Digital Commons Network^™

Combination Therapy: Parp Inhibitor Synergizes The Therapeutic Efficacy Of Doxorubicin In The Treatment Of Prostate Cancer, Momin Ansare

Electronic Theses & Dissertations

Men are most susceptible to prostate cancer in the United States. The general treatment options include surgery, hormone therapy, chemotherapy, and radiation therapy. But in recent days, the nanoformulation have shown promising applications in overcoming the drawbacks of the currently available treatment options. To complement, we tried to enhance the capability of the nanoparticle formulation by loading them with a novel drug combination for the treatment of prostate cancer. Herein, we synthesized folate conjugated iron oxide nanoparticles encapsulated with doxorubicin and olaparib for imaging and targeted treatment of prostate cancer. Both drugs are approved by FDA for clinical cancer treatment. …

Using Games To Teach English In Chinese High School Classroom, Wenyu Zhu

Master's Projects and Capstones

In the 20th century, English played an important role in international communication as an international language. English is a bridge between countries' economies, cultures, and trade. However, current English education in Chinese high schools is still test-oriented which is ineffective, and students are tired of it. Moreover, teachers also have trouble engaging students in the class. The purpose of this project is to create a curriculum for high school English teachers in China to use games to teach English language skills. Krashen’s (1982) Theory of Second Language Acquisition contains five main hypotheses which support this project. The project includes twenty-three …

Community, Preservation, And Street Art: A Proposal For San Francisco’S Mission District, Marissa Nadeau

Master's Projects and Capstones

The Latinx community is an integral part of San Francisco’s rich history. From Mexican missions in the late 1700s to an influx of immigrants from various Latin countries starting in the early 1900s, the Mission District (‘the Mission’) of San Francisco has served as a hub for this mix of residents, fondly called “Raza,” emphasizing the people of a community rather than the country they have come from. Wars and issues dealt in their homelands were close to the hearts of the entirety of the Latinx population of the Mission, and their voices and opinions were heard through a type …

Raising Oas Cahps Scores: Using Patient Education, Katrina Pangilinan

Master's Projects and Capstones

At the Golden Gate Endoscopy Center (GGEC), the Consumer Assessment of Healthcare Providers and Systems Outpatient and Ambulatory Surgery (OAS CAHPS) survey results on patient satisfaction have been below the 50th percentile for the last three quarters of 2018. Patient satisfaction scores are a quality measure for the patient care experience and important for the success of the organization and its providers. Based on patient comments from previous surveys, patients feel that the center does not explain the possible side effects of the anesthesia in a way they can understand. Other patient comments and concerns included confusion regarding dietary restrictions …

Bullying In Schools: Exploring The Lived Experiences Of Early-Career Elementary School Principals, Jason Q. Harris

Theses and Dissertations

Since the latter part of the 19th Century, researchers have been studying the bullying phenomenon and the devastating short- and long-term impact it has on children’s lives. In an attempt to reduce bullying incidents that arise in school, many have set up anti-bullying programs. The goal of these programs is twofold: (a) to reduce the number of bullying incidents in school and (b) create a safe and welcoming learning environment for all students. Although principals work tirelessly to establish conditions to sustain learning for others, they receive very little support for their own learning and development. As principals’ on-going experiences …

The Fight Before The Fight: Weight-Cutting In Mixed Martial Arts, Michael T. Desantis

Capstones

For professional mixed martial artists, fighting may not even be the most dangerous aspect of the job. Many of these athletes consider weight-cutting to be a fight itself, one that could have deadly consequences. Fighters, coaches, doctors, nutritionists and other experts discuss the state of weight-cutting in MMA, why it's done, how it's dangerous, and the potential solutions to making it safer.

https://medium.com/@michaeltdesantis24/the-fight-before-the-fight-weight-cutting-in-mixed-martial-arts-6a920ad5e37b

The Cult Of Names, Shaydanay A. Urbani

Capstones

The Mormon church keeps extensive records of its members. This is a personal story about how I tried to get my record removed, 15 years after leaving the church, as well as a short history of naming, women, and theology.

From Virtual To Physical: Video Game Streaming Communities, Avery Miles

Capstones

This is an exploration of the inner lives of video game streamers, how they interact with their audiences and the social phenomenon of live streaming. It encompasses streamers, viewers, professional eSports athletes and indie game designers.

www.averykmiles.com

Telling The Good News, Allyson R. Escobar

Capstones

In light of recent clergy abuse scandals, cover-ups and leadership shake-downs, it is a divided time in the Catholic Church: but this isn’t the whole story. My final capstone project is a critical essay of how Catholicism (and religion overall) is represented in mainstream media--particularly in secular news publications and entertainment (horror films) in the United States. By examining the coverage and how conversations differ within members of the Catholic Church--from journalists and critics to active Catholics, religious men and women--this project calls for greater accountability, fairness, faith representation in all media, and the overall claim that there are Catholic …

Dios, Drogas, Dinero: ¿QuiéN Gana Con El Traslado De Adictos De Puerto Rico A Ee.Uu.?, Claudia E. Irizarry Aponte, Eliana Y. Perez

Capstones

For the last 25 years, evangelical leaders have been shipping off opioid addicts in Puerto Rico to cities in the mainland US, mainly New York City, Chicago and Philadelphia--under the promise they’ll receive state-of-the-art rehabilitation treatment, only to end up in unregulated transitional homes and flophouses where they don’t receive proper medical care or psychotherapy. In turn, many of these unregulated transitional homes, also run by evangelical leaders, may charge Medicaid kickbacks from their “patients.”

While this so-called “air bridge” from Puerto Rico to the U.S. goes back decades, it gained momentum from 2005 to 2014, when evangelical leaders joined …

Adapting To $15: As The Minimum Wage Approaches $15 In Nyc, Business Owners Are Finding Ways To Make It Work, Alexandra Semenova, Sharif Paget

Capstones

This project examines the impact of minimum wage increases across major industries in New York City and State and concludes they have been manageable and even fueled broader economic growth. Since the incremental wage hikes were first signed into law in 2015, data and anecdotal evidence has shown business owners have been able to make it work and many of critics' concerns that the higher labor costs would lead to disemployment have been misplaced. The story provides an in-depth analysis of how restaurant and food establishments, health care and retail employers have adapted to higher labor costs by innovating their …

The Struggle Is Eternal, Joseph R. Fitzgerald

Civil Rights

Many prominent and well-known figures greatly impacted the civil rights movement, but one of the most influential and unsung leaders of that period was Gloria Richardson. As the leader of the Cambridge Nonviolent Action Committee (CNAC), a multifaceted liberation campaign formed to target segregation and racial inequality in Cambridge, Maryland, Richardson advocated for economic justice and tactics beyond nonviolent demonstrations. Her philosophies and strategies—including her belief that black people had a right to self–defense—were adopted, often without credit, by a number of civil rights and black power leaders and activists.

The Struggle Is Eternal: Gloria Richardson and Black Liberation explores …

2018 Fall Commencement Program: Winona State University, Winona State University

WSU Commencement Programs

This is the Winona State University Fall 2017 commencement program. Commencement was on Friday, December 14, 2018.

Meeting Minutes - 12/14/2018, Magnolia Steering Committee

Steering Committee Meetings

No abstract provided.

Short Sleep Duration And Obesity Among Children: A Meta-Analysis, Katherine Faye Real Villar

International Nursing Research Congress (INRC)

This meta-analytical study examined whether there is an association between lesser sleep duration and risk of childhood obesity and to determine which gender is more common in childhood obesity.

Improving Nursing Communication Outcomes Through The Tell-Us Card, Brittney Pilker, Jillian Cule, Laura Le, Nina Park, Jeffrey Salao, Maricarmen Reyes

Master's Projects and Capstones

Nursing communication plays a pivotal role in patient-centered care. However, statistics have shown that failures in communication exist in more than 20% of all hospital settings (Sethi & Rani, 2017). Within the explored microsystem, a gap in patient communication was identified through the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) surveys. Reports revealed that the microsystem was performing at 69%, which is 11% below the national average for nursing communication (Centers for Medicare and Medicaid Services [CMS], 2018). After performing a microsystem assessment, there was a measurable communication opportunity between the patients and nurses. It was determined that …

Multilingual Museums: A Proposal To Increase Linguistic Diversity In Contemporary Art Museums, Jennifer Cha

Master's Projects and Capstones

The U.S. population is becoming more ethnically, racially, and linguistically diverse. It is estimated that by the year 2050, the U.S. will shift to a majority-minority population, meaning that the total minority population will become the majority of the U.S. population. But while the U.S. is diversifying, the current museum visitorship demographic is not representative of or on track to measure up to these changes in the future. If museums are valuable civic spaces with several associated health, social, and educational benefits, and a large percentage of the population have low-English proficiency and cannot access the information, then there is …

Board Of Trustees Minutes, December 14, 2018, Coastal Carolina University

Board of Trustees Meeting Minutes

No abstract provided.

Board Of Trustees Minutes, December 14, 2018, Revised, Coastal Carolina University

Board of Trustees Meeting Minutes

No abstract provided.

Audit Committee, December 14, 2018, Revised, Coastal Carolina University

Board of Trustees Committee Minutes

No abstract provided.

Development Of Chloroquine-Containing Hpma Copolymers For Drug Delivery, Fei Yu

Theses & Dissertations

Abstract

Development of Chloroquine-containing HPMA Copolymers for Drug Delivery

Fei Yu, Ph.D.

University of Nebraska Medical Center, 2018

Supervisor: David Oupický, Ph.D.

Synthetic polymers have been extensively explored for improved delivery of anticancer agents. Polymers can be designed as either carriers of existing drugs or as polymeric drugs with intrinsic pharmacological activity. Advantages of such polymeric drugs include common positive features of polymer-drug conjugates, such as targeted delivery of drugs, altered pharmacokinetic and biodistribution, improved drug safety, but also favorable pharmacological activities due to multivalent receptor-ligand interactions.

Chloroquine (CQ) and hydroxychloroquine (HCQ) are safe drugs that have been in clinical …

Development Of Glucocorticoid Prodrug For The Treatment Of Lupus Nephritis, Xiaobei Wang

Theses & Dissertations

Nephritis is one of the major complications of systemic lupus erythematosus (SLE). While glucocorticoids (GC) are frequently used as the first line treatment for lupus nephritis, long-term GC usage is often complicated by severe adverse effects. To address this challenge, we have developed a polyethylene glycol (PEG)-based macromolecular prodrug (ZSJ-0228) of dexamethasone, which self-assembles into micelles in aqueous media. When compared to the dose equivalent daily dexamethasone 21-phosphate disodium (Dex) treatment, monthly intravenous administration of ZSJ-0228 for two months significantly improved the survival of lupus-prone NZB/W F1 mice and was much more effective in normalizing proteinuria, with clear histological evidence …

Delineation Of New Mechanisms Of Dna Double Strand Break Repair, Songli Zhu

Theses & Dissertations

DNA damage is frequently induced in cells by both endogenous and exogenous agents. DNA damage, particular double strand breaks (DSBs) may lead to genomic instability, and the progression of cancer, aging, neurodegeneration, and other human diseases. The cell employs two major DSB repair pathways, including homologous recombination (HR) and Non-homologous end joining (NHEJ), but the detailed mechanisms of DSB repair remain to be further revealed.

In the first part of this study, we characterized a plasmid-based assay to investigate NHEJ repair in Xenopus egg extracts. Our data argued for a preference for the precise repair by the NHEJ machinery and …

Developing Of Micellar Drug Carriers For The Treatment Of Breast Cancer Bone Metastasis, Tong Liu

Theses & Dissertations

Breast cancer (BC) remains one of the most frequently diagnosed cancer worldwide. Bone is one of the most common sites and often the first clinical indication of metastatic progression of BC. Current treatments including radiation, surgery, and chemotherapy are rarely curative with limited effect in overall survival. The challenge is true especially for patients with triple-negative BC that are not responsive to receptor-targeted therapy, or patients who had exposure to chemotherapy before and might already gain the resistance to some of the drugs.

Here we took advantage of the aminobisphosphonate, alendronate (ALN), that can bind to the bone mineral efficiently …

Battlefield Mementos Care Of And Restitution Of Japanese 'Good Luck Flags' And Cultural Heritage Objects From War In Museum Collections, Andrew Armstrong

Master's Projects and Capstones

In World War II one of the most common objects found on the battlefield in the Pacific Theater was that of the Japanese Yosegaki Hinomaru or “Good Luck Flag” These objects were some of the most looted items from the war and soon found themselves in the possession of veterans of World War II and their families. In the past few decades as these veterans pass, increasing numbers of veterans and their families attempt to return the flags to Japan, or museums in the United States, believing they are the most suited to care for such objects. However this presents …

Use Of Co-Immunoprecipitations And 2d Gel Electrophoresis To Identify Protein-Protein Interactions Of Maturase K, Lauren Angello

Honors Theses

Maturase K (MatK) is the only group II intron encoded protein in the chloroplast of land plants. Maturases are prokaryotic enzymes that catalyze formation of the lariat structure needed for intron removal from precursor RNAs. The chloroplast maturase MatK, is a descendant of prokaryotic maturases, however, unlike its prokaryotic relatives, MatK is thought to catalyze excision of, not only its own intron, but also the introns of other group II introns in the plastome. Similar to the multiprotein and snRNA spliceosomal complex of the nucleus, it is postulated that MatK is not working alone to excise these introns but most …

Development Of Polymeric Carriers For The Treatment Of Acute Kidney Injury, Yi Chen

Theses & Dissertations

Acute kidney injury (AKI) is a major kidney disease associated with high mortality and morbidity. Long-term AKI may lead to chronic kidney disease and end-stage renal disease. Several clinical trials failed due to lack of efficacy and undesired side effects. Studies showed that macromolecular delivery systems would be a promising method to target kidney, however, little is known about how physicochemical properties affects the polymers deposition in ischemia-reperfusion (I/R) AKI.

Gene therapy has been well studied as a promising therapeutic agent for several diseases, including cancer and AKI. Although small interfering RNA (siRNA) has been commonly used to treat AKI …

Modulating Hallmarks Of Cholangiocarcinoma, Cody Wehrkamp

Theses & Dissertations

How are cholangiocarcinoma cells different from non-malignant cholangiocytes?

All of the hallmarks of cancer apply- those reported in this dissertation include cell proliferation, migration, apoptosis, and evasion of growth suppression. My studies began with testing how apoptosis might be regulated through embelin, a small molecule reported to sensitize cells to apoptosis by blocking XIAP. My data however revealed that embelin reduced the proliferative capacity in cholangiocarcinoma cells, but did not increase cell death. Malignant cells exhibit dysregulation of microRNA processing and expression. Hence, my studies seeking ways that cholangiocarcinoma eludes apoptosis transitioned to the oncomiR miR-106b, which is overexpressed in …

Regulation Of Canonical And Non-Canonical Hippo Pathway Components In Mitosis And Cancer, Seth Stauffer

Theses & Dissertations

The Hippo pathway is conserved regulator of organ size through control of proliferation, apoptosis, and stem-cell self-renewal. In addition to this important function, many of the canonical signaling members have also been shown to be regulated during mitosis. Importantly, Hippo pathway components are frequently dysregulated in cancers and have attracted attention as possible targets for improved cancer therapeutics. Further exploration of Hippo-YAP (yes-associated protein) signaling has revealed new regulators and effectors outside the canonical signaling network and has revealed a larger non-canonical network of signaling proteins in which canonical Hippo pathway components crosstalk with important cellular homeostasis and apoptosis signaling …

Red Panda: A Novel Method For Detecting Variation In Single-Cell Rna Sequencing, Adam Cornish

Theses & Dissertations

Single-cell sequencing enables the rapid acquisition of genomic and transcriptomic data from individual cells to better understand genetic diseases, such as cancer or autoimmune disorders, which are often affected by changes in rare cells. Currently, no existing software is aimed at identifying single nucleotide variations or micro (1-50bp) insertions and deletions in single-cell RNA sequencing (scRNA-seq) data. However, generating high quality data is vital to the study of the aforementioned diseases, among others. Our goal is to create such a tool and use in-house sequencing to validate its effectiveness. Our software employs the unique information found in scRNA-seq data to …