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Mechanisms And Potential Therapy On Disrupted Blood Pressure Circadian Rhythm In Diabetes, Tianfei Hou

Theses and Dissertations--Pharmacology and Nutritional Sciences

Arterial blood pressure (BP) undergoes a 24-hour oscillation that peaks in the active day and reaches a nadir at night during sleep in humans. Reduced nocturnal BP fall (also known as non-dipper) is the most common disruption of BP circadian rhythm and is associated with increased risk of untoward cardiovascular events and target organ injury. Up to 75% of diabetic patients are non-dippers. However, the mechanisms underlying diabetes associated non-dipping BP are largely unknown. To address this important question, we generated a novel diabetic db/db-mPer2^Luc mouse model (db/db-mPer2^Luc) that allows quantitatively measuring of mPER2 protein oscillation …

Chemical Composition And Suitability Of Some Turkish Thermal Muds As Peloids, Muazzez Çeli̇k Karakaya, Necati̇ Karakaya

Turkish Journal of Earth Sciences

Thermal muds have been used in many spas for the treatment of different diseases as well as to clean and beautify the skin and in different forms such as mud baths, masks, and cataplasms. Mineralogical and chemical compositions and the possible toxicity of the peloids were investigated and compared with some limits to determine whether they have any health benefits and potential applications for pelotherapeutic treatments. The studied peloid samples were collected from 19 spas in different parts of Turkey and they were classified as neutral to slightly alkaline, with a high electrical conductivity value that had a high chlorine …

Vulnerability And The Intergenerational Transmission Of Psychosocial Harm, Isabel Karpin

Emory Law Journal

In the field of science known as the developmental origins of health and disease (DOHaD), there is an emergent body of research examining the biological impact of the psychosocial dimension of harm resulting from sexual and physical abuse. A particular focus has been the way these assaults, when enacted against women, cause levels of stress that can have a biological impact on their future children. In the following Parts, I take a close look at scientific studies that reveal an intergenerational impact resulting from harms perpetrated on a woman prior to the conception and birth of her children, with a …

Endocrine And Hematobiochemical Profile Of Lambs Raised In A Semiaridregion With Different Growth Potentials During The Postweaning Period, Shiva Pratap Singh, Gopal Dass, Ramachandran Natesan, Yogender Kushwah, Nandini Sharma, Ashok Kumar

Turkish Journal of Veterinary & Animal Sciences

This study was conducted for establishment of the relationship of blood variables with growth rate of postweaned lambs. Eight lambs each of fast growth (FG; 11.6 ± 0.5 kg live wt. at weaning) and slow growth (SG; 7.7 ± 0.5 kg live wt. at weaning) were monitored fortnightly for endocrine and hematobiochemical variables along with parasitic load and growth performance. Recording of body weight (BW) and average daily gain (ADG) was performed monthly from birth to 180 days. Triiodothyronine (T3) and thyroxine (T4) were significantly (P < 0.05) higher while thyroid-stimulating hormone (TSH) and insulin-like growth factor-1 (IGF-1) were significantly (P < 0.05) lower in FG lambs compared to SG lambs. Blood cell counts, hematocrit, hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin were significantly (P < 0.05) higher in FG lambs compared to SG lambs. Except for the birth wt., the BW and ADG of FG lambs were significantly (P < 0.05) higher at all time points. Liver enzymes (alkaline phosphatase and alanine aminotransferase) and triglyceride were significantly (P < 0.05) higher in SG lambs compared to FG lambs. These findings indicate a significant influence of growth rate on peripheral concentrations of endocrine and some hematobiochemical variables in lambs. These selected variables can be used for early identification and culling of slow-growing lambs for better economic return to lamb producers.

Comparison Of Pre- And Postpartum Serum Leptin, Ghrelin, And Lipid Levels In Sheep, Ethem Mutlu Temi̇zel, Hüseyi̇n Ci̇han, Pinar Levent, Ahmet Saril, Yeşi̇m Özarda, Zeki̇ Yilmaz

Turkish Journal of Veterinary & Animal Sciences

Serum leptin and ghrelin play important roles in energy metabolism and inducing appetite during pregnancy and lactation. We investigated the serum levels of leptin and ghrelin and their relationship with the duration of lactation and serum biochemical responses during the prepartum (last week before lambing) and postpartum periods in sheep. They were also evaluated between pregnant and nonpregnant (control ewes) ewes. For these purposes, pregnant (n = 15) and control Awassi ewes (n = 15) that were 2 years of age were used in this study. Blood samples were collected 1 week before the expected date of lambing (baseline) and …

Alterations Of Circulating Cortisol, Igf-1, And Thyroid Hormones In Darehshori Horses During A Year, Aliasghar Chalmeh, Mehrdad Pourjafar, Khalil Badiei, Mohammad Mazrouei Sebdani, Ali Sadeghpour, Hasan Sheikhi, Ali Khezri

Turkish Journal of Veterinary & Animal Sciences

Season may be considered as a factor that affects the equine endocrine profile. Hence, from January to November 2015, 27 clinically healthy adult Darehshori racehorses were selected. Thirteen of them were stallions and the others were mares. Ten of them were more than 10 years old and 17 horses were under the age of 10 years. None of them were pregnant or lactating during the study. Body condition scores of 12 horses were below and the others were above 5. Blood samplings and body condition score evaluations were performed every 45 days during a year. Serum levels of cortisol, IGF-1, …

Investigation Of The Efficiency And Safety Of Tilmicosin Phosphate In Treating Experimentalmycoplasmal Infections In Pigs, Xiaohui Zhang, Jinzhe Pan, Ning Wu, Shu Tang, Xiangdong Lei, Yangyang Sun, Joerg Hartung, Endong Bao

Turkish Journal of Veterinary & Animal Sciences

In order to evaluate the in vivo therapeutic effect of oral administration of tilmicosin phosphate on mycoplasmal pneumonia in swine and its safety for the infected swine, the model of mycoplasmal pneumonia disease in swine was established by artificial infection, and indices such as efficiency, cure rate, death rate, the score of lung lesion, and the routine blood tests, blood biochemistry, and routine urine tests of tested swine were determined. The results showed that all of the dosage groups of 100 mg/L, 80 mg/L, 60 mg/L of 10% tilmicosin phosphate soluble powder demonstrated distinct therapeutic effects on mycoplasmal pneumonia in …

Effects Of The Supplementation Of Lamb Rations With Oregano Essential Oil On Theantimicrobial And Antioxidant Metabolism In Meat, Hali̇t İmi̇k, Sevda Urçar, Meryem Aydemi̇r Atasever, Recep Gümüş, Hayrunni̇sa Özlü

Turkish Journal of Veterinary & Animal Sciences

Although oregano essential oil has common use in the cosmetics, pharmaceutical, and food sectors, information on its effects on meat quality and shelf life, when incorporated into lamb feed rations, is scarce. In this study, the effects of oregano essential oil (OEO) in feed on the water activity, pH, lipid peroxidation, color parameters, and microbial counts of the Musculus longissimus dorsi (MLD) were investigated. The control group was fed a basal ration and the OEO1 and OEO2 groups were fed a basal ration supplemented with 200 mg/kg and 400 mg/kg OEO, respectively. Akkaraman lambs were fed experimental rations for a …

Cover And Contents

Turkish Journal of Veterinary & Animal Sciences

No abstract provided.

Investigation Of The Relationship Between Oxidative Stress Andscube1 Levels In High Fat Diet-Induced Obese Rats, Akin Bodur, Cemi̇l Kahraman, Di̇ler Us Altay, Taghi Ahmadi Rendi, Ahmet Menteşe, Ahmet Alver

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate signal peptide-Cub-EGF domain-containing protein 1 (SCUBE1) levels and oxidative stress (OS) in a high fat diet (HFD)-induced obese rat model. Materials and methods: Fourteen rats were randomly divided into two groups. Group 1, the control group, was given a standard diet (10% calories of fat) and Group 2, the obese group, was given a HFD (60% calories of fat), both for 70 days. Rats were then sacrificed and serum samples were collected. Serum glucose and triglyceride concentrations were determined using an autoanalyzer. Serum SCUBE1, adiponectin, and plasminogen activator inhibitor-1 levels were determined using an …

Peritoneal Dialysis In Neonates: Six Years Of Single Center Experience, Ferda Özlü, Hacer Yapicioğlu Yildizdaş, Gül Şeker, Hüseyi̇n Şi̇mşek, Aysun Karabay Bayazit, Mehmet Satar

Turkish Journal of Medical Sciences

Background/aim: Peritoneal dialysis (PD) is generally considered the practical dialysis modality for neonates in the treatment of acute kidney injury (AKI) and metabolic disturbances. e aim of this study was to evaluate the indications, complications, and outcomes of PD between January 2011 and December 2016. Materials and methods: This study included all 56 neonates that underwent PD over six years in our neonatal intensive care unit (NICU). A retrospective chart review was performed for all patients in our institution. Results: The incidence of PD was 1.32% (56/4230 patients) during this period. Mean birth weight of the patients was 2267.77 ± …

Risk Factor Assessment For Breast Cancer In North Cyprus: A Comprehensive Case-Control Study Of Turkish Cypriot Women, Ruqiya Pervaiz, Özgür Tosun, Hasan Besim, Nedi̇me Serakinci

Turkish Journal of Medical Sciences

Background/aim: This case-control study aims to assess the strength of associations between reproductive, lifestyle, sociodemographic, and dietary factors as well as other potential breast cancer risks and breast cancer (BC) in a North Cyprus population. Materials and methods: The study includes 408 BC patients and 412 age-matched controls recruited from Near East Hospital and Dr. Burhan Nalbantoglu State Hospital in North Cyprus. Information regarding clinical and epidemiological characteristics was collected through a standardized interview. Age-adjusted odds ratios (ORs) and 95% con dence intervals (CIs) were calculated by logistic regression before and a er adjusting for the potential confounders. Results: In …

Increased Concentrations Of Serum Nesfatin-1 Levels In Childhood With Idiopathic Chronic Malnutrition, Sezer Acar, Gönül Çatli, Tuncay Küme, Hale Ünver Tuhan, Özlem Gürsoy Çalan, Korcan Demi̇r, Ece Böber, Ayhan Abaci

Turkish Journal of Medical Sciences

Background/aim: Nesfatin-1, an anorexigenic molecule, seems to play a role in appetite regulation and energy homeostasis. e goal of this study was to evaluate the relation of nesfatin-1 with anthropometric and metabolic (ghrelin, leptin) parameters in children with idiopathic chronic malnutrition. Materials and methods: The study included 37 underweight and 38 healthy children who were similar regarding age, sex, and pubertal status. Anthropometric and biochemical (nesfatin-1, ghrelin, and leptin levels) variables were assessed. Results: A total of 37 underweight subjects (mean age 10.5 ± 2.6 years) and 38 heathy subjects (mean age 10.3 ± 2.3 years) were recruited. Underweight children …

Microdeletion And Mutation Analysis Of The Shox Gene In Patients With Idiopathic Short Stature With Fish And Sequencing, Abdullati̇f Bakir, Meral Yi̇rmi̇beş Karaoğuz, Ferda Emri̇ye Perçi̇n, Esra Tuğ, Peyami̇ Ci̇naz, Mehmet Ali̇ Ergün

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the prevalence of the microdeletions and mutations of the SHOX gene in children with idiopathic short stature (ISS) by the usage of uorescence in situ hybridization (FISH) and direct sequencing technique. Materials and methods: Thirty-seven children referred to our clinic because of short stature were classi ed as having ISS a er clinical examination. Chromosome analyses, FISH analysis of the SHOX gene, and direct sequencing of the coding exons of SHOX, through the second to the sixth exon, in 24 of the 37 patients were also performed. Results: All children had …

A Survey On Rectal Bleeding In Children, A Report From Iran, Seyed Mohsen Dehghani, Iraj Shahramian, Maryam Ataollahi, Ali Bazi, Nosaibe Seirfar, Mojtaba Delaramnasab, Ali Reza Sargazi, Mahsa Shariat Razavi

Turkish Journal of Medical Sciences

Background/aim: Studies on the epidemiology of rectal bleeding in children are limited in Iran. Our aim was to assess etiologies of rectal bleeding in children in Iran. Materials and methods: We enrolled 730 children with rectal bleeding. All the patients underwent colonoscopy, and 457 were further evaluated with histopathology. Results: According to colonoscopy and histopathology, respectively, in ammatory bowel disease (IBD) (29.4%, 15.8%), nodular hyperplasia (NH) (24.9%, 10%), and juvenile polyposis (JP) (12.6%, 9.9%) were the most common causes of rectal bleeding. Other conditions were solitary rectal ulcer (5.3%), chronic colitis (4.6%), allergic colitis (3.3%), focal colitis (1.3%), and infectious …

Serum Vasohibin-1 And Suppression Of Tumorigenicity-2 Levels In Children Withpredialysis Chronic Kidney Disease, Nuran Çeti̇n, Nadi̇de Meli̇ke Sav

Turkish Journal of Medical Sciences

Background/aim: Chronic kidney disease (CKD), which is one of the most important health problems worldwide, could be considered as an immune inflammatory disease. A prognostic biomarker may be helpful in determining the progression of CKD in children. We aimed to investigate the serum vasohibin-1 and soluble suppression of tumorigenicity-2 (sST2) levels as potential biomarkers in children with predialysis CKD. Materials and methods: Forty-seven children with stage 2-4 CKD and 20 healthy controls were included in this cross-sectional study. Glomerular filtration rate (GFR) and urinary excretion of protein were measured in 24-h urine samples. Serum vasohibin-1 levels and sST2 were measured. …

Role Of The Gut Microbiota As A Natural Adjuvant For Vaccine, Nicole Benn, Gerard F. Hoyne

Health Sciences Papers and Journal Articles

Vaccines have provided the most beneficial contribution to public health. Generating antigen specific antibody responses and long lasting memory are crucial for the protective immunity offered by vaccination. Unfortunately, not all individuals respond in the same manner to vaccine formulations. The microbiota is established during postnatal development and remains relatively stable for long periods. Our understanding that the microbiota can have beneficial effects on human health has led immunologists to investigate how these organisms may shape the innate and adaptive immune responses of the host. In this review we examine the impact of the microbiota on the host immune responses …

Do Frailty And Comorbidity Indices Improve Risk Prediction Of 28-Day Ed Reattendance? Reanalysis Of An Ed Discharge Nomogram For Older People, Evert Gips, Katrina Spilsbury, Claus Boecker, Rebecca Ng, Glenn Arendts

Health Sciences Papers and Journal Articles

Background: In older people, quantification of risk of reattendance after emergency department (ED) discharge is important to provide adequate post ED discharge care in the community to appropriately targeted patients at risk.

Methods: We reanalysed data from a prospective observational study, previously used for derivation of a nomogram for stratifying people aged 65 and older at risk for ED reattendance. We investigated the potential effect of comorbidity load and frailty by adding the Charlson or Elixhauser comorbidity index and a ten-item frailty measure from our data to develop four new nomograms. Model I and model F built on the …

Occupational Deprivation In Adolescents From Low-Income And Food Insecure Homes: A Screening Tool And After School Program, Claire Eidenschink

Occupational Therapy Capstones

Adolescents who experience food insecurity are exposed to an increased risk of health disparities related to cognitive, psychosocial, and physical functioning (Cook & Frank, 2007). Each of these domains of functioning impacts occupational performance in all roles that an adolescent assumes. Of note, the role of a student is drastically impacted. Therefore, a program to address strategies for meeting basic needs within a familiar setting, such as a school, is relevant and necessary for this population. Such a program would offer an opportunity to close the gap in disparities and increase health outcomes of adolescents who experience food insecurity as …

Generationactive: Creating Healthier Communities Two Generations At A Time, Jerrica Thiel, Mallory Manecke

Occupational Therapy Capstones

Obesity has become an epidemic across all ages, as the prevalence of obesity has nearly tripled over the last 40 years (World Health Organization, 2017-a). Obesity can have a detrimental impact on the health and future of Americans, as many diseases are correlated with obesity. Diabetes, which often occurs secondary to obesity and is the 7th leading cause of death in America, is similarly on the rise (CDC, 2012). To combat these issues, there is a great need for a health promotion initiative that provides individuals of all ages an opportunity to learn about health and wellness, to take steps …

2018-2019 Undergraduate Bulletin, Rochester Institute Of Technology

RIT Digital Archives

No abstract provided.

Comprehensive Functional And Transcriptional Analysis Of Human Pancreatic Islets From Controls And Individuals With Type 1 Diabetes (T1d), Shristi Shrestha

Dissertations

Type 1 Diabetes is chronic disease where immune moderated destruction of insulin producing β cells disrupts normal glucose homeostasis in the body. Recent findings show that few β cells remain in the pancreatic islets decades after disease onset challenging the previous understanding that β cells are completely destroyed. Overcoming the limited availability of T1D tissues, we studied functional and molecular features of pancreatic islets from individuals with T1D and investigated the nature of the remaining β cells. We found that remnant β cells have normal insulin secretory function and normally express key transcription factor that regulates β cell function. On …

Reading Achievement Of Middle School Boys In Single-Gender And Coeducational School, Jean Hunter-Batty

Walden Dissertations and Doctoral Studies

The problem addressed in the study was the lack of evidence on the efficacy of the single-gender educational model as compared to the coeducational model in increasing reading achievement for middle school boys in the local school district. Leaders in the district implemented the single-gender model to address the problem of an ongoing reading achievement gap among middle school boys and girls. The gap has also been noted nationally and leads to limited reading-dependent opportunities for boys. The purpose of this quantitative study was to compare the two educational models to determine whether the single-gender model offered advantages over the …

Focus, 2018, Winter, Andrews University

Focus

FOCUS (ISSN 1077-9345) is published quarterly, free of charge, for alumni and friends of Andrews University, an institution owned and operated by the Seventh-day Adventist Church.

Mission: Fully Alive: Wellness Transformation For Life: An Introductory Guide To Kickstart The Process (Self-Guided), Dominique Gummelt

Publications

MISSION: FULLY ALIVE is not a program—it is a lifestyle, it is a choice to transform fully in sustainable ways and it is the motto at Andrews University Health & Wellness. No matter where you are in your life journey, you can benefit from embarking on this Wellness Transformation for life. Now is the time.

Ellen White, Health, And The Third Angel’S Message: Part 3– Recognizing Environmental Hazards And Minimizing Their Impact, Warren A. Shipton

Journal of the Adventist Theological Society

Satan’s rebellion in heaven centered around his dissatisfaction with the principles and organization of the heavenly domain (Isa 14:12–14). In his first recorded interchange on earth after his expulsion from heaven, Satan inferred there was a moral defect in God’s character in the words “You will not surely die” (Gen 3:4) in response to Eve’s repetition of God’s advice that death would follow disobedience (v. 3). Eve was deceived by his persuasive reasoning. After Adam’s choice to follow Eve in rebellion, God’s portrait (image) commenced to be erased in humanity through disbelief and disobedience. This process has continued with the …

Preschool Teacher Characteristics: Professional Development And Classroom Quality, Jillian Connelly

Open Access Master's Theses

Effects of professional development, moderated by teacher characteristics, on classroom quality in early childhood settings were evaluated using secondary data from the Teacher Professional Development Study (funded by the NCRECE), as accessed through Inter-university Consortium for Political and Social Research (ICPSR). 210 teachers in early childhood settings received different forms of professional development and were randomly assigned to treatment groups. The goal of the professional development was to increase classroom quality as measured by the Classroom Assessment Scoring System (CLASS). At the completion of the study, four groups existed: Course and Consultancy, Course only, Consultancy only, and Control. Initial results …

The Microbiome Of Four North American Nicrophorus Species (Coleoptera: Silphidae): Implications For Parental Care Behavior In Insects, Morgan Olmstead

Master's Theses and Capstones

Nicrophorus (Coleoptera: Silphidae) are a unique genus of beetles in which both parents exhibit parental care. The female parents maintain the carcass resource for the young and directly feed growing larvae, while often the males maintain the carcass and prevent usurpation from congeners and conspecifics in search of the ephemeral resource. The beetles in this genus are known to compete with both animal carcass microbiota and soil microbiota, thus developing several mechanisms to combat these microbes. In this study, four North Americanus Nicrophorus spp. microbiomes were characterized and compared to each other in effort to determine the core Nicrophorus microbiome. …

Under Armour: Repositioning For The Global Stage, Constance R. James Ph.D., Keith Whitney J.D.

All Faculty Open Access Publications

Over the last two decades, Under Armour has emerged from being the “underdog” in the Sports Apparel and Sporting Goods Industry to a leader in the industry, with a fierce attention to performance and great skill at picking up-and-coming athletes who emerge as superstars. This case underscores its administrative heritage, competitive strategy and growth potential as a global player in a highly competitive industry. It addresses the tension between being a performance brand while launching lines for women versus technology applications and conflicts between its growth strategy and macroeconomic forces. It highlights areas in which Under Armour has succeeded in …

Health Consciousness And The Theory Of Planned Behavior: The Role Of Health Consciousness With The On-Campus Use Of Reusable Water Bottle Among Chulalongkorn Freshmen, Aruch Patumtaewapibal

Chulalongkorn University Theses and Dissertations (Chula ETD)

Use of reusable water container on Chulalongkorn University campus, though is pro-environmental, is currently limited among the students. The present study investigated antecedents of such behavior, using the theory of planned behavior (TPB) with health consciousness as an addition to the model. One-hundred and twenty Chulalongkorn freshmen filled out a TPB-based questionnaire with a health consciousness scale. Data analyses using LISREL reveal an excellent fit for the TPB model. Specifically, attitude, perceived norms, and perceived behavioral control significantly and positively predicted intention and the behavior. Health consciousness indirectly influence intention and behavior via attitude, perceived norms, and perceived behavioral control. …