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Articles 89581 - 89587 of 89587
Full-Text Articles in Entire DC Network
A New Use Of Β-Ala-Lys (Amca) As A Transport Reporter For Pept1 And Pept2 In Renal Brush Border Membrane Vesicles From The Outer Cortex And Outer Medulla., Othman A. Alghamdi, Nicola King, Graham L. Jones, Pierre D.J. Moens
A New Use Of Β-Ala-Lys (Amca) As A Transport Reporter For Pept1 And Pept2 In Renal Brush Border Membrane Vesicles From The Outer Cortex And Outer Medulla., Othman A. Alghamdi, Nicola King, Graham L. Jones, Pierre D.J. Moens
School of Biomedical Sciences
Integral membrane proteins PEPT1 and PEPT2 are essential for reabsorbing almost all hydrolysed or filtered di- and tripeptides alongside a wide range of peptidomimetic drugs in the kidney. The aim of this study was to investigate the potential use of the fluorophore-conjugated dipeptide β-Ala-Lys (AMCA) as a biosensor for measuring peptide transport activity in brush border membrane vesicles isolated from the outer cortex (BBMV-OC) and outer medulla (BBMV-OM) (representing PEPT1 and PEPT2 respectively). The vesicles were isolated using a dual magnesium precipitation and centrifugation technique. Intravesicular fluorescence accumulation was measured after incubating extra-vesicular media at pH6.6 and different concentrations of …
Prevention Of Tuberculosis In Rhesus Macaques By A Cytomegalovirus-Based Vaccine, Scott G. Hansen, Daniel E. Zak, Guangwu Xu, Julia C. Ford, Emily E. Marshall, Daniel Malouli, Roxanne M. Gilbride, Colette M. Hughes, Abigail B. Ventura, Emily Ainslie, Kurt T. Randall, Andrea N. Selseth, Parker Rundstrom, Lauren Herlache, Matthew S. Lewis, Haesun Park, Shannon L. Planer, John M. Turner, Miranda Fischer, Christina Armstrong, Robert C. Zweig, Joseph Valvo, Jackie M. Braun, Smitha Shankar, Lenette Lu, Andrew W. Sylwester, Alfred W. Legasse, Martin Messerle, Michael A. Jarvis, Michael A. Jarvis, Alan Aderem, Galit Alter, Dominick J. Laddy, Michele Stone, Aurelio Bonavia, Thomas G. Evans, Michael K. Axthelm, K Fruh, Paul T. Edlefsen, Louis J. Picker
Prevention Of Tuberculosis In Rhesus Macaques By A Cytomegalovirus-Based Vaccine, Scott G. Hansen, Daniel E. Zak, Guangwu Xu, Julia C. Ford, Emily E. Marshall, Daniel Malouli, Roxanne M. Gilbride, Colette M. Hughes, Abigail B. Ventura, Emily Ainslie, Kurt T. Randall, Andrea N. Selseth, Parker Rundstrom, Lauren Herlache, Matthew S. Lewis, Haesun Park, Shannon L. Planer, John M. Turner, Miranda Fischer, Christina Armstrong, Robert C. Zweig, Joseph Valvo, Jackie M. Braun, Smitha Shankar, Lenette Lu, Andrew W. Sylwester, Alfred W. Legasse, Martin Messerle, Michael A. Jarvis, Michael A. Jarvis, Alan Aderem, Galit Alter, Dominick J. Laddy, Michele Stone, Aurelio Bonavia, Thomas G. Evans, Michael K. Axthelm, K Fruh, Paul T. Edlefsen, Louis J. Picker
School of Biomedical Sciences
No abstract provided.
Parallel Genome-Wide Profiling Of Coding And Non-Coding Rnas To Identify Novel Regulatory Elements In Embryonic And Maturated Heart, Davood Sabour, Rui S.R. Machado, José P. Pinto, Susan Rohani, Raja G.A. Sahito, Jürgen Hescheler, Matthias E. Futschik, Agapios Sachinidis
Parallel Genome-Wide Profiling Of Coding And Non-Coding Rnas To Identify Novel Regulatory Elements In Embryonic And Maturated Heart, Davood Sabour, Rui S.R. Machado, José P. Pinto, Susan Rohani, Raja G.A. Sahito, Jürgen Hescheler, Matthias E. Futschik, Agapios Sachinidis
School of Biomedical Sciences
No abstract provided.
Effect Of Exercise Therapy On Established And Emerging Circulating Biomarkers In Patients With Heart Failure: A Systematic Review And Meta-Analysis, Melissa J. Pearson, Nicola King, Neil A. Smart
Effect Of Exercise Therapy On Established And Emerging Circulating Biomarkers In Patients With Heart Failure: A Systematic Review And Meta-Analysis, Melissa J. Pearson, Nicola King, Neil A. Smart
School of Biomedical Sciences
No abstract provided.
Hybrid Coronary Revascularization Versus Conventional Coronary Artery Bypass Grafting: Systematic Review And Meta-Analysis, Alexander C. Reynolds, Nicola King
Hybrid Coronary Revascularization Versus Conventional Coronary Artery Bypass Grafting: Systematic Review And Meta-Analysis, Alexander C. Reynolds, Nicola King
School of Biomedical Sciences
No abstract provided.
Foxn1-Dependent Thymic Epithelial Cells Promote T-Cell Leukemia Development, Marinella N. Ghezzo, Mónica T. Fernandes, Ivette Pacheco-Leyva, Pedro M. Rodrigues, Rui S. Machado, Mas Araujo, Ravi K. Kalathur, Matthias E. Futschik, Nuno L. Alves, Santos Nr Dos
Foxn1-Dependent Thymic Epithelial Cells Promote T-Cell Leukemia Development, Marinella N. Ghezzo, Mónica T. Fernandes, Ivette Pacheco-Leyva, Pedro M. Rodrigues, Rui S. Machado, Mas Araujo, Ravi K. Kalathur, Matthias E. Futschik, Nuno L. Alves, Santos Nr Dos
School of Biomedical Sciences
No abstract provided.
Cd44 Is Required For The Pathogenesis Of Experimental Crescentic Glomerulonephritis And Collapsing Focal Segmental Glomerulosclerosis, Jennifer Eymael, S Sharma, Markus A. Loeven, Jack F. Wetzels, Fieke Mooren, Sandrine Florquin, Jeroen K. Deegens, Brigith K. Willemsen, V Sharma, Kuppevelt Th Van, Marinka A. Bakker, Tammo Ostendorf, Marcus J. Moeller, Henry B. Dijkman, Bart Smeets, Der Vlag J Van
Cd44 Is Required For The Pathogenesis Of Experimental Crescentic Glomerulonephritis And Collapsing Focal Segmental Glomerulosclerosis, Jennifer Eymael, S Sharma, Markus A. Loeven, Jack F. Wetzels, Fieke Mooren, Sandrine Florquin, Jeroen K. Deegens, Brigith K. Willemsen, V Sharma, Kuppevelt Th Van, Marinka A. Bakker, Tammo Ostendorf, Marcus J. Moeller, Henry B. Dijkman, Bart Smeets, Der Vlag J Van
School of Biomedical Sciences
© 2017 International Society of Nephrology. A key feature of glomerular diseases such as crescentic glomerulonephritis and focal segmental glomerulosclerosis is the activation, migration and proliferation of parietal epithelial cells. CD44-positive activated parietal epithelial cells have been identified in proliferative cellular lesions in glomerular disease. However, it remains unknown whether CD44-positive parietal epithelial cells contribute to the pathogenesis of scarring glomerular diseases. Here, we evaluated this in experimental crescentic glomerulonephritis and the transgenic anti-Thy1.1 model for collapsing focal segmental glomerulosclerosis in CD44-deficient (cd44-/-) and wild type mice. For both models albuminuria was significantly lower in cd44-/- compared to wild type …