Digital Commons Network^™

Biological Therapy In The Treatment Of Melanoma, Simona Roxana Georgescu, Mihaela Roxana Ioghen, Maria Isabela Sarbu, Alexandra-Florentina Ion, Ela Ghita, Cristina-Iulia Mitran, Madalina-Irina Mitran, Vasile Benea, Mircea Tampa

Journal of Mind and Medical Sciences

Melanoma is one of the most aggressive tumors and its incidence is on the rise. The low rates of survival in metastatic melanoma has led to the development of new drugs for this type of patient, such as biological therapy which has shown remarkable results. This therapy is based on stimulation of the immune system to fight tumoral cells through: injection of cytokines with immunomodulatory properties (interleukin-2, alpha-interferon), vaccination with tumor antigens or immune cells that process tumor antigens, adoptive immunotherapy, inhibition of immune checkpoints (PD-1, CTLA-4), inhibition or stimulation of immune modulator molecules (OX-40, LAG-3), inhibition of signaling pathways …

Keeping Safe On Campus

St. Norbert Times

• News
  • Keeping Safe on Campus
  • SNC Political Life: Promoting voting
  • SNC’s Heroes Without Capes
  • Seeing Signs on Campus Plants?
• Opinion
  • Hello, My Name Is…
  • Today, I am Angry
  • The Kavanaugh Accusations
  • Go Vote!
  • Sudoku
  • Trivia
  • “Maximum Ride”
• Features
  • Playing for a Cure
  • Let’s talk about Title IX
• Entertainment
  • Event Spotlight
  • Book Review: “Heretics Anonymous” by Katie Henry
  • “Game of Thrones” Spinoff Prequel
  • Classics Review: “The White Album”- The Beatles
  • Junk Drawer: Fall Films We Want to See
• Sports
  • SNC Football Sets Record
  • Athlete Spotlight: Graceanna Tarsa
  • SNC Radio Features New Sports Talk Shows
  • Athlete Spotlight: Ben Prange
  • Bored?
  • Green Knights …

We Are ... Marshall, October 3, 2018, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Commonwealth Times 2018-10-03

Commonwealth Times, 1969-

No abstract provided.

"The Crescent" Student Newspaper, October 3, 2018, George Fox University Archives

"The Crescent" Student Newspaper

The Student Newspaper of George Fox University.

The Anchor, Volume 132.05: October 3, 2018, Hope College

The Anchor: 2018

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.

A Dexterous, Glove-Based Teleoperable Low-Power Soft Robotic Arm For Delicate Deep-Sea Biological Exploration, Brennan T. Phillips, Kaitlyn P. Becker, Shunichi Kurumaya, Kevin C. Galloway, Griffin Whittredge, Daniel M. Vogt, Clark B. Teeple, Michelle H. Rosen, Vincent A. Pieribone, David F. Gruber, Robert J. Wood

Publications and Research

Modern marine biologists seeking to study or interact with deep-sea organisms are confronted with few options beyond industrial robotic arms, claws, and suction samplers. This limits biological interactions to a subset of “rugged” and mostly immotile fauna. As the deep sea is one of the most biologically diverse and least studied ecosystems on the planet, there is much room for innovation in facilitating delicate interactions with a multitude of organisms. The biodiversity and physiology of shallow marine systems, such as coral reefs, are common study targets due to the easier nature of access; SCUBA diving allows for in situ delicate …

The Coliform Kind: E. Coli And Its “Cousins” The Good, The Bad, And The Deadly, Alan L. Gillen, Matthew Augusta

Faculty Publications and Presentations

Even though some intestinal bacteria strains are pathogenic and even deadly, most coliforms strains still show evidence of being one of God’s “very good” creations. In fact, bacteria serve an intrinsic role in the colon of the human body. These bacteria aid in the early development of the immune system and stimulate up to 80% of immune cells in adults. In addition, digestive enzymes, Vitamins K and B12, are produced byEscherichia coli and other coliforms. E. coli is the best-known bacteria that is classified as coliforms. The term “coliform” name was historically attributed due to the “Bacillus coli …

The Parthenon, October 3, 2018, Sadie Helmick, Sarah Ingram, Rick Farlow, Franklin Norton, Heather Barker

The Parthenon

The Parthenon, Marshall University’s student newspaper, was published by students Monday through Friday during the regular semester and weekly on Thursdays during the summer. Due to budgetary constraints, beginning with the 2018 Fall semester, the newspaper is only published one day a week. The editorial staff is responsible for the news and the editorial content.

Design And Development Of A Preliminary Virtual Endoluminal Surgical Simulation (Vess) For Endoscopic Submucosal Dissection (Esd) Surgery, Berk Cetinsaya

Theses and Dissertations

Endoscopic Submucosal Dissection (ESD) is an endoscopic technique for en bloc resection of gastrointestinal lesions. Inadequate training platforms and lack of established training curricula have restricted its wide acceptance in the US. Thus, we aim to develop a Virtual Endoluminal Surgery Simulator (VESS) for objective ESD training and assessment. We performed a detailed colorectal ESD task analysis and identified the critical ESD steps. We constructed a hierarchical task tree that elaborates the order of tasks in these steps. Furthermore, we generated quantitative ESD performance metrics. We measured task times and scores of 16 ESD surgeries performed by four different endoscopic …

The Lumberjack, October 03, 2018

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Oxygen Deprivation Influences The Survival Of Listeria Monocytogenes In Gerbils, Jillian Harris, Oindrila Paul, Si Hong Park, Sally White, Khemraj Budachetri, Daniel M. Mcclung, Jessica G. Wilson, Alicia K. Olivier, Justin A. Thornton, Paul R. Broadway, Steven C. Ricke, Janet R. Donaldson

Faculty Publications

Listeria monocytogenes is a facultative anaerobic foodborne pathogen capable of surviving harsh environments. Recent work has indicated that anaerobic conditions increase the resistance capability of certain strains to environmental stressors. The goal of the study was to conduct a preliminary study to determine whether exposure to anaerobic conditions prior to infection increases the ability to survive in vivo. Gerbils were inoculated with one of five doses of the L. monocytogenes strain F2365 by oral gavage: phosphate-buffered saline (control), 5 × 10⁶ colony forming units aerobic culture (low aerobic), 5 × 10⁸ aerobic culture (high aerobic), 5 × 10 …

Cellular Network Modeling And Single Cell Gene Expression Analysis Reveals Novel Hepatic Stellate Cell Phenotypes Controlling Liver Regeneration Dynamics, Daniel Cook, Sirisha Achanta, Jan B. Hoek, Babatunde A. Ogunnaike, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background: Recent results from single cell gene and protein regulation studies are starting to uncover the previously underappreciated fact that individual cells within a population exhibit high variability in the expression of mRNA and proteins (i.e., molecular variability). By combining cellular network modeling, and high-throughput gene expression measurements in single cells, we seek to reconcile the high molecular variability in single cells with the relatively low variability in tissue-scale gene and protein expression and the highly coordinated functional responses of tissues to physiological challenges. In this study, we focus on relating the dynamic changes in distributions of hepatic stellate cell …

Sex Offending Patterns Of Convicted Male Sex Offenders Who Were Sexually Victimized During Childhood: A Qualitative Study, Mollee Katherin Steely

Theses and Dissertations

The cycle of violence hypothesis assumes individuals who are subjected to abuse as children have an increased probability of becoming sexual abusers in the future. This hypothesis has frequently been applied to the etiological development of sex offending. The majority of existing literature has focused on long-term consequences of child sexual abuse for females, neglecting how sexual victimization can affect males. The purpose of the current study is to examine the relationship between adult male sex offenders and their abusers in efforts to understand their experiences with sexual abuse. Data was derived from 40 interviews with adult male sex offenders …

Molecular Characterization Of Penstemon Scariosus (Plantaginaceae), Mikel R. Stevens

Journal of Undergraduate Research

The objectives of this project: Our objective was “to develop an understanding of the genetic structure of the varieties within P. scariosus. With a specific intent to test the hypothesis that P. scariosus var. albifluvis is distinct within P. scariosus” while mentoring no less than four undergraduate students. We have meet and exceeded the academic objectives proposed and then funded by this MEG as attested to in the following paragraphs and attachments to this report. As a result of our most excellent success in this project we have four additional students who are volunteering on the project. It is our …

Physical Models Can Provide Superior Learning Opportunities Beyond The Benefits Of Active Engagements, Dina L. Newman, Megan Stefkovich, Catherine Clasen, Margaret A. Franzen, Leslie Kate Wright

Articles

The essence of molecular biology education lies in understanding of gene expression, with subtopics including the central dogma processes, such as transcription and translation. While these concepts are core to the discipline, they are also notoriously difficult for students to learn, probably because they cannot be directly observed. While nearly all active learning strategies have been shown to improve learning compared with passive lectures, little has been done to compare different types of active learning. We hypothesized that physical models of central dogma processes would be especially helpful for learning, because they provide a resource that students can see, touch, …

Spartan Daily, October 3, 2018, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2018

Volume 151, Issue 19

Forensic Art In Law Enforcement: The Art And Science Of The Human Head, Kourtnei F. Rodriguez

Theses

Forensic art is a highly specialized career field, but there are very few full-time forensic artists working today. There is only one school in the world that offers a degree in forensic art and it is located in Dundee, Scotland at the University of Dundee. The university’s School of Science and Engineering offers a Master of Science (MSc) in Forensic Art and Facial Identification. However, there have been a variety of training courses and workshops provided for individuals interested in studying forensic art locally throughout the United States. Some people may have heard the term used before, but they still …

The Paradox Of Christian-Based Political Advocacy: A Reply To Professor Calhoun, Wayne R. Barnes

Washington and Lee Law Review Online

Professor Calhoun, in his Article around which this symposium is based, has asserted that it is permissible for citizens to publicly argue for laws or public policy solutions based on explicitly religious reasons. Calhoun candidly admits that he has “long grappled” with this question (as have I, though he for longer), and, in probably the biggest understatement in this entire symposium, notes that Professor Kent Greenawalt identified this as “a particularly significant, debatable, and highly complex problem.” Is it ever. I have a position that I will advance in this article, but I wish to acknowledge at the outset that …

Documents From The October 3, 2018 Meeting Of The Associated Students Of The University Of Montana (Asum), University Of Montana--Missoula. Associated Students

Senate Meeting Agendas and Minutes, 2007-Present

Agenda and meeting minutes from the October 3, 2018 meeting of the Associated Students of the University of Montana (ASUM).

Federalism And Phantom Economic Rights In Nfib V. Sebelius, Matthew J. Lindsay

University of Cincinnati Law Review

No abstract provided.

Syriac Chant And The Limits Of Modality, Sarah Bakker Kellogg

Yale Journal of Music & Religion

A book review is presented for Sense and Sadness: Syriac Chant in Aleppo, by Tala Jarjour. Oxford: Oxford University Press, 2018. 250 pp. ISBN: 978-0-190-63525-1.

Giltner Brothers - Eminence, Kentucky (Sc 3264), Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid and scans (Click on "Additional Files" below) for Manuscripts Small Collection 3264. Certificates and associated correspondence relating to the sale of a Polled Hereford bull, “Plutocrat 5th," to Charles Settle, Springfield, Kentucky, by Giltner Brothers Kentucky Herefords, Eminence, Kentucky. Includes Certificates of Entry for the bull’s pedigree and a letter with information on the Giltner Brothers herd.

The Indiana Statesman, October 2, 2018, Indiana State University

Student Newspaper

Hispanic Heritage Month food fiesta series: Chile; Financial literacy 101; From justice to forgiveness: Rachel Denhollander’s path to empowerment; In Las Vegas, it’s called ‘1 October’: how the horrific mass shooting got its unussal name

Mason Faulkner Manages His Herd, Waldron Center

Waldron Center for Entrepreneurship Blog

No abstract provided.

8th Annual Postdoctoral Science Symposium, University Of Texas Md Anderson Cancer Center Postdoctoral Association

Annual Postdoctoral Science Symposium Abstracts

The mission of the Annual Postdoctoral Science Symposium (APSS) is to provide a platform for talented postdoctoral fellows throughout the Texas Medical Center to present their work to a wider audience. The MD Anderson Postdoctoral Association convened its inaugural Annual Postdoctoral Science Symposium (APSS) on August 4, 2011.

The APSS provides a professional venue for postdoctoral scientists to develop, clarify, and refine their research as a result of formal reviews and critiques of faculty and other postdoctoral scientists. Additionally, attendees discuss current research on a broad range of subjects while promoting academic interactions and enrichment and developing new collaborations.

Melvin Richardson V. Superintendent Coal Township S

2018 Decisions

USDC for the Eastern District of Pennsylvania

The Juggler Of Notre Dame And The Medievalizing Of Modernity, Volume 4: Picture That — Making A Show Of The Jongleur, Jan M. Ziolkowski

Juggling for Mary

This ambitious and vivid study in six volumes explores the journey of a single, electrifying story, from its first incarnation in a medieval French poem through its prolific rebirth in the nineteenth and twentieth centuries. The Juggler of Notre Dame tells how an entertainer abandons the world to join a monastery, but is suspected of blasphemy after dancing his devotion before a statue of the Madonna in the crypt; he is saved when the statue, delighted by his skill, miraculously comes to life.

Jan Ziolkowski tracks the poem from its medieval roots to its rediscovery in late nineteenth-century Paris, before …

The Prospector, October 2, 2018, Utep Student Publications

The Prospector

Headline: UTEP Celebrates Homecoming Week

Correcting Glucose-6-Phosphate Dehydrogenase Deficiency With A Small-Molecule Activator, Sunhee Hwang, Karen Mruk, Simin Rahighi, Andrew G. Raub, Che-Hong Chen, Lisa E. Dorn, Naoki Horikoshi, Soichi Wakatsuki, James K. Chen, Daria Mochly-Rosen

Pharmacy Faculty Articles and Research

Glucose-6-phosphate dehydrogenase (G6PD) deficiency, one of the most common human genetic enzymopathies, is caused by over 160 different point mutations and contributes to the severity of many acute and chronic diseases associated with oxidative stress, including hemolytic anemia and bilirubin-induced neurological damage particularly in newborns. As no medications are available to treat G6PD deficiency, here we seek to identify a small molecule that corrects it. Crystallographic study and mutagenesis analysis identify the structural and functional defect of one common mutant (Canton, R459L). Using high-throughput screening, we subsequently identify AG1, a small molecule that increases the activity of the wild-type, the …