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Intratumoral Sting Activation Sensitizes Poorly Immunogenic Cancers To Checkpoint Blockade Immunotherapy, Casey Ager

Dissertations and Theses (Open Access)

Unprecedented durable tumor regression can be achieved in patients with checkpoint blockade immunotherapy, yet these responses are rare and are not observed in all tumor types. Castration resistant prostate cancer (CRPC) and pancreatic adenocarcinoma (PDAC) are two common lethal cancers that remain refractory to checkpoint blockade, requiring development of new therapeutic approaches to promote responsivity in patients with these diseases. Both CRPC and PDAC are characterized by an immunosuppressive tumor milieu rich in cells of the myeloid lineage, which regulate T cell activity in many ways independent of the coinhibitory receptor axis. We investigated whether activation of acute inflammatory signaling …

Bayesian Integrative Analysis Of Omics Data, Youyi Zhang

Dissertations and Theses (Open Access)

Technological innovations have produced large multi-modal datasets that range in multiplatform genomic data, pathway data, proteomic data, imaging data and clinical data. Integrative analysis of such data sets have potentiality in revealing important biological and clinical insights into complex diseases like cancer. This dissertation focuses on Bayesian methodology establishment in integrative analysis of radiogenomics and pathway driver detection applied in cancer applications. We initially present Radio-iBAG that utilizes Bayesian approaches in analyzing radiological imaging and multi-platform genomic data, which we establish a multi-scale Bayesian hierarchical model that simultaneously identifies genomic and radiomic, i.e., radiology-based imaging markers, along with the latent …

The Progress Of Tobacco Control Research In Sub-Saharan Africa In The Past 50 Years: A Systematic Review Of The Design And Methods Of The Studies, Hadii M. Mamudu, Pooja Subedi, Ali E. Alamin, Sreenivas P. Veeranki, Daniel Owusu, Amy Poole, Lazarous Mbulo, A. E. Ogwell Ouma, Adekunle Oke

ETSU Faculty Works

Over one billion of the world’s population are smokers, with increasing tobacco use in low-and middle-income countries. However, information about the methodology of studies on tobacco control is limited. We conducted a literature search to examine and evaluate the methodological designs of published tobacco research in Sub-Saharan Africa (SSA) over the past 50 years. The first phase was completed in 2015 using PubMed, Embase, CINAHL, and Cochrane Central Register of Controlled Trials. An additional search was completed in February 2017 using PubMed. Only tobacco/smoking research in SSA countries with human subjects and published in English was selected. Out of 1796 …

Quantitative Dna Methylation Analysis Of Dlgap2 Gene Using Pyrosequencing In Schizophrenia With Tardive Dyskinesia: A Linear Mixed Model Approach, Yanli Li, Kesheng Wang, Ping Zhang, Junchao Huang, Huimei An, Nianyang Wang, Fu De Yang, Zhiren Wang, Shuping Tan, Song Chen, Yunlong Tan

ETSU Faculty Works

Tardive dyskinesia (TD) is a side effect of antipsychotic medications used to treat schizophrenia (SCZ) and other mental health disorders. No study has previously used pyrosequencing to quantify DNA methylation levels of the DLGAP2 gene; while the quantitative methylation levels among CpG sites within a gene may be correlated. To deal with the correlated measures among three CpG sites within the DLGAP2 gene, this study analyzed DNA methylation levels of the DLGAP2 gene using a linear mixed model (LMM) in a Chinese sample consisting of 35 SCZ patients with TD, 35 SCZ without TD (NTD) and 34 healthy controls (HCs) …

Attitudes Toward Penile Transplantation Among Urologists And Health Professionals, Bobby Najari, Ryan Flannigan, Jackson Hobgood, Darius Paduch

ETSU Faculty Works

Introduction: Penile transplantation, in its infancy, has the potential to reestablish functional outcomes for men with penile loss and disfigurement. However, significant bioethical considerations are pertinent, and systematic discussions are necessary to safely progress implementation. Aim: To determine the attitude of health practitioners toward the penile transplant and identify the key aspects of concern pertinent to the operation and clinical care. Methods: Health care professionals from the United States responded to either email invitation, web link, or social media post on Facebook to complete a questionnaire investigating perceptions and attitudes toward penile transplantation. Main Outcome Measures: Respondents' attitude toward penile …

Effects Of Weightlifting Training On Isometric Mid-Thigh Pull Rate Of Force Development, Dylan G. Suarez, Kristina Ushakova, Satoshi Mizuguchi, Guy Hornsby, Michael H. Stone

ETSU Faculty Works

PURPOSE: To examine the influence of three distinct training phases on isometric mid-thigh pull (IMTP) measures in well-trained weightlifters. METHODS: Pre- and post-block IMTP data from 11 collegiate weightlifters was used for analysis. The mean of the best two attempts from each athlete for measures of PF and RFD from 0-50ms, 0-100ms, 0-150ms, 0-200ms, and 0-250ms were used for comparison. In total, results from five timepoints for each of the 11 athletes were examined in order to compare the effects of the three training phases. RESULTS: A repeated measures ANOVA revealed no statistically significant (p ≥ 0.05) effects of training …

Painted Ferocity: The Social Behaviors Of African Wild Dogs, Threats To Survival, And Resulting Conservation Initiatives, Alexis Valdes

Senior Honors Theses

African Wild Dogs (Lycaon pictus) are an endangered species of canid from Sub-Saharan Africa. They are very social communal hunters, and are capable of chasing down prey for long stretches of time. Wild dogs benefit a savannah ecosystem by regulating the populations of their prey so that it does not become unhealthy and overgrown. Like many organisms, wild dogs are also in competition with other predators for resources, namely lions and hyenas, who are capable of stealing their kills and occasionally injuring and killing them. Due to the depletion of their wild prey, wild dogs may also prey …

The Helper Therapy Principle: Using The Power Of Service To Save Addicts, Stefan J. Padfield, Maria E. Pagano

University of Memphis Law Review

No abstract provided.

Annual Report On Energy-Efficient Purchasing, Central Procurement Office, Fiscal Year 2017-2018, Tennessee. Department Of General Services.

Energy-Efficiency Reports

No abstract provided.

Front Matter

Hofstra Law Review

No abstract provided.

No Longer Private: On Human Rights And The Public Facet Of Social Network Sites, Noa Mor

Hofstra Law Review

No abstract provided.

Any Man Can Be A Father, But Should A Dead Man Be A Dad: An Approach To The Formal Legalization Of Posthumous Sperm Retrieval And Posthumous Reproduction In The United States, Jean Denise Krebs

Hofstra Law Review

No abstract provided.

Transgender Beneficiaries: In Becoming Who You Are, Do You Lose The Benefits Attached To Who You Were, Ashleigh C. Rousseau

Hofstra Law Review

Suppose William Smith, father of Joseph Smith, executes a will to leave his estate to his children. In his will, the phrase "to my son, Joseph" is used, preceding a bequest for property. Before William dies, Julia embraces her transgender identity, obtains a lawful name change to Julia, obtains a lawful gender marker change, and undergoes sex confirmation surgery. William dies, and his estate is divided. Is Julia still entitled to Joseph's portion of William's estate? In embracing her transgender identity, is she deprived of her right to inherit?

Women In The Legal Academy: A Brief History Of Feminist Legal Theory, Robin West

Georgetown Law Faculty Publications and Other Works

Women’s entry into the legal academy in significant numbers—first as students, then as faculty—was a 1970s and 1980s phenomenon. During those decades, women in law schools struggled: first, for admission and inclusion as individual students on a formally equal footing with male students; then for parity in their numbers in classes and on faculties; and, eventually, for some measure of substantive equality across various parameters, including their performance and evaluation both in and in front of the classroom, as well as in the quality of their experiences as students and faculty members and in the benefits to be reaped from …

Photocatalytic Degradation Of Simazine Using Zno/Go Composites, Kenneth Ray Flores

Theses and Dissertations

The photocatalytic degradation of simazine (SIM) by Zinc oxide/graphene oxide (ZnO/GO) composites, under visible light irradiation, was investigated to determine various reaction parameters, of initial pH, ZnO loading on GO, and catalyst mass. A pH of 2 was determined to be the optimal reaction pH for all ZnO/GO catalysts. A loading mass of 40mg for the 20 & 30mmol composites; whereas a 10mg mass was determined to be most effective for the 10mmol composite. The reaction followed second order kinetics for the degradation process, the reaction dependence was determined to be on the concentration of SIM in solution. All ZnO/GO …

Measuring Connective Capacity Throughout The Gulf Of Mexico Fishery Management Network, Anthony Rocha Lima

Theses and Dissertations

The Gulf of Mexico provides substantial resources along its 1,680-mile coastline, spanning 5 U.S. states and providing millions of pounds of seafood and hundreds of millions in revenue annually. Continued success of the fishery relies on the ability of a large, complex, multiagency network to find the best solutions to balance the needs of humans, as well as ensure long-term sustainability. Organizations with varying objectives require effective communication when addressing intricate ecosystem-based management topics such as endangered species and regional economies.

To better understand the connectivity within the Gulf fishery management network, an IRB reviewed survey was dispersed to the …

Higher Education Social Responsibility: An Empirical Analysis And Assessment Of A Hispanic-Serving Institution's Commitment To Community-Engaged Scholarship, Student Integration And Sense Of Belonging, Juan Salinas Jr.

Theses and Dissertations

Current efforts in higher education institutions to increase persistence and success among Hispanic students continue to be ineffective and thus new conceptual frameworks need to be explored. Data from the Hispanic Association of Colleges and Universities asserts that increasing the number of Hispanics that graduate is vital for our country’s future. In turn, Hispanic-Serving Institutions need to nourish and nurture their students to ensure that they graduate and institutional frameworks would benefit from cultural and epistemological congruence with Hispanic students, their families, and their communities.

Educational leaders have urged educators to take on the responsibility and commitment to students’ success …

A Systematic Approach To High Blood Pressure Risk Analysis And Healthcare Cost Reduction In Young Adults [Metodología Sistemática Para El Análisis De Riesgo Y Reducción De Costos De Servicios Médicos De Hipertensión En Adultos Jóvenes], Francisco Rafael Torres Diaz

Theses and Dissertations

The purpose of this research is to utilize publicly available data to estimate the current rate of occurrence of undiagnosed High Blood Pressure (HBP) in young adults (18 to 24 years old) and the out-of-pocket healthcare expenses associated with complications of HBP, to provide feasible alternatives to mitigate the effects on a region's economy. This has been done by building a Risk Factor Simulation Model that utilizes known HBP risk factors’ correlation to HBP, insurance coverage data, and rate of diagnosis to formulate the average Risk Factor Value for a region, which through an Annual Expected Cost Function estimates the …

Improving Ductility Of Slender Reinforced Concrete Shear Walls With Frp Sheets And Splay Anchors, Luke M. Ostrom

Architectural Engineering

The Sylmar earthquake of 1971 caused significant damage to slender, non-ductile reinforced concrete (RC) shear wall buildings in California. A later survey by the Concrete Coalition in 2011, under the guidance of EERI members, indicated that there are over 3000 vulnerable concrete buildings in California [8]. This led to City of Los Angeles (LA) Ordinance 193893 enacted in 2015, which requires mandatory upgrades to these concrete buildings by 2035. Current practice to meet the requirements of this ordinance, with respect to RC wall buildings, involves adding new shear walls to the building plan or increasing the cross-sectional area of existing …

Automation Of Post-Earthquake Civil Infrastructure Reconnaissance, Jack Bergquist

Architectural Engineering

Traditionally post-earthquake structural engineering reconnaissance consists of a team of experts who are deployed to the field to record and capture earthquake damage data, which is later uploaded into online repositories. Despite many advances to these data archives in recent years, the entries in online repositories often have limited metadata which make it difficult and time consuming to extract specific damage evidence that can be used for meaningful analysis. This report outlines the author’s contributions to overcoming these challenges via the development of a neural network that automatically filters and classifies post-earthquake civil infrastructure damage data after a seismic event. …

Arkansas Soybean Research Studies 2017, Jeremy Ross

Arkansas Agricultural Experiment Station Research Series

No abstract provided.

Forensic Nursing: Overview Of A Growing Profession, Julie L. Valentine

Faculty Publications

IN THE CURRENT ERA of the #MeToo movement and prominent sexual assault disclosures, these types of crimes are finally receiving the attention they deserve. Our society is acknowledging what research has been telling us for years about the high incidence of sexual violence in the United States. According to a recent Centers for Disease Control and Prevention (CDC) report, more than 36% of women have experienced contact sexual violence in their lifetime and 19% have experienced attempted or completed rape. Men also report high rates of sexual violence; more than 17% have experienced some form of contact sexual violence in …

Investigating The Association Between Fantasy Proneness And Emotional Distress: The Mediating Role Of Cognitive Coping Strategies, Am Bacon, Jj Charlesford

School of Psychology

Fantasy proneness (FP; the tendency to immersion in imagination) is linked to psychopathology and suggested to be a maladaptive coping strategy. However, some evidence suggests it can be a positive trait. We examined whether the FP-emotional distress relationship is mediated by coping strategy. Participants completed the Depression, Anxiety and Stress Scale, the Cognitive Emotion Regulation Questionnaire measure of coping strategies, the Creative Experiences Questionnaire FP scale (Study 1; N=248) and the newly developed Fantasy Questionnaire which measures fantasy across two subscales, creative and imaginative (Study 2; N=208). In Study 1, FP presented positive associations with emotional distress, with maladaptive coping …

How Gender Norms Impact Women's Access To Financial Inclusion, Caitlyn Goodman

Economics Undergraduate Honors Theses

The purpose of this paper is to determine if there is a relationship between gender norms and women's access to financial resources. Using data from the World Bank and the World Values Survey, I use a linear regression model to assess how attitudes toward education, jobs, and over-all equal rights impact women's account ownership.

Community-Based Research Methods To Inform Public Health Practice And Policy: The Case Of Lead In The Mississippi Delta, Mary Alexandra Fratesi

Honors Theses

Environmental health issues are complex and require interdisciplinary and community engagement approaches to better understand them and inform policy. As one example, lead exposure has a number of dangerous neurological effects, including developmental delays and learning deficits. Potential lead exposure through drinking water and paint are areas of concern. In a 2018 document, the Environmental Protection Agency (EPA) estimated that up to 20% of lead exposure comes from drinking water alone. By using a type of engagement research called community-based research (CBR), this project began to address this major public health issue. CBR can be used to connect residents, their …

Triggers, Protectors, And Predictors In Episodic Migraine., Michael J. Marmura

Department of Neurology Faculty Papers

PURPOSE OF REVIEW: A wide variety of triggers prompt attacks in episodic migraine. Although experimental triggers such as glyceryl trinitrate reliably produce migraine, natural triggers are much less predictable and vary in importance between individuals. This review describes the most common triggers in episodic migraine and provides strategies for managing them in clinical practice.

RECENT FINDINGS: Multiple migraine attack triggers have been established based on patient surveys, diary studies, and clinical trials. Stress, menstrual cycle changes, weather changes, sleep disturbances, alcohol, and other foods are among the most common factors mentioned. Clinical studies have verified that fasting, premenstrual periods in …

Medial Temporal Lobe Functional Connectivity Predicts Stimulation-Induced Theta Power., E. A. Solomon, J. E. Kragel, R. Gross, B. Lega, M. R. Sperling, G. Worrell, S. A. Sheth, K. A. Zaghloul, B. C. Jobst, J. M. Stein, S. Das, R. Gorniak, C. S. Inman, S. Seger, D. S. Rizzuto, M. J. Kahana

Department of Neurology Faculty Papers

Focal electrical stimulation of the brain incites a cascade of neural activity that propagates from the stimulated region to both nearby and remote areas, offering the potential to control the activity of brain networks. Understanding how exogenous electrical signals perturb such networks in humans is key to its clinical translation. To investigate this, we applied electrical stimulation to subregions of the medial temporal lobe in 26 neurosurgical patients fitted with indwelling electrodes. Networks of low-frequency (5-13 Hz) spectral coherence predicted stimulation-evoked increases in theta (5-8 Hz) power, particularly when stimulation was applied in or adjacent to white matter. Stimulation tended …

Ros-Related Mitochondrial Dysfunction In Skeletal Muscle Of An Als Mouse Model During The Disease Progression, Yajuan Xiao, Chehade Karam, Jianxun Yi, Lin Zhang, Xuejun Li, Dosuk Yoon, Huan Wang, Kamal Dhakal, Paul Ramlow, Tian Yu, Zhaohui Mo, Jianjie Ma, Jingsong Zhou

Faculty and Staff Publications

In amyotrophic lateral sclerosis (ALS), mitochondrial dysfunction and oxidative stress form a vicious cycle that promotes neurodegeneration and muscle wasting. To quantify the disease-stage-dependent changes of mitochondrial function and their relationship to the generation of reactive oxygen species (ROS), we generated double transgenic mice (G93A/cpYFP) that carry human ALS mutation SOD1G93A and mt-cpYFP transgenes, in which mt-cpYFP detects dynamic changes of ROS-related mitoflash events at individual mitochondria level. Compared with wild type mice, mitoflash activity in the SOD1G93A (G93A) mouse muscle showed an increased flashing frequency prior to the onset of ALS symptom (at the age of 2 months), whereas …

Irisin Protects Heart Against Ischemia-Reperfusion Injury Through A Sod2-Dependent Mitochondria Mechanism, Zhen Wang, Ken Chen, Yu Han, Hua Zhu, Xinyu Zhou, Tao Tan, Jing Zeng, Jun Zhang, Yukai Liu, Yu Li, Yonggang Yao, Jianxun Yi, Duofen He, Jingsong Zhou, Jianjie Ma, Chunyu Zeng

Faculty and Staff Publications

Irisin, a muscle-origin protein derived from the extracellular domain of the fibronectin domain-containing 5 protein (FNDC5), has been shown to modulate mitochondria welfare through paracrine action. Here, we test the hypothesis that irisin contributes to cardioprotection after myocardial infarction by preserving mitochondrial function in cardiomyocytes. Animal model studies show that intravenous administration of exogenous irisin produces dose-dependent protection against ischemia/reperfusion (I/R)-induced injury to the heart as reflected by the improvement of left ventricular ejection fraction and the reduction in serum level of cTnI (n = 15, P < 0.05). I/R-induced apoptosis of cardiomyocytes is reduced after irisin treatment. The irisin-mediated protection has, at least in part, an effect on mitochondrial function because administration of irisin increases irisin staining in the mitochondria of the infarct area. Irisin also reduces I/R-induced oxidative stress as determined by mitochondrial membrane potential evaluation and superoxide FLASH event recording (n = 4, P < 0.05). The interaction between irisin and superoxide dismutase2 (SOD2) plays a key role in the protective process because irisin treatment increases SOD activity (n = 10, P < 0.05) and restores the mitochondria localization of SOD2 in cardiomyocytes (n = 5, P < 0.05). These results demonstrate that irisin plays a protective role against I/R injury to the heart. Targeting the action of irisin in mitochondria presents a novel therapeutic intervention for myocardial infarction.

Mindset, Mentor, And Money: How Each Influences College Success, Malachi Nichols

Graduate Theses and Dissertations

Across society, the consistent influx of students enrolling in higher education institutions without a comparable increase in degree attainment has produced a heightened awareness and a desire to identify the factors related to influencing college success. This dissertation aims to develop a greater understanding of three potentially relevant factors and their respective influences in facilitating college success at the University of Arkansas. First, I evaluate the Student Talent Enrichment Program (STEP) Grant program, designed to fulfill low-income first-year students’ financial needs and encourage their persistence on to their second year of college. Second, I study the effectiveness of the BounceBack …