of these ecomorphs. Using principal component analysis, PERMANOVA, ANOVA, and phylogenetic reconstructions, we examined the evolution of ecomorphs in the Lonchodinae stick insects of Papua New Guinea. Phylogenetic reconstructions were performed via maximum likelihood and Bayesian methods and ecomorphs were mapped onto recovered topologies to …

Genetic Basis For Elevated Rheumatic Heart Disease Susceptibility In Samoa, John Bowen Allen

Theses and Dissertations

Rheumatic heart disease is an inflammatory heart disease that affects millions of people around the world. Especially high rates of the disease can be found in Oceania, including the island nation of Samoa. Genetic studies of immune response genes have provided insight into a possible genetic link to increased susceptibility to rheumatic heart disease, including the genes that code for the toll-like receptor (TLR) protein family. One of the functions of TLR proteins is to recognize the presence of bacteria via identification of bacterial flagella. My evaluation of a Samoan family identified a variant in the TLR-5 gene that would …

Subdermal Ultrasound Contrast Agent Injection For Sentinel Lymph Node Identification: An Analysis Of Safety And Contrast Agent Dose In Healthy Volunteers., Priscilla Machado, Maria Stanczak, Ji-Bin Liu, Jason N. Moore, John R. Eisenbrey, Laurence Needleman, Walter K. Kraft, Flemming Forsberg

Department of Radiology Faculty Papers

Objectives—Mapping of the lymphatic chain for identification of the sentinel lymph node (SLN) is an important aspect of predicting outcomes for breast cancer patients, and it is usually performed as an intraoperative procedure using blue dye and/or radiopharmaceuticals agents. Recently the use of contrast-enhanced ultrasound (CEUS) has been proposed as an alternative imaging technique for this mapping. The objective of this study was to evaluate the use of subdermal administration of the ultrasound contrast agent Sonazoid (GE Healthcare) in terms of patient safety and to select the dose to be used for lymphatic applications in humans.

Methods—This study …

Effect Of Institution On Production Cost Efficiency Of Organic Rice Farming In Indonesia, Ignatius Suprih Sudrajat, Endang Siti Rahayu, Kusnandar Supriyadi

DLSU Business & Economics Review

This study is about the effect of an institution on the production cost efficiency of organic rice farming. This research used the stochastic frontier approach with cross-section data and estimated with maximum likelihood estimation (MLE). This study aims to determine the effect of institution variables on production cost inefficiency. A survey was conducted on 216 organic rice farmers during two planting seasons using purposive sampling method in Dlingo Village, Mojosongo, Boyolali, Central Java, Indonesia. The result of the research shows that the average value of production cost efficiency is 0.4268. The role of farmer groups and agricultural counselors is the …

Acute Salivary Cortisol Response Among Mexican American Adolescents In Immigrant Families, Su Yeong Kim, Minyu Zhang, Katharine H. Zeiders, Lester Sim, Marci E. J. Gleason

Research Collection School of Social Sciences

Objectives: Though previous research has indicated that language brokering can be stressful, the findings are mixed, pointing to potential moderators of the association. Guided by an ecological perspective, we examined the role of individual, family, and environmental factors in Mexican American adolescents’ acute cortisol responses to language brokering. Method: The study consisted of 46 Mexican American adolescents recruited around a metropolitan city in Central Texas. Participants translated a difficult medical document from English to Spanish for their parents, followed by an arithmetic task (modeled after the Trier Social Stress Test [TSST]). Participants’ perceptions (perceived efficacy and parental dependence), parental hostility, …

The Perception Of Spontaneous And Volitional Laughter Across 21 Societies, Gregory A. Bryan, Daniel M. Fessler, Riccardo Fusaroli, Edward Clint, Dorsa Amir, Brenda Chavez, Kaleda K. Denton, Cinthya Diaz, Lealaiailoto T. Duran, Jana Fancovicova, Michal Fux, Erni F. Ginting, Youssef Hasan, Anning Hu, Shanmukh V. Kamble, Tatsuya Kameda, Kiri Kuroda, Norman P. Li, Et Al

Research Collection School of Social Sciences

Laughter is a nonverbal vocalization occurring in every known culture, ubiquitous across all forms of human socialinteraction. Here, we examined whether listeners around the world, irrespective of their own native language andculture, can distinguish between spontaneous laughter and volitional laughter—laugh types likely generated by differentvocal-production systems. Using a set of 36 recorded laughs produced by female English speakers in tests involving 884participants from 21 societies across six regions of the world, we asked listeners to determine whether each laugh wasreal or fake, and listeners differentiated between the two laugh types with an accuracy of 56% to 69%. Acoustic analysisrevealed that …

Small Non-Coding Rna Expression And Vertebrate Anoxia Tolerance, Claire L. Riggs, Amanda Summers, Daniel E. Warren, Göran E. Nilsson, Sjannie Lefevre, W. W. Dowd, Sarah Milton, Jason E. Podrabsky

Biology Faculty Publications and Presentations

Background: Extreme anoxia tolerance requires a metabolic depression whose modulation could involve small non-coding RNAs (small ncRNAs), which are specific, rapid, and reversible regulators of gene expression. A previous study of small ncRNA expression in embryos of the annual killifish Austrofundulus limnaeus, the most anoxiatolerant vertebrate known, revealed a specific expression pattern of small ncRNAs that could play important roles in anoxia tolerance. Here, we conduct a comparative study on the presence and expression of small ncRNAs in the most anoxia-tolerant representatives of several major vertebrate lineages, to investigate the evolution of and mechanisms supporting extreme anoxia tolerance. The epaulette …

Assembly And Analysis Of Unmapped Genome Sequence Reads Reveal Novel Sequence And Variation In Dogs, Lindsay Adrian Holden, Meharji Arumilli, Marjo K. Hytönen, Sruthi Hundi, Jarkko Salojärvi, Kim H. Brown, Hannes Lohi

Biology Faculty Publications and Presentations

Dogs are excellent animal models for human disease. They have extensive veterinary histories, pedigrees, and a unique genetic system due to breeding practices. Despite these advantages, one factor limiting their usefulness is the canine genome reference (CGR) which was assembled using a single purebred Boxer. Although a common practice, this results in many high-quality reads remaining unmapped. To address this whole-genome sequence data from three breeds, Border Collie (n = 26), Bearded Collie (n = 7), and Entlebucher Sennenhund (n = 8), were analyzed to identify novel, non- CGR genomic contigs using the previously validated pseudo-de novo assembly pipeline. We …

The Bulletin: Sidney Kimmel Medical College At Thomas Jefferson University, Volume 67, Issue 2, Spring/Summer 2018

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

This issue includes:

• Exposure: Michael Weinstein, MD '94, had a plan to take his own life; now he is back to living it
• Medical School 2.0: JeffMD - A New Way to Train Physicians
• 25 Years of JeffHOPE Clinics: Student Volunteers Shape Patients' Lives - and Their Own
• Caring for the Most Vulnerable a "Moral, Ethical, Medical Responsibility": Jefferson's Latina Women's Clinic Dispenses Care and Compassion
• The Dean's Column
• Findings: New Look at Eye's Immune Status
• Home at Last: A message from Elizabeth Dale
• Endowed Professorships
• Time Capsule
• On Campus
• Feeling all the Bumps: Jefferson Oncologist Looks at the World …

Factors Influencing Preclinical Medical Students Of Thammasat University's Decisions On Attending Live Lectures, Thanapon Roddaje, Nichayada Hirunwattana, Numwong Tapsirisuntorn, Nuchanart Suealek, Panadda Rojpibulstit

Asian Medical Journal and Alternative Medicine

Introduction: Lecture-based learning has all along been the main method used among almost all curriculum worldwide. However, it is concerned that new generation students tend to avoid complying with these traditional scheme by missing lecture classes, likewise in Thammasat medical school. In order to encourage the students’ class participation, this study, hence, aims to explore the factors affecting not only their decisions on attending class but also their concentration during the lectures. Moreover, we try to address their main purpose of studying whether it would be either their examination scores or their future clinical application.

Method:  A descriptive cross-sectional …