Digital Commons Network^™

Side Chain Modifications To Improve Peptide Structure–Activity Relations, Neelam Lahankar

Seton Hall University Dissertations and Theses (ETDs)

While natural peptides, are ideal starting points for peptide-based drug design and development, they suffer from high conformational instability, which results in susceptibility to proteolytic degradation and poor bioavailability. Peptidomimetics in recent years has helped circumvent these shortcomings by improving the pharmacological properties of polypeptides. Peptidomimetics contain essential elements (pharmacophores) that mimic a natural peptide or protein in 3D space and retain the ability to interact with the biological target producing the same biological effect. In contrast, they offer conformationally restricted structures, potentially minimizing cross-target interactions, which leads to better transport properties through biologic membranes and resistance to immune responses. …

Wave Energy In America, Chris Sukstorf

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

The United States has an untapped energy goldmine: our shores. According to the National Oceanic and Atmospheric Administration (NOAA), the United States his home to over 95,000 miles of shoreline. This shoreline is home to beaches, homes, and wildlife, but it could be home to more: wave energy.

Wave energy comes in many forms: some use the bobbing up and down motion of waves to generate energy in a similar motion of a piston; others store water during high tide and then release it during low tide like a dam. All said and done, the United States has the ability …

Why Lincoln Needs To Get Ahead Of The Emerald Ash Borer Outbreak, Bryce Meyer

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

The emerald ash borer was recently sighted in Lincoln, Nebraska this August. This was to be expected as they were also located in Douglas and Cass county. The emerald ash borer has been making its way west from Michigan and has also been detected in 61 counties in Iowa.

The emerald ash borer is a metallic green colored beetle that feeds on green ash, black ash, blue ash, and white ash trees. The insect can kill up to 99% of the ash trees that they come in contact with. The beetle is native to north-eastern Asia and is considered an …

“On-Bill Financing: A Bright Idea For Nebraska”, Lauren Taylor

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

In over 29 states, a program called On-Bill Financing (OBF) is being utilized to improve the energy efficiency of homes and livelihoods of the people living in them. These programs have been implemented all over the country for many years, in states like Colorado, Hawaii, Iowa, and Michigan. According to the Environmental and Energy Study Institute (EESI), OBF has been wildly successful, reducing energy inefficiency, cutting energy bills, and improving the comfort of homes across the country with no upfront costs.

But what exactly is this mysterious money-saving program, and why hasn’t Nebraska tapped into it yet?

The Department of …

Looking At The True Costs Of Environmental Degradation, Zachery Sehnert

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

Progress is why we change, and innovation drives that progress. It is already very clear to scientists around the globe that our current framework for living is not sustainable. 97 percent of climate scientists are in consensus that there is a major threat to our ecosystem and action needs to be taken. Overpopulation, pollution, water scarcity, natural disasters, overfishing, deforestation are all issues that must be reevaluated with sustainability in mind. However only 49 percent of the general population share this belief, and even less, only 29 percent of CEOs are actively addressing climate change. The shortcoming for the general …

“Renewable Energy Implementation”, William Newcomb

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

Finding and providing ways to produce energy in an environmentally clean way is becoming a major push for countries all around the world today. Renewable energy provides a clean way to produce energy efficiently without using our planets non-renewable resources. Renewable energy has been growing substantially in the United States in the last decade and is making its way towards becoming a major energy production method. So, what is stopping the United States from implementing renewable energy production into our country at a mass scale?

There are many barriers that are keeping renewable energy from becoming a main source of …

Nebraska’S Public Power Is Proof That Renewables Are (Literally) In The Public’S Best Interest, Jacob Monti

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

Nebraska is the only state that has every electric utility publicly owned. This gives Nebraska a unique advantage of serving its customers rather than out-of-state shareholders. Since the goal is cheap power instead of profit margins and keeping shareholders happy, Nebraska rates are 16.8% below the national average. (EIA.gov)

So what does that mean for Renewable sources of electricity if cheap power is the main focus? Does cheap but dirty coal reign supreme?

Some might think that’d be a death blow for Renewables. Renewables (wind, solar, and hydro-electric power) are expensive and not profitable, right? WRONG.

Renewables make up just …

Lift On E15 Ban: Should Nebraskan Farmers Be Cheering?, Samantha Wattier

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

The common gasoline-ethanol mixture available at gas station pumps is 10% ethanol (E10). The Environmental Protection Agency had a ban on 15% ethanol (E15) during summer months. The news has been covering the talks of President Trump to lifting this summer ban and supporters in Iowa are excited.

Should Nebraska shout Hoorah, too? It is common knowledge Nebraska is better than Iowa. We should be excited, too, right?! NO.

Iowa has been tracking Fuel Revenue sales including those from ethanol blends and has been pushing for the E15 ban lift. Considering Iowa produces MORE corn and MORE ethanol than …

Recycling Just Got More Expensive. Can It Be Done Better?, Zachery Homolka

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

There was a time in history that America led the world in recycling. In World War Two, Americans were asked to recycle tin, steel, paper, and rubber for the war effort. The University of Southern Carolina states that children were so eager to participate, they went door to door collecting recyclable scraps to turn in to be made into tanks, planes, and ammunition. Yet, in 2017 the National Geographic estimated about 91% of plastic produced globally has not been recycled and instead is landfilled or littered into the environment. America is no longer leading the recycling charge, the World Economic …

Social Change For A Global Problem, Isabella Catalano

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

Recently, the United Nations' International Panel on Climate Change (IPCC) released a new report[1], warning us that storms are becoming more volatile, sea surface temperatures are getting higher, global environment as a whole growing less predictable: in other words, things are about to get a whole lot worse than we predicted.

Unless, of course, we do something about it. The IPCC recommends cutting CO₂ emissions by 45% in order to curb just the worst of climate change's many effects.

There are a plethora of articles on the topic of just what, exactly, we as individuals can do: …

Interference And Control Of The Nosocomial Transmission Of Methicillin-Resistant Staphylococcus Aureus, Sen Pei, Flaviano Morone, Fredrik Liljeros, Hernan Makse, Jeffrey L. Shaman

Publications and Research

Methicillin-resistant Staphylococcus aureus (MRSA) is a continued threat to human health in both community and healthcare settings. In hospitals, control efforts would benefit from accurate estimation of asymptomatic colonization and infection importation rates from the community. However, developing such estimates remains challenging due to limited observation of colonization and complicated transmission dynamics within hospitals and the community. Here, we develop an inference framework that can estimate these key quantities by combining statistical filtering techniques, an agent-based model, and real-world patient-to-patient contact networks, and use this framework to infer nosocomial transmission and infection importation over an outbreak spanning 6 years in …

Moral Philosophy: A Contemporary Introduction, Daniel R. Denicola

Gettysburg College Faculty Books

Moral Philosophy: A Contemporary Introduction is a compact yet comprehensive book offering an explication and critique of the major theories that have shaped philosophical ethics. Engaging with both historical and contemporary figures, this book explores the scope, limits, and requirements of morality. DeNicola traces our various attempts to ground morality: in nature, in religion, in culture, in social contracts, and in aspects of the human person such as reason, emotions, caring, and intuition.

12-18-2018 Wright Family Scholarship Fund Established At Swosu, Southwestern Oklahoma State University

THE BARK ARCHIVE 2018

Southwestern Oklahoma State University (SWOSU) with locations in Weatherford and Sayre has announced the creation of the Wright Family Scholarship Fund.

Determination Of Chemical Speciation Of Arsenic And Selenium In High-As Coal Combustion Ash By X-Ray Photoelectron Spectroscopy: Examples From A Kentucky Stoker Ash, Biao Fu, James C. Hower, Shifeng Dai, Sarah M. Mardon, Guijian Liu

Center for Applied Energy Research Faculty and Staff Publications

Knowledge of the chemical speciation of arsenic and selenium in coal fly ash is essential in the evaluation of the environmental behavior of fly ash disposed in a landfill in a natural environment. In this study, a series of high-As coal fly ash from stoker boilers were collected to determine the chemical forms of arsenic and selenium. The ash surface chemical characteristics and the speciation of arsenic and selenium were characterized by X-ray photoelectron spectroscopy and X-ray-induced Auger electron spectroscopy. The results indicate that the surface enrichment ratio for selenium (63.3–309.5) is higher than that of arsenic (1.2–21.2). The Wagner …

Predator Cues Increase Silkmoth Mortality, Alex K. Baranowski, Evan L. Preisser

Biological Sciences Faculty Publications

While prey responses to predators reduce the threat of consumption, the physiological costs of these responses can be considerable. This is especially true for organisms that lack effective anti-predator defenses and must rely on camouflage or mimicry for protection. The luna moth, Actias luna, is a large saturniid native to Eastern North America that is preyed on and parasitized by a wide variety of predators and parasitoids. We report the results of two separate experiments assessing the responses of Actias larvae to predatory wasps (Vespula maculifrons) that were rendered non-lethal but remained able to move freely, as …

Virtual Robot Climbing Using Reinforcement Learning, Ujjawal Garg

Master's Projects

Reinforcement Learning (RL) is a field of Artificial Intelligence that has gained a lot of attention in recent years. In this project, RL research was used to design and train an agent to climb and navigate through an environment with slopes. We compared and evaluated the performance of two state-of-the-art reinforcement learning algorithms for locomotion related tasks, Deep Deterministic Policy Gradients (DDPG) and Trust Region Policy Optimisation (TRPO). We observed that, on an average, training with TRPO was three times faster than DDPG, and also much more stable for the locomotion control tasks that we experimented. We conducted experiments and …

Deep Visual Recommendation System, Raksha Sunil

Master's Projects

Recommendation system is a filtering system that predicts ratings or preferences that a user might have. Recommendation system is an evolved form of our trivial information retrieval systems. In this paper, we present a technique to solve new item cold start problem. New item cold start problem occurs when a new item is added to a shopping website like Amazon.com. There is no metadata for this item, no ratings and no reviews because it’s a new item in the system. Absence of data results in no recommendation or bad recommendations. Our approach to solve new item cold start problem requires …

Uncovering The Voices That Have Been Silenced: How The Cherokee Young Women Are Continuing The Traditions Of Their Ancestors Through Literature And Rhetoric, Carly L. Callister

Student Works

When the Cherokee women, back in 1817, first heard the news that they were being stripped of their lands and being forced to journey through the Trail of Tears, they decided to fight for what was right by speaking up and using their voices to be heard around the world. They created petitions and speeches, explaining their love for their people, motherhood, and the land, and how it was “their duty as mothers” to fight for the right to stay in the southeastern part of the United States (Lauter 2399). Though the Cherokee women’s voices were silenced when their petitions …

Quantifying Mg 2+ Binding To Ssdna Oligomers: A Self-Consistent Field Theory Study At Varying Ionic Strengths And Grafting Densities, Merina Jahan, Mark J. Uline

Faculty Publications

The performance of aptamer-based biosensors is crucially impacted by their interactions with physiological metal ions, which can alter their structures and chemical properties. Therefore, elucidating the nature of these interactions carries the utmost importance in the robust design of highly efficient biosensors. We investigated Mg ²⁺ binding to varying sequences of polymers to capture the effects of ionic strength and grafting density on ion binding and molecular reorganization of the polymer layer. The polymers are modeled as ssDNA aptamers using a self-consistent field theory, which accounts for non-covalent ion binding by integrating experimentally-derived binding constants. Our model captures the typical …

Longitudinal Chromatic Aberration And Polychromatic Image Quality Metrics Of Intraocular Lenses, G Łabuz, E Papadatou, R Khoramnia, Gu Auffarth

School of Health Professions

PURPOSE:To measure longitudinal chromatic aberration (LCA) of various intraocular lenses (IOLs) and to assess LCA effects on polychromatic image quality with a focus on multifocal IOL designs. METHODS:The LCA values of four multifocal IOL models (three diffractive models: AT LARA 829MP and AT LISA 809M [both from Carl Zeiss Meditec AG, Jena, Germany] and Restor SN6AD1 [Alcon Laboratories, Inc., Fort Worth, TX] and one refractive model [Mini Well Ready; SIFI Medtech, Sant'Antonio, Italy]) were compared with that of their monofocal counterparts. Optical properties were assessed using an optical bench device with spectral filters. LCA was calculated as a difference of …

Spoil Type Influences Soil Genesis And Forest Development On An Appalachian Surface Coal Mine Ten Years After Placement, Kenton L. Sena, Carmen T. Agouridis, Jarrod Miller, Christopher D. Barton

Lewis Honors College Faculty Publications

Surface mining for coal (or other mineral resources) is a major driver of land-use change around the world and especially in the Appalachian region of the United States. Intentional and well-informed reclamation of surface-mined land is critical for the restoration of healthy ecosystems on these disturbed sites. In Appalachia, the pre-mining land cover is predominately mixed hardwood forest, with rich species diversity. In recent years, Appalachian mine reforestation has become an issue of concern, prompting the development of the Forestry Reclamation Approach, a series of mine reforestation recommendations. One of these recommendations is to use the best available soil substitute; …

Meditation On The Soles Of The Feet Practice Provides Some Control Of Aggression For Individuals With Alzheimer’S Disease, Nirbhay N. Singh, Giulio E. Lancioni, Oleg N. Medvedev, Rachel E. Myers

Faculty Articles

Alzheimer’s disease is a progressive neurodegenerative condition that affects cognition, mental and physical health, and functionality of older people. As the disease progresses from the mild to moderate stage, there is a concomitant increase in several behavioral variables, chiefly agitation, anger, and aggression. Currently, there are no evidence-based treatments for these behaviors in this population. Three individuals with moderate Alzheimer’s disease were taught an informal mindfulness practice, meditation on the Soles of the Feet (SoF), as a self-management strategy within a multiple-baseline design across participants. All three were able to learn and use the SoF practice to manage their verbal …

State V. Osborn Clerk's Record Dckt. 46389

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Methods, Antibodies, And Vaccines Utilizing Epitopes Of Alpha Synuclein For Treatment Of Parkinsons Disease, Chuanhai Cao, Xiaoyang Lin

USF Patents

The present invention pertains to a dendritic cell-based vaccine against rh-α-Syn, α-synuclein specific peptide antibodies and related vaccines, and methods of treating, preventing, and/or vaccinating against Parkinson's Disease (PD), or symptoms thereof.

Micromechanical Devices Based On Piezoelectric Resonators, I-Tsang Wu, Julio Mario Dewdney, Jing Wang

USF Patents

A piezoelectrically transduced resonator device includes a wafer having a substrate, a buried oxide layer formed on the substrate, and a device layer formed on the buried oxide layer, and a resonator suspended within an air gap of the wafer above the substrate, the resonator including a portion of the device layer, a piezoelectric layer, and top and bottom electrodes contacting top and bottom sides of the piezoelectric layer, wherein the portion of the device layer is not directly connected to the wafer and wherein the resonator is configured to move relative to the substrate under electrostatic force to tune …

Detecting Radio Agn Signatures In Red Geysers, Namrata Roy, Kevin Bundy, Wiphu Rujopakarn, Michele Cappellari, Francesco Belfiore, Renbin Yan, Tim Heckman, Matthew Bershady, Jenny Greene, Kyle Westfall, Niv Drory, Kate Rubin, David Law, Kai Zhang, Joseph Gelfand, Dmitry Bizyaev, David Wake, Karen Masters, Daniel Thomas, Cheng Li, Rogemar A. Riffel

Physics and Astronomy Faculty Publications

A new class of quiescent galaxies harboring possible AGN-driven winds has been discovered using spatially resolved optical spectroscopy from the ongoing SDSS-IV MaNGA survey. These galaxies, termed "red geysers," constitute 5%–10% of the local quiescent population and are characterized by narrow bisymmetric patterns in ionized gas emission features. Cheung et al. argued that these galaxies host large-scale AGN-driven winds that may play a role in suppressing star formation at late times. In this work, we test the hypothesis that AGN activity is ultimately responsible for the red geyser phenomenon. We compare the nuclear radio activity of the red geysers to …

Unique Major A 'Godsend' For Chsp Graduate (December 18, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

The Medieval Best-Seller: Part Ii, Jillian Ewalt

Marian Library Blog Archive

Ever wondered what the Nativity looked like to Medieval eyes? Why is Mary always on the left (... and frequently blond)? And what does Bridget of Sweden have to do with it?

Magmatic Response To Subduction Initiation: Part 1. Fore-Arc Basalts Of The Izu-Bonin Arc From Iodp Expedition 352, John W. Shervais, Mark Reagan, Emily A. Haugen, Renat R. Almeev, Julian A. Pearce, Julie Prytulak, Jeffrey G. Ryan, Scott A. Whattam, Marguerite Godard, Timothy Chapman, Hongyan Li, Walter Kurz, Wendy R. Nelson, Daniel Heaton, Maria Kirchenbaur, Kenji Shimizu, Tetsuya Sakuyama, Yibing Li, Scott K. Vetter

Geosciences Faculty Publications

The Izu-Bonin-Mariana (IBM) fore arc preserves igneous rock assemblages that formed during subduction initiation circa 52 Ma. International Ocean Discovery Program (IODP) Expedition 352 cored four sites in the fore arc near the Ogasawara Plateau in order to document the magmatic response to subduction initiation and the physical, petrologic, and chemical stratigraphy of a nascent subduction zone. Two of these sites (U1440 and U1441) are underlain by fore-arc basalt (FAB). FABs have mid-ocean ridge basalt (MORB)-like compositions, however, FAB are consistently lower in the high-field strength elements (TiO2, P2O5, Zr) and Ni compared to MORB, with Na2O at the low …

Magnetic Field-Driven Convection For Directed Surface Patterning Of Colloids, Jin Gyun Lee, Vanel Porter, William A. Shelton, Bhuvnesh Bharti

Faculty Publications

Drying sessile droplets is a promising route to transform colloidal dispersions into surface coatings, which are widely used in material design and biochemical detection. However, directing the assembly of the particles within drying droplets and achieving surface patterns beyond the well-known coffee-ring formation remain a challenge. Here, we present a new principle of directing the assembly of nonmagnetic colloidal particles dispersed in a magnetic fluid and generating unusual surface patterns. We use the ability of ferrofluids to change phases with the application of magnetic fields to program the assembly of nonmagnetic microparticles present in drying sessile droplets. We show that …