Digital Commons Network^™

Thrombospondin Receptor Α2Δ-1 Promotes Synaptogenesis And Spinogenesis Via Postsynaptic Rac1, W. Chris Risher, Namsoo Kim, Sehwon Koh, Ji‑Eun Cho, Petar Mitev, Erin F. Spence, Louis‑Jan Pilaz, Dongqing Wang, Guoping Feng, Debra L. Silver, Scott H. Soderling, Henry H. Yin, Cagla Eroglu

Biomedical Sciences

Astrocytes control excitatory synaptogenesis by secreting thrombospondins (TSPs), which function via their neuronal receptor, the calcium channel subunit α2δ-1. α2δ-1 is a drug target for epilepsy and neuropathic pain; thus the TSP–α2δ-1 interaction is implicated in both synaptic development and disease pathogenesis. However, the mechanism by which this interaction promotes synaptogenesis and the requirement for α2δ-1 for connectivity of the developing mammalian brain are unknown. In this study, we show that global or cell-specific loss of α2δ-1 yields profound deficits in excitatory synapse numbers, ultrastructure, and activity and severely stunts spinogenesis in the mouse cortex. Postsynaptic but not presynaptic α2δ-1 …

Theobromine And Related Methylxanthines As Inhibitors Of Primary Amine Oxidase, Padraig Shanahan, Jeffrey O’Sullivan, Keith Tipton, Gemma Kinsella, Barry Ryan, Gary Henehan

Articles

Methylxanthines are the most widely consumed drugs in the world and evidence of their health benefits has been growing in recent years. Primary Amine Oxidase (PrAO) has been recognised as a therapeutic target for amelioration of inflammatory, vascular and neurodegenerative diseases. Previous work in our laboratories showed that caffeine inhibited Bovine PrAO with a Ki of 1.0mM using benzylamine as substrate.

This study aimed to extend our previous work and explore the possibility that related methylxanthines might influence PrAO activity. While paraxanthine, theophylline and 7-methylxanthine had little effect on PrAO, theobromine was a noncompetitive inhibitor with a Ki of 276±44µM. …

In Consumer Protection We Trust? Re-Thinking The Legal Framework For Country Of Origin Cases, Shmuel I. Becher, Jessica C. Lai

San Diego Law Review

Markets are becoming more complicated in an ever faster changing world. New findings pertaining to human behavior and consumer markets constantly challenge traditional legal and policy assumptions. Social science offers a myriad of insights into the ways trust, identity, ideology, and preferences interact and impact one another. Against this background, the need to advance a nuanced legal framework is increasingly vital.

Consumer law policy requires an interdisciplinary and holistic approach. Recent scholarship has acknowledged this need, proposing novel ways to enrich the academic discourse and develop consumer law policy. Along these lines, a growing body of literature examines how notions …

The Effectiveness Of Journals As Arbiters Of Scientific Impact, C. E. Timothy Paine, Charles W. Fox

Entomology Faculty Publications

Academic publishers purport to be arbiters of knowledge, aiming to publish studies that advance the frontiers of their research domain. Yet the effectiveness of journal editors at identifying novel and important research is generally unknown, in part because of the confidential nature of the editorial and peer review process. Using questionnaires, we evaluated the degree to which journals are effective arbiters of scientific impact on the domain of Ecology, quantified by three key criteria. First, journals discriminated against low‐impact manuscripts: The probability of rejection increased as the number of citations gained by the published paper decreased. Second, journals were more …

Animal Science Department News, Department Of Animal Science

Animal Science Newsletters

No abstract provided.

Analyzing Gun-Violence-Prevention Taxes Under Emerging Firearm Fee Jurisprudence, Hannah E. Shearer, Allison S. Anderman

Southern Illinois University Law Journal

Gun and ammunition taxes and fees have long been used to fund wildlife conservation programs and regulatory schemes that ensure guns are being purchased and possessed lawfully. In recent years, taxes have been proposed as a policy tool to help mitigate the staggering social and economic costs of gun violence by providing a reliable source of funding for gun safety and violence prevention programs. These proposed “gun-violence-prevention taxes” have been met with opposition, including from Second Amendment litigants who argue that courts should strike down gun and ammunition taxes under the Supreme Court’s First Amendment fee jurisprudence—a body of cases …

To Dust You Shall Return: A Theological Argument For The Human Compost Movement, Sydney N. Ederer

Undergraduate Honors Theses

This research paper analyzes Catholic, Daoist, and Jewish beliefs on death, the body, the soul, afterlife, and after death rituals in order to build a connection between these beliefs and human composting practices. It uses these three religious traditions to find support for and recognize potential opposition against the human compost movement. These conclusions are in turn used to make a claim for human composting. Thorough research and a careful analysis of religious beliefs and traditions surrounding death and the body provides theological support for human composting as a recommended method for body disposal after death. Therefore, this research is …

Post-Accountability Accountability, Nicole Stelle Garnett

University of Michigan Journal of Law Reform

Over the past few decades, parental choice has exploded in the United States. Yet, despite early proponents’ hopes that parental choice would eliminate the need to regulate school quality—since parents’ choices would serve an accountability function—demands to use the law to hold chosen schools accountable for their academic performance are central features of education-reform debates today. This is an opportune time to consider the issue of academic accountability and parental choice. Parental choice has gained a firm foothold in the American educational landscape. As it continues to expand, debates about accountability for chosen schools will only intensify. The questions of …

Cobra Jiboia (Boa Constrictor), Gianna Patchett

USU Student Folklore Fieldwork

I heard a story about a snake that can control people with its stare. When it is looking at you, you walk in circles until you get tired and sit, at which point the snake eats you. If you notice that you are walking in circles, you have to break the snake’s concentration somehow, such as by taking your shirt off and putting it back on inside out or shooting a gun.

Hear No Evil, See No Evil: How Technology Influences The Ethics Of Life Inside The Womb, Abigael B. Hawthorne

Senior Honors Theses

Abortion is a very prevalent occurrence in the U.S. and for some time has even been encouraged as emergency birth control. However, many women are not educated about the life they are terminating when deciding to have an abortion. In fact, many women are even lied to in order to persuade them to have an abortion because abortion clinics are looking to profit. Technology like ultrasounds help women see, hear, and understand the physical life that is growing in them, and can help them make an informed decision. This documentary takes a closer look into how advanced technology can impact …

Metagenomics Reveal Triclosan-Induced Changes In The Antibiotic Resistome Of Anaerobic Digesters, M. Fujimoto, Daniel Elliott Carey, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

Triclosan (TCS) is a broad-spectrum antimicrobial used in a variety of consumer products. While it was recently banned from hand soaps in the US, it is still a key ingredient in a top-selling toothpaste. TCS is a hydrophobic micropollutant that is recalcitrant under anaerobic digestion thereby resulting in high TCS concentrations in biosolids. The objective of this study was to determine the impact of TCS on the antibiotic resistome and potential cross-protection in lab-scale anaerobic digesters using shotgun metagenomics. It was hypothesized that metagenomics would reveal selection for antibiotic resistance genes (ARGs) not previously found in pure culture studies or …

An Environmental Science And Engineering Framework For Combating Antimicrobial Resistance, Amy Pruden, Reinaldo E. Alcalde, Pedro J.J. Alvarez, Nicholas Ashbolt, Heather Bischel, Natalie L. Capiro, Emily Crossette, Dominic Frigon, Kassandra Grimes, Charles N. Haas, Kaoru Ikuma, Anthony D. Kappell, Timothy M. Lapara, Lee K. Kimbell, Mengyan Li, Xu Li, Patrick J. Mcnamara, Youngwoo Seo, Mark D. Sobsey, Emanuele Sozzi, Tala Navab-Daneshmand, Lutgarde Raskin, Maria Virginia Riquelme, Peter Vikesland, Krista Wigginton, Zhi Zhou

Civil and Environmental Engineering Faculty Research and Publications

On June 20, 2017, members of the environmental engineering and science (EES) community convened at the Association of Environmental Engineering and Science Professors (AEESP) Biennial Conference for a workshop on antimicrobial resistance. With over 80 registered participants, discussion groups focused on the following topics: risk assessment, monitoring, wastewater treatment, agricultural systems, and synergies. In this study, we summarize the consensus among the workshop participants regarding the role of the EES community in understanding and mitigating the spread of antibiotic resistance via environmental pathways. Environmental scientists and engineers offer a unique and interdisciplinary perspective and expertise needed for engaging with other …

Consumer Perceptions Of Egg-Laying Hen Housing Systems, Daniel S. Ochs, Christopher A. Wolf, Nicole Olynk Widmar, Courtney Bir

Department of Agricultural Economics Faculty Publications

The egg industry has transitioned, or is in the process of transitioning, from conventional cages to alternative hen housing systems in response to legal changes in many states across the United States (US). However, consumers find it is increasingly difficult to understand the details behind those labels and specific attributes conveyed. There are multiple hen housing options with a wide range of costs and impacts on hens, workers, and the environment. This research furthers the understanding of US public perceptions and attitudes related to hen housing systems and corresponding animal welfare, worker, economic, and environmental effects. Results reveal that the …

Patterns And Drivers Of Recent Disturbances Across The Temperate Forest Biome, Andreas Sommerfeld, Cornelius Senf, Brian Buma, Anthony W. D'Amato, Tiphaine Despres, Ignacio Díaz-Hormazábal, Shawn Fraver, Lee E. Frelich, Alvaro G. Gutiérrez, Sarah J. Hart, Brian J. Harvey, Hong S. He, Tomáš Hlásny, Andrés Holz, Multiple Additional Authors

Geography Faculty Publications and Presentations

Increasing evidence indicates that forest disturbances are changing in response to global change, yet local variability in disturbance remains high. We quantified this considerable variability and analyzed whether recent disturbance episodes around the globe were consistently driven by climate, and if human influence modulates patterns of forest disturbance. We combined remote sensing data on recent (2001–2014) disturbances with in-depth local information for 50 protected landscapes and their surroundings across the temperate biome. Disturbance patterns are highly variable, and shaped by variation in disturbance agents and traits of prevailing tree species. However, high disturbance activity is consistently linked to warmer and …

Why Is Invasive Species Education Important, Alexandra Crofts

School of Education and Leadership Student Capstone Theses and Dissertations

This research question addressed the importance of invasive species education in the Midwest Great Lakes Regions. Invasive species threaten most ecosystems around the world and can lead to decreasing biodiversity and even the extinction of native species. Humans are one of the largest vectors responsible for the transportation of invasive species. This research focused on providing evidence of the negative impact aquatic invasive species can have on native fish populations. Fish population data was collected using gill nets in the East Metro Area of the Twin Cities in Minnesota in the 2018 field season. This data was compared to Minnesota’s …

Hindsight Bias In Antitrust Law, Christopher R. Leslie

Vanderbilt Law Review

The modern field of study into hindsight bias was launched by Baruch Fischhoff. Fischhoff provided his research subjects with a primer on the 1810s conflict between British forces and Nepalese Gurkhas near Northern India. He suggested four possible outcomes: British victory, Gurkha victory, a peace settlement, and a military stalemate with no peace settlement. The subjects were then divided into five groups. One group was given no information about the ultimate outcome of the conflict. Subjects in each of the remaining four groups were told that one of the four outcomes had, in fact, occurred. The subjects were then asked …

A Blade Of Grass Magazine Issue 1: Where?, A Blade Of Grass

A Blade of Grass

Issue 1: Where?

This inaugural issue of A Blade of Grass Magazine engages the tendency of socially engaged art to inhabit everyday places, not just those meant for art.

Developmental Chromatin Restriction Of Pro‐Growth Gene Networks Acts As An Epigenetic Barrier To Axon Regeneration In Cortical Neurons, Ishwariya Venkatesh, Vatsal Mehra, Zimei Wang, Ben Califf, Murray G. Blackmore

Biomedical Sciences Faculty Research and Publications

Axon regeneration in the central nervous system is prevented in part by a developmental decline in the intrinsic regenerative ability of maturing neurons. This loss of axon growth ability likely reflects widespread changes in gene expression, but the mechanisms that drive this shift remain unclear. Chromatin accessibility has emerged as a key regulatory mechanism in other cellular contexts, raising the possibility that chromatin structure may contribute to the age‐dependent loss of regenerative potential. Here we establish an integrated bioinformatic pipeline that combines analysis of developmentally dynamic gene networks with transcription factor regulation and genome‐wide maps of chromatin accessibility. When applied …

Indigenous Nations Studies Newsletter, Fall 2018, Portland State University. Indigenous Nations Studies

Indigenous Nations Studies Newsletter

Table of Contents:
-- Welcoming New INST Director by Dr. Winston Grady-Willis
--Fall 2018 Welcoming by Dr. Ted Van Alst
-- Events
-- Winter 2019 courses
-- Student Reflection: Abroad in South Africa
-- Student Reflection: Walking Time
-- New Works: Ho'esta Mo'e'hahne
-- Recent Publication: Sacred Smokes
-- Dear Native College Student: You are loved
-- Course Planning Guide: INNAS Major & INST Minor

Changes In Cortical Activity In Stroke Survivors Undergoing Botulinum Toxin Therapy For Treatment Of Focal Spasticity, Kelsey Dianne Tynes

Master's Theses (2009 -)

Functional magnetic resonance imaging (fMRI) has provided evidence of neuroplastic changes following rehabilitation in stroke survivors. Botulinum toxin (BoNT) injection therapy has become a common approach to combating spasticity—a motor disorder characterized by a velocity dependent increase in muscle tone. The neurotoxin acts to inhibit muscle contraction, relieving spasticity symptoms with peak effects occurring between 4 and 6 weeks. With decreases in muscle tone, BoNT injections could free arm movement for rehabilitation, creating the opportunity for enhanced control of the upper limb, which would have underpinnings in altered brain activity. Given evidence of cortical activation changes following other stroke rehabilitative …

Pedestrian Pedagogy Of Place: Nurturing An Ecological Consciousness Through Slow Explorations Of The Public Realm, Kevin M. Pozzi

Leadership for Sustainability Education Comprehensive Papers

As increasing institutional paralysis and polarization demonstrate, citizens are not engaged or motivated by ecological challenges because they struggle to identify with our catastrophic relationship to nature in this urban, anthropocentric, and climactically-fraught modern era. Rather than focus solely on natural areas as a pathway to ecological consciousness and action, educators can inspire citizens through a “Pedestrian Pedagogy of Place” that brings wonder and enchantment into our urban public realm. Using the principles of sustainability education and place-based education as a framework, this pedagogy recognizes the sidewalk and pedestrian experience as a shared classroom through sensory, awareness-based learning modalities.

Orecchio: Extending Body-Language Through Actuated Static And Dynamic Auricular Postures, Da-Yuan Huang, Teddy Seyed, Jun Gong, Zhihao Yao, Yuchen Jiao, Xiang Anthony Chen, Xing-Dong Yang

Dartmouth Scholarship

In this paper, we propose using the auricle – the visible part of the ear – as a means of expressive output to extend body language to convey emotional states. With an initial exploratory study, we provide an initial set of dynamic and static auricular postures. Using these results, we examined the relationship between emotions and auricular postures, noting that dynamic postures involving stretching the top helix in fast (e.g., 2Hz) and slow speeds (1Hz) conveyed intense and mild pleasantness while static postures involving bending the side or top helix towards the center of the ear were associated with intense …

The Evidence Of Things Unseen: Experimental Form As Black Feminist Praxis, Shelly J. Eversley

Publications and Research

This essay reads Carlene Hatcher Polite's little-known experimental novel Sister X and the Victims of Foul Play and situates it within Black Aesthetics and black feminist theory to argue that experimental forms is crucial to black feminist praxis. The form also exposes critical violences that not only diminish and obscure black feminist writing, but also black women writers.

Offending Moral Decency: The Love-Lust Controversy Of 1969 And The Sexual Revolution In New Mexico, Jordan Biro Walter

New Mexico Historical Review

No abstract provided.

Embodied Vs. Non-Embodied Modes Of Knowing In Aquinas: Different Universals, Different Intelligible Species, Different Intellects, Therese Scarpelli Cory

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Andean Condor Nesting And Behavior: A Study Of A Free-Living Pair And Chick As Well As Population Behavior Near Antisana Ecological Reserve, Ecuador, Ian Handler

Independent Study Project (ISP) Collection

The behavior of the Andean condor (Vultur gryphus), especially nest behavior, is little known outside of captivity. More information on chick-parent interactions and parenting dynamics of successful condor pairs is needed in order to help create an effective conservation plan for a species in peril of extinction. Study of nest home used by a free-living pair of condors and home to a five-month old juvenile began on November 11, 2018 and continued through November 29, 2018. The nest is located in Antisanilla Biological Reserve and nearby Antisana Ecological Reserve. The chick was also tagged with numbers and a tracking device …

Large Mammals Of The High Andes A Survey Of Community Composition And Habitat Usage In The Highlands Of Angochagua, Sage Fox

Independent Study Project (ISP) Collection

The large mammal community of the high Andes may be the least understood in South America. It contains multiple threatened and charismatic species including the Andean Bear, Mountain Tapir, Red Brocket Deer, Northern Pudu, and Puma. Many of these species are lacking in distribution and population data. The highlands of the Parroquia de Angochagua were once overgrazed by livestock, but have been mostly restored over the last 20 years through conservation efforts by the local community. These highlands are thought to have populations of all the previously mentioned species, though they had not been surveyed before this study. Transect surveys …

La Influencia Del Quechua En El Castellano De La Isla De Taquile / The Influence Of Quechua In The Castilian Of The Island Of Taquile, Gianna Macri

Independent Study Project (ISP) Collection

Esta investigación explora el español de la gente que vive en la isla de Taquile. Esta población habla quechua principalmente, pero es importante aprender la lengua española para comunicarse con los turistas, y el español se enseña en la escuela. En una situación como esta de contacto entre dos lenguas, ambas pueden cambiar su estructura, sus características gramaticales y su vocabulario. En otras comunidades quechuahablantes, se describe una variedad de la lengua, el “castellano andino”. Los resultados muestran que el español de Taquile también tiene variaciones similares por la influencia del quechua: el orden de las palabras más común en …

La Tierra Aquí Es Amable: Soil Macrofauna Density And Producer Perceptions Of Agricultural Soil Fertility In Cerro Punta, Chiriquí, Clara Fernandez Odell

Independent Study Project (ISP) Collection

Ethnopedology, as a subfield of ethnoecology, is the study of localized symbols and values, knowledge, and practices relating to soils. One key framework for ethnopedological studies is the Kosmos-Corpus-Praxis model, which synthesizes local and traditional ecological into three overlapping, interrelated spheres. Cerro Punta, Chiriquí is the primary vegetable-growing region in Panama, an industry highly dependent on the region’s fertile volcanic soils. Semi-structured interviews (n=8) and soil macrofauna density surveys as an indicator of soil fertility (n=9) were used to gather information regarding producers’ beliefs, knowledge, and decisions about soil fertility.

Among producers in Cerro Punta, religious beliefs and land symbolism …

Balance And Imbalance: The Necessity Of Natural Disasters In Balinese Hinduism, Lorin Foster Demuth

Independent Study Project (ISP) Collection

No abstract provided.