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Volume 38, Number 4, December 2018 Olac Newsletter, Marcia Barrett, Debra Spidal, Richard N. Leigh, Jan Mayo, Yoko Kudo, Jay Weitz, Lisa Romano

OLAC Newsletters

Digitized December 2018 issue of the OLAC Newsletter.

Effect Of Differences In Metabolic Activity Of Melanoma Models On Response To Lonidamine Plus Doxorubicin., Kavindra Nath, Jeffrey Roman, David S. Nelson, Lili Guo, Seung-Cheol Lee, Stepan Orlovskiy, Kevin Muriuki, Daniel F. Heitjan, Stephen Pickup, Dennis B. Leeper, Ian A. Blair, Mary E. Putt, Jerry D. Glickson

Department of Radiation Oncology Faculty Papers

Lonidamine (LND), a metabolic modulator, sensitizes DB-1 human melanoma to doxorubicin (DOX) chemotherapy by acidifying and de-energizing the tumor. This report compares the effects of LND on two human melanoma lines, DB-1 and WM983B, which exhibit different metabolic properties. Using liquid chromatography mass spectrometry and Seahorse analysis, we show that DB-1 was more glycolytic than WM983B in vitro. ³¹P magnetic resonance spectroscopy (MRS) indicates that LND (100 mg/kg, i.p.) induces similar selective acidification and de-energization of WM983B xenografts in immunosuppressed mice. Over three hours, intracellular pH (pHi) of WM983B decreased from 6.91 ± 0.03 to 6.59 ± 0.10 (p …

Spaceoar To Improve Dosimetric Outcomes For Monotherapy High-Dose-Rate Prostate Implantation In A Patient With Ulcerative Colitis., Michael Trager, Benjamin Greenberger, Amy S. Harrison, James Keller, Robert B. Den

Department of Radiation Oncology Faculty Papers

High-dose-rate (HDR) brachytherapy is an attractive option for patients receiving definitive radiation therapy for prostate cancer with decreased overall dose to the pelvis. However, ulcerative colitis increases rectal toxicity risk and may be a contraindication. A synthetic hydrogel, SpaceOAR (Augmentix Inc., Waltham, MA, USA), can facilitate the use of HDR brachytherapy for patients where rectal toxicity is a limiting factor. SpaceOAR gel (13.19 cc) was utilized in a monotherapy HDR prostate treatment with Ir-192 under transrectal ultrasound guidance, with the intention of decreasing rectal dose. SpaceOAR gel was inserted transperineally into the patient 18 days prior to the procedure. The …

Sumo-Mediated Regulation Of Nlrp3 Modulates Inflammasome Activity., Rachael Barry, Sidonie Wicky John, Gianmaria Liccardi, Tencho Tenev, Isabel Jaco, Chih-Hong Chen, Justin Choi, Paulina Kasperkiewicz, Teresa Fernandes-Alnemri, Emad S Alnemri, Marcin Drag, Yuan Chen, Pascal Meier

Department of Biochemistry and Molecular Biology Faculty Papers

The NLRP3 inflammasome responds to infection and tissue damage, and rapidly escalates the intensity of inflammation by activating interleukin (IL)-1β, IL-18 and cell death by pyroptosis. How the NLRP3 inflammasome is negatively regulated is poorly understood. Here we show that NLRP3 inflammasome activation is suppressed by sumoylation. NLRP3 is sumoylated by the SUMO E3-ligase MAPL, and stimulation-dependent NLRP3 desumoylation by the SUMO-specific proteases SENP6 and SENP7 promotes NLRP3 activation. Defective NLRP3 sumoylation, either by NLRP3 mutation of SUMO acceptor lysines or depletion of MAPL, results in enhanced caspase-1 activation and IL-1β release. Conversely, depletion of SENP7 suppresses NLRP3-dependent ASC oligomerisation, …

Factors Associated With Follow-Up Compliance Among Clients Referred By A Local Health Department For Hiv Pre-Exposure Prophylaxis, Lauren R. Cirrincione

Capstone Experience: Master of Public Health

Background: Pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) is a public health strategy to limit HIV infection among at-risk populations. Local health departments (LHDs) promote PrEP initiation by referring patients to private and academic specialty care centers. However, low follow-up compliance remains a challenge in this setting. Between January 2016 and September 2018, Douglas County Health Department, a LHD in Omaha, Nebraska, externally referred 126 clients for PrEP at an academic specialty care center, and only 20 (15%) clients completed a PrEP initiation follow-up appointment. The purpose of this study is to describe the characteristics of clients referred by …

Examining The Impact Of Hiv Medical And Social Case Management Program On Viral Load For Clients Living With Hiv/Aids In Nebraska, Abdulla Munir

Capstone Experience: Master of Public Health

Abstract

Case management (CM) is one of the standard practices that has been implemented since 1990 to help people living with HIV/AIDS (PLWHA) in the United States. The program is designed for low-income populations and it aims to address the barriers related to access to health care and improve the HIV outcomes. Previous studies identified a positive association with the provision of CM and improvement in viral outcomes. Increasing the viral suppression rates among HIV diagnosed individuals proved to reduce the risk of transmitting the infection, and disease incidence. Although CM program is provided to Nebraskans diagnosed with HIV, but …

Ethical Cannabis Lawyering In California, Francis J. Mootz Iii

St. Mary's Journal on Legal Malpractice & Ethics

Cannabis has a long history in the United States. Originally, doctors and pharmacists used cannabis for a variety of purposes. After the Mexican Revolution led to widespread migration from Mexico to the United States, many Americans responded by associating this influx of foreigners with the use of cannabis, and thereby racializing and stigmatizing the drug. After the collapse of prohibition, the federal government repurposed its enormous enforcement bureaucracy to address the perceived problem of cannabis, despite the opposition of the American Medical Association to this new prohibition. Ultimately, both the states and the federal government classified cannabis as a dangerous …

Autonomy Isn't Everything: Some Cautionary Notes On Mccoy V. Louisiana, W. Bradley Wendel

St. Mary's Journal on Legal Malpractice & Ethics

The Supreme Court’s May 2018 decision in McCoy v. Louisiana has been hailed as a decisive statement of the priority of the value of a criminal defendant’s autonomy over the fairness and reliability interests that also inform both the Sixth Amendment and the ethical obligations of defense counsel. It also appears to be a victory for the vision of client-centered representation and the humanistic value of the inherent dignity of the accused. However, the decision is susceptible to being read too broadly in ways that harm certain categories of defendants. This paper offers a couple of cautionary notes, in response …

Conflicts Of Interest And Law-Firm Structure, Cassandra Burke Robertson

St. Mary's Journal on Legal Malpractice & Ethics

Business and law are increasingly practiced on a transnational scale, and law firms are adopting new business structures in order to compete on this global playing field. Over the last decade, global law firms have merged into so-called “mega-brands” or “mega-firms”—that is, associations of national or regional law firms that join together under a single brand worldwide. For law firms, the most common mega-firm structure has been the Swiss verein, though the English “Company Limited by Guarantee” structure is growing in popularity as well, as is the similar “European Economic Interest Grouping.” All of these structures allow related entities to …

A Heuristic Inquiry Into Female Student-Athletes' Experiences Of Identity Loss After Retirement From Sport, Catherine Cody Wooten

Dissertations

The purpose of this study was to explore the lived experiences of retired female athletes after they have retired from Division I athletics. The study sought to understand retired female athletes' subsequent transition out of athletics and their loss in identity, if any. With increased understanding of psychological and emotional facets of retired female athletes, counselors may be able to provide more appropriate and well-tailored interventions, support, and guidance required for adaptive transitions in identity. Six retired female athletes were recruited to describe their lived experiences of transition out of athletics in a single semi-structured audio interview. Data comprised participants' …

Uis Bulletin, Volume 60, No. 2, December 2018, Efraín Mercado

KIP Articles

Contents: Editorial: Facing the future while living the present -- The President's Column: You are the UIS -- International Year of Caves and Karst: A Call to Action -- The International Standardization of Karst Research and Management -- Report of Activities 2018: History Commission -- 18th International Symposium on Vulcanospeleology -- UIS Supported the Meeting "125 Years of Das Karstphänomen" -- Innovation in Show Cave Management: The 2018 ISCA Congress -- 12th Balkan Caver's Camp 2018 -- The France Habe Prize 2019 Regulations -- Research on the 60 years of UIS History -- The UIS through the Pins -- Cave …

Eurospeleo Newsletter, December 2018, Bureau Of The European Speleological Federation

KIP Articles

Contents: Editorial -- Hirlatzhöhle (Austria) much extended -- EEB Board elections -- Cave and Karst related events -- Casola 2018 - Nuvole -- 13th Eurospeleo Forum 2019 26-29 September, Sofia, Bulgaria -- The EuroSpeleo Protection Label 2018

Developing Cultural Competency In Anesthesia Through Student Registered Nurse Anesthetists, Emma To

Doctoral Projects

Certified Registered Nurse Anesthetists (CRNAs) are the main anesthesia providers in over 70% of rural hospitals providing anesthesia. Each year, over 2,000 student registered nurse anesthetists (SRNAs) graduate and continue as licensed CRNAs. This Doctor of Nurse Practice (DNP) project emphasizes the importance of developing culturally competent providers in anesthesia by promoting early outreach in cultural competence education of SRNAs. Cultural competence is described as possessing characteristics of congruent attitudes, awareness, and conduct that provides and enables effective skills in cross-cultural encounters. Encompassing cultural competency education early in the SRNAs profession may provide valuable lifelong cultural skills that will benefit …

The Single Mitochondrion Of The Kinetoplastid Parasite Crithidia Fasciculata Is A Dynamic Network., John Dimaio, Gordon Ruthel, Joshua J. Cannon, Madeline F. Malfara, Megan L. Povelones

Department of Medical Laboratory Sciences & Biotechnology Faculty Papers

Mitochondria are central organelles in cellular metabolism. Their structure is highly dynamic, allowing them to adapt to different energy requirements, to be partitioned during cell division, and to maintain functionality. Mitochondrial dynamics, including membrane fusion and fission reactions, are well studied in yeast and mammals but it is not known if these processes are conserved throughout eukaryotic evolution. Kinetoplastid parasites are some of the earliest-diverging eukaryotes to retain a mitochondrion. Each cell has only a single mitochondrial organelle, making them an interesting model for the role of dynamics in controlling mitochondrial architecture. We have investigated the mitochondrial division cycle in …

Journal Of Food Law & Policy - Volume 14 Fall 2018, Journal Editors

Journal of Food Law & Policy

No abstract provided.

A Case Study Of The Implementation Of Co-Teaching In A Steam Elementary Magnet School In A Midwestern State, Ashley Lane Copley

Dissertations

Although research is limited on the effectiveness of co-teaching as a service delivery model for students with disabilities, through observation, many educators have reported positive outcomes with co-teaching (Beninghof, 2011). This case study was designed to examine the implementation of co-teaching in an elementary magnet school in a Midwestern school district driven by science, technology, engineering, arts, and mathematics (STEAM) and with a strong emphasis on personalized learning. General education teachers, special education teachers, and administrators were interviewed three times during the initial implementation school year. In addition, journaling was documented by three of the participants, and co-teaching fidelity checks …

Methane Oxidation Potential Of Uncomposted Yard Waste As A Landfill Biocover, Gomathy Radhakrishna Iyer

Civil Engineering Dissertations - Archive

Biocovers are widely used in landfills to oxidize emissions of the greenhouse gas methane. Biocovers used till date are fully or partially made of composts. Compost takes time and effort to create, and costs about $10 per cubic yard on an average. Even more importantly, however, production of compost, although theoretically an aerobic process, actually generates methane, from 3.2 to 362 kg CO2-equivalents per ton of wet waste composted, depending on the type of waste, whether open or enclosed composting technology is used, and other factors. To reduce the net greenhouse gas emissions from biocovers, this research explores the potential …

Hpfrc And Rc Slab-Beam-Column Connections Under Extreme Earthquake Loading And Further Improvement Of Novel Double-Beam-Coupling Beams, Youngjae Choi

Civil Engineering Dissertations - Archive

The work presented in this dissertation is divided into two parts. Each part has drawn its own results. Reinforced concrete (RC) buildings resist a strong earthquake through structural foundations, diaphragms, and vertical elements. Moment-resisting frames and shear walls are primary-used vertical elements in RC buildings. The moment-resisting frames consist of columns, beams that frame into the column and beam column joints where the columns and beams meet. A key point of designing the moment-resisting frames against a strong earthquake is to ensure beam-column connections to dissipate as much energy possible. The shear wall often becomes two separate slender cantilever walls …

Novel Infrastructure Monitoring Using Multifaceted Unmanned Aerial Vehicle Systems - Close Range Photogrammetry (Uav - Crp) Data Analysis, Surya Sarat Chandra Congress

Civil Engineering Dissertations - Archive

Remote sensing is a method of collecting data without making any physical contact with the object under inspection. Modern day remote sensing kicked off with the invention of the camera and continued on to the invention of advanced satellite mounted sensors. Photogrammetry is defined as a science that measures distances using one or more images captured remotely. Remote collection of images within a range of 1000 ft is termed close-range photogrammetry (CRP). Unmanned aerial vehicle systems (UAV or UAS) have become a popular means of remotely gathering information and assessing infrastructure conditions due to their versatile nature. Multirotor and fixed-wing …

Utilization Of Geocell-Reinforced Rap Material Base Layer In Flexible Pavements: Experimental And Numerical Studies, Anu Muthumala George

Civil Engineering Dissertations - Archive

Reclaimed asphalt pavement (RAP) materials have been considered as one of the most sustainable and cost-effective options in the pavement industry. The use of RAP materials in pavement construction reduces natural resources depletion and the volume of construction debris discarded into the landfills. However, the low shear strength and high permanent deformation (PD) of RAP materials often limit their application in road bases. Utilization of mechanical stabilizers, such as geocell, for stabilizing RAP bases, have found to be effective in improving the pavement performance. The main objective of this study is to assess the efficacy of high-density polyethylene (HDPE) geocell …

Development Of The Urban Passenger Transportation Life Cycle Inventory For Comparison Across Modes Model (Transportlifecamm), Alma Angelica Hernandez Ruiz

Civil Engineering Dissertations - Archive

Against the backdrop of the increasingly complex urban passenger transportation challenges associated with megacities during the 21st century, and the effort to find the most sustainable modes of transportation for them, the spreadsheet-based model TransportLifeCAMM was developed. This model allows users in the US and Mexico to compare life cycle environmental impacts from automobile, bus, and/or subway. While other models to estimate environmental burdens from transportation exist, few of them consider emissions or energy consumption over the entire life cycle of the vehicle and the fuel (including vehicle manufacture, fuel production, maintenance, and end-of-life disposal). Furthermore, even fewer of the …

Post-Disaster Construction Labor Cost Fluctuations: Measurement And Modeling, Navid Ahmadi Esfahani

Civil Engineering Dissertations - Archive

The United States has been one of the top five countries most frequently hit by natural disasters. The post-disaster survival of cities and communities depend on their capabilities to reconstruct and repair damages to buildings and other infrastructure systems. The significant increase in the repair costs following large-scale natural disasters, also called “demand surge,” slows down the repair process that impacts many lives touched by large-scale natural disasters. Previous studies showed that post-disaster construction labor cost escalation drives the total post-disaster construction cost escalation in the U.S. The ultimate goal of this research is to (1) measure post-disaster construction labor …

Simulation Of Climate Across The Permian-Triassic Boundary With A Focus On Phytogeographical Data Analysis, Mitali Dinesh Gautam

Earth & Environmental Sciences Theses - Archive

The present study aims at reconstructing the paleoclimate across the Permian-Triassic Boundary (PTB, 251.9 ± 0.024 Ma) which encompasses one of the major mass extinction events of the Earth’s history. Results are analyzed from sensitivity experiments that have been previously been carried out with a community climate system model (CCSM3) for 4x CO2 higher than the pre-industrial levels of 280 ppmv, 12.7x CO2 and 12.7x CO2 with a lower cloud cover . This study attempts to reconstruct the climate using the floristic patterns derived from plant-fossil data. Finally, simulated biomes are compared with data-derived biomes, in order to validate the …

Commencement Program 2018 December: College Of Liberal Arts, The University Of Texas At Arlington

Commencement Programs, Photos, and Video

No abstract provided.

Commencement Program 2018 December: College Of Engineering, The University Of Texas At Arlington

Commencement Programs, Photos, and Video

No abstract provided.

Commencement Program 2018 December: College Of Business, The University Of Texas At Arlington

Commencement Programs, Photos, and Video

No abstract provided.

Commencement Program 2018 December: College Of Education; College Of Science, The University Of Texas At Arlington

Commencement Programs, Photos, and Video

No abstract provided.

Academics: The Newsletter Of The Swosu College Of Arts And Sciences, Peter Grant

aCAdemicS: The Newsletter of the SWOSU College of Arts & Sciences

No abstract provided.

From Arcades To Online: Updating Copyright To Accommodate Viodeo Game Streaming, Nicholas Robinson

North Carolina Journal of Law & Technology

No abstract provided.

Critical Reflection And Mainstream Teachers’ Implementation Of Sheltered Instruction Observation Protocol For English Language Learners: A Case Study, Teneisha Mcneil

CUP Ed.D. Dissertations

The researcher in this study investigated questions that explored (a) what are the frames of reference of mainstream teachers who instruct English learners in the mainstream classroom, (b) how the use of critical reflection and implementation of sheltered instruction observation protocol (SIOP) influence mainstream teachers’ efficacy of instructional delivery, and (c) how do mainstream teachers construct meaning and encourage their professional growth through their use of critical reflection and sheltered instruction observation protocol. Using a case study methodology, the researcher sought to answer these questions using relative literature and theories that exist within the field of education. The goal of …