Digital Commons Network^™

Implementing A Surgical Infection Prevention Practice In An Integrated Healthcare System, Tammy Peacock

Doctor of Nursing Practice (DNP) Projects

Problem: One of the most preventable health care associated infections (HAI) is surgical site infection (SSI). Approximately sixty percent of SSI’s could be prevented. The devastation of an SSI to the patient can be catastrophic. The cost to the health care system for treating SSI’s can be substantial (Ban et al., 2017).

Context: The rate of surgical site infections has been on the increase over the past three years. The concern for the amount of harm affecting our patients was worrisome. The cost of reputation and the bottom line to the organization was recognized by senior leadership. The support from …

New Treatment Options For Tardive Dyskinesia, Haron N. Manwa

Nursing Capstones

No abstract provided.

Mineralogy, Petrology, And Geochemistry Of The Unique Silica-Rich Ungrouped Achondrite Northwest Africa 11575, Mya Ann Habermann

Earth and Planetary Sciences ETDs

We report here on a unique, newly discovered, silica-rich ungrouped achondrite Northwest Africa 11575 (NWA 11575). NWA 11575 is one of four known silica-rich ungrouped achondrites, presenting evidence for igneous processes resulting in evolved compositions early in the history of the solar system. It is unique from the other silica-rich ungrouped achondrites in that it has pyroxene compositional trends matching those of lunar samples and martian meteorites; contains quartz and potassium feldspar; and contains oxygen, hydrogen, and chromium isotopes that are similar to those of LL chondrites. Together, these four silica-rich ungrouped achondrites provide evidence for evolved compositions resulting from …

Multilingual Museums: A Proposal To Increase Linguistic Diversity In Contemporary Art Museums, Jennifer Cha

Master's Projects and Capstones

The U.S. population is becoming more ethnically, racially, and linguistically diverse. It is estimated that by the year 2050, the U.S. will shift to a majority-minority population, meaning that the total minority population will become the majority of the U.S. population. But while the U.S. is diversifying, the current museum visitorship demographic is not representative of or on track to measure up to these changes in the future. If museums are valuable civic spaces with several associated health, social, and educational benefits, and a large percentage of the population have low-English proficiency and cannot access the information, then there is …

Perceptions And Clinical Applications Of Feedback Type If Dental Hygiene, Elmer Eleazar Gonzalez

Individual, Family, and Community Education ETDs

Purpose/Objectives: The study assesses whether or not feedback type and feedback delivery method play a significant role in students’ learning and clinical performance. The study explores Ego Stroking Sandwich feedback and Non-Sandwich feedback as the feedback types and Instructors feedback vs. Scoring guide feedback as the feedback delivery method. Students’ perceptions and clinical applications were considered as part of the study.

Methods: Eleven participants were included in the study. One group was the Ego Stroking Sandwich type feedback (n=5) and the other was the Non-Sandwich Type feedback (n=6). Each group performed two dental impressions (a maxillary and a mandibular) while …

Delivery Of Microrna With Cxcr4-Targeted Nanoparticles In Metastatic Cancer Treatment, Ying Xie

Theses & Dissertations

Metastasis is the main contributor to cancer-associated deaths. Inhibition of CXCR4 emerged as one promising approach in metastatic cancer therapy. MiRNAs represent a new class of therapeutics for cancer treatment through RNA interference-mediated gene silencing. Polymeric CXCR4 antagonist (PCX) is a dual-functional polycation to inhibit CXCR4 and deliver nucleic acids. This dissertation hypothesized that blockade of CXCR4 by PCX combined with delivery of miRNA cooperatively enhances metastatic cancer therapy.

In chapter 1, an overview of CXCR4 inhibition, miRNA delivery and CXCR4 targeted nanomedicine in cancer therapy is given.

Chapter 2 reports that PCX can effectively deliver miR-200c mimic and that …

Effects Of Class Ii Correctors And Functional Appliances On The Periodontal Health Of The Mandibular Incisors – A Prospective Cone-Beam Computed Tomography (Cbct) Study, David C. Duevel

Theses & Dissertations

The purpose of this investigation was to evaluate the effects of Class II correctors and functional appliances on the dentoalveolar support of the mandibular incisors during orthodontic treatment. Twenty six patients who were treated with a Forsus^TM, Herbst, or MARA participated this study. Lateral cephalometric radiographs, limited field-of-view CBCTs, and periodontal measurements were collected both the day of appliance activation and day of appliance deactivation. Ten hard tissue measurements on all four mandibular incisors were collected at each time point on CBCT images. Bone thickness increased at 6 and 9 mm apical from the cementoenamel junction (CEJ) on …

Neuronal And Glial Expression Of Glun2c And Glun2d Nmda Receptor Subunit Mrna In Different Regions Of The Mouse Forebrain, Hassan Alsaad

Theses & Dissertations

N-methyl-D-aspartate (NMDA) receptors are a subtype of glutamate receptors that are widely expressed in the brain, where they mediate critical functions. While the actions of the predominate GluN2 NMDAR subunits, GluN2A and GluN2B are relatively well understood, the function of GluN2C and GluN2D in the telencephalon is largely unknown. To better understand the possible role of GluN2C and GluN2D subunits, we used fluorescence in situ hybridization together with multiple cell markers to define the distribution and type of cells expressing GluN2C and GluN2D mRNA. Also, a GluN2C-KO mouse was used as a negative control.

GluN2C mRNA expression was only found …

Development Of The University Of New Mexico Spectrometer For High-Resolution Fission Product Yield Data, Richard Emery Blakeley

Nuclear Engineering ETDs

Well-defined fission product yield data has been of increasing interest in various applications within the nuclear industry. With this need in mind, a fission fragment mass spectroscopy system was designed and developed at the University of New Mexico in collaboration with the Los Alamos National Laboratories with a stated goal of attaining a mass resolution of ≤ 1 % (FWHM/centroid) for light fragments and near 1 % for heavy fragments. The mass spectrometer utilized in this work consists of a transmission time-of-flight detection system to measure fission product velocity and an axial ionization chamber to measure the fission product energy, …

Under Pressure: Tailored Cpr With Stress Management For Formerly Incarcerated Individuals, Amanda Lee

Master's Projects and Capstones

Purpose: The purpose of this study was to increase rates of Cardiopulmonary Resuscitation (CPR) training and bystander response to Sudden Cardiac Arrest (SCA). This was accomplished by providing a short, one hour adapted CPR course with a stress management component targeting common barriers (e.g. psychological concerns) to bystander response for formerly incarcerated individuals at the Delancey Street Foundation.

Methods: The CPR course was adapted based off a literature review on the learning needs and preferences of this population. Data collection included:1) instructor evaluation of skills based on oral and simulation examination by students (adapted from the standard American Heart Association …

Micrat: A Novel Algorithm For Inferring Gene Regulatory Networks Using Time Series Gene Expression Data, Bei Yang, Yaohui Xu, Andrew Maxwell, Wonryull Koh, Ping Gong, Chaoyang Zhang

Faculty Publications

Background: Reconstruction of gene regulatory networks (GRNs), also known as reverse engineering of GRNs, aims to infer the potential regulation relationships between genes. With the development of biotechnology, such as gene chip microarray and RNA-sequencing, the high-throughput data generated provide us with more opportunities to infer the gene-gene interaction relationships using gene expression data and hence understand the underlying mechanism of biological processes. Gene regulatory networks are known to exhibit a multiplicity of interaction mechanisms which include functional and non-functional, and linear and non-linear relationships. Meanwhile, the regulatory interactions between genes and gene products are not spontaneous since various …

Establishing And Evaluating Agricultural Plantings And Supplemental Cover On Reservoir Mudflats As A Means To Increase Juvenile Game Fish Abundance And Growth, Hunter R. Hatcher

Theses and Dissertations

Reservoirs throughout the country exhibit degraded shorelines and simplified littoral habitats because of aging. This study evaluated the establishment of agricultural plantings on reservoir mudflats and the effectiveness of supplemental brush pile structures in providing recruitment habitat for juvenile fish. The mudflats of Enid Reservoir, Mississippi were seeded during the winter drawdown in October of 2016 and 2017 with agricultural plantings. Monitoring of plantings found grasses performed best in terms of establishment and providing potential fish habitat. During Summer 2017 brush piles and control sites, without brush, were sampled in Enid Reservoir using rotenone to evaluate juvenile fish use. Juvenile …

Exploration Of Factors Affecting Single Black Mothers' Facilitation Of Father-Child Relationships, Shawn'ta Gardner

Theses and Dissertations

Literature shows that when fathers are involved in their children’s lives, their children have better outcomes and neighborhoods are safer. However, father involvement is often limited in situations where the father is a non-residential parent. Previous research has indicated that there are several factors that may influence a custodial mother’s facilitation of the father-child relationship. These factors may include the existing co-parenting relationship between mother and father and the mother’s perception of the father’s appreciation of her mothering of the child. Particularly in low-income families, the struggle to simply meet economic demands overrides a custodial parent’s desire to facilitate the …

Ab Initio Molecular Dynamics Simulations To Understand Speciation And Solvation Structure Of Common Herbicides, Zachary W. Windom

Theses and Dissertations

The application of commercial herbicide restricts weed growth and significantly improves control over crop vitality and yield. Despite their utility in the agriculture sector, herbicides have the potential to contaminate local water sources. To minimize environmental impacts, the development of efficient separation processes to clean-up contaminated water bodies is necessary. However, complex speciation and conformational flexibility in the condensed phase poses a significant challenge. In this work, we investigate structure and speciation of three common organic herbicides (glyphosate, atrazine, and metolachlor) in aqueous solution. We employ the PBE-D3 density functional to perform ab initio molecular dynamics (MD) simulations in the …

A Comparison Of Phytoplankton Nutrient Limitation Between The Marsh And Beach Environments Of Waties Island, Sc, Raymond Sgambati, George Boneillo

Honors Theses

The aim of this study was to investigate the differences in nutrient limitation within the beach and marsh environments at Waties Island, SC. Conducting the experiment on Waties Island allowed most physical factors to be held as constant, meaning the marsh and beach environments would serve as the only variables. Experiments were performed in the winter, spring, summer and fall of 2018 to determine temporal changes in limitation to phytoplankton and cyanobacteria growth. Nutrient additions included dissolved inorganic nitrogen (nitrate, nitrite, and ammonium), dissolved organic nitrogen (urea), and phosphate. To test for co-limitation, a nitrate & phosphate treatment was also …

Use Of Co-Immunoprecipitations And 2d Gel Electrophoresis To Identify Protein-Protein Interactions Of Maturase K, Lauren Angello

Honors Theses

Maturase K (MatK) is the only group II intron encoded protein in the chloroplast of land plants. Maturases are prokaryotic enzymes that catalyze formation of the lariat structure needed for intron removal from precursor RNAs. The chloroplast maturase MatK, is a descendant of prokaryotic maturases, however, unlike its prokaryotic relatives, MatK is thought to catalyze excision of, not only its own intron, but also the introns of other group II introns in the plastome. Similar to the multiprotein and snRNA spliceosomal complex of the nucleus, it is postulated that MatK is not working alone to excise these introns but most …

Development Of Polymeric Carriers For The Treatment Of Acute Kidney Injury, Yi Chen

Theses & Dissertations

Acute kidney injury (AKI) is a major kidney disease associated with high mortality and morbidity. Long-term AKI may lead to chronic kidney disease and end-stage renal disease. Several clinical trials failed due to lack of efficacy and undesired side effects. Studies showed that macromolecular delivery systems would be a promising method to target kidney, however, little is known about how physicochemical properties affects the polymers deposition in ischemia-reperfusion (I/R) AKI.

Gene therapy has been well studied as a promising therapeutic agent for several diseases, including cancer and AKI. Although small interfering RNA (siRNA) has been commonly used to treat AKI …

An Evaluation Of Deferred Time-Out, Abigail Kennedy

Theses & Dissertations

Although substantial research has shown time-out to be an effective treatment for children’s problem behavior, time-out resistance (i.e., failure to go to time-out, escape from time-out, as well as negative vocalizations and aggression occurring between the time-out instruction and the completion of time-out) has the potential to decrease time-out’s suppressive effect, increase use of more intrusive and effortful administrative methods and escape contingencies, and negatively affect parental adherence. The primary purpose of this study was to evaluate the effect of deferred time-out (DTO) on time-out resistance in a clinic and home setting. In addition, this research provided a preliminary evaluation …

Acquiring Knowledge About The Use Of A Newly Developed Electronic Fetal Heart Rate Monitor: A Qualitative Study Among Birth Attendants In Tanzania, Sara Rivenes Lafontan, Johanne Sundby, Hussein Kidanto, Columba Mbekenga, Hege L. Ersdal

School of Nursing & Midwifery, East Africa

In an effort to reduce newborn mortality, a newly developed strap-on electronic fetal heart rate monitor was introduced at several health facilities in Tanzania in 2015. Training sessions were organized to teach staff how to use the device in clinical settings. This study explores skilled birth attendants’ perceptions and experiences acquiring and transferring knowledge about the use of the monitor, also called Moyo. Knowledge about this learning process is crucial to further improve training programs and ensure correct, long-term use. Five Focus group discussions (FGDs) were carried out with doctors and nurse-midwives, who were using the monitor in the labor …

Modulating Hallmarks Of Cholangiocarcinoma, Cody Wehrkamp

Theses & Dissertations

How are cholangiocarcinoma cells different from non-malignant cholangiocytes?

All of the hallmarks of cancer apply- those reported in this dissertation include cell proliferation, migration, apoptosis, and evasion of growth suppression. My studies began with testing how apoptosis might be regulated through embelin, a small molecule reported to sensitize cells to apoptosis by blocking XIAP. My data however revealed that embelin reduced the proliferative capacity in cholangiocarcinoma cells, but did not increase cell death. Malignant cells exhibit dysregulation of microRNA processing and expression. Hence, my studies seeking ways that cholangiocarcinoma eludes apoptosis transitioned to the oncomiR miR-106b, which is overexpressed in …

Health-Related Perception And Responsibility Behavior Among Individuals With And Without Chronic Illness, Danielle Dohrmann

Theses & Dissertations

Few studies have examined perceptions of responsibility attribution and well-being, and health responsibility behaviors in individuals with none, one, and multiple chronic illnesses. Adults (N = 421) in medical clinics completed questionnaires for this cross-sectional descriptive study. The Revised Causal Dimensional Scale measured responsibility attribution whereas sub-sections of the Chronic Disease Self-Management Program evaluation measured well-being perception and the health responsibility behavior of communication associated with a clinic visit. Chi-square, Wilcoxon-Mann-Whitney U, and Kruskal-Wallace tests were used to examine demographic characteristics and group differences. Individuals with multiple morbidities and of advanced age perceived their illnesses as more stable and rated …

Red Panda: A Novel Method For Detecting Variation In Single-Cell Rna Sequencing, Adam Cornish

Theses & Dissertations

Single-cell sequencing enables the rapid acquisition of genomic and transcriptomic data from individual cells to better understand genetic diseases, such as cancer or autoimmune disorders, which are often affected by changes in rare cells. Currently, no existing software is aimed at identifying single nucleotide variations or micro (1-50bp) insertions and deletions in single-cell RNA sequencing (scRNA-seq) data. However, generating high quality data is vital to the study of the aforementioned diseases, among others. Our goal is to create such a tool and use in-house sequencing to validate its effectiveness. Our software employs the unique information found in scRNA-seq data to …

Changes In The Transverse Dimension Of The Nasomaxillary Complex Following Rapid Palatal Expansion – A Post-Retention, Cbct Evaluation, Allison Schubert

Theses & Dissertations

Purpose: The purpose of this investigation was to evaluate the immediate and long-term effects of palatal expansion on the transverse dimension of the nasomaxillary complex.

Materials and Methods: Twenty-eight patients’ CBCTs were obtained at four time points: pre-expansion (T₁), post-expansion (T₂), pre-treatment (T₃), and middle or end of orthodontic treatment (T₄). The patients’ age, sex, cervical vertebral maturation stage, and the number of instructed expander turns were recorded. Measurements of the nasal floor, nasal passage, maxillary sinus, maxillary first molar mesiolingual cusp, maxillary first molar palatal cusp, maxillary first molar buccal cortical …

Development Of Preclinical Magnetic Resonance Imaging Relational Database And Interactive Analytical Tool For Diffusion Tensor Imaging, Ahmad Tanwir

Theses & Dissertations

Databases have become an essential component for any organization to collect and manage the information. Similar to other domains, by implementing a database management system (DBMS), data storage, access, analysis and updates can be automated and optimized in the biological, medical and preclinical research areas. This work demonstrated the development of a preclinical database, which contains the processed results from different magnetic resonance imaging (MRI) techniques with relevant biological information. In addition, we designed and implemented an interactive analytical tool to format and analyze diffusion tensor imaging (DTI) data and automatically generate results in the forms of box plot, bar …

Hearing Loss And Hearing Protection Use Among Midwestern Farmers, Josie J. Ehlers

Theses & Dissertations

Many farmers have noise-induced hearing loss, yet few use hearing protection when working around loud noise. A point source intervention (storing hearing protection devices near sources of noise) was implemented to help farmers overcome accessibility barriers related to using hearing protection. Intervention farmers (n=53) received education and the point source intervention; control farmers (n=36) received education only. During each year of the study, all farmers completed a questionnaire about their perceptions of hearing protection and participated in an audiometric test at their farm. Ambient sound pressure levels were taken during tests. The main objectives of this dissertation were to evaluate …

Pupillometry As A Test Of Infant Word Recognition, Amy Vinyard

Masters Theses, 2010-2019

Pupillometry holds great promise as a tool for infant language research but has not yet been used to probe word recognition. The goal of the described study was to design a functioning method that can later be used to test the possibility of using pupil dilation as a gauge of word recognition in 11-month-olds. To do this, we used the methods of an existing study (The Role of Accentual Pattern in Early Lexical Representation, Vihman, Nakai, DePaolis, & Hallé 2004) with modifications. Our method ran a one-sided head turn preference paradigm with the addition of an eye tracker for pupil …

The Effects Of An Interprofessional Emergent Writing Intervention For Preschoolers, Danika L. Pfeiffer

Dissertations, 2014-2019

This pre-post design study explored the effects of an emergent writing interprofessional education (IPE) experience for preprofessional speech-language pathology (SLPs) and occupational therapy (OT) students. Six preprofessional SLP students and three preprofessional OT students participated in the study, which had two conditions: (a) unpaired SLPs, and (b) SLP and OT pairs. The preprofessional students delivered 8-10 emergent writing interventions to preschoolers in small groups. The preprofessional students’ learning about emergent writing concepts and interprofessional collaborative practice (IPP) was supported through structured debriefs with their clinical supervisors after each session, as well as facilitated discussions to discuss supplemental readings and their …

Evaluating Rater Effects In The Context Of Ethical Reasoning Essay Assessment: An Application Of The Many-Facets Rasch Measurement Model, Madison A. Holzman

Dissertations, 2014-2019

Performance assessments are an often desired type of assessment due to their potential for alignment between the assessment and reality. However, due to the rater-mediated nature of scoring (Eckes, 2015), performance assessments have psychometric challenges that cannot be ignored in testing and assessment work. Specifically, performance assessment scores are prone to rater effects, or systematic differences in how raters evaluate performance assessment products (Myford & Wolfe, 2003). The purpose of this project was to evaluate ethical reasoning essay scores for rater effects. The Many-Facets Rasch Measurement (MFRM) model was used to evaluate ethical reasoning essay scores for rater leniency/severity effects, …

Overall Sound Pressure Level Contours Of Jet Noise By Cartesian Acquisition Grid, Stephen Perry

Theses and Dissertations

Noise pollution from aircraft is an ever-increasing issue in urban areas. Venting exhaust over body panels could reduce perceived sound pressure levels (SPL) by absorption or redirection. This paper investigates the farield spectra and sound propagation of a flat panel held near an axis-symmetric supersonic jet. In contrast to typical radial acquisition, Overall sound pressure level (OASPL) contours are constructed from a 9 by 23 cartesian acquisition gird, spaced equidistantly at 3.67 Jet Diameters (Dj). Three panel configurations each at three nozzle pressure ratios (NPR) are discussed. Additionally, a source finding algorithm is developed and shows source locations by frequency. …

Mechanical Property Development And Numerical Modeling Of Ultra-High Performance Concrete Focused On Isothermal Curing Conditions, Thomas Allard

Theses and Dissertations

Ultra-high performance concrete (UHPC) has progressively gained interest because of its favorable strength and durability properties. Literature shows that curing temperature has a significant effect on the resultant mechanical properties of UHPC, generally resulting in increased compressive strength. However, limited datasets are currently available to ascertain the degree of change related to compressive strength as a function of curing temperature and conditions. This study investigates the effect of isothermal and submerged curing temperature conditions, ranging from 10°C to 90°C, on the compressive strength and elastic modulus development of UHPC and generates a numerical model to capture these effects. The extent …