Digital Commons Network^™

Antibacterial S-Heterosubstituted Disulfides, Edward Turos, Praveen Ramaraju

USF Patents

Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.

Synthetic Vaginal Cuff Model And Method Of Simulating Vaginal Cuff Closure, Mario Alves Simoes, Stuart Richard Hart, Omar Carambot, Mark Evans Armstrong

USF Patents

A vaginal cuff surgical model and methods of manufacture and use thereof. The model includes a body (resembling a vaginal cuff) and appendages (resembling uterosacral ligaments) extending from the body. The model (body and appendages) is formed of silicone, rubber, a polymer, or other suitable material with one or more layers of mesh embedded within the polymeric material. The embedded mesh permits suture between the components of the model. The surgical model permits surgical practice of this important component of a total hysterectomy procedure via suturing across the model and to the appendages.

Compositions, Methods Of Use, And Methods Of Treatment, Roman Manetsch, Lindsey Neil Shaw, Kurt Steven Van Horn, Whittney Nicole Burda

USF Patents

Embodiments of the present disclosure, in one aspect, relate to a 2,4-diaminoquinazoline compound, pharmaceutical compositions including a 2,4-diaminoquinazoline compound, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

The Current Volume 29 : Issue 7, Nova Southeastern University

Student Newspapers

No abstract provided.

Volume 116, Number 2 - Tuesday, September 25, 2018, Saint Mary's College Of California

The Collegian

No abstract provided.

Physiological And Behavioral Plasticity Of The Sea Cucumber Holothuria Forskali (Echinodermata, Holothuroidea) To Acidified Seawater, Xiutang Yuan, Sophie J. Mccoy, Yongfen Du, Stephen Widdicombe, Jason M. Hall-Spencer

School of Biological and Marine Sciences

No abstract provided.

Reasonable Action: Reproductive Rights, The Free Exercise Clause, And Religious Freedom In The United States And The Republic Of Ireland, Liam Ray

St. John's Law Review

(Excerpt)

This Note will argue that by denying certiorari in Stormans v. Wiesman, the Supreme Court missed an important opportunity to provide guidance to the states as to how the Free Exercise Clause applies to the kind of stocking and dispensing regulations adopted by the State of Washington. This Note will further argue from a policy perspective that the approach to these kinds of regulations adopted by the Republic of Ireland (“ROI”) presents the best approach for states to adopt because it provides a balance in terms of respecting the free exercise rights of pharmacists and pharmacy owners with …

Endangered Deference: Separation Of Powers And Judicial Review Of Agency Interpretation, Kathryn M. Baldwin

St. John's Law Review

(Excerpt)

This Note proceeds in four parts: Part I consists of a brief history of the development of agency deference doctrine. Part II examines the decline of deference from the perspective of all three branches of government: the overuse by the executive agency that catalyzed deference’s denouement, the underuse by the United States Supreme Court and renewed separation of powers challenges, and the parallel assault from Congress under the pending SOPRA. Part III addresses the proposed de novo review standard and highlights the deficiencies in that solution, emphasizing instead the tools that Congress already employs to meaningfully check agency interpretations. …

An Antitrust Approach To Corporate Free Exercise Claims, Ronald J. Colombo

St. John's Law Review

(Excerpt)

This Article suggests that antitrust law’s concept of market power could similarly be employed in balancing the free exercise rights of a corporation or any for-profit business venture against the rights of individuals. When a business enterprise seeks a religious liberty exemption from a rights-granting law, a major factor in assessing its claim should be the degree to which it wields market power in the relevant market. If the business is a monopolist, and, a fortiori, wielding tremendous market power, its claim for a free exercise exemption should probably fail. If, conversely, the business is but a minor marketplace …

Locked Up, Shut Up: Why Speech In Prison Matters, Evan Bianchi, David Shapiro

St. John's Law Review

(Excerpt)

This Article proceeds in three Parts. Part I describes the deferential Turner standard that governs First Amendment claims brought by prisoners. Virtually every word uttered or written to a prisoner and virtually every word uttered or written by a prisoner receives extremely limited legal protection. Largely as a result of this legal regime, senseless censorship is all too common in American prisons. Jailers and prison officials seem to have received the message that they can ban speech with impunity.

Part II argues that the combination of Turner deference and mass incarceration divests prisoners of expressive power, thereby distorting public …

Indoor Air Quality And Thermal Comfort For Elderly Residents In Houston Tx—A Case Study, Amir Baniassadi, David J. Sailor, Cassandra R. Olenick

International Building Physics Conference 2018

The elderly population is more vulnerable to poor indoor environmental quality. They also spend a larger portion of their time indoors than the general public, further exacerbating the associated health risks. As part of a larger study which aims to understand the health risks for the elderly population resulting from extreme heat events in Houston, TX, this study gathered empirical data on thermal comfort and air quality in existing assisted living facilities and in individual homes of the elderly. We made continuous measurements of indoor dry-bulb temperature, relative humidity, carbon dioxide (CO2) levels and occupancy status in 25 buildings during …

Searching For The Parental Causes Of The School-To-Prison Pipeline Problem: A Critical, Conceptual Essay, Reginald Leamon Robinson

Journal of Civil Rights and Economic Development

(Abstract)

In this critical, conceptual essay, the author argues that the School-to-Prison Pipeline (“STPP”) simply does not exist. Long before Columbine and the enactment of zero tolerance, caregivers have been wrongly harming their children, something causing them toxic stress that triggers their stress-response system, and making it nigh impossible for children easily ensnared by suspensions, expulsions, referrals to alternative schools, and SRO arrests to have the best developmental start and cognitive abilities to succeed in public schools. Further, teachers and administrators who are pressured to report great educational metrics, and for their own childhood reasons have a near inflexible need …

The Drive To Commercialize: Implications Of Women Rice Farmers’ Differential Resource Access For Market-Oriented Development Intervention In Southwestern Burkina Faso, Millie Varley

Geography Honors Projects

This research questions the theory-of-change underlying market-oriented agricultural development intervention. In particular, this research interrogates divergent commercialization experiences for women, depending on their differential access to resources. The sample covers women rice farmers in five villages in southwestern Burkina Faso, of which three villages are included in a market-oriented development program. I investigate the links between three resources: women’s level of land tenure security, their access to organic fertilizer, and the distribution of time spent on fieldwork. The most significant relationship is an association between women’s land tenure security and the dietary diversity scores of their household, across all wealth …

Curricular Changes Proposed For 2019-2021 Morris Catalog, Curriculum Committee

Curriculum Committee Reports

No abstract provided.

Eumeces Fasciatus, Roger W. Barbour

Roger W. Barbour Slide Collection

Eumeces fasciatus

New Functions For The Proprioceptive System In Skeletal Biology, Ronen Blecher, Lia Heinemann-Yerushalmi, Eran Assaraf, Nitzan Konstantin, Jens R. Chapman, Timothy C. Cope, Guy S. Bewick, Robert W. Banks, Elazar Zelzer

Neuroscience, Cell Biology & Physiology Faculty Publications

Muscle spindles and Golgi tendon organs (GTOs) are two types of sensory receptors that respond to changes in length or tension of skeletal muscles. These mechanosensors have long been known to participate in both proprioception and stretch reflex. Here, we present recent findings implicating these organs in maintenance of spine alignment as well as in realignment of fractured bones. These discoveries have been made in several mouse lines lacking functional mechanosensors in part or completely. In both studies, the absence of functional spindles and GTOs produced a more severe phenotype than that of spindles alone. Interestingly, the spinal curve phenotype, …

Griffithsin Carrageenan Fast Dissolving Inserts Prevent Shiv Hsv-2 And Hpv Infections In Vivo, Nina Derby, Manjari Lal, Meropi Aravatinou, Larisa Kizima, Patrick Barnable, Axia Rodriguez, Manshun Lai, Asa Wesenberg, Shweta Ugaonkar, Keith Levendosky, Olga Mizenina, Kyle Kleinbeck, Jeffrey D. Lifson, M. Melissa Peet, Zachary Lloyd, Michael Benson, Walid Heneine, Barry R. O'Keefe, Melissa Robbiani, Elena Martinelli, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Natalia Teleshova, José Fernández-Romero, Thomas M. Zydowsky

Publications and Research

Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) strategies with proven in vivo efficacy rely on antiretroviral drugs, creating the potential for drug resistance and complicated treatment options in individuals who become infected. Moreover, ondemand products are currently missing from the PrEP development portfolio. Griffithsin (GRFT) is a non-antiretroviral HIV entry inhibitor derived from red algae with an excellent safety profile and potent activity in vitro. When combined with carrageenan (CG), GRFT has strong activity against herpes simplex virus-2 (HSV-2) and human papillomavirus (HPV) in vitro and in vivo. Here, we report that GRFT/CG in a freeze-dried fast dissolving insert (FDI) …

The Statesman, V. 62, I. 05, Stony Brook University

Stony Brook Statesman-Sucolian

v. 62, i. 05;

The Tiger Vol. 112 Issue 17 2018-09-24, Clemson University

Tiger Newspapers 2018

No abstract provided.

09.24.18., Sam Johnson

ASWC Meeting Minutes

No abstract provided.

Bone Morphogenetic Protein Signaling Is Required For Rad51-Mediated Maintenance Of Genome Integrity In Vascular Endothelial Cells, Sanna Vattulainen-Collanus, Mark Southwood, Xu Dong Yang, Stephen Moore, Prajakta Ghatpande, Nicholas W. Morrell, Giorgio Lagna, Akiko Hata

Biology

The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2) gene cause hereditary vascular disorders, including pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, suggesting that BMPR2 and its downstream signaling pathway are pivotal to the maintenance of vascular integrity through an unknown molecular mechanism. Here we report that inactivation of BMPR2 in pulmonary vascular endothelial cells results in a deficit of RAD51, an enzyme essential for DNA repair and replication. Loss of RAD51, which causes DNA damage and cell death, is also detected in animal models and human …

Bdnf-Induced Release Of Endogenous Cannabinoids At Inhibitory And Excitatory Synapses, Rajamani Selvam

Doctoral Dissertations

Endocannabinoids (eCBs) are important mediators of synaptic plasticity, acting as retrograde messengers because they are released on demand from postsynaptic sites and activate presynaptic type I cannabinoid (CB1) receptors to suppress neurotransmitter release at both excitatory and inhibitory synapses. Similarly, brain derived neurotrophic factor (BDNF) is also a potent neuromodulator of synaptic transmission. The effect of BDNF on synaptic transmission is mediated by tropomyosin receptor kinase B (trkB) receptors. Both CB1 and trkB receptors are highly expressed at synapses throughout the neocortex and hippocampus. There is a growing evidence of cross talk between eCB and BDNF signaling. In particular, studies …

Applications Of Magnetotactic Bacteria, Magnetosomes And Magnetosome Crystals In Biotechnology And Nanotechnology: Mini-Review, Gabriele Vargas, Jefferson Cypriano, Tarcisio Correa, Pedro Leão, Dennis A. Bazylinski, Fernanda Abreu

Life Sciences Faculty Research

Magnetotactic bacteria (MTB) biomineralize magnetosomes, which are defined as intracellular nanocrystals of the magnetic minerals magnetite (Fe3O4) or greigite (Fe3S4) enveloped by a phospholipid bilayer membrane. The synthesis of magnetosomes is controlled by a specific set of genes that encode proteins, some of which are exclusively found in the magnetosome membrane in the cell. Over the past several decades, interest in nanoscale technology (nanotechnology) and biotechnology has increased significantly due to the development and establishment of new commercial, medical and scientific processes and applications that utilize nanomaterials, some of which are biologically derived. One excellent example of a biological nanomaterial …

Mmu: 09/24/18–09/30/18, Student Bar Association

Monday Morning Update

SOFTBALL

Mass Schedule

Follow the Crossings Café

LEGAL WRITING CENTER

INVITATION TO ALL NDLS STUDENT GROUPS

Health & Wellness Information

This Week @ NDLS

1L OF THE WEEK: Nick Osterman.

Managing Diffuse Phosphorus At The Source Versus At The Sink, Katrina A. Macintosh, Brooke K. Mayer, Richard W. Mcdowell, Stephen M. Powers, Lawrence A. Baker, Treavor H. Boyer, Bruce E. Rittmann

Civil and Environmental Engineering Faculty Research and Publications

Judicious phosphorus (P) management is a global grand challenge and critical to achieving and maintaining water quality objectives while maintaining food production. The management of point sources has been successful in lowering P inputs to aquatic environments, but more difficult is reducing P discharges associated with diffuse sources, such as nonpoint runoff from agriculture and urban landscapes, as well as P accumulated in soils and sediments. Strategies for effective diffuse-P management are imperative. Many options are currently available, and the most cost-effective and practical choice depends on the local situation. This critical review describes how the metrics of P quantity …

Noncontact Speckle Contrast Diffuse Correlation Tomography Of Blood Flow Distributions In Tissues With Arbitrary Geometries, Siavash Mazdeyasna, Chong Huang, Mingjun Zhao, Nneamaka B. Agochukwu, Ahmed A. Bahrani, Lesley Wong, Guoqiang Yu

Biomedical Engineering Faculty Publications

A noncontact electron multiplying charge-coupled-device (EMCCD)-based speckle contrast diffuse correlation tomography (scDCT) technology has been recently developed in our laboratory, allowing for noninvasive three-dimensional measurement of tissue blood flow distributions. One major remaining constraint in the scDCT is the assumption of a semi-infinite tissue volume with a flat surface, which affects the image reconstruction accuracy for tissues with irregular geometries. An advanced photometric stereo technique (PST) was integrated into the scDCT system to obtain the surface geometry in real time for image reconstruction. Computer simulations demonstrated that a priori knowledge of tissue surface geometry is crucial for precisely reconstructing the …

The Daily Gamecock, Monday, September 24, 2018, University Of South Carolina, Office Of Student Media

September

No abstract provided.

Characterization Of The Neuroinflammatory Response To Thiol-Ene Shape Memory Polymer Coated Intracortical Microelectrodes, Andrew J. Shoffstall, Marina Yu, Jennifer E. Paiz, Elizabeth Mancuso, Hillary W. Bedell, Jeffrey R. Capadona

Faculty Scholarship

Thiol-ene based shape memory polymers (SMPs) have been developed for use as intracortical microelectrode substrates. The unique chemistry provides precise control over the mechanical and thermal glass-transition properties. As a result, SMP substrates are stiff at room temperature, allowing for insertion into the brain without buckling and subsequently soften in response to body temperatures, reducing the mechanical mismatch between device and tissue. Since the surface chemistry of the materials can contribute significantly to the ultimate biocompatibility, as a first step in the characterization of our SMPs, we sought to isolate the biological response to the implanted material surface without regards …

The Bg News September 24, 2018, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. September 24, 2018. Volume 98-Issue 10.

The Guardian, Week Of September 24, 2018, Wright State University Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of September 24, 2018. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.