Digital Commons Network^™

Network Pharmacology-Guided Development Of A Novel Integrative Regimen To Prevent Acute Graft-Vs.-Host Disease, Ming Lyu, Zhengcan Zhou, Xiaoming Wang, Hong Lv, Mei Wang, Guixiang Pan, Yuefei Wang, Guanwei Fan, Xiumei Gao, Benjamin Feng, Yan Zhu

Peer Reviewed Articles

Lapses in the graft-vs.-host disease (GVHD) prophylaxis and side effects of current standard care following allogeneic hematopoietic stem cell transplantation (allo-HSCT) call for novel regimens. Traditional approaches targeting T cells showed limited success in preventing acute GVHD (aGVHD). System medicine showed promising results treating complex diseases such as sepsis and multi-organ dysfunction syndrome (MODS). Adapting established network pharmacology analysis methods, we aimed to develop novel integrative regimens to prevent aGVHD. Our network pharmacology analysis predicted that Xuebijing injection (XBJ) targets a series of key node proteins in aGVHD network. It also unveiled that Salviae miltiorrhizae (Danshen), an herb in Xuebijing …

The Diamond, December 13, 2018, Dordt College

Dordt Diamond

• Front Page: Dordt Volleyball Season Closes, Seniors Leave Lasting Legacy; Christmas at the Centre Mall; Driving Home for Dummies
• News: Domestic Violence in the NBA; Why Do Only Women Work the Information Desk?; The Tie Guy; California Wildfires Cause Widespread Destruction Throughout 2018; New Airport to Land in Maurice; Swinging in a Winter Wonderland; I'll Be at Dordt for Christmas; Former Sioux Center Christian School Teacher Pleads Guilty; Growing Ag Education
• Arts & Entertainment: Top 10 Music Releases of 2018; Aquaman: The Next Wonder Woman?; The New World Theatre: Where the Memories Live; What Is a Christmas Movie?
• Opinion: …

Ohio University Earns Four Case Awards (December 13, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Assessing Elements Of Urban Public Space Under Elevated Freeways: Application To The West End’S Dallas, Adrianna E. Tobias

Landscape Architecture Masters & Design Theses - Archive

This thesis investigates the revitalization of spaces found underneath elevated freeways into valued urban public spaces. These spaces are created when elevated freeways carve through dense city centers. Literature addressing the history of freeways, their sometimes-destructive impact on the urban fabric of cities and the unique role elevated freeways place in this destruction is reviewed. A brief review of an unintended consequence of elevated freeways as well as the impacts elevated freeways have had in Texas is also reviewed. The research employs three methods which rely on the collecting and synthesizing of data from literature reviews, case studies, site observation …

Education Reform And Detroit’S Right To Literacy Litigation, Kristine L. Bowman

Washington and Lee Law Review Online

Ongoing education reform litigation arising out of Detroit, Michigan presents an innovative claim: Children have an unenumerated federal constitutional right of access to literacy. On June 29, 2018, the district court granted defendants’ motion to dismiss. The case is now on appeal to the Sixth Circuit and is expected to be argued in the first half of 2019. This litigation has already broken new ground and, regardless of the ultimate outcome, it is valuable because it invites us to revisit fundamental questions about rights, remedies, and the role of courts in education reform.

Board Of Trustees Meeting Minutes, December 13-14, 2018

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on December 13-14, 2018.

Subjective Cognitive Functioning Relates To Parenting In Mothers With Chronic Pain, Denae S. Clohessy

University Honors Theses

Individuals with chronic pain commonly report problems with daily cognitive functioning. This feeling of decreased subjective cognitive functioning (SCF) can be distressing due to its impact on daily life and relationships. Children of parents with chronic pain are at an increased risk for the development of chronic pain and related impairment and it is possible that lower parental SCF could increase this risk. Specifically, mothers with lower SCF may have difficulty completing day-to-day caregiving activities as well as responding flexibly to children’s behaviors. The present study focused on examining the impact of SCF on parenting in mothers with chronic pain. …

Adolescent Female Substance Abuse: Risk And Resiliency Factors, Mary Bemker

Dissertations

Alcohol, tobacco, and other drug (ATOD) abuse is a major social and health concern for adolescent females. For the first time, female use patterns are converging with male patterns among U.S. adolescents. Despite evidence that gender differences could be associated with ATOD origin and precipitating factors, little attention has been directed to female adolescents and ATOD use. Therefore, the purpose of this investigation was to explore the experiences of adolescent females in relation to ATOD risk and resiliency factors present in their lives. This investigation used the Neuman systems model as its theoretical framework. Grounded theory methodology was employed to …

St-07 - New Mexico - 2018-12-13, Bradley Carrington

State Representatives

No abstract provided.

Internet Based Interventions For Improving Mental Health On College Campuses: A Scoping Review Of Ibis, Caceti Dobrowolski

Honors Theses

BACKGROUND Over the past decade, Internet Based Interventions (IBI) have emerged as a possible mental health approach, reported to reduce cost and provide access to needed services. There is a dearth of literature that clearly defines the scope and components of IBIs and its efficacy. Moreover, little is known about the efficacy of IBI for college students, a population that reportedly underutilizes mental health services.

OBJECTIVE The purpose of this scoping review was to assess the efficacy of IBI as a mental health intervention for college students.

METHODS Three databases were used to initially identify 400 studies and through the …

Psychological Effects And Treatment Of An Injury On An Athlete: Suggested Treatment Plan For Athletic Trainers And Physical Therapist, Odell Miller

Honors Theses

Injuries that force athletes to lose participation in their sport and or training have a tremendous impact on their mental health. Mental health issues can be detrimental, but often times go unnoticed. For example in 2010, Kenny McKinley, a wide receiver for the Denver Broncos, was found dead after killing himself with a gun. After suffering a knee injury, he had become progressively depressed. Investigators reported that there are statements saying that McKinley didn’t know what he would do without football. According to NCAA’s Sports Science Institute (2017), the psychological response to injury can trigger mental health issues such as: …

Precision Medicine In Pediatric Cancer: Current Applications And Future Prospects., Atif Ahmed, Divya S. Vundamati, Midhat S. Farooqi, Erin M. Guest

Manuscripts, Articles, Book Chapters and Other Papers

Precision oncologic medicine is an emerging approach for cancer treatment that has recently taken giant steps in solid clinical practice. Recent advances in molecular diagnostics that can analyze the individual tumor's variability in genes have provided greater understanding and additional strategies to treat cancers. Although tumors can be tested by several molecular methods, the use of next-generation sequencing (NGS) has greatly facilitated our understanding of pediatric cancer and identified additional therapeutic opportunities. Pediatric tumors have a different genetic make-up, with a fewer number of actionable targets than adult tumors. Nevertheless, precision oncology in the pediatric population has greatly improved the …

The Role Of Cognitive Behavioral Therapy In Treating Substance Use Disorders, Jessica M. Johnson

Nursing Capstones

No abstract provided.

Pharmacologic Treatment Of Agitation In Traumatic Brain Injuries, Brianna L. Pankratz

Nursing Capstones

No abstract provided.

Manganese-Enhanced Magnetic Resonance Imaging: Overview And Central Nervous System Applications With A Focus On Neurodegeneration, Ryan A. Cloyd, Shon A. Koren, Jose F. Abisambra

Physiology Faculty Publications

Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and other body systems. MEMRI has since been employed in the investigation of physiology in many animal models and in humans. Here, we review historical perspectives that follow the evolution of applied MRI research into MEMRI with particular focus on its potential toxicity. Furthermore, we discuss the more current in vivo investigative uses of MEMRI in CNS investigations and …

A Simple Graphene Nh3 Gas Sensor Via Laser Direct Writing, Dezhi Wu, Qianqian Peng, Shan Wu, Guangshun Wang, Lei Deng, Huiling Tai, Lingyun Wang, Yajie Yang, Linxi Dong, Yang Zhao, Jinbao Zhao, Daoheng Sun, Liwei Lin

Publications

Ammonia gas sensors are very essential in many industries and everyday life. However, their complicated fabrication process, severe environmental fabrication requirements and desorption of residual ammonia molecules result in high cost and hinder their market acceptance. Here, laser direct writing is used to fabricate three parallel porous 3D graphene lines on a polyimide (PI) tape to simply construct an ammonia gas sensor. The middle one works as an ammonia sensing element and the other two on both sides work as heaters to improve the desorption performance of the sensing element to ammonia gas molecules. The graphene lines were characterized by …

Implementation Of A Delirium Protocol In A Community Living Center: A Short And Long-Term Care Facility, Marguerite C. Burch

Graduate Theses, Dissertations, and Capstones

Delirium is the most frequent complication associated with hospitalizations of older adults and is responsible for 17.5 million hospital days at a cost of more than $6 billion each year. It is estimated delirium occurs in approximately 14 – 56% of all hospitalized elderly patients. Outcomes associated with delirium in the adult population are prolonged hospital lengths of stay, increased mortality, and post-hospitalization cognitive impairment. Hospitalized patients diagnosed with delirium may be discharged to rehabilitation centers or nursing homes for recuperation, and/or for permanent residence.

Delirium is often misdiagnosed because the presentation of signs and symptoms mimic other medical conditions …

Parental Verbal Mediation For Children's Internet Use, Daeun Grace Lee

Graduate Theses, Dissertations, and Capstones

This study explores the different communication strategies parents employ when speaking to their children about their Internet use. The Internet is continuously and rapidly expanding in terms of content range and mobility, and is becoming more and more an integrated and essential part of children across the nation. Thus, parents must be willing and equipped to educate their children about their habits of Internet use through effective mediation strategies. The goal of this study is to understand not only how parents speak to their children about their Internet use, but also how parents currently perceive the significance of these conversations. …

Teaching Sbirt Through Simulation: Educational Case Studies From Nursing, Psychology, Social Work, And Medical Residency Programs, Diane King, Lucía L. Neander, Bridget L. Hanson, Alexndra Edwards, Ryan Shercliffe, Emilie Cattrell

ISER Articles

The prevalence of substance use disorders remains high in the United States and healthcare professionals are largely ill-equipped to intervene with patients experiencing substance misuse or use disorders. To address this issue, substance abuse intervention curricula such as Screening, Brief Intervention, and Referral to Treatment (SBIRT) are being integrated into university healthcare programs through the use of simulation to provide healthcare students with the necessary skills to address patient substance use. Teaching SBIRT with simulation provides students with an authentic clinical environment in which to learn and refine clinical skills. Simulation also supports reflective practice by providing an opportunity for …

A Mobile Phone Hiv Medication Adherence Intervention: Care4today Mobile Health Manager, C. Andrew Martin

Dissertations

This paper presents the findings of a qualitative study designed to describe the experience of HIV medication adherence using a mobile phone application. For the purpose of this qualitative study, nine semi-structured focus group discussions were conducted over a three-month period at an AIDS service organization in Central Texas. The data were analyzed following the principles of thematic analysis.

Transition From Nursing Student To Registered Nurse In Singapore: The Personal Experiences, Ming Wei Jeffrey Woo, Stuart Andrew Newman

General Submissions: Presentations (Oral and Poster)

Background: Transition experience to professional nursing practice is well documented as complex and multi-faceted process. The quality of the transition experience affects how well new graduate registered nurses (NGRNs) integrate into their new identity and impact on their short and long term commitment toward the profession. NGRNs transition experience from nursing student to registered nurse in Singapore however remain under-evaluated owing to limited studies presented in local context. Purpose: The aim of this study sought to examine; (i) how do new graduate registered nurses in Singapore personally experience transition from nursing student to registered nurse? (ii) what are the factor(s) …

One-Sentence, One-Word: An Innovative Data Collection Method To Enhance Exploration Of The Lived Experiences, Shannon L. Sibbald, Dylan Brennan, Aleksandra Zecevic

The Qualitative Report

Experienced-based methods are growing in popularity and are increasingly being utilized in a variety of research programs and investigations. They enable researchers and participants to co-design research strategies and outcomes and subsequently propose solutions to potential problems in the partnership. By applying an experience-based methods lens, we sought to augment traditional qualitative interviewing methodologies by using a novel method we named “one-sentence, one-word” (1S1W). To apply our 1S1W method, we used a phenomenological study that examined the relationship between the risk of falling and the desire of master athletes to engage in competitive sports. Participants reflected and recorded their subjective …

Organizing The Three Forms Of Qualitative Inquiry: A Book Review Of Qualitative Inquiry – Thematic, Narrative And Arts-Based Perspectives, Umair Majid

The Qualitative Report

In this book review, I examine the structure, form, content, and purpose of Qualitative Inquiry: Thematic, Narrative and Arts-Based Perspectives by Lynn Butler-Kisber. This book aims to augment the teaching and learning of investigators engaging in qualitative inquiry. First, I explicate my positionality and reflexivity to contextualize the approach of this book review. Following this discussion, I analyze the book’s structure and content by comparing the alignment between the background, exemplars, and strategies with the intended purpose of the book. I conclude this book review with a summary of its benefits to novice investigators.

Aberrant Structural And Functional Connectivity And Neurodevelopmental Impairment In Preterm Children, Cynthia E Rogers, Rachel E Lean, Muriah D Wheelock, Christopher D Smyser

Open Access Publications

BACKGROUND: Despite advances in antenatal and neonatal care, preterm birth remains a leading cause of neurological disabilities in children. Infants born prematurely, particularly those delivered at the earliest gestational ages, commonly demonstrate increased rates of impairment across multiple neurodevelopmental domains. Indeed, the current literature establishes that preterm birth is a leading risk factor for cerebral palsy, is associated with executive function deficits, increases risk for impaired receptive and expressive language skills, and is linked with higher rates of co-occurring attention deficit hyperactivity disorder, anxiety, and autism spectrum disorders. These same infants also demonstrate elevated rates of aberrant cerebral structural and …

Dopamine Perturbation Of Gene Co-Expression Networks Reveals Differential Response In Schizophrenia For Translational Machinery, Mark Z. Kos, Jubao Duan, Alan R. Sanders, Lucy Blondell, Eugene I. Drigalenko, Melanie A. Carless, Pablo V. Gejman, Harald H. H. Goring

School of Medicine Publications

The dopaminergic hypothesis of schizophrenia (SZ) postulates that positive symptoms of SZ, in particular psychosis, are due to disturbed neurotransmission via the dopamine (DA) receptor D2 (DRD2). However, DA is a reactive molecule that yields various oxidative species, and thus has important non-receptor-mediated effects, with empirical evidence of cellular toxicity and neurodegeneration. Here we examine non-receptor-mediated effects of DA on gene co-expression networks and its potential role in SZ pathology. Transcriptomic profiles were measured by RNA-seq in B-cell transformed lymphoblastoid cell lines from 514 SZ cases and 690 controls, both before and after exposure to DA ex vivo (100 μM). …

Kenyon Collegian - December 13, 2018

The Kenyon Collegian

No abstract provided.

Meta-Modeling Constructs For Requirements Reuse (Rr): Software Requirements Patterns, Variability And Traceability, Badamasi Imam Ya’U, Azlin Nordin, Norsaremah Salleh

Malaysian Journal of Computing (MJoC)

Reuse is a fundamental activity, which increases quality and productivity of software products. Reuse of software artifacts, such as requirements, architectures, and codes can be employed at any developmental stage of software. However, reuse at a higher level of abstraction, for instance at requirements level, provides greater benefits in software development than when applied at lower level of abstraction for example at coding level. To achieve full benefits of reuse, a systematic approach and appropriate strategy need to be followed. Although several reuse approaches are reported in the literature, these approaches lack a key strategy to synergize some essential drivers …

Implementation Of A Pediatric Post-Operative Hand-Off Tool: A Patient Safety Project, Kaye Remo

Master's Projects and Capstones

Abstract

Problem: The clinical nurse leader (CNL) performed a microsystem assessment using the Dartmouth assessment tool to evaluate the microsystem’s readiness to provide safe care for pediatric post-operative cardiovascular patients. The microsystem is a 12-bed unit caring for critically ill pediatric patients requiring intensive monitoring and therapy. The microsystem’s interdisciplinary team is comprised of medical doctors, nurses, respiratory therapists, social workers, nutritionists, child life specialists, and pharmacists. During assessment and gap analysis, the CNL identified gaps in nursing knowledge and skills to deliver safe care for this patient population during the immediate post-operative phase of recovery. There is a …

Exercise-Based Cardiac Rehabilitation Improves Exercise Capacity And Health-Related Quality Of Life In People With Atrial Fibrillation: A Systematic Review And Meta-Analysis Of Randomised And Non-Randomised Trials., Na Smart, N King, Jd Lambert, Mj Pearson, Jl Campbell, Ss Risom, Rs Taylor

School of Biomedical Sciences

No abstract provided.

A High-Throughput And Open-Source Platform For Embryo Phenomics, Oliver Tills, John I. Spicer, Andrew Grimmer, Simone Marini, Vun Wen Jie, Ellen Tully, Simon D. Rundle

School of Biological and Marine Sciences

No abstract provided.