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Research News. Publications, 2018. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period July 1 through December 31, 2018

2006 - Salinas Valley Integrated Regional Water Management Functionally Equivalent Plan Summary Document Update

Miscellaneous Monterey and San Luis Obispo County Documents and Reports

The California Department of Water Resources (DWR) and the State Water Resources Control Board (SWRCB) are encouraging local and regional water management planners to establish integrated regional water management plans through the collaboration of planning efforts and project coordination. The intent is to encourage planners to implement projects focused on meeting multiple water resources needs on a regional basis. Jointly, both agencies are soliciting grant applications for Proposition 50 Chapter 8 grant funding, which was established to provide a fiscal tool to support integrated regional water management. In order to take advantage of this funding opportunity, Monterey County Water Resources …

Developing Of Micellar Drug Carriers For The Treatment Of Breast Cancer Bone Metastasis, Tong Liu

Theses & Dissertations

Breast cancer (BC) remains one of the most frequently diagnosed cancer worldwide. Bone is one of the most common sites and often the first clinical indication of metastatic progression of BC. Current treatments including radiation, surgery, and chemotherapy are rarely curative with limited effect in overall survival. The challenge is true especially for patients with triple-negative BC that are not responsive to receptor-targeted therapy, or patients who had exposure to chemotherapy before and might already gain the resistance to some of the drugs.

Here we took advantage of the aminobisphosphonate, alendronate (ALN), that can bind to the bone mineral efficiently …

Social Media Utilisation, Study Habit And Undergraduate Students’ Academic Performance In A University Of Education In Nigeria, Emmanuel Olabanji Obadara Dr, Stephen Olufemi Olaopa Mr

Library Philosophy and Practice (e-journal)

This paper examined the correlation between social media utilisation, study habit and undergraduate students’ academic performance in Tai Solarin University of Education, Ogun State, Nigeria. The study used descriptive survey design. A sample of 2 departments from each of the 4 colleges existed in the university in 2012/2013 session was drawn using simple random sampling technique, Also, a sample 2905 students out 9692 students in the university during the academic session under study was drawn using purposive sampling technique. This comprised the total number of students in all the Departments sampled. The study developed and used a questionnaire tagged “Social …

Progress On Identifying And Characterizing The Human Proteome: 2018 Metrics From The Hupo Human Proteome Project., Gilbert S Omenn, Lydie Lane, Christopher M Overall, Fernando J Corrales, Jochen M Schwenk, Young-Ki Paik, Jennifer E Van Eyk, Siqi Liu, Michael Snyder, Mark S Baker, Eric W Deutsch

Articles, Abstracts, and Reports

The Human Proteome Project (HPP) annually reports on progress throughout the field in credibly identifying and characterizing the human protein parts list and making proteomics an integral part of multiomics studies in medicine and the life sciences. NeXtProt release 2018-01-17, the baseline for this sixth annual HPP special issue of the Journal of Proteome Research, contains 17 470 PE1 proteins, 89% of all neXtProt predicted PE1-4 proteins, up from 17 008 in release 2017-01-23 and 13 975 in release 2012-02-24. Conversely, the number of neXtProt PE2,3,4 missing proteins has been reduced from 2949 to 2579 to 2186 over the past …

Whalesong 2018-12-07, Erin Laughlin, Kortney Stevens, Jordan Lewis, Sierra Lissick, Caitlin Burnham, Khrystl Brouillette, Melissa Scriven, Alyssa Madrid

Whalesong

No abstract provided.

Sitc 2018 Workshop Report: Immuno-Oncology Biomarkers: State Of The Art., Lisa H Butterfield, Mary L Disis, Bernard A Fox, David R Kaufman, Samir N Khleif, Ena Wang

Articles, Abstracts, and Reports

Identification of biomarkers in cancer immunotherapy that predict therapeutic response and/or limit adverse events are a critical need in the field. To address recent progress and hurdles around cancer biomarker development and utilization, the Society for Immunotherapy of Cancer (SITC) convened a workshop, "Immuno-Oncology Biomarkers: State of the Art," on May 16-17, 2018. Topics discussed included challenges in handling biospecimens, identification and validation of new biomarkers, data sharing, and collaborating across disciplines to advance biomarker development. Panel discussions followed session presentations to help foster participant conversation and discuss future projects and collaborations. The results of the Workshop include the development …

Chemical And Biological Studies Of Cannabis Sativa Roots, Mostafa Elhendawy, Amira S. Wanas, Mohamed M. Radwan, N. Azzaz, Elshahat S. Toson, Mahmoud A. Elsohly

Faculty and Student Publications (Open Access)

No abstract provided.

Procedurally Generating Biologically Driven Bird And Non-Avian Dinosaur Feathers, Jessica Renee Baron

All Theses

A key element in computer-graphics research is representing the world around us, and immense inspiration may be found in nature. Algorithms and procedural models may be developed that can describe the three-dimensional shape of objects and how they interact with light. This thesis focuses particularly on bird and other dinosaur feathers and their structure. More specifically, it addresses the problem of procedurally generating biologically driven geometry for modeling feathers in computer graphics. As opposed to previously published methods for generated feather geometry, data is derived from a myriad of real-world specimens of feathers and used in creating graphical models of …

Green Synthesis/Biosynthesis Of Silver Nanoparticles By Using Orange Peel Extract, Leela Joshi

Theses and Dissertations

Joshi, Leela, Green Synthesis/Biosynthesis of Silver Nanoparticles by Using Orange Peel Extract. Master of Science (MS), December, 2018, 40 pages, 23 figures, references, 36 titles. In this work, we report synthesis of silver nanoparticles (AgNPs) with an average size of ~6 nm. The aqueous solution of Ag+ ions is reduced using an aqueous extract from orange peel (Citrus Sinensis) at varying pHs. Reduction of Ag+ ions in solution was monitored using UV-visible absorption spectroscopy, and the corresponding surface plasmon resonance of AgNPs at 435 nm. The solution changed color from yellow to reddish-brown upon bioreduction of silver nitrate in orange …

Prioritizing Chemical Constituents In Tobacco Products And Smoke To Predict Developmental Osteotoxicity In Human Embryonic Stem Cells, Joseph Madrid

Electronic Theses, Projects, and Dissertations

Though it is well known that tobacco related products can cause prenatal maldevelopment, very little is known on how tobacco products affect bone tissue as it develops in the embryo. Identifying which chemicals can induce the greatest harm to the prenatal skeletal system is an improbable task as there are over 7,000 chemicals in tobacco smoke alone. We hypothesized that the Toxicological Priority Index (ToxPI) program can be used to rank osteogenic cytotoxicity potential to aid in the assessment of what chemicals out of the thousands can cause osteogenic differentiation inhibition. ToxPI aggregates information from various assays and incorporates them …

Understanding The Role Of Epstein - Barr Virus Encoded Rnas (Ebers) In Ebv Biology, Waqar Ahmed

Medical Education Dissertations

Epstein Barr virus (EBV) is an oncogenic herpesvirus aetiologically linked to several human malignancies of epithelial and lymphoid origins. An accumulating body of data indicates that EBV-infected cells release specific viral components in nano-vesicles called exosomes. Epstein-Barr virus encoded RNAs (EBER1 and EBER2) are two highly abundant, non-protein coding RNAs that are consistently expressed in all EBV latency programs. Conventional in situ hybridization (ISH) studies have indicated that these RNAs are typically found in the nucleus of EBV-infected cells. Recently, it was reported that EBERs are released out of the infected cells. However, the mechanism by which these highly abundant …

Multifunctional Coatings For Biodegradable Biomedical Devices, Sankalp Agarwal

Doctoral

Magnesium (Mg) and its alloys have been widely explored for orthopaedic applications due to its biodegradable nature, biocompatibility and closely related mechanical properties with bone. However, rapid degradation of Mg alloys under physiological conditions is a major challenge for biomedical industries and clinicians. Amongst the various methods employed, deposited coatings have been widely favoured to enhance the corrosion resistance and compatibility of the Mg alloys. This study focused on developing multifunctional coatings on AZ31 Mg alloy having a corrosion resistant, osteoinductive and antibacterial properties for orthopaedic applications. The aim of this study was achieved through the following objectives: - Fabrication …

Carbon Monoxide On Demand: Light-Induced Co Release Of Flavonols, Stacey N. Anderson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Carbon monoxide (CO) is an extremely useful molecule with applications in industrial manufacturing, synthetic procedures as a C1 building block, and as a potential pharmaceutical to produce anti-inflammatory effects and vasodilation. However, the toxicity associated with CO has prevented its full utilization. In order to safely handle CO, compounds and molecules have been developed that act as storage materials for the gas. Ideal storage platforms only release CO upon stimulation via a trigger. Light activation is the most desirable trigger as it can be regulated in terms of the intensity and the wavelength of light used. The majority of light-induced …

Perceptions Of Commercial And Recreational Fishers On The Potential Ecological Impacts Of The Block Island Wind Farm (Us), Talya S. Ten Brink, Tracey Dalton

Marine Affairs Faculty Publications

Offshore wind is gaining momentum in the United States as a viable source for meeting domestic energy needs. Although offshore wind farms have been developed in Europe and Asia, the Block Island Wind Farm (BIWF) is the first offshore wind farm built in North America. To improve marine resource management, it is critical to understand the impacts of the wind farm on marine resource users in context. Little is known about the impacts of offshore wind farms on marine resource users in the United States. This study investigates recreational and commercial fishers' perceptions of the impacts of the BIWF on …

Distinct Proteostasis Circuits Cooperate In Nuclear And Cytoplasmic Protein Quality Control, Rahul S. Samant, Christine M. Livingston, Emily M. Sontag, Judith Frydman

Biological Sciences Faculty Research and Publications

Protein misfolding is linked to a wide array of human disorders, including Alzheimer’s disease, Parkinson’s disease and type II diabetes^1,2. Protective cellular protein quality control (PQC) mechanisms have evolved to selectively recognize misfolded proteins and limit their toxic effects^{3,4,5,6,7,8,9}, thus contributing to the maintenance of the proteome (proteostasis). Here we examine how molecular chaperones and the ubiquitin–proteasome system cooperate to recognize and promote the clearance of soluble misfolded proteins. Using a panel of PQC substrates with distinct characteristics and localizations, we define distinct chaperone and ubiquitination circuitries that execute quality control in the cytoplasm and nucleus. …

Acoustofluidics And Soft Materials Interfaces For Biomedical Applications, Frank A. Fencl

Biomedical Engineering ETDs

This dissertation describes fabrication of devices and other tools for biomedical applications through the integration of acoustofluidic systems with bio separation assays, instrumentation components, and soft materials interfaces. For example, we engineer a new class of transparent acoustic flow chambers ideal for optical interrogation. We demonstrate efficacy of these devices by enhancing the signal for high throughput acoustic flow cytometry, capable of robust particle focusing across multiple parallel flowing streams. We also investigate an automated sampling system to determine the parameters of transient particle stream focusing in between sample boluses and air bubbles to model a high throughput, multi-sampling acoustic …

Development Of Functional Chemical Probes For The Study Of Viscosity, Fe(Ii), And Ferroptosis And Photo-Triggered Drug Delivery, Yongyi Wei

Chemistry and Chemical Biology ETDs

Small molecule probes are useful tools for the study of biology. In particular, the dye derived fluorescence probes enable to spatiotemporally monitor the events of analytes of interest. The noninvasive feature is particularly attractive for the biological studies in live cells. The challenge is to develop chemical probes capable of detection of the analyte of interest with high specificity.

Toward this end, my Ph. D. study centers on the development of novel chemical probes for the study and understanding of the alternation of important cellar contents and substances and their functions and relationship between normal and disease states. In the …

Validation Of A New Concept For Measuring Respirable Dusts, Xiao Liu

USF Tampa Graduate Theses and Dissertations

Sampling of airborne dust in industry is influenced by the potential health effects associated with human exposure. Health effects depend on mass concentration and particle size which influences the site of pulmonary deposition. Occupational diseases tend to be associated with dust deposition in specific regions of the respiratory tract. The ACGIH size selective TLVs are expressed in three forms: Inhalable Particulate Matter, Thoracic Particulate Matter, and Respirable Particulate Matter. In pneuomoconioses, the amount of dust deposited in the lungs can be estimated by sampling the respirable fraction. Dose-response relationships are derived by relating the health experience of workers to the …

Intranasal Rapamycin Ameliorates Alzheimer-Like Cognitive Decline In A Mouse Model Of Down Syndrome, Antonella Tramutola, Chiara Lanzillotta, Eugenio Barone, Andrea Arena, Ilaria Zuliani, Luciana Mosca, Carla Blarzino, D. Allan Butterfield, Marzia Perluigi, Fabio Di Domenico

Chemistry Faculty Publications

Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles. Our laboratory recently demonstrated the disturbance of PI3K/AKT/mTOR axis in DS brain, prior and after the development of Alzheimer Disease (AD). The aberrant modulation of the mTOR signalling in DS and AD age-related cognitive decline affects crucial neuronal pathways, including insulin signaling and autophagy, involved in pathology onset and progression. Within this context, the therapeutic use of mTOR-inhibitors may prevent/attenuate the neurodegenerative phenomena. By our work we aimed to rescue mTOR signalling …

Antibiotic-Resistant Escherichia Coli From Retail Poultry Meat With Different Antibiotic Use Claims, Gregg S. Davis, Kara Waits, Lora Nordstrom, Heidi Grande, Brett Weaver, Katerina Papp, Joseph Horwinski, Benjamin Koch, Bruce A. Hungate, Cindy M. Liu, Lance B. Price

Civil and Environmental Engineering and Construction Faculty Research

Background We sought to determine if the prevalence of antibiotic-resistant Escherichia coli differed across retail poultry products and among major production categories, including organic, “raised without antibiotics”, and conventional. Results We collected all available brands of retail chicken and turkey—including conventional, “raised without antibiotic”, and organic products—every two weeks from January to December 2012. In total, E. coli was recovered from 91% of 546 turkey products tested and 88% of 1367 chicken products tested. The proportion of samples contaminated with E. coli was similar across all three production categories. Resistance prevalence varied by meat type and was highest among E. …

Environmental Water Transactions In The Colorado River Basin: A Closer Look, Leon Szeptycki, David Pilz, Rachel O'Connor, Beatrice Gordon

All In-stream Flows Material

Over the last 30 years, the voluntary transfer of water and water rights for environmental uses has become a recognized strategy for restoring streamflow in the Western United States.¹ Historically, taking water out of a stream was a legally required element of an appropriative water right. Water rights holders who left all or a portion of their right instream to enhance fish populations, riparian habitat or recreation, risked forfeiture or diminishment of their water right. Beginning in the 1980’s, state laws began to recognize both the appropriation of new water rights for instream use and to allow the transfer …

Interactions Between Spermine-Derivatized Tentacle Porphyrins And The Human Telomeric Dna G-Quadruplex, Navin C. Sabharwal , '14, Jessica Chen , '17, Joo Hyun Lee , '17, C. M. A. Gangemi, A. D'Urso, Liliya A. Yatsunyk

Chemistry & Biochemistry Faculty Works

G-rich DNA sequences have the potential to fold into non-canonical G-Quadruplex (GQ) structures implicated in aging and human diseases, notably cancers. Because stabilization of GQs at telomeres and oncogene promoters may prevent cancer, there is an interest in developing small molecules that selectively target GQs. Herein, we investigate the interactions of meso-tetrakis-(4-carboxysperminephenyl)porphyrin (TCPPSpm4) and its Zn(II) derivative (ZnTCPPSpm4) with human telomeric DNA (Tel22) via UV-Vis, circular dichroism (CD), and fluorescence spectroscopies, resonance light scattering (RLS), and fluorescence resonance energy transfer (FRET) assays. UV-Vis titrations reveal binding constants of 4.7 × 10⁶ and 1.4 × 10⁷ M⁻¹ and binding stoichiometry of …

Synthesis And Biological Evaluation Of Phaeosphaeride A Derivatives As Antitumor Agents, Victoria Abzianidze, Petr Beltyukov, Sofya Zakharenkova, Natalia Moiseeva, Jennifer Mejia, Alvin Holder, Yuri Trishin, Alexander Berestetskiy, Victor Kuznetsov

Chemistry & Biochemistry Faculty Publications

New derivatives of phaeosphaeride A (PPA) were synthesized and characterized. Anti-tumor activity studies were carried out on the HCT-116, PC3, MCF-7, A549, К562, NCI-Н929, Jurkat, THP-1, RPMI8228 tumor cell lines, and on the HEF cell line. All of the compounds synthesized were found to have better efficacy than PPA towards the tumor cell lines mentioned. Compound 6 was potent against six cancer cell lines, HCT-116, PC-3, K562, NCI-H929, Jurkat, and RPMI8226, showing a 47, 13.5, 16, 4, 1.5, and 7-fold increase in anticancer activity comparative to those of etoposide, respectively. Compound 1 possessed selectivity toward the NCI-H929 cell line (IC …

Multi-Element Fingerprinting Of Waters To Evaluate Connectivity Among Depressional Wetlands, Yuxiang Yuan, Xiaoyan Zhu, David M. Mushet, Marinus L. Otte

United States Geological Survey, Northern Prairie Wildlife Research Center: Publications

Establishing the connectivity among depressional wetlands is important for their proper management, conservation and restoration. In this study, the concentrations of 38 elements in surface water and porewater of depressional wetlands were investigated to determine chemical and hydrological connectivity of three hydrological types: recharge, flow-through, and discharge, in the Prairie Pothole Region of North America. Most element concentrations of porewater varied significantly by wetland hydrologic type (p < 0.05), and increased along a recharge to discharge hydrologic gradient. Significant spatial variation of element concentrations in surface water was observed in discharge wetlands. Generally, higher element concentrations occurred in natural wetlands compared to wetlands with known disturbances (previous drainage and grazing). Electrical conductivity explained 42.3% and 30.5% of the variation of all element concentrations in porewater and surface water. Non-metric multidimensional scaling analysis showed that the similarity decreased from recharge to flowthrough to discharge wetland in each sampling site. Cluster analysis confirmed that element compositions in porewater of interconnected wetlands were more similar to each other than to those of wetlands located farther away. Porewater and surface water in a restored wetland showed similar multi-element characteristics to natural wetlands. In contrast, depressional wetlands connected by seeps along a deactivated drain-tile path and a grazed wetland showed distinctly different multi-element characteristics compared to other wetlands sampled. Our findings confirm that the multi-element fingerprinting method can be useful for assessing hydro-chemical connectivity across the landscape, and indicate that element concentrations are not only affected by land use, but also by hydrological characteristics.

Hyperspectral Imaging For Characterizing Single Plasmonic Nanostructure And Single-Cell Analysis, Nishir Sanatkumar Mehta

LSU Master's Theses

Orientation of plasmonic nanostructures is an important feature in many nanoscale applications such as photovoltaics, catalyst, biosensors DNA interactions, protein detections, hotspot of surface-enhanced Raman spectroscopy (SERS), and fluorescence resonant energy transfer (FRET) experiments. Silver nanocubes with significant spectral signatures between 400-700 nm are observed in this experimental research. Whereas study of single cells will enable the analysis of cell-to-cell variations within a heterogeneous population. These variations are important for further analysis and understanding of disease propagation, drug development, stem cell differentiation, embryos development, and how cells respond to each other and their environment. Adipose-derived mesenchymal stem cells possess the …

Vaccine Myths: Setting The Record Straight, Julie A. Boom, Rachel M. Cunningham, Lindy U. Mcgee

Journal of Family Strengths

Despite their standing as one of the most remarkable public health achievements, vaccines have been surrounded by dangerous myths since the development of the smallpox vaccine in the 18th century. In recent decades, with the publication of a fraudulent article linking vaccines to autism, the involvement of celebrities in the debate, and the rise of the internet and social media as sources for information for patients, these myths have become more widespread. This paper reviews four common vaccine myths: vaccines cause autism, vaccines are not safe, too many vaccines are given too soon, and the influenza vaccine is not necessary. …

Dual Inhibition Of Bcl-2/Bcl-Xl And Xpo1 Is Synthetically Lethal In Glioblastoma Model Systems, Enyuan Shang, Yiru Zhang, Chang Shu, Chiaki Tsuge Ishida, Elena Bianchetti, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin

Publications and Research

XPO1 has recently emerged as a viable treatment target for solid malignancies, including glioblastoma (GBM), the most common primary malignant brain tumor in adults. However, given that tumors become commonly resistant to single treatments, the identification of combination therapies is critical. Therefore, we tested the hypothesis that inhibition of anti-apoptotic Bcl-2 family members and XPO1 are synthetically lethal. To this purpose, two clinically validated drug compounds, the BH3-mimetic, ABT263, and the XPO1 inhibitor, Selinexor, were used in preclinical GBM model systems. Our results show that inhibition of XPO1 reduces cellular viability in glioblastoma cell cultures. Moreover, addition of ABT263 significantly …

Tumour-Immune Dynamics With An Immune Checkpoint Inhibitor, Elpiniki Nikolopoulou

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Computational Optics (Engr 030) Syllabus, Vidya Ganapati

Digital Humanities Curricular Development

This course provides an introduction to computational optics and imaging, where camera hardware is co-designed with processing algorithms. Topics may include: geometrical and wave optics, PSF engineering, light field imaging, compressed sensing, time-of-flight imaging, Fourier optics, super-resolution, medical imaging, and virtual and augmented reality. Students will also investigate ethical and artistic questions in image collection and processing.