Digital Commons Network^™

Expanding The Use Of Spectral Libraries In Proteomics., Eric W Deutsch, Yasset Perez-Riverol, Robert J Chalkley, Mathias Wilhelm, Stephen Tate, Timo Sachsenberg, Mathias Walzer, Lukas Käll, Bernard Delanghe, Sebastian Böcker, Emma L Schymanski, Paul Wilmes, Viktoria Dorfer, Bernhard Kuster, Pieter-Jan Volders, Nico Jehmlich, Johannes P C Vissers, Dennis W Wolan, Ana Y Wang, Luis Mendoza, Jim Shofstahl, Andrew W Dowsey, Johannes Griss, Reza M Salek, Steffen Neumann, Pierre-Alain Binz, Henry Lam, Juan Antonio Vizcaíno, Nuno Bandeira, Hannes Röst

Articles, Abstracts, and Reports

The 2017 Dagstuhl Seminar on Computational Proteomics provided an opportunity for a broad discussion on the current state and future directions of the generation and use of peptide tandem mass spectrometry spectral libraries. Their use in proteomics is growing slowly, but there are multiple challenges in the field that must be addressed to further increase the adoption of spectral libraries and related techniques. The primary bottlenecks are the paucity of high quality and comprehensive libraries and the general difficulty of adopting spectral library searching into existing workflows. There are several existing spectral library formats, but none captures a satisfactory level …

Flexible And Fast Mapping Of Peptides To A Proteome With Proteomapper., Luis Mendoza, Eric W Deutsch, Zhi Sun, David S Campbell, David Shteynberg, Robert L Moritz

Articles, Abstracts, and Reports

Bottom-up proteomics relies on the proteolytic or chemical cleavage of proteins into peptides, the identification of those peptides via mass spectrometry, and the mapping of the identified peptides back to the reference proteome to infer which possible proteins are identified. Reliable mapping of peptides to proteins still poses substantial challenges when considering similar proteins, protein families, splice isoforms, sequence variation, and possible residue mass modifications, combined with an imperfect and incomplete understanding of the proteome. The ProteoMapper tool enables a comprehensive and rapid mapping of peptides to a reference proteome. The indexer component creates a segmented index for an input …

American Dream Gone Wrong: Patricia Highsmith’S Dark Suburban Domesticity, Katie Liggett

Honors Projects

This thesis explores how Patricia Highsmith’s novels, The Blunderer and Deep Water, critique the American suburbs and show how the American Dream is more of a fantasy, than a realistic goal that people can achieve. Her novels reveal how the American dream becomes unattainable, or one’s pursuit of it somehow goes wrong, leaving their lives unfulfilled and them resentful. Furthermore, I argue that the American Dream, itself, goes wrong for some individuals, and the pursuit of this unrealistic Dream can lead individuals to trouble in their personal or professional lives. Ultimately, through my analysis of Highsmith’s texts, it becomes …

The Shifting Politics Of Patient Activism: From Bio-Sociality To Bio-Digital Citizenship, Alison Anderson, Alan Petersen, Allegra Clare Schermuly

School of Law, Humanities and Social Sciences

Digital media provide novel tools for patient activists from disease- and condition-specific communities. While those with debilitating conditions or disabilities have long recognised the value of collective action for advancing their interests, digital media offers activists unparalleled opportunities to fulfil their goals. This article explores the shifting politics of ‘activism’ in the increasingly digitally mediated, commercialised context of healthcare, asking: what role have digital media played in the repertoire of activists’ strategies? And, to what extent and how has the use of such media impacted the very concept of activism? Building on sociological ideas on emergent forms of ‘biological citizenship’ …

Lindenwood Digest, December 7, 2018, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

Identification Of Experimental And Control Areas For Cctv Effectiveness Assessment—The Issue Of Spatially Aggregated Data, Adam Dabrowski, Piotr Matczak, Andrzej Wójtowicz, Michael Leitner

Faculty Publications

Progress in surveillance technology has led to the development of Closed-Circuit Television (CCTV) systems in cities around the world. Cameras are considered instrumental in crime reduction, yet existing research does not unambiguously answer the question whether installing them affects the number of crimes committed. The quasi-experimental method usually applied to evaluate CCTV systems’ effectiveness faces difficulties with data quantity and quality. Data quantity has a bearing on the number of crimes that can be conclusively inferred using the experimental procedure. Data quality affects the level of crime data aggregation. The lack of the exact location of a crime incident in …

The Nature Of Ephemeral Secrets In Reverse Engineering Tasks, Antonio Miguel Espinoza

Computer Science ETDs

Reverse engineering is typically carried out on static binary objects, such as files or compiled programs. Often the goal of reverse engineering is to extract a secret that is ephemeral and only exists while the system is running. Automation and dynamic analysis enable reverse engineers to extract ephemeral secrets from dynamic systems, obviating the need for analyzing static artifacts such as executable binaries.

I support this thesis through four automated reverse engineering efforts: (1) named entity extraction to track Chinese Internet censorship based on keywords; (2) dynamic information flow tracking to locate secret keys in memory for a live program; …

How Student Loans Affect College Students With Regional Analysis, Brandon E. Kavaliunas

Honors Capstones

With the burden of student debt growing, it is important to study how this increasing debt is affecting individuals and look at the impact it has on the nation as a whole. By analyzing statewide data and comparing the different states, we can try to find what states are doing well, and begin to look at how we can improve in states that have an increased amount of student debt. Different regions were found to have varying amounts of debt. A linear regression model was used to test if the average amount of debt per state is affected by per …

Kenyon Collegiate - December 7, 2018

Kenyon Collegiate

No abstract provided.

Ohio Staff Learn And Practice Emergency Preparedness (December 7, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Facilities Website User Survey Deadline Is Dec. 21 (December 7, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Global Perspectives Faculty Learning Community Returns In Spring (December 7, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Adaptation Mechanism And Tolerance Of Rhodopseudomonas Palustris Psb-S Under Pyrazosulfuron-Ethyl Stress, Xiang-Wen Luo, De-Yang Zhang, Teng-Hui Zhu, Xuguo Zhou, Jing Peng, Song-Bai Zhang, Yong Liu

Entomology Faculty Publications

Background: Pyrazosulfuron-ethyl is a long lasting herbicide in the agro-ecosystem and its residue is toxic to crops and other non-target organisms. A better understanding of molecular basis in pyrazosulfuron-ethyl tolerant organisms will shed light on the adaptive mechanisms to this herbicide.

Results: Pyrazosulfuron-ethyl inhibited biomass production in Rhodopseudomonas palustris PSB-S, altered cell morphology, suppressed flagella formation, and reduced pigment biosynthesis through significant suppression of carotenoids biosynthesis. A total of 1127 protein spots were detected in the two-dimensional gel electrophoresis. Among them, 72 spots representing 56 different proteins were found to be differently expressed using MALDI-TOF/TOF-MS, including 26 up- and 30 …

A Hierarchical Spectrum Access Scheme For Tv White Space Coexistence In Hetergeneous Networks, Mohammad Zaeri-Amirani, Fatemeh Afghah, Sherali Zeadally

Information Science Faculty Publications

Among current techniques for dynamic access to television (TV) white space (TVWS), geolocation database-based access provides a promising performance in protecting the TV-band incumbents from interference that cannot be efficiently achieved in other license-exempt models. However, in heterogeneous wireless networks, most portable devices do not have such access and may cause interference to TV incumbents. We propose a hierarchical model for spectrum sharing in TVWS that includes a wide range of fixed and portable devices. In the first tier, the TV broadcaster can lease the spectrum bands to local fixed users based on a soft license agreement. The fixed users …

Religious Motivation, Priming And Their Effects On Sexist Language, Bridget Bard, Hank Rothgerber

Undergraduate Theses

This experiment delves into the potential effects of sexist language used in the Christian religious context on increased use of sexist language, and endorsement of sexism on an individual level. In order to demonstrate a relationship between these two variables, an experiment was designed. Participants were exposed to either a religious or neutral priming session and were then immediately asked to complete several scales and measures of sexist language, sexism, and their level of intrinsic religious motivation. The hypothesis was that participants who ranked lower on intrinsic religious motivation, and who received a religious prime, would generate increased sexist language …

The Daily Gamecock, Semester In Review, Fall 2018, University Of South Carolina, Office Of Student Media

December

No abstract provided.

Exploring Principals' Perceptions About Efficacy In Arizona Urban Schools Designated For The School Improvement Process, Charlotte Patterson

Seton Hall University Dissertations and Theses (ETDs)

Studies have determined a positive relationship exists between the self-efficacy of students and academic achievement, and teacher efficacy and student achievement. For over a decade schools have been publicly targeted for school improvement in a process with implications for efficacy. The purpose of this qualitative study was to determine if principals’ perceptions about efficacy impacted their practices leading school improvement. Principals’ responses to two research questions led this study:

1. How do principals describe their perceptions about the efficacy of their school community relative to the school improvement status, label, or rating for their school?

2. How do principals describe …

Whalesong 2018-12-07, Erin Laughlin, Kortney Stevens, Jordan Lewis, Sierra Lissick, Caitlin Burnham, Khrystl Brouillette, Melissa Scriven, Alyssa Madrid

Whalesong

No abstract provided.

Disparity Does Not Mean Bias: Making Sense Of Observed Racial Disparities In Fatal Officer-Involved Shootings With Multiple Benchmarks, Brandon Tregle, Justin Nix, Geoffrey P. Alpert

Criminology and Criminal Justice Faculty Publications

Racial disparities in officer-involved shootings have dominated the national discourse recently. Unfortunately, we have yet to identify an appropriate benchmark, or at-risk population, to put these observed racial disparities into context. In this article, we use seven benchmarks—based on population data from the US Census, police-citizen interaction data from the Police-Public Contact Survey, and arrest data from the Uniform Crime Report—to compare OIS fatality rates for black and white citizens from 2015 to 2017. Using population, police-citizen interactions, or total arrests as a benchmark, we observe that black citizens appear more likely than white citizens to be fatally shot by …

Nature Economy Fact Sheet #1 12.7.18_Final, Shannon Rogers

UNH Cooperative Extension

No abstract provided.

How To Turn Down Political Heat On Supreme Court And Federal Judges: Stop Signing Opinions, Scott S. Boddery

Political Science Faculty Publications

Chief Justice John Roberts rightly — albeit in an uncharacteristically direct manner — defended the integrity of the federal judiciary and its members from a direct affront from the president of the United States. Roberts’s defense sent President Donald Trump atwitter in a series of messages that doubled down on his previous ridicule of an “Obama Judge” from the “total disaster” Ninth Circuit Court of Appeals. [except]

Audit Of The Exchange Stabilization Fund's Financial Statements For The Fiscal Years 2018 And 2017, United States: Department Of The Treasury: Office Of The Inspector General

Documents

No abstract provided.

Haiti And The Uses Of America: Post-U.S. Occupation Promises, By Chantalle F. Verna, Matthew Casey

Faculty Publications

No abstract provided.

Postoperative Pain In Instrumented Spinal Surgery: A Policy For Intraoperative Dexmedetomidine Use, Clinton Whitley

Doctoral Projects

Instrumented multilevel spine surgery is associated with a large amount of opioid consumption, difficult mobilization, and significant pain in a population of patients who are predominantly already chronic pain sufferers (Mathiesen et al., 2013). The Health Resources and Services Administration (2018) recently claimed that our nation is in the midst of an opioid epidemic, with more than 115 opioid-related deaths occurring every year. As a result of this epidemic, many anesthesia providers have become aware and are attempting to do something about it. Organizations such as the Society for Opioid Free Anesthesia are at the forefront of the battle against …

Helping Children Overcome Reading Difficulties Using Response To Intervention, Corinne M. Sannino

Theses and Dissertations

The purpose of this qualitative study was to determine if Argryis and Schon's (1974) Theory-of-Action framework could be used as a viable professional development tool to improve teachers' professional practices when providing Tier II literacy interventions within the context of a Response to Intervention (RTI) program in an elementary school. This multicase study sought to understand more deeply the espoused beliefs and theories-in-use of four elementary literacy interventionists' when delivering intensive literacy interventions to students not reading on grade level within the context of the RTI program by using semi-structured interviews, collection of student work, and classroom observations. Discrepancies were …

Commencement Ceremonies, University Of North Florida

Commencement Printed Materials

Program for the Fall Commencement ceremonies.

Solvent Stable Microbial Lipases: Current Understanding And Biotechnological Applications, Barry Ryan, Priyanka Priyanka, Yeqi Tan, Gemma K Kinsella, Gary T. Henehan

Articles

Objective: This review examines on our current understanding of microbial lipase solvent tolerance, with a specific focus on the molecular strategies employed to improve lipase stability in a non-aqueous environment.

Results: It provides an overview of known solvent tolerant lipases and of approaches to improving solvent stability such as; enhancing stabilising interactions, modification of residue flexibility and surface charge alteration. It shows that judicious selection of lipase source supplemented by appropriate enzyme stabilisation, can lead to a wide application spectrum for lipases.

Conclusion: Organic solvent stable lipases are, and will continue to be, versatile and adaptable biocatalytic workhorses commonly employed …

Higher Education Reform: A Time For Action, The Lincy Institute

Brookings Scholar Lecture Series

The Lincy Institute has been at the forefront of research and analysis on higher education governance reform in Nevada. Following numerous statewide studies, The Lincy Institute has produced reports and policy briefs recommending significant structural changes to the State’s higher education landscape. To provide future generations of students with quality education and training in our 21st-century economy, researchers summarized findings and presented model legislation to improve the quality of education offered by Nevada’s eight institutions of higher learning. All Nevadans should demand an honest and transparent discussion of higher education reform. The 2019 legislative session will be a time for …

Scrud, Cy Robinson

USU Student Folklore Fieldwork

Equipment: a pool table and two billiard balls

The object of the game is to be the last player at the billiards table. You are no longer an eligible player if you have received 4 letters (the amount of letters can change to the groups liking)

Starting the game:

To start the game the object ball is placed in the center of the table between the second diamonds, (the position called the kitchen in normal pool) The game starts with everyone standing around the table, this determines the throwing order. Each individual throws after the person on their right. So …

Desecration With A Wonderful Meaning, Alexa Bills

USU Student Folklore Fieldwork

The Semi Colon tattoo is a part of a movement for mental health awareness. The punctuation mark is used when you can choose to end a sentence but decide not to. The tattoo has a similar meaning. It’s meant to indicate that you have power over yourself and can decide what happens. You can choose to continue your story. It’s also a symbol of comradery amongst those who have suffered from depression. A lot of people have this tattoo, a lot of people have struggled with their mental health. And seeing that, seeing people with similar struggles, people that have …