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2018

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Characterizing The Gut Microbiota During Plasmodium Infection And Antimalarial Treatment., Joshua E. Denny Dec 2018

Characterizing The Gut Microbiota During Plasmodium Infection And Antimalarial Treatment., Joshua E. Denny

Electronic Theses and Dissertations

Plasmodium, the parasitic cause of malaria, is a global pathogen, annually causing 216 million infections and 445,000 deaths. As drug resistance continues develop and no effective vaccine is available, it is critical to understand the factors underlying the severity of this disease. Plasmodium is an extra-gastrointestinal tract infection where the parasite infects red blood cells causing clinical malaria. However, recent publications have pointed to interactions between the gut microbiota and malaria. With this in mind, the role of the gut microbiota in malaria infection was studied. C57BL/6 mice from different vendors displayed differential resistance and susceptibility to severe malaria, …

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Physical Education Activity Courses: An Exploration Of How Enrollment Influences Student Retention Rates., Dylan J. Naeger Dec 2018

Physical Education Activity Courses: An Exploration Of How Enrollment Influences Student Retention Rates., Dylan J. Naeger

Electronic Theses and Dissertations

Nationally, student retention rates continue to be a problem, as the National Center for Education Statistics (2018) found the six-year undergraduate graduation rate for students who started college in fall 2010 was around 60%. An area not yet investigated is if any association exists between enrollment in a university physical education activity course (BIP) and academic success. The purpose of this study was to determine how enrollment in a BIP course affected undergraduate student retention rates. This study examined whether enrollment in BIP courses influenced student retention of all first-time, full-time, baccalaureate degree-seeking students enrolled at a public research university …

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Modeling And Simulation Methodologies For Spinal Cord Stimulation., Saliya Kumara Kirigeeganage Dec 2018

Modeling And Simulation Methodologies For Spinal Cord Stimulation., Saliya Kumara Kirigeeganage

Electronic Theses and Dissertations

The use of neural prostheses to improve health of paraplegics has been a prime interest of neuroscientists over the last few decades. Scientists have performed experiments with spinal cord stimulation (SCS) to enable voluntary motor function of paralyzed patients. However, the experimentation on the human spinal cord is not a trivial task. Therefore, modeling and simulation techniques play a significant role in understanding the underlying concepts and mechanics of the spinal cord stimulation. In this work, simulation and modeling techniques related to spinal cord stimulation were investigated. The initial work was intended to visualize the electric field distribution patterns in …

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Student Perception Of The Effects Of Out Of School Suspension On Academic Motivation., Dawn Boone Roseberry Dec 2018

Student Perception Of The Effects Of Out Of School Suspension On Academic Motivation., Dawn Boone Roseberry

Electronic Theses and Dissertations

Historically, the response to rule violations and misbehavior in schools was to punish students by using methods such as exclusionary discipline. Exclusionary discipline may lead to poor academic outcomes for the student, increased likelihood of dropping out of school, and an introduction to the criminal justice system (Cueller and Markowitz, 2015). Being suspended from school also increases the chances a student will feel disconnected, intensify conflict with adults, and impact a youth’s choice to engage in criminal activities (Skiba et al., 2006). Researchers have concluded that suspension is also a predictor of future suspensions, not a deterrent (Rafaele & Mendez, …

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Furthering Understanding Of Forensic Units: A Detailed Examination Of Knoxville Police Department's Crime Scene Unit., Cassandra Christina Rausch Dec 2018

Furthering Understanding Of Forensic Units: A Detailed Examination Of Knoxville Police Department's Crime Scene Unit., Cassandra Christina Rausch

Electronic Theses and Dissertations

Throughout the past three decades, the criminal justice system has decidedly employed new technologies for the purposes of establishing guilt or innocence. Forensic science, with its synthesis of scientific methodology and investigative considerations of law enforcement, ushered in the development of DNA profiling and forever changed the process of crime scene investigation.This shift in focus also led to a shift in the individuals involved in investigation, producing the widespread formation of stand-alone crime scene units. Utilizing both civilian and sworn employees of a law enforcement agency, these units became responsible for the documentation, collection, and preservation of evidence that would …

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Is The Sum Greater Than The Parts? A Qualitative Case Study Of Cross-Functional Team Creativity., Tracy J. Richardson Dec 2018

Is The Sum Greater Than The Parts? A Qualitative Case Study Of Cross-Functional Team Creativity., Tracy J. Richardson

Electronic Theses and Dissertations

Creativity is an important capability for organizations to develop solutions for complex challenges. Cross-functional teams are often used within organizations in the hope of leveraging diverse perspectives to develop creative ideas. However, the process by which cross-functional teams generate new ideas is often elusive in practice and poorly understood in research. A case-study design was used to explore the complex nature of the creative process within a services industry organization, which is an understudied context for creativity. The study focused on the knowledge sharing and knowledge integration processes for cross-functional teams as well as overall team effectiveness. The results of …

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Effects Of Hydrogen Sulfide In Hyperhomocysteinemia-Mediated Skeletal Muscle Myopathy., Avisek Majumder Dec 2018

Effects Of Hydrogen Sulfide In Hyperhomocysteinemia-Mediated Skeletal Muscle Myopathy., Avisek Majumder

Electronic Theses and Dissertations

Although hyperhomocysteinemia (HHcy) occurs due to a deficiency in cystathionine-β-synthase (CBS), causing skeletal muscle myopathy, it is still unclear whether this effect is mediated through oxidative, endoplasmic reticulum (ER) stress, both or something else. Cystathionine γ-lyase (CSE) and CBS are the main H2S producing enzymes, which produce Hydrogen sulfide (H2S) from Hcy in the transsulfuration reaction. H2S is an anti-oxidant compound and patients with a CBS deficiency cannot produce enough H2S, thus rendering them vulnerable to excess Hcy-mediated damage. Both in-vitro (C2C12 cells) and in-vivo (CBS+/- mice) models were used to …

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Lead And Crime: An Ecological Study Between Lead Contaminated Topsoil And Violent Crime., Brian Guinn Dec 2018

Lead And Crime: An Ecological Study Between Lead Contaminated Topsoil And Violent Crime., Brian Guinn

Electronic Theses and Dissertations

Lead is a known neurotoxicant. Human exposure to lead comes primarily through environmental exposures, including remnant lead paint, lead contaminated topsoil and lead contaminated water. Prenatal and early life lead exposure has been associated with numerous neurocognitive and neuropsychiatric disorders. This dissertation presents findings from an ecological study which evaluated the geospatial association between topsoil lead content and the incidence of FBI designated violent crime in Jefferson County, Kentucky. A total of 412 topsoil samples were collected along roadways (n=300) and from Louisville Metro Parks (n=112). Jefferson County crime data was obtained from the Louisville Metro Police Department – Crime …

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Impacts Of Ammonia And Temperature On Freshwater Snail Behavior And Physiology., Megan Christine Dewhatley Dec 2018

Impacts Of Ammonia And Temperature On Freshwater Snail Behavior And Physiology., Megan Christine Dewhatley

Electronic Theses and Dissertations

Gastropods are one of the most imperiled groups of animals in North America, yet there are major gaps in the literature pertaining to pollutants and climate change, and especially sublethal impacts. This dissertation assesses the effects of climate warming and unionized ammonia (NH3), one of the most abundant water pollutants, on the behavior and physiology of two caenogastropod snails: fine-ridged elimia (Elimia semicarinata) and Shawnee rocksnails (Lithasia obovata) (Gastropoda: Neotaenioglossa: Pleuroceridae). Righting behavior, or the movement used by snails to turn themselves right-side-up, was used as the main endpoint; delays in this behavior compromise …

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Role Of Trkb-Signaling In Taste Development And Function., Jennifer Rios-Pilier Dec 2018

Role Of Trkb-Signaling In Taste Development And Function., Jennifer Rios-Pilier

Electronic Theses and Dissertations

In the geniculate ganglion, taste neurons likely differentiate into subtypes during development, but very little is known about how these neurons are defined molecularly or how they differentiate. Embryonically, geniculate neuron development is regulated by the growth factor, brain ­derived neurotrophic factor (BDNF). Postnatally, BDNF becomes restricted to subpopulations of taste receptor cells with specific functions, primarily sour responding. I hypothesized that during development, the receptor for BDNF, tropomyosin kinase B receptor (TrkB), also becomes restricted to a neuronal subset. I used transgenic mouse models to label and quantify both geniculate sensory neurons (Phox2b+), and those expressing TrkB (GFP) across …

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Association Between Cigarette Smoking And Ovarian Reserve Among Women Seeking Fertility Treatment With Effect Modification By Race And Nat2 Genotype., Islamiat A. Oladipupo Dec 2018

Association Between Cigarette Smoking And Ovarian Reserve Among Women Seeking Fertility Treatment With Effect Modification By Race And Nat2 Genotype., Islamiat A. Oladipupo

Electronic Theses and Dissertations

Cigarette smoking in women has been associated with adverse reproductive outcomes such as reduced ovarian reserve, poorer in vitro fertilization (IVF) outcomes and increased adverse pregnancy outcomes. This study examined the association of smoking with ovarian reserve in a cross-sectional study of women seeking fertility treatment, and potential effect modification by race and NAT2 acetylator phenotype. Data from 265 women from the Louisville Tobacco Smoke, Genetic Susceptibility, and Infertility (LOUSSI) Study were analyzed. A total of 265 women were recruited through a single infertility clinic between September 2016 and June 2018. Information on current smoking status was assessed using a …

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Assessing The Affects Of Treatment Services, Financial Assistance, Race/Ethnicity, And Income On The Criminal Justice Outcomes Of Women On Probation., Jordan Wilfong Dec 2018

Assessing The Affects Of Treatment Services, Financial Assistance, Race/Ethnicity, And Income On The Criminal Justice Outcomes Of Women On Probation., Jordan Wilfong

Electronic Theses and Dissertations

The aim of this study is to examine the affect that treatment services have on the criminal justice outcomes of women on probation. The research to date on the treatment services provided to the criminal justice population has tended to focus on prisoners rather than probationers, with even fewer studies that include samples of women on probation. This study will investigate the impact on criminal justice outcomes of services intended to treat issues identified to increase recidivism among female probationers, such as substance use disorders, illicit drug use, mental health issues, and poverty. An additional assessment is conducted to determine …

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Assessing The Role Of Arsenite In Disrupting The Egfr Signaling Axis., Christine Kim Dec 2018

Assessing The Role Of Arsenite In Disrupting The Egfr Signaling Axis., Christine Kim

Electronic Theses and Dissertations

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase localized on the cell surface. Overexpression of EGFR has been used as biomarkers for many different types of cancers, including lung cancer. There is a strong association between arsenic and lung cancer development, although the mechanism is unclear. We hypothesize that chronic exposure of “a physiologically relevant” level of arsenite disrupts the EGFR endocytic trafficking. The goal of this project is to identify molecular mechanisms and roles of chronic arsenite-induced EGFR overexpression in lung cancer development. A non-malignant human bronchial epithelial cell line, Beas-2B cells were exposed to 100 …

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The Migration And Developmental Remodeling Of Intrinsic Interneurons In Visual Thalamus And The Role Of Retinal Signaling., Naomi E. Charalambakis Dec 2018

The Migration And Developmental Remodeling Of Intrinsic Interneurons In Visual Thalamus And The Role Of Retinal Signaling., Naomi E. Charalambakis

Electronic Theses and Dissertations

The dorsal lateral geniculate nucleus (dLGN) of the mouse is a model system to study the development of thalamic circuitry. While most studies focus on relay neurons of dLGN, little is known about the factors regulating the development of the other principal cell type, intrinsic interneurons. To date, the targeting and migratory path of dLGN interneurons as well as their morphological development remains unclear. Here we examined whether the migration, structure, and function of interneurons relies on retinal signaling. We took a loss-of-function approach and crossed GAD67-GFP mice, which express green fluorescent protein (GFP) in dLGN interneurons, with math5 nulls …

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Is Macrolide And Beta-Lactam Combination Therapy Associated With Early Clinical Stability Or 30 Day Mortality In Hospitalized Patients With Pneumonia? An Assessment Of Confounding By Indication., Evangeline Pierce Dec 2018

Is Macrolide And Beta-Lactam Combination Therapy Associated With Early Clinical Stability Or 30 Day Mortality In Hospitalized Patients With Pneumonia? An Assessment Of Confounding By Indication., Evangeline Pierce

Electronic Theses and Dissertations

Pneumonia and influenza are one of the leading causes of infectious disease-related deaths worldwide. Current guidelines for the treatment of hospitalized patients with community acquired pneumonia (CAP) include empiric antimicrobial therapy with a macrolide and a beta-lactam. There is little consensus among studies as to which antimicrobial regimen is best. The confusing results seen may very well be due to lack of assessment of confounding by indication (CBI). This analysis was a secondary analysis from Hospitalized Adults with Pneumococcal Pneumonia: Incidence Study (HAPPI). The study participants were those in HAPPI who had received either macrolide and beta-lactam combination therapy or …

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Investigating The Unique Reactivity Of Novel Hx (X=Cl, Br) Reagents With Alkenes And Alkynes., Rene E. Ebule Dec 2018

Investigating The Unique Reactivity Of Novel Hx (X=Cl, Br) Reagents With Alkenes And Alkynes., Rene E. Ebule

Electronic Theses and Dissertations

The addition of hydrogen halides to carbon-carbon unsaturated systems is a classic synthetic transformation that gives rise to a variety of halogenated products as well as building blocks.1 The different routes to achieve hydrohalogenation make use of the hydrogen halides either in the gaseous form2 or in solution3, or their surrogates4. Only second to dihalogens, hydrogen halides are the most atom efficient source of halogenation. However, hydrogen halides are reactive gases at ambient temperature, posing a major challenge in their application. Handling gaseous hydrogen halide reagents requires expert knowledge and specialized equipment. We have …

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Influence Of Bilberry-Derived Anthocyanidins On Key Regulators Of Colorectal Cancer Development., Ashley M. Mudd Dec 2018

Influence Of Bilberry-Derived Anthocyanidins On Key Regulators Of Colorectal Cancer Development., Ashley M. Mudd

Electronic Theses and Dissertations

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths within the United States. A variety of factors including exposure to environmental carcinogens, such as benzo[a]pyrene (B[a]P), dysbiosis of the gut microbiome and hereditary influences, including APC mutations, have been shown to lead to an increased risk of developing colorectal cancer. Given the recent alarming rise in cases of colorectal cancer diagnosed in individuals under the age of 40, further insight into developing novel and effective prevention and treatment strategies are warranted. The family of plant pigments known as the anthocyanins has been identified with …

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Repetitive Negative Thinking Styles And First-Semester Academic Performance: Psychological Risk And Resilience Among Low-Income College Students., Darlene M. Davis Dec 2018

Repetitive Negative Thinking Styles And First-Semester Academic Performance: Psychological Risk And Resilience Among Low-Income College Students., Darlene M. Davis

Electronic Theses and Dissertations

College students face significant mental health and academic challenges their first academic year. The college transition period can be stressful. In addition, students are increasingly endorsing anxious and depressive symptoms. Depressive and anxious symptoms are linked to repetitive negative thinking styles that present in college students, which contributes to academic interference. The first year of college can be challenging for students who are unable to adjust and adapt. Students who struggle and feel overwhelmed by life stressors experience psychological disruption that interferes with academic performance. Growing up in poverty has been associated with lower grade point averages and poorer graduation …

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How Do Entrepreneurs React To Investor Rejection, Try Harder Or Move On?, Yuhan Hua Dec 2018

How Do Entrepreneurs React To Investor Rejection, Try Harder Or Move On?, Yuhan Hua

Electronic Theses and Dissertations

Rejected by the investor is a common challenge that entrepreneurs face in the startup process. This study investigates how entrepreneurs respond to investor rejection. The results indicate the rejection can motivate entrepreneurs to learn from the rejection and improve venture image. Meanwhile, investor rejection can also increase entrepreneurs’ tendency of withdrawal from the investor and exit intention. Rejected by investor also increase entrepreneurs’ doubts about the investors’ competency. This study finds both the alternative funding source and the fairness of the rejection can impact entrepreneurs’ rejection responses. Also, the individual difference influences how entrepreneurs deal with investors’ rejection. The empirical …

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Commencement Program 2018 December: College Of Architecture, Planning And Public Affairs; Division Of Student Success; School Of Social Work, The University Of Texas At Arlington Dec 2018

Commencement Program 2018 December: College Of Architecture, Planning And Public Affairs; Division Of Student Success; School Of Social Work, The University Of Texas At Arlington

Commencement Programs, Photos, and Video

No abstract provided.

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Effects Of Calcium Fertilization On Growth, Yield, And Nutrient Content Of Hydroponically Grown Radish Microgreens, Cady C. Goble Dec 2018

Effects Of Calcium Fertilization On Growth, Yield, And Nutrient Content Of Hydroponically Grown Radish Microgreens, Cady C. Goble

Graduate Theses/Dissertations

Radish microgreens were grown in a hydroponic wicking system and subjected to a range of calcium chloride (Ca) solutions to evaluate growth, yield, and mineral content. A solution range of 0 to 160 mM Ca was applied to determine upper limits of Ca fertilization. Solutions above 20 mM Ca showed toxic effects to germination and growth, while 5 and 10 mM Ca resulted in the greatest percent of shoots that grew to a desired size for harvest (%H), as well as greater average hypocotyl length per plant (HL) and cotyledon surface area per plant (CSA). For subsequent experiments, Ca solution …

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Impacts Of Cover Crop Mixtures On Productivity Of Cropping Systems, Brionna Lee West Dec 2018

Impacts Of Cover Crop Mixtures On Productivity Of Cropping Systems, Brionna Lee West

Graduate Theses/Dissertations

A field study and a meta-analysis were conducted to compare the impact of cover crops on carbon and nitrogen dynamics and cash crop yield. The field study included six treatments: winter cereal rye, winter cereal rye-Austrian winter pea at two seeding rates, cereal rye-Austrian winter pea-radish at two seeding rates, and a no cover control. Meta-analysis data sets were compiled from studies published between 1994 and 2017. Treatments were grouped into the following classifications: monoculture, binary mix, polyculture, or control. In both the field study and meta-analysis, cover crops did not affect cash crop yield. However, plant biomass and plant …

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Effects Of Irrigation On Forage Growth Rates On Rotational Grazing Dairies, Zachary Davis Dec 2018

Effects Of Irrigation On Forage Growth Rates On Rotational Grazing Dairies, Zachary Davis

Graduate Theses/Dissertations

The amount and timing of rainfall in Missouri can be very irregular. This causes issues for producers of agronomic products in the state who rely on forages for income. The most sensible approach to the problem is the use of irrigation. But there is little useful information to reference when implementing this management decision. By studying three different styles of irrigation (center pivot, spider, and k-line) on 4 species of forages native to Missouri (alfalfa, crabgrass, perennial ryegrass, and tall fescue/clover), this study provides valuable insight as to the cost and benefit of irrigation. The main goal is to produce …

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Relative Contribution Of Physical Interference And Allelopathy To Weed Suppression By Winter Annual Cover Crop Mixtures, Alyssa D. Travlos Dec 2018

Relative Contribution Of Physical Interference And Allelopathy To Weed Suppression By Winter Annual Cover Crop Mixtures, Alyssa D. Travlos

Graduate Theses/Dissertations

Cover cropping systems are widely used in crop production systems to prevent erosion, improve soil health, and suppress weeds. Common cover cropping systems include combinations of cereal rye (Secale cereale L.), Brassica species, legumes, and other winter annual species. Three cover crop mixtures (cereal rye alone, cereal rye plus winter pea, and cereal rye plus winter pea plus radish) were applied using three methods (fresh residue, dried leached residue, and leachate) to common waterhemp (Amaranthus tuberculatus var. rudis) and large crabgrass [Digitaria sanguinalis (L.) Scop.]. The experiment was conducted once in a greenhouse and once in a …

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Missouri Meat Goat Producers: A Focus Group Approach To Identify Opportunities And Challenges, Samantha N. Riley Dec 2018

Missouri Meat Goat Producers: A Focus Group Approach To Identify Opportunities And Challenges, Samantha N. Riley

Graduate Theses/Dissertations

This study was conducted to better understand opportunities and challenges for Missouri meat goat producers. The meat goat industry is expanding and is one of the fastest growing segments of livestock production in the United States, both in inventory and markets for products produced from goats. This study used focus groups as a way to determine what a sampling of producers in Missouri see as opportunities and challenges based on themes and patterns found in the focus groups. The participants in the three focus groups did not always agree with the literature, but they did see the following as opportunities …

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An Adaptive Memory-Based Reinforcement Learning Controller, Keith August Cissell Dec 2018

An Adaptive Memory-Based Reinforcement Learning Controller, Keith August Cissell

Graduate Theses/Dissertations

Recently, the use of autonomous robots for exploration has drastically expanded--largely due to innovations in both hardware technology and the development of new artificial intelligence methods. The wide variety of robotic agents and operating environments has led to the creation of many unique control strategies that cater to each specific agent and their goal within an environment. Most control strategies are single purpose, meaning they are built from the ground up for each given operation. Here we present a single, reinforcement learning control solution for autonomous exploration intended to work across multiple agent types, goals, and environments. The solution presented …

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How God Writes History: A Gramscian Analysis Of Religion And Nature In The Writings, Life, And Legacy Of John Muir, Daniel R. Jones Dec 2018

How God Writes History: A Gramscian Analysis Of Religion And Nature In The Writings, Life, And Legacy Of John Muir, Daniel R. Jones

Graduate Theses/Dissertations

Representations of John Muir, America’s most famous environmentalist, and religion have been highly variegated. A mythological figure of American environmental politics, Muir and his legacy have been an ideological apparatus for presidents, environmentalists, and naturalists performing acts of identification for themselves and their country. Furthermore, religion and environmental scholars have often used Muir as a case study for what they call “nature religion.” Lost in this myth-making labor are the politics of sacred spaces and national discourse. Italian political theorist Antonio Gramsci developed the concept of common sense and the intellectual, which this thesis uses to analyze John Muir’s poetics …

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Commencement Program 2018 December: College Of Nursing And Health Innovation, The University Of Texas At Arlington Dec 2018

Commencement Program 2018 December: College Of Nursing And Health Innovation, The University Of Texas At Arlington

Commencement Programs, Photos, and Video

No abstract provided.

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Novel Regulatory Pathways Of Protein Channels, Sheenah Lynn Bryant Dec 2018

Novel Regulatory Pathways Of Protein Channels, Sheenah Lynn Bryant

Boise State University Theses and Dissertations

Since the proposal of the fluid mosaic model of a cell membrane, substantial scientific evidence has shown that the cell membrane is not simply an inert structure with the sole role of separating two chemically different environments. The cell membrane dynamically satisfies basic needs, such as water, ion and nutrient transport, without which the cell could not survive. It is a structure which actively participates in a great variety of physiological functions. The activity of the cell membrane is responsible for the contraction of our muscles and information processing in our brain. In order to participate in such a wide …

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Comparison Of Organic And Inorganic Solar Photovoltaic Systems, Khulan Orgil Dec 2018

Comparison Of Organic And Inorganic Solar Photovoltaic Systems, Khulan Orgil

Electrical Engineering

This senior project report addresses the consumer’s need for accurate and easily accessible information when making a solar panel purchasing decision. Thus, the project analyzes and compares the costs and benefits of organic and inorganic photovoltaic systems during their life cycle. The cost comparison includes analysis of the environmental and economic costs of materials, production, installation, and disposal. The benefit comparison includes analysis of the economic, environmental, and social benefits accrued during the system’s lifetime. With the project’s data, consumers can make more informed decisions to fit their specific needs.

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