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2018

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Articles 86221 - 86250 of 89615

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Regulation Of Amyloid-Β Dynamics And Pathology By The Circadian Clock, Geraldine J. Kress, Fan Liao, Julie Dimitry, Michelle R. Cedeno, Garret A Fitzgerald, David M. Holtzman, Erik S. Musiek Jan 2018

Regulation Of Amyloid-Β Dynamics And Pathology By The Circadian Clock, Geraldine J. Kress, Fan Liao, Julie Dimitry, Michelle R. Cedeno, Garret A Fitzgerald, David M. Holtzman, Erik S. Musiek

Open Access Publications

Nighttime restlessness and daytime drowsiness are common and early symptoms of Alzheimer's Disease (AD). This symptomology implicates dysfunctional biological timing, yet the role of the circadian system in AD pathogenesis is unknown. To evaluate the role of the circadian clock in amyloid-β (Aβ) dynamics and pathology, we used a mouse model of β-amyloidosis and disrupted circadian clock function either globally or locally in the brain via targeted deletion of the core clock gene


Cell Circuits Between B Cell Progenitors And Il-7+ Mesenchymal Progenitor Cells Control B Cell Development, Chris Fistonich, Sandra Zehentmeier, Jeffrey J. Bednarski, Runfeng Miao, Hilde Schjerven, Barry P Sleckman, João P Pereira Jan 2018

Cell Circuits Between B Cell Progenitors And Il-7+ Mesenchymal Progenitor Cells Control B Cell Development, Chris Fistonich, Sandra Zehentmeier, Jeffrey J. Bednarski, Runfeng Miao, Hilde Schjerven, Barry P Sleckman, João P Pereira

Open Access Publications

B cell progenitors require paracrine signals such as interleukin-7 (IL-7) provided by bone marrow stromal cells for proliferation and survival. Yet, how B cells regulate access to these signals in vivo remains unclear. Here we show that proB and IL-7


Trisomy Of Human Chromosome 21 Enhances Amyloid-Β Deposition Independently Of An Extra Copy Of App, Frances K. Wiseman, Fan Liao, Floy Stewart, David M. Holtzman, Et Al Jan 2018

Trisomy Of Human Chromosome 21 Enhances Amyloid-Β Deposition Independently Of An Extra Copy Of App, Frances K. Wiseman, Fan Liao, Floy Stewart, David M. Holtzman, Et Al

Open Access Publications

No abstract provided.


Walking, Gross Motor Development, And Brain Functional Connectivity In Infants And Toddlers, Natasha Marrus, Adam T. Eggebrecht, Alexandre Todorov, Lyndsey Cole, Cheryl L. Klohr, Chloe M. Adams, Kelly N. Botteron, Robert C. Mckinstry, John N. Constantino, The Ibis Network, Bradley L. Schlaggar, John R. Pruett Jr, Et Al Jan 2018

Walking, Gross Motor Development, And Brain Functional Connectivity In Infants And Toddlers, Natasha Marrus, Adam T. Eggebrecht, Alexandre Todorov, Lyndsey Cole, Cheryl L. Klohr, Chloe M. Adams, Kelly N. Botteron, Robert C. Mckinstry, John N. Constantino, The Ibis Network, Bradley L. Schlaggar, John R. Pruett Jr, Et Al

Open Access Publications

No abstract provided.


Data-Driven Models Of Dominantly-Inherited Alzheimer’S Disease Progression, Neil P. Oxtoby, Alexandra L. Young, David M. Cash, Tammie L.S. Benzinger, Anne M. Fagan, John C. Morris, Randall J. Bateman, Nick C. Fox, Jonathan M. Schott, Daniel C. Alexander Jan 2018

Data-Driven Models Of Dominantly-Inherited Alzheimer’S Disease Progression, Neil P. Oxtoby, Alexandra L. Young, David M. Cash, Tammie L.S. Benzinger, Anne M. Fagan, John C. Morris, Randall J. Bateman, Nick C. Fox, Jonathan M. Schott, Daniel C. Alexander

Open Access Publications

No abstract provided.


Longo: An R Package For Interactive Gene Length Dependent Analysis For Neuronal Identity, Matthew J. Mccoy, Alexander J. Paul, Matheus B. Victor, Michelle Richner, Harrison W. Gabel, Haijun Gong, Andrew S. Yoo, Tae-Hyuk Ahn Jan 2018

Longo: An R Package For Interactive Gene Length Dependent Analysis For Neuronal Identity, Matthew J. Mccoy, Alexander J. Paul, Matheus B. Victor, Michelle Richner, Harrison W. Gabel, Haijun Gong, Andrew S. Yoo, Tae-Hyuk Ahn

Open Access Publications

Motivation: Reprogramming somatic cells into neurons holds great promise to model neuronal development and disease. The efficiency and success rate of neuronal reprogramming, however, may vary between different conversion platforms and cell types, thereby necessitating an unbiased, systematic approach to estimate neuronal identity of converted cells. Recent studies have demonstrated that long genes (>100 kb from transcription start to end) are highly enriched in neurons, which provides an opportunity to identify neurons based on the expression of these long genes.

Results: We have developed a versatile R package, LONGO, to analyze gene expression based on gene length. We propose …


Multiethnic Meta-Analysis Identifies Ancestry-Specific And Cross-Ancestry Loci For Pulmonary Function, Mary F. Feitosa, Mary K. Wojczynski, Michael A. Province Jan 2018

Multiethnic Meta-Analysis Identifies Ancestry-Specific And Cross-Ancestry Loci For Pulmonary Function, Mary F. Feitosa, Mary K. Wojczynski, Michael A. Province

Open Access Publications

No abstract provided.


Safety Of The Deferral Of Coronary Revascularization On The Basis Of Instantaneous Wave-Free Ratio And Fractional Flow Reserve Measurements In Stable Coronary Artery Disease And Acute Coronary Syndromes, Javier Escaned, Jasvindar Singh, Et Al Jan 2018

Safety Of The Deferral Of Coronary Revascularization On The Basis Of Instantaneous Wave-Free Ratio And Fractional Flow Reserve Measurements In Stable Coronary Artery Disease And Acute Coronary Syndromes, Javier Escaned, Jasvindar Singh, Et Al

Open Access Publications

No abstract provided.


Version 3 Of The Alzheimer Disease Centers’ Neuropsychological Test Battery In The Uniform Data Set (Uds), Sandra Weintraub, John C. Morris, Et Al. Jan 2018

Version 3 Of The Alzheimer Disease Centers’ Neuropsychological Test Battery In The Uniform Data Set (Uds), Sandra Weintraub, John C. Morris, Et Al.

Open Access Publications

No abstract provided.


Evaluation Of Avoralstat, An Oral Kallikrein Inhibitor, In A Phase 3 Hereditary Angioedema Prophylaxis Trial: The Opus-2 Study, M. A. Riedl, H. J. Wedner, Et Al Jan 2018

Evaluation Of Avoralstat, An Oral Kallikrein Inhibitor, In A Phase 3 Hereditary Angioedema Prophylaxis Trial: The Opus-2 Study, M. A. Riedl, H. J. Wedner, Et Al

Open Access Publications

No abstract provided.


Congenital Titinopathy: Comprehensive Characterization And Pathogenic Insights, Emily C. Oates, Alan Pestronk, Anne M. Connolly, Et Al Jan 2018

Congenital Titinopathy: Comprehensive Characterization And Pathogenic Insights, Emily C. Oates, Alan Pestronk, Anne M. Connolly, Et Al

Open Access Publications

No abstract provided.


A Direct Test Of The Diathesis–Stress Model For Depression, L Colodro-Conde, B Couvy-Duchesne, G Zhu, Wl Coventry, Em Byrne, S Gordon, Mj Wright, Gw Montgomery, Paf Madden, Major Depressive Disorder Working Group Of The Psychiatric Genomics Consortium, S Ripke, Lj Eaves, Ac Heath, Nr Wray, Se Medland, Ng Martin Jan 2018

A Direct Test Of The Diathesis–Stress Model For Depression, L Colodro-Conde, B Couvy-Duchesne, G Zhu, Wl Coventry, Em Byrne, S Gordon, Mj Wright, Gw Montgomery, Paf Madden, Major Depressive Disorder Working Group Of The Psychiatric Genomics Consortium, S Ripke, Lj Eaves, Ac Heath, Nr Wray, Se Medland, Ng Martin

Open Access Publications

No abstract provided.


In Vivo Monitoring Of Intracellular Ca2+ Dynamics In The Pancreatic Β-Cells Of Zebrafish Embryos, Reka Lorincz, Christopher H. Emfinger, Andrea Walcher, Michael Giolai, Claudia Krautgasser, Maria S. Remedi, Colin G. Nichols, Dirk Meyer Jan 2018

In Vivo Monitoring Of Intracellular Ca2+ Dynamics In The Pancreatic Β-Cells Of Zebrafish Embryos, Reka Lorincz, Christopher H. Emfinger, Andrea Walcher, Michael Giolai, Claudia Krautgasser, Maria S. Remedi, Colin G. Nichols, Dirk Meyer

Open Access Publications

No abstract provided.


Risk Of Subsequent Joint Arthroplasty In Contralateral Or Different Joint After Index Shoulder, Hip, Or Knee Arthroplasty: Association With Index Joint, Demographics, And Patient-Specific Factors, Joseph D. Lamplot, Anchal Bansal, Joseph T. Nguyen, Robert H. Brophy Jan 2018

Risk Of Subsequent Joint Arthroplasty In Contralateral Or Different Joint After Index Shoulder, Hip, Or Knee Arthroplasty: Association With Index Joint, Demographics, And Patient-Specific Factors, Joseph D. Lamplot, Anchal Bansal, Joseph T. Nguyen, Robert H. Brophy

Open Access Publications

No abstract provided.


Transvaginal Fast-Scanning Optical-Resolution Photoacoustic Endoscopy, Yuan Qu, Chiye Li, Junhui Shi, Ruimin Chen, Song Xu, Hasan Rafsanjani, Konstantin Maslov, Hannah Krigman, Laura Garvey, Peng Hu, Peinan Zhao, Karen Meyers, Emily Diveley, Stephanie Pizzella, Lisa Muench, Nina Punyamurthy, Naomi Goldstein, Oji Onwumere, Mariana Alisio, Kaytelyn Meyenburg, Jennifer Maynard, Kristi Helm, Janessia Slaughter, Sabrina Barber, Tracy Burger, Christine Kramer, Jessica Chubiz, Monica Anderson, Ronald Mccarthy, Sarah K. England, George A. Macones, Qifa Zhou, K. Kirk Shung, Jun Zhou, Molly J. Stout, Methodius Tuuli, Lihong V. Wang Jan 2018

Transvaginal Fast-Scanning Optical-Resolution Photoacoustic Endoscopy, Yuan Qu, Chiye Li, Junhui Shi, Ruimin Chen, Song Xu, Hasan Rafsanjani, Konstantin Maslov, Hannah Krigman, Laura Garvey, Peng Hu, Peinan Zhao, Karen Meyers, Emily Diveley, Stephanie Pizzella, Lisa Muench, Nina Punyamurthy, Naomi Goldstein, Oji Onwumere, Mariana Alisio, Kaytelyn Meyenburg, Jennifer Maynard, Kristi Helm, Janessia Slaughter, Sabrina Barber, Tracy Burger, Christine Kramer, Jessica Chubiz, Monica Anderson, Ronald Mccarthy, Sarah K. England, George A. Macones, Qifa Zhou, K. Kirk Shung, Jun Zhou, Molly J. Stout, Methodius Tuuli, Lihong V. Wang

Open Access Publications

No abstract provided.


Capillaria Ova And Diagnosis Of Trichuris Trichiura Infection In Humans By Kato-Katz Smear, Liberia, Kerstin Fischer, Abakar Gankpala, Lincoln Gankpala, Fatorma K. Bolay, Kurt C. Curtis, Gary J. Weil, Peter U. Fischer Jan 2018

Capillaria Ova And Diagnosis Of Trichuris Trichiura Infection In Humans By Kato-Katz Smear, Liberia, Kerstin Fischer, Abakar Gankpala, Lincoln Gankpala, Fatorma K. Bolay, Kurt C. Curtis, Gary J. Weil, Peter U. Fischer

Open Access Publications

No abstract provided.


Safety Of Overlapping Inpatient Orthopaedic Surgery: A Multicenter Study, Christopher J. Dy, Daniel A. Osei, Travis G. Maak, Michael B. Gottschalk, Alan L. Zhang, Michael D. Maloney, Angela P. Presson, Regis J. O'Keefe Jan 2018

Safety Of Overlapping Inpatient Orthopaedic Surgery: A Multicenter Study, Christopher J. Dy, Daniel A. Osei, Travis G. Maak, Michael B. Gottschalk, Alan L. Zhang, Michael D. Maloney, Angela P. Presson, Regis J. O'Keefe

Open Access Publications

No abstract provided.


Systemic Anti-Cancer Therapy In Synovial Sarcoma: A Systematic Review, Richard F. Riedel, Robin L. Jones, Antoine Italiano, Chet Bohac, Juliette C. Thompson, Kerstin Mueller, Zaeem Khan, Seth M. Pollack, Brian A. Van Tine Jan 2018

Systemic Anti-Cancer Therapy In Synovial Sarcoma: A Systematic Review, Richard F. Riedel, Robin L. Jones, Antoine Italiano, Chet Bohac, Juliette C. Thompson, Kerstin Mueller, Zaeem Khan, Seth M. Pollack, Brian A. Van Tine

Open Access Publications

No abstract provided.


Long‐Term Effects Of Crizotinib In Alk‐Positive Tumors (Excluding Nsclc): A Phase 1b Open‐Label Study, Carlo Gambacorti-Passerini, Brian A. Van Tine, Et Al Jan 2018

Long‐Term Effects Of Crizotinib In Alk‐Positive Tumors (Excluding Nsclc): A Phase 1b Open‐Label Study, Carlo Gambacorti-Passerini, Brian A. Van Tine, Et Al

Open Access Publications

No abstract provided.


Electrocortical Responses To Emotional Stimuli In Psychotic Disorders: Comparing Schizophrenia Spectrum Disorders And Affective Psychosis, Adam J. Culbreth, Dan Foti, Deanna M. Barch, Greg Hajcak, Roman Kotov Jan 2018

Electrocortical Responses To Emotional Stimuli In Psychotic Disorders: Comparing Schizophrenia Spectrum Disorders And Affective Psychosis, Adam J. Culbreth, Dan Foti, Deanna M. Barch, Greg Hajcak, Roman Kotov

Open Access Publications

No abstract provided.


Catheter Removal And Outcomes Of Multidrug-Resistant Central-Line-Associated Bloodstream Infection, Jason P. Burnham, Rebecca P. Rojek, Marin H. Kollef Jan 2018

Catheter Removal And Outcomes Of Multidrug-Resistant Central-Line-Associated Bloodstream Infection, Jason P. Burnham, Rebecca P. Rojek, Marin H. Kollef

Open Access Publications

No abstract provided.


Protein Network Analysis Reveals Selectively Vulnerable Regions And Biological Processes In Ftd, Celeste M. Karch, Natalie Wen, Aaron Ofori-Kuragu Jan 2018

Protein Network Analysis Reveals Selectively Vulnerable Regions And Biological Processes In Ftd, Celeste M. Karch, Natalie Wen, Aaron Ofori-Kuragu

Open Access Publications

No abstract provided.


Shea Neonatal Intensive Care Unit (Nicu) White Paper Series: Practical Approaches To Clostridioides Difficile Prevention, Thomas J. Sandora, Kristina K. Bryant, Joseph B. Cantey, Alexis M. Elward, Deborah S. Yokoe, Allison H. Bartlett Jan 2018

Shea Neonatal Intensive Care Unit (Nicu) White Paper Series: Practical Approaches To Clostridioides Difficile Prevention, Thomas J. Sandora, Kristina K. Bryant, Joseph B. Cantey, Alexis M. Elward, Deborah S. Yokoe, Allison H. Bartlett

Open Access Publications

No abstract provided.


Protein Production Is An Early Biomarker For Rna‐Targeted Therapies, Wade K. Self, Kathleen M. Schoch, Jacob Alex, Nicolas Barthélemy, James G. Bollinger, Chihiro Sato, Tracy Cole, Holly B. Kordasiewicz, Eric Swayze, Randall J. Bateman, Timothy M. Miller Jan 2018

Protein Production Is An Early Biomarker For Rna‐Targeted Therapies, Wade K. Self, Kathleen M. Schoch, Jacob Alex, Nicolas Barthélemy, James G. Bollinger, Chihiro Sato, Tracy Cole, Holly B. Kordasiewicz, Eric Swayze, Randall J. Bateman, Timothy M. Miller

Open Access Publications

No abstract provided.


Utility Of Perfusion Pet Measures To Assess Neuronal Injury In Alzheimer's Disease, Nelly Joseph-Mathurin, Tyler M. Blazey, Mateusz Jasielec, Andrei Vlassenko, Karl Friedrichsen, Brian A. Gordon, Russ C. Hornbeck, Lisa Cash, Beau M. Ances, Virginia Buckles, Nigel J. Cairns, Carlos Cruchaga, Celeste Karch, Daniel S. Marcus, Eric Mcdade, Chengjie Xiong, John C. Morris, Randall J. Bateman, Tammie L.S. Benzinger, Et Al Jan 2018

Utility Of Perfusion Pet Measures To Assess Neuronal Injury In Alzheimer's Disease, Nelly Joseph-Mathurin, Tyler M. Blazey, Mateusz Jasielec, Andrei Vlassenko, Karl Friedrichsen, Brian A. Gordon, Russ C. Hornbeck, Lisa Cash, Beau M. Ances, Virginia Buckles, Nigel J. Cairns, Carlos Cruchaga, Celeste Karch, Daniel S. Marcus, Eric Mcdade, Chengjie Xiong, John C. Morris, Randall J. Bateman, Tammie L.S. Benzinger, Et Al

Open Access Publications

No abstract provided.


Csf Progranulin Increases In The Course Of Alzheimer's Disease And Is Associated With Strem2, Neurodegeneration And Cognitive Decline, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Katrina Paumier, Randall J. Bateman, Anne M. Fagan, John C. Morris, Et Al Jan 2018

Csf Progranulin Increases In The Course Of Alzheimer's Disease And Is Associated With Strem2, Neurodegeneration And Cognitive Decline, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Katrina Paumier, Randall J. Bateman, Anne M. Fagan, John C. Morris, Et Al

Open Access Publications

No abstract provided.


Plasticity Of Differentiated Cells In Wound Repair And Tumorigenesis, Part Ii: Skin And Intestine, Joseph Burclaff, Jason C. Mills Jan 2018

Plasticity Of Differentiated Cells In Wound Repair And Tumorigenesis, Part Ii: Skin And Intestine, Joseph Burclaff, Jason C. Mills

Open Access Publications

No abstract provided.


Cryptococcus Neoformans Cda1 And Its Chitin Deacetylase Activity Are Required For Fungal Pathogenesis, Rajendra Upadhya, Lorina G. Baker, Woei C. Lam, Charles A. Specht, Maureen J. Donlin, Jennifer K. Lodge Jan 2018

Cryptococcus Neoformans Cda1 And Its Chitin Deacetylase Activity Are Required For Fungal Pathogenesis, Rajendra Upadhya, Lorina G. Baker, Woei C. Lam, Charles A. Specht, Maureen J. Donlin, Jennifer K. Lodge

Open Access Publications

No abstract provided.


Automated Real-Time Collection Of Pathogen-Specific Diagnostic Data: Syndromic Infectious Disease Epidemiology, Gregory A. Storch, Et Al Jan 2018

Automated Real-Time Collection Of Pathogen-Specific Diagnostic Data: Syndromic Infectious Disease Epidemiology, Gregory A. Storch, Et Al

Open Access Publications

No abstract provided.


Mouse Microbiota Models: Comparing Germ-Free Mice And Antibiotics Treatment As Tools For Modifying Gut Bacteria, Elizabeth A. Kennedy, Katherine Y. King, Megan T. Baldridge Jan 2018

Mouse Microbiota Models: Comparing Germ-Free Mice And Antibiotics Treatment As Tools For Modifying Gut Bacteria, Elizabeth A. Kennedy, Katherine Y. King, Megan T. Baldridge

Open Access Publications

No abstract provided.