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2018

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Challenges In Learning Unified Modeling Language: From The Perspective Of Diagrammatic Representation And Reasoning, Zixing Shen, Songxin Tan, Keng Siau Sep 2018

Challenges In Learning Unified Modeling Language: From The Perspective Of Diagrammatic Representation And Reasoning, Zixing Shen, Songxin Tan, Keng Siau

Business and Information Technology Faculty Research & Creative Works

Unified modeling language (UML) is widely taught in the information systems (IS) curriculum. To understand UML in IS education, this paper reports on an empirical study that taps into students' learning of UML. The study uses a concept-mapping technique to identify the challenges in learning UML notational elements. It reveals that some technical properties of UML diagrammatic representation, coupled with students' cognitive attributes, hinder both perceptual and conceptual processes involved in searching, recognizing, and inferring visual information, which creates learning barriers. This paper also discusses how to facilitate perceptual and conceptual processes in instruction to overcome learning challenges. The study …


And A Cloud Of Witnesses, James C. Schaap Sep 2018

And A Cloud Of Witnesses, James C. Schaap

Pro Rege

No abstract provided.


Exit West (Book Review), Howard Schaap Sep 2018

Exit West (Book Review), Howard Schaap

Pro Rege

Reviewed Title: Exit West by Mohsin Hamid. New York: Riverhead, 2017. 231 pp. ISBN: 9780735212176.


Early Term Effects Of Rhbmp-2 On Pedicle Screw Fixation In A Sheep Model: Histomorphometric And Biomechanical Analyses, Jeffrey M. Toth, Mei Wang, Chetan Patel, Akshi Arora Sep 2018

Early Term Effects Of Rhbmp-2 On Pedicle Screw Fixation In A Sheep Model: Histomorphometric And Biomechanical Analyses, Jeffrey M. Toth, Mei Wang, Chetan Patel, Akshi Arora

Biomedical Engineering Faculty Research and Publications

Background: The effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) on pedicle screw pullout force and its potential to improve spinal fixation have not previously been investigated. rhBMP-2 on an absorbable collagen sponge (ACS) carrier was delivered in and around cannulated and fenestrated pedicle screws in a sheep lumbar spine instability model. Two control groups (empty screw and ACS with buffer) were also evaluated. We hypothesized that rhBMP-2 could stimulate bone growth in and around the cannulated and fenestrated pedicle screws to improve early bone purchase.

Methods: Eight skeletally mature sheep underwent destabilizing laminectomies at L2–L3 and L4–L5 followed by …


Sex Differences In Rhesus Monkeys’ Digit Ratio (2d:4d Ratio) And Its Association With Maternal Social Dominance Rank, Alexander Baxter, Elizabeth K. Wood, Parker Jarman, Ashley N. Cameron, John P. Capitanio, James Dee Higley Sep 2018

Sex Differences In Rhesus Monkeys’ Digit Ratio (2d:4d Ratio) And Its Association With Maternal Social Dominance Rank, Alexander Baxter, Elizabeth K. Wood, Parker Jarman, Ashley N. Cameron, John P. Capitanio, James Dee Higley

Faculty Publications

Prenatal androgen exposure (PAE) plays a pivotal role in masculinizing the developing body and brain, and extreme exposure may contribute to autism, anxiety disorder and schizophrenia. One commonly used biomarker for PAE is the pointer-to-ring-finger digit length (2D:4D) ratio. Although this biomarker is widely used in human studies, relatively few studies have investigated 2D:4D ratio in nonhuman primates, particularly rhesus macaques (Macaca mulatta), one of the most commonly used animals in biomedical research. Thus far, data suggest that sexual dimorphism in 2D:4D ratio may be in the opposite direction in some monkey species, when compared to the pattern …


A Hybrid Model For Identity Obfuscation By Face Replacement, Qianru Sun, Ayush Tewari, Weipeng Xu, Mario Fritz, Christian Theobalt, Bernt Schiele Sep 2018

A Hybrid Model For Identity Obfuscation By Face Replacement, Qianru Sun, Ayush Tewari, Weipeng Xu, Mario Fritz, Christian Theobalt, Bernt Schiele

Research Collection School Of Computing and Information Systems

As more and more personal photos are shared and tagged in social media, avoiding privacy risks such as unintended recognition, becomes increasingly challenging. We propose a new hybrid approach to obfuscate identities in photos by head replacement. Our approach combines state of the art parametric face synthesis with latest advances in Generative Adversarial Networks (GAN) for data-driven image synthesis. On the one hand, the parametric part of our method gives us control over the facial parameters and allows for explicit manipulation of the identity. On the other hand, the data-driven aspects allow for adding fine details and overall realism as …


A Vector Field Design Approach To Animated Transitions, Yong Wang, Daniel Archambault, Carlos E. Scheidegger, Huamin Qu Sep 2018

A Vector Field Design Approach To Animated Transitions, Yong Wang, Daniel Archambault, Carlos E. Scheidegger, Huamin Qu

Research Collection School Of Computing and Information Systems

Animated transitions can be effective in explaining and exploring a small number of visualizations where there are drastic changes in the scene over a short interval of time. This is especially true if data elements cannot be visually distinguished by other means. Current research in animated transitions has mainly focused on linear transitions (all elements follow straight line paths) or enhancing coordinated motion through bundling of linear trajectories. In this paper, we introduce animated transition design, a technique to build smooth, non-linear transitions for clustered data with either minimal or no user involvement. The technique is flexible and simple to …


Serum Vitamin D3 Levels In Women With And Without Uterine Fibroids, Shahla Fekri Najeeb, Lilyan W. Sersam Sep 2018

Serum Vitamin D3 Levels In Women With And Without Uterine Fibroids, Shahla Fekri Najeeb, Lilyan W. Sersam

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Uterine leiomyomas are the most common benign tumours of the female genital tract. They are a major source of morbidity for women and a frequent indication of gynecological surgery. Understanding the etiology of uterine fibroids remains incomplete. Vitamin D may be an unrecognized risk factor for their development. OBJECTIVE: To assess serum vitamin D3 levels in women with and without uterine fibroids and to identify whether serum vitamin D3 levels correlate with the severity of uterine fibroids disease. METHODS: This prospective case- control study involved 150 women in their premenopausal state who presented at the outpatient gynecology clinic …


Role Of Caregiver-Reported Outcomes In Identification Of Children With Prenatal Alcohol Exposure During The First Year Of Life, Ludmila N Bakhireva, Jean Lowe, Laura M Garrison, Sandra Cano, Yuridia Leyva, Fares Qeadan, Julia M Stephen Sep 2018

Role Of Caregiver-Reported Outcomes In Identification Of Children With Prenatal Alcohol Exposure During The First Year Of Life, Ludmila N Bakhireva, Jean Lowe, Laura M Garrison, Sandra Cano, Yuridia Leyva, Fares Qeadan, Julia M Stephen

Pediatrics Research and Scholarship

BACKGROUND: Earlier identification of children with prenatal alcohol exposure (PAE) remains a challenge. The objective of this study was to identify neurobehavioral (NB) outcomes associated with PAE in infants.

METHODS: This manuscript evaluates NB outcomes at 6.33±1.12 months of age in 93 infants (39 PAE and 54 No-PAE) recruited prospectively into the ENRICH cohort. PAE was assessed by prospective repeated TLFB interviews and a panel of ethanol biomarkers. NB outcomes were evaluated by the Bayley Scales of Infant Development (BSID-III), Parenting Stress Index (PSI), Infant Behavior Questionnaire (IBQ-R), and Infant Sensory Profile (ISP).

RESULTS: Mean maternal age at enrollment was …


Bridging Theory To Practice: Utilizing The Culture-Centered Approach (Cca) To Address Gaps In Community Based Participatory Research (Cbpr) Processes, Sydney Dillard, Agaptus Anaele, Rati Kumar, Raihan Jamil Sep 2018

Bridging Theory To Practice: Utilizing The Culture-Centered Approach (Cca) To Address Gaps In Community Based Participatory Research (Cbpr) Processes, Sydney Dillard, Agaptus Anaele, Rati Kumar, Raihan Jamil

All Works

The purpose of this study is to provide recommendations to bridging the "theoretical" with the "practical" in developing community-based participatory research (CBPR) health communication projects. As illustrated through a review of several case studies from health campaigns using CBPR, often times the theoretical orientations of CBPR become secondary to its praxis, with unspoken motives and agendas become motivating factors in guiding the initiatives. These motives may come in the form of funding organization priorities, funded grant proposal constraints, and the desire to continue relationships that are fostered in the development of CBPR projects. In response, this essay reintroduces the culture-centered …


Flipping The Classroom To Train Citizen Scientists In Invasive Species Detection And Response, Daniel J. Larkin, Megan M. Weber, Susan M. Galatowitsch, Angela S. Gupta Sep 2018

Flipping The Classroom To Train Citizen Scientists In Invasive Species Detection And Response, Daniel J. Larkin, Megan M. Weber, Susan M. Galatowitsch, Angela S. Gupta

Journal of Extension

Extension educators are increasingly using flipped classrooms, wherein online content delivery precedes in-person learning. We have applied this approach to two Extension programs in which citizen scientists are trained in early detection of invasive species. Our goal in using the tool of flipped classrooms is to accommodate large amounts of content while focusing classroom time on skills development. In 2017, we assessed efficacy of the flipped classroom through knowledge tests and surveys completed by 174 participants and 106 participants, respectively. Results demonstrated large knowledge gains and high participant satisfaction. We encourage Extension professionals to consider whether use of the flipped …


Augmented Reality: Exploring Its Potential For Extension, Heather S. Wallace Sep 2018

Augmented Reality: Exploring Its Potential For Extension, Heather S. Wallace

Journal of Extension

Augmented reality (AR) is quickly becoming commonplace in our daily lives and in many information-sharing fields. This article addresses how Extension is exploring its application and utility for our consumers. In the article, I provide a clear definition of AR and an explanation of how it differs from virtual reality, followed by examples of AR applications within and external to Extension. I describe the origin of, development process for, and lessons learned from an eXtension Foundation–funded AR project in the hope of offering a roadmap to others. Additionally, I present findings from a statewide survey of Extension professionals about AR's …


The Rationale For Taxpayer Support For Primary Industry Research And Innovation In Western Australia, Ross Kingwell Sep 2018

The Rationale For Taxpayer Support For Primary Industry Research And Innovation In Western Australia, Ross Kingwell

Research Reports

During the 2000s a common view in government circles was that governments were over-investing in primary industry research and innovation. In agreement with this view, the Western Australian (WA) government lessened its support for primary industry research and innovation over the last decade. The impacts of this reduced support are seen clearly in the Department of Primary Industries and Regional Development (DPIRD). In 2008–09 its agricultural staff count was 1518, yet by the end of 2017–18 this will be under 800, with remaining staff working mostly in regulation, biosecurity and corporate services rather than research. So great has been the …


Three Siblings With Charcot-Marie-Tooth Disease With No Other Family History, Prem Chand, Pooja Manglani, Faiq Amin, Fazal Manzoor Arain Sep 2018

Three Siblings With Charcot-Marie-Tooth Disease With No Other Family History, Prem Chand, Pooja Manglani, Faiq Amin, Fazal Manzoor Arain

Pakistan Journal of Neurological Sciences (PJNS)

Charcot-Marie-Tooth (CMT) disease is one of the most common inherited disorders of the peripheral nervous system. Patients diagnosed with CMT disease have axonal degeneration which results in muscle wasting, sensory loss and weakness. These patients have a very characteristic walking gait and shape of hands, along with other changes. Despite many common visible changes, no singular common genetic mutation for this disease or its cure has been identified. Therefore more case series for this disease needs to be identified so that future studies increase our knowledge about this disease. Here, we present a case series of 3 out of 4 …


Status Update On The Threat Of Babesiosis Returning To The United States, Jason Tidwell, Christopher Vitek, Donald B. Thomas, John M. Thomas Sep 2018

Status Update On The Threat Of Babesiosis Returning To The United States, Jason Tidwell, Christopher Vitek, Donald B. Thomas, John M. Thomas

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Babesiosis is a hemolytic disease caused by protozoan parasites in the genus Babesia, transmitted through the saliva of infected ticks. The most economically important species, Babesia bigemina and B. bovis, infect cattle and are the etiological agents of bovine babesiosis. In the southern United States, eradication efforts directed against the tick vectors, Boophilus spp., began in the early 1900s. A quarantine zone in south Texas along the US/Mexico border was subsequently established following the eradication of the disease in the US. The permanent quarantine zone, spanning approximately 33% of the total shared border between Texas and Mexico, has helped limit …


Crispr Knockouts Reveal An Endogenous Role For Ancient Neuropeptides In Regulating Developmental Timing In A Sea Anemone, Nagayasu Nakanishi, Mark Q. Martindale Sep 2018

Crispr Knockouts Reveal An Endogenous Role For Ancient Neuropeptides In Regulating Developmental Timing In A Sea Anemone, Nagayasu Nakanishi, Mark Q. Martindale

Biological Sciences Faculty Publications and Presentations

Neuropeptides are evolutionarily ancient peptide hormones of the nervous and neuroendocrine systems, and are thought to have regulated metamorphosis in early animal ancestors. In particular, the deeply conserved Wamide family of neuropeptides—shared across Bilateria (e.g. insects and worms) and its sister group Cnidaria (e.g. jellyfishes and corals)—has been implicated in mediating life-cycle transitions, yet their endogenous roles remain poorly understood. By using CRISPR-Cas9-mediated reverse genetics, we show that cnidarian Wamide—referred to as GLWamide—regulates the timing of life cycle transition in the sea anemone cnidarian Nematostella vectensis. We find that mutant planula larvae lacking GLWamides transform into morphologically normal polyps …


The Impact Of Perineuronal Net Digestion Using Chondroitinase Abc On The Intrinsic Physiology Of Cortical Neurons, Philip Chu, Reena Abraham, Kumarie Budhu, Usma Khan, Natalie De Marco Garcia, Joshua C. Brumberg Sep 2018

The Impact Of Perineuronal Net Digestion Using Chondroitinase Abc On The Intrinsic Physiology Of Cortical Neurons, Philip Chu, Reena Abraham, Kumarie Budhu, Usma Khan, Natalie De Marco Garcia, Joshua C. Brumberg

Publications and Research

Perineuronal nets (PNNs) are a form of aggregate Extracellular Matrix (ECM) in the brain. Recent evidence suggests that the postnatal deposition of PNNs may play an active role in regulating neuroplasticity and, potentially, neurological disorders. Observations of high levels of PNNs expression around somas, proximal dendrites, and axon initial segments of a subtype of neurons have also led to proposals that PNNs may modulate the intrinsic properties of the neurons they ensheathe. While high levels of PNNs are postnatally expressed throughout the neocortex, it is still unclear how they impact the neuronal physiology of the many classes and subtypes of …


The Power Of Play: A Pediatric Role In Enhancing Development In Young Children, Michael Yogman, Andrew Garner, Jeffrey Hutchinson, Kathy Hirsh-Pasek, Roberta Michnick Golinkoff, Virginia Keane, Rebecca Baum, Thresia Gambon, Arthur Lavin, Gerri Mattson, Lawrence Wissow, Sahron Berry, Amy Starin, Edward Christopherson, Abigail Schlesinger, Karen S. Smith, David L. Hill, Nusheen Ameenuddin, Yolanda Reid Ghassiakos, Corinn Cross, Rhea Boyd, Robert Mendelson, Megan A. Moreno, Wendy Sue Swanson, Justin Smith, Kristopher Kaliebe, Jennifer Pomeranz, Brian Wilcox, Thomas Mcpheron Sep 2018

The Power Of Play: A Pediatric Role In Enhancing Development In Young Children, Michael Yogman, Andrew Garner, Jeffrey Hutchinson, Kathy Hirsh-Pasek, Roberta Michnick Golinkoff, Virginia Keane, Rebecca Baum, Thresia Gambon, Arthur Lavin, Gerri Mattson, Lawrence Wissow, Sahron Berry, Amy Starin, Edward Christopherson, Abigail Schlesinger, Karen S. Smith, David L. Hill, Nusheen Ameenuddin, Yolanda Reid Ghassiakos, Corinn Cross, Rhea Boyd, Robert Mendelson, Megan A. Moreno, Wendy Sue Swanson, Justin Smith, Kristopher Kaliebe, Jennifer Pomeranz, Brian Wilcox, Thomas Mcpheron

College of Nursing Faculty Research and Publications

Children need to develop a variety of skill sets to optimize their development and manage toxic stress. Research demonstrates that developmentally appropriate play with parents and peers is a singular opportunity to promote the social-emotional, cognitive, language, and self-regulation skills that build executive function and a prosocial brain. Furthermore, play supports the formation of the safe, stable, and nurturing relationships with all caregivers that children need to thrive.


A Macro-Level Order Metric For Self-Organizing Adaptive Systems, David W. King, Gilbert L. Peterson Sep 2018

A Macro-Level Order Metric For Self-Organizing Adaptive Systems, David W. King, Gilbert L. Peterson

Faculty Publications

Analyzing how agent interactions affect macro-level self-organized behaviors can yield a deeper understanding of how complex adaptive systems work. The dynamic nature of complex systems makes it difficult to determine if, or when, a system has reached a state of equilibrium or is about to undergo a major transition reflecting the appearance of self-organized states. Using the notion of local neighborhood entropy, this paper presents a metric for evaluating the macro-level order of a system. The metric is tested in two dissimilar complex adaptive systems with self-organizing properties: An autonomous swarm searching for multiple dynamic targets and Conway's Game of …


Propofol Inhibits The Voltage-Gated Sodium Channel Nachbac At Multiple Sites., Yali Wang, Elaine Yang, Marta M. Wells, Vasyl Bondarenko, Kellie Woll, Vincenzo Carnevale, Daniele Granata, Michael L. Klein, Roderic G. Eckenhoff, William P. Dailey, Manuel Covarrubias, Pei Tang, Yan Xu Sep 2018

Propofol Inhibits The Voltage-Gated Sodium Channel Nachbac At Multiple Sites., Yali Wang, Elaine Yang, Marta M. Wells, Vasyl Bondarenko, Kellie Woll, Vincenzo Carnevale, Daniele Granata, Michael L. Klein, Roderic G. Eckenhoff, William P. Dailey, Manuel Covarrubias, Pei Tang, Yan Xu

Department of Neuroscience Faculty Papers

Voltage-gated sodium (NaV) channels are important targets of general anesthetics, including the intravenous anesthetic propofol. Electrophysiology studies on the prokaryotic NaV channel NaChBac have demonstrated that propofol promotes channel activation and accelerates activation-coupled inactivation, but the molecular mechanisms of these effects are unclear. Here, guided by computational docking and molecular dynamics simulations, we predict several propofol-binding sites in NaChBac. We then strategically place small fluorinated probes at these putative binding sites and experimentally quantify the interaction strengths with a fluorinated propofol analogue, 4-fluoropropofol. In vitro and in vivo measurements show that 4-fluoropropofol and propofol have similar effects …


Proposal For A Tiered Dietary Bioaccumulation Testing Strategy For Engineered Nanomaterials Using Fish, Rd Handy, J Ahtiainen, Navas J Maria, G Goss, Eaj Bleeker, Der Kammer F Von Sep 2018

Proposal For A Tiered Dietary Bioaccumulation Testing Strategy For Engineered Nanomaterials Using Fish, Rd Handy, J Ahtiainen, Navas J Maria, G Goss, Eaj Bleeker, Der Kammer F Von

School of Biological and Marine Sciences

No abstract provided.


Rocky Mountain Trefoil Beef, Kailie Leggett, Roslynn Mccann, Jennifer W. Macadam, Juan J. Villalba Sep 2018

Rocky Mountain Trefoil Beef, Kailie Leggett, Roslynn Mccann, Jennifer W. Macadam, Juan J. Villalba

All Current Publications

This fact sheet describes Rocky Mountain trefoil beef and how researchers at USU are exploring the use of tannin-containing legumes as a method fr finishing cattle to address environmental and efficiency concerns associated with the most common current beef production systems.


Domain-Specific Knowledge Exploration With Ontology Hierarchical Re-Ranking And Adaptive Learning And Extension, Grace G. Zhao Sep 2018

Domain-Specific Knowledge Exploration With Ontology Hierarchical Re-Ranking And Adaptive Learning And Extension, Grace G. Zhao

Dissertations, Theses, and Capstone Projects

The goal of this research project is the realization of an artificial intelligence-driven lightweight domain knowledge search framework that returns a domain knowledge structure upon request with highly relevant web resources via a set of domain-centric re-ranking algorithms and adaptive ontology learning models. The re-ranking algorithm, a necessary mechanism to counter-play the heterogeneity and unstructured nature of web data, uses augmented queries and a hierarchical taxonomic structure to get further insight into the initial search results obtained from credited generic search engines. A semantic weight scale is applied to each node in the ontology graph and in turn generates a …


The Inter-Subject Correlation Of Eeg In Response To Naturalistic Stimuli, Samantha S. Cohen Sep 2018

The Inter-Subject Correlation Of Eeg In Response To Naturalistic Stimuli, Samantha S. Cohen

Dissertations, Theses, and Capstone Projects

Inter-subject correlation is a measure of the similarity of the brain activity of a group of people as they respond to the same naturalistic stimulus, typically a story or video, meant to simulate a real world experience. This thesis tests the hypothesis that the correlation of the brain responses of a group of people is indicative of stimulus engagement. The rationale is that the content of the stimulus drives brain activity in a consistent manner, while internal thoughts are divergent and result in uncorrelated activity. The inter-subject correlation (ISC) of neural responses have previously been assessed with fMRI, EEG, and …


Insurgent Difference: An Ethnography Of An Indian Resource Frontier, Madhuri Karak Sep 2018

Insurgent Difference: An Ethnography Of An Indian Resource Frontier, Madhuri Karak

Dissertations, Theses, and Capstone Projects

This work analyzes resource extraction and development as mutually constitutive logics of rule in India’s bauxite-rich, densely forested Niyamgiri Hills. Nestled in the southwestern corner of Odisha state, the region is marginal to both colonial and postcolonial orders, an inaccessible resource frontier. I discuss how Dongria Kondh and Kutia Kondh communities threatened with displacement by bauxite mining – two of India’s 75 Particularly Vulnerable Tribal Groups – draw on historically oppositional subjectivities to re-envision relations of power between the state, the market and the commons.

Over the past decade, new forms of sociality borne out of Niyamgiri’s anti-mining social movement …


Toward A Posthuman Ecology: Evolutionary Aesthetics In Transatlantic Romanticism, Kaitlin Mondello Sep 2018

Toward A Posthuman Ecology: Evolutionary Aesthetics In Transatlantic Romanticism, Kaitlin Mondello

Dissertations, Theses, and Capstone Projects

My dissertation traces the vibrant interchange between Romantic literature and science in the nineteenth century that necessitated new forms of aesthetics. I argue that Romantic writers and scientists co-created a new way of understanding nature that moved away from hierarchical anthropocentrism toward what I call “posthuman ecology.” This work explores shared scientific, literary, and philosophical sources for Erasmus and Charles Darwin, Mary and Percy Shelley, Ralph Waldo Emerson, and Emily Dickinson. I connect aesthetic innovation to ethics to ask more broadly how literature can provide an affective and effective space to represent and engage scientific discourse. I conclude that understanding …


Software Of The Oppressed: Reprogramming The Invisible Discipline, Erin R. Glass Sep 2018

Software Of The Oppressed: Reprogramming The Invisible Discipline, Erin R. Glass

Dissertations, Theses, and Capstone Projects

This dissertation offers a critical analysis of software practices within the university and the ways they contribute to a broader status quo of software use, development, and imagination. Through analyzing the history of software practices used in the production and circulation of student and scholarly writing, I argue that this overarching software status quo has oppressive qualities in that it supports the production of passive users, or users who are unable to collectively understand and transform software code for their own interests. I also argue that the university inadvertently normalizes and strengthens the software status quo through what I call …


Parents Frame Childhood For The World To See In Digital Media Postings, Aysenur Benevento Sep 2018

Parents Frame Childhood For The World To See In Digital Media Postings, Aysenur Benevento

Dissertations, Theses, and Capstone Projects

With the wellbeing of children being at the center of contemporary media discourse (Livingstone & Bovill, 2013), developmental studies are ever more challenged to understand both children’s and adults’ behavior in online spaces. Parents and children are involved in the human development process in complementary ways (Johansson, 2010; Uprichards, 2008) while using media platforms. As the development and use of innovative media technology are accelerating at a fast pace, theory and methods for analyzing uses of digital media for human development have lagged behind. This study examines adults’ postings of photos of their children on social media and offers a …


Manifest Density: Decentering The Global Western Film, Michael D. Phillips Sep 2018

Manifest Density: Decentering The Global Western Film, Michael D. Phillips

Dissertations, Theses, and Capstone Projects

The Western is often seen as a uniquely American narrative form, one so deeply ingrained as to constitute a national myth. This perception persists despite its inherent shortcomings, among them its inapplicability to the many instances of filmmakers outside the United States appropriating the genre and thus undercutting this view of generic exceptionalism. As the Western has migrated across geographical boundaries, it has accrued potential significations that bring into question its direct alignment with national ideology and history. Rather than attempting to define the Western in terms of nation or myth, we should attend to how each new text reconfigures …


Compact Gene Regulatory Cassettes Support Hallmark Features Of T-Cell Receptor (Tcr)-Alpha Gene Locus Control Region (Lcr) Activity, Jordana Lovett Sep 2018

Compact Gene Regulatory Cassettes Support Hallmark Features Of T-Cell Receptor (Tcr)-Alpha Gene Locus Control Region (Lcr) Activity, Jordana Lovett

Dissertations, Theses, and Capstone Projects

Despite the promise of emerging stem cell transplant gene therapy strategies, there remains a gap in the ability to predictably generate robust, temporally controlled long-lasting, therapeutic gene expression in specific target cell lineages following stem cell differentiation. There exists a locus control region (LCR) in the mouse T-cell receptor (TCR)-α locus that confers an ab TCR-like spatiotemporal expression pattern upon a linked transgene, regardless of its site of integration in the genome. These properties are well suited to direction of high-level, physiological expression of therapeutic antigen receptor genes to the T cell progeny of vector-transduced stem cells. The endogenous LCR …