Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2018

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 22411 - 22440 of 23962

Full-Text Articles in Entire DC Network

Application Of Crispr/Cas9 Genome Editing Technology For The Improvement Of Crops Cultivated In Tropical Climates: Recent Progress, Prospects, And Challenges, Effi Haque, Hiroaki Taniguchi, Md. Mahmudul Hassan, Pankaj Bhowmik, M. Rezaul Karim, Magdalena Śmiech, Kaijun Zhao, Mahfuzur Rahman, Tofazzal Islam Jan 2018

Application Of Crispr/Cas9 Genome Editing Technology For The Improvement Of Crops Cultivated In Tropical Climates: Recent Progress, Prospects, And Challenges, Effi Haque, Hiroaki Taniguchi, Md. Mahmudul Hassan, Pankaj Bhowmik, M. Rezaul Karim, Magdalena Śmiech, Kaijun Zhao, Mahfuzur Rahman, Tofazzal Islam

Faculty & Staff Scholarship

The world population is expected to increase from 7.3 to 9.7 billion by 2050. Pest outbreak and increased abiotic stresses due to climate change pose a high risk to tropical crop production. Although conventional breeding techniques have significantly increased crop production and yield, new approaches are required to further improve crop production in order to meet the global growing demand for food. The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 (CRISPR-associated protein9) genome editing technology has shown great promise for quickly addressing emerging challenges in agriculture. It can be used to precisely modify genome sequence of any organism including plants …

Go to article

Cone Phosphodiesterase-6Γ’ Subunit Augments Cone Pde6 Holoenzyme Assembly And Stability In A Mouse Model Lacking Both Rod And Cone Pde6 Catalytic Subunits, Wen-Tao Deng, Saravanan Kolandaivelu, Astra Dinculescu, Jie Li, Ping Zhu, Vince A. Chiodo, Visvanathan Ramamurthy, William W. Hauswirth Jan 2018

Cone Phosphodiesterase-6Γ’ Subunit Augments Cone Pde6 Holoenzyme Assembly And Stability In A Mouse Model Lacking Both Rod And Cone Pde6 Catalytic Subunits, Wen-Tao Deng, Saravanan Kolandaivelu, Astra Dinculescu, Jie Li, Ping Zhu, Vince A. Chiodo, Visvanathan Ramamurthy, William W. Hauswirth

Faculty & Staff Scholarship

Rod and cone phosphodiesterase 6 (PDE6) are key effector enzymes of the vertebrate phototransduction pathway. Rod PDE6 consists of two catalytic subunits PDE6α and PDE6β and two identical inhibitory PDE6γ subunits, while cone PDE6 is composed of two identical PDE6α’ catalytic subunits and two identical cone-specific PDE6γ’ inhibitory subunits. Despite their prominent function in regulating cGMP levels and therefore rod and cone light response properties, it is not known how each subunit contributes to the functional differences between rods and cones. In this study, we generated an rd10/cpfl1 mouse model lacking rod PDE6β and cone PDE6α’ subunits. Both rod and …

Go to article

Effects Of Housing Management On Vaccination Success Against Eimeria Infection In Chickens, Louis Wilson Benton Jan 2018

Effects Of Housing Management On Vaccination Success Against Eimeria Infection In Chickens, Louis Wilson Benton

Honors Theses

Coccidiosis is a disease of the gastrointestinal system of commercially raised chickens (Gallus gallus). The infection is caused by multiple parasitic species of the coccidian genus Eimeria. Eimeria proliferate within large poultry houses leading to decreased nutrient absorption, anorexia, and death of the host. Scheduled vaccination with live coccidian oocysts should minimize production losses, but various management factors may contribute to variation in the outcome. I investigated whether by tracking infection cycles in detail it might be possible to improve poultry production. Feces were collected daily from four farms across a two-month period to understand how peaks in oocyst shedding …

Go to article

The Yasuní Itt Initiative And The Creation Of Global Green Sovereignty, Marlarose Gridley Jan 2018

The Yasuní Itt Initiative And The Creation Of Global Green Sovereignty, Marlarose Gridley

Honors Theses

The Yasuní-ITT Initiative was an international financing scheme in which the Ecuadorian government agreed to forgo drilling in the Yasuní National Park in exchange for foreign compensation in the amount of $3.6 billion USD over 12 years. Embedded in a global framework of revenue redistribution for development, the Yasuní-ITT Initiative established a model of global environmental care based on global North-South difference and historical ecological debt. In doing so, it impacted, through prospective flows of aid, the conceptualization of Ecuadorian sovereignty.

Go to article

Development Of A Scn1a Null Zebrafish Model For Screening Potential Anti-Epileptic Natural Products, Patricia Ann Lipson Jan 2018

Development Of A Scn1a Null Zebrafish Model For Screening Potential Anti-Epileptic Natural Products, Patricia Ann Lipson

Honors Theses

Epilepsy affects around 50 million people in the world. Thus, it is imperative that new more effective and safe treatments be found. This study was designed to use zebrafish to screen potential anti-epileptic natural products. We utilized two scn1Lab null zebrafish models (morpholino-injected fish where scn1Lab was transiently knocked down and a transgenic scn1Lab -/- fish line). Alternatively, we used AB wildtype fish to test compounds in a chemically-induced seizure model. Natural compounds including cannabidiol, CBD, and Tapinanthus globiferous, TG, extracts were screened for their anti-seizure activity. When scn1Lab -/- fish were treated with CBD (0.075 and 0.3 mg/L) from …

Go to article

Water, Women, And Migration: Examining The Interconnections Between Water Scarcity, Environmental Migration, And Women In Bolivia, Sarah T. Meeks Jan 2018

Water, Women, And Migration: Examining The Interconnections Between Water Scarcity, Environmental Migration, And Women In Bolivia, Sarah T. Meeks

Honors Theses

Water insecurity has received growing attention as climate change is worsening environmental conditions, and research has established how water insecurity has differentiated impacts according to one's gender. In light of both an increasing trend in environmental migration and extreme weather events in Bolivia, this paper sought to establish environmental migration's explicit role in the relationship between water scarcity and gendered effects. To do so, it addressed the question, how does environmental migration influence the relationship between gendered effects and water scarcity? and hypothesized that migration is a more subtle and overlooked contributor to the gendered effects of water scarcity. The …

Go to article

Synthesis Of (2r,6r)-Hydroxy-Norketamine For Evaluation Of Antidepressant Effects, Savannah Fairley Jan 2018

Synthesis Of (2r,6r)-Hydroxy-Norketamine For Evaluation Of Antidepressant Effects, Savannah Fairley

Honors Theses

Major Depressive Disorder, colloquially known as depression, is a devastating mental illness that affects a large portion of today's population. Following a drug side-effect that caused depression, the monoamine theory of depression was created, stating that depressive symptoms were caused by a decrease in concentrations of vital monoamine neurotransmitters at the synaptic cleft. Pharmaceutical remedies to combat depression were first introduced in the 1950s and to this date, most available drugs follow the monoamine theory. These drugs have a large loading dose lag time, numerous negative side effects, and still many patients do not experience relief from symptoms. In 2000, …

Go to article

Connecting The Mind And Body In Ancient Greek Medicine, Taylor Ferris Jan 2018

Connecting The Mind And Body In Ancient Greek Medicine, Taylor Ferris

Honors Theses

I investigated Greek medicine and healing shrines in antiquity and focused on the issue of the mind-body connection and how this phenomenon was understood in antiquity. I researched the Athenian plague of 430-425 B.C., sleep and dreams, particularly in the Rites of Incubation, and Hippocratic medicine as well as religious medicine in order to understand more deeply the origins of Greek medicine and how the healing phenomena were practiced and understood. I have come to a greater understanding of this connection between the mind and the body and have come to redefine the placebo effect and argue that the mind …

Go to article

The Cinematic South: A Look Into The South According To Quentin Tarantino, Justin Tyler Necaise Jan 2018

The Cinematic South: A Look Into The South According To Quentin Tarantino, Justin Tyler Necaise

Honors Theses

This thesis examines the eight films directed by Quentin Tarantino. More specifically, it examines how Tarantino portrays the American South, southernness, and southerners throughout his filmography. I watched each film countless times, read each screenplay, and read many articles written about the films. I also read many biographies, and I watched many interviews with Quentin Tarantino. In this work, I find that Tarantino exploits the South in order to create much more despicable characters, which furthers the stereotype that the South is in some way lesser to the rest of the United States. The South according to Quentin Tarantino is …

Go to article

An Analysis Of Mississippi Tax Incentives, Bruce H. Brawner Jan 2018

An Analysis Of Mississippi Tax Incentives, Bruce H. Brawner

Honors Theses

The locational decisions of firms present a complex economic and political problem for State Legislatures across the United States of America. It is well known that individual states compete against one another, offering large packages of incentives to firms who open within their borders — a process popularly known as the race to the bottom. This thesis examines public subsidy information reported by the Mississippi Development Authority alongside wage and employment data from 1990 to 2016 in a local projection framework to examine whether or not treatment effects of local government spending are significant. I then employ the same method …

Go to article

Surrendering To The Tangle: Essays, Caroline Abide Jan 2018

Surrendering To The Tangle: Essays, Caroline Abide

Honors Theses

A collection of creative nonfiction essays exploring the author's gender and sexuality, changing worldviews, and coming of age (under the direction of Kiese Laymon).

Go to article

Child Sexploitation: A Study Of Machismo And The Commercial Sexual Exploitation Of Children In Latin America, Courtney M. Cone Jan 2018

Child Sexploitation: A Study Of Machismo And The Commercial Sexual Exploitation Of Children In Latin America, Courtney M. Cone

Honors Theses

This thesis attempts to explore how the inextricable relationship between machismo and poverty connects to the commercial sexual exploitation of children in Latin America through predatory behaviors in order to provide insight to anti-trafficking campaigns. The overt Latin American culture of machismo contributes to the discrimination of women and children, enhancing their inherent dependency on men for economic survival. The inevitable pattern of dependency on patriarchal figures out of vulnerability to societal constructions is evident in economic, political and social structures. The pervasiveness of dependency is seen through patterns of violence against women, patterns of child abuse, and patterns of …

Go to article

Corporate Accountancy Case Research And Analytics, Elizabeth Clutton Jan 2018

Corporate Accountancy Case Research And Analytics, Elizabeth Clutton

Honors Theses

Corporate accounting is an ever-evolving beast that ebbs and flows with social and technological trends. Management faces new challenges with every interaction and must deal with the consequences. Accounting firms pioneer strategies and solutions to cope with changing regulations and accounting methods while abiding by their governing bodies. The Public Company Accounting Oversight Board as established by the Sarbanes-Oxley Act of 2002 is responsible for monitoring and correcting public companies. The Financial Accounting Standards Board established by the Financial Accounting Foundation is considered to be the Generally Accepted Accounting Standard setting body for the PCAOB. The cases discussed below all …

Go to article

The Role Of Children In Seventeenth-Century Dutch Paintings: Social Distinction And National Identity, Helena Enders Jan 2018

The Role Of Children In Seventeenth-Century Dutch Paintings: Social Distinction And National Identity, Helena Enders

Senior Independent Study Theses

No abstract provided.

Go to article

Modern Electronic Commerce: A Primer For Business Students, Harika Rao Jan 2018

Modern Electronic Commerce: A Primer For Business Students, Harika Rao

Lynn University Digital Press Books

Modern Electronic Commerce: A Primer for Business Students was created for BUS 255: Fundamentals of E-Business, and serves as an introduction to conducting e-commerce. The interactive textbook focuses on the basics of internet business operations and details e-commerce theories on infrastructure, presence, strategies, SEO, and law and ethics. The material is further enhanced by the inclusion of hands-on widgets, videos, and case studies that supplement the theory and practice presented in the textual content. Course: BUS 255

Go to article

Top Tens In 2017: Patent, Trademark, Copyright And Trade Secret Cases, Stephen M. Mcjohn Jan 2018

Top Tens In 2017: Patent, Trademark, Copyright And Trade Secret Cases, Stephen M. Mcjohn

Suffolk University Law School Faculty Works

The Supreme Court loosened the grip of patentees on their products, holding that contractual restrictions on patented product are ineffective to preserve patent rights. The Court also loosened the grip of the Eastern District of Texas on patent cases, announcing a narrower standard that will send more cases to Delaware. The Federal Circuit cases piled up on applying the Alice standard to filter nonpatentable abstract ideas from patentable inventions. Meanwhile, even as the constitutionality of the Patent Trial and Appeals Board pends before the Supreme Court, hundreds of PTAB decisions on the validity of patents move onward to the Federal …

Go to article

Culture And Time Perception: Implications For Mental Representation And Decisions, Siew Hong Tan Jan 2018

Culture And Time Perception: Implications For Mental Representation And Decisions, Siew Hong Tan

School of Psychology Theses

This thesis examines cultural variations in time perception, as well as the possible influences on mental representation and decisions. Building on prior research on cultural differences in time-related perceptions, two main time perceptions were identified and focused on, namely temporal orientation and the use of time metaphor. The temporal orientation line of investigation explores the implications of a stronger future versus past orientation among English and Mandarin-speakers respectively. Based on Construal Level Theory, temporal orientation is expected to be related to psychological distance, which in turn affects the mental representations individuals form. The findings supported a stronger future orientation among …

Go to article

Universal Target‐Enrichment Baits For Anthozoan (Cnidaria) Phylogenomics: New Approaches To Long‐Standing Problems, Andrea M. Quattrini, Brant C. Faircloth, Luisa F. Dueñas, Tom C.L. Bridge, Mercer R. Brugler, Iván F. Calizto-Botía, Danielle M. Deleo, Sylvain Forêt, Santiago Herrera, Simon M.Y. Lee, David J. Miller, Carlos Prada, Gandhi Rádis-Baptista, Catalina Ramirez-Portilla, Juan A. Sánchez, Estefanía Rodriguez, Catherine S. Mcfadden Jan 2018

Universal Target‐Enrichment Baits For Anthozoan (Cnidaria) Phylogenomics: New Approaches To Long‐Standing Problems, Andrea M. Quattrini, Brant C. Faircloth, Luisa F. Dueñas, Tom C.L. Bridge, Mercer R. Brugler, Iván F. Calizto-Botía, Danielle M. Deleo, Sylvain Forêt, Santiago Herrera, Simon M.Y. Lee, David J. Miller, Carlos Prada, Gandhi Rádis-Baptista, Catalina Ramirez-Portilla, Juan A. Sánchez, Estefanía Rodriguez, Catherine S. Mcfadden

Biological Sciences Faculty Publications

Anthozoans (e.g., corals, anemones) are an ecologically important and diverse group of marine metazoans that occur from shallow to deep waters worldwide. However, our understanding of the evolutionary relationships among the ~7,500 species within this class is hindered by the lack of phylogenetically informative markers that can be reliably sequenced across a diversity of taxa. We designed and tested 16,306 RNA baits to capture 720 ultraconserved element loci and 1,071 exon loci. Library preparation and target enrichment were performed on 33 taxa from all orders within the class Anthozoa. Following Illumina sequencing and Trinity assembly, we recovered 1,774 of 1,791 …

Go to article

An Ecossaise Exercise: Lesson Plan And Materials For A Class In The Second Week On Tonicization, Jonathan Guez Jan 2018

An Ecossaise Exercise: Lesson Plan And Materials For A Class In The Second Week On Tonicization, Jonathan Guez

Journal of Music Theory Pedagogy

This lesson plan and accompanying slide show (PowerPoint and PDF) present secondary functions as energetic, goal-directed chords that contain a leading tone and therefore mimic the voice leading of dominant-to-tonic progressions. It is designed for use in the second week on tonicization, after students have been introduced to secondary functions. In presenting secondary dominants as chords that contain local leading tones that demand upward resolution (onto their local “tonics”), it embodies a pedagogical approach that stresses the importance of identifying a local leading tone and its upwards resolution as a prerequisite for understanding secondary function. Here, secondary leading tones are …

Go to article

Functional Role Of The Type 1 Pilus Rod Structure In Mediating Host-Pathogen Interactions, Caitlin N. Spaulding, Henry Louis Schreiber Iv, Weili Zheng, Karen W. Dodson, Jennie E. Hazen, Matt S. Conover, Fengbin Wang, Pontus Svenmarker, Areli Luna-Rico, Olivera Francetic, Magnus Andersson, Scott Hultgren, Edward H. Egelman Jan 2018

Functional Role Of The Type 1 Pilus Rod Structure In Mediating Host-Pathogen Interactions, Caitlin N. Spaulding, Henry Louis Schreiber Iv, Weili Zheng, Karen W. Dodson, Jennie E. Hazen, Matt S. Conover, Fengbin Wang, Pontus Svenmarker, Areli Luna-Rico, Olivera Francetic, Magnus Andersson, Scott Hultgren, Edward H. Egelman

Open Access Publications

No abstract provided.

Go to article

Diffusion Basis Spectrum And Diffusion Tensor Imaging Detect Hippocampal Inflammation And Dendritic Injury In A Virus-Induced Mouse Model Of Epilepsy, Jie Zhan, Tsen-Hsuan Lin, Jane E. Libbey, Peng Sun, Zezhong Ye, Chunyu Song, Michael Wallendorf, Honghan Gong, Robert S. Fujinami, Sheng-Kwei Song Jan 2018

Diffusion Basis Spectrum And Diffusion Tensor Imaging Detect Hippocampal Inflammation And Dendritic Injury In A Virus-Induced Mouse Model Of Epilepsy, Jie Zhan, Tsen-Hsuan Lin, Jane E. Libbey, Peng Sun, Zezhong Ye, Chunyu Song, Michael Wallendorf, Honghan Gong, Robert S. Fujinami, Sheng-Kwei Song

Open Access Publications

No abstract provided.

Go to article

Parathyroid Hormone-Related Peptide Elicits Peripheral Trpv1-Dependent Mechanical Hypersensitivity, Andrew J. Shepherd, Aaron D. Mickle, Suraj Kadunganattil, Hongzhen Hu, Durga P. Mohapatra Jan 2018

Parathyroid Hormone-Related Peptide Elicits Peripheral Trpv1-Dependent Mechanical Hypersensitivity, Andrew J. Shepherd, Aaron D. Mickle, Suraj Kadunganattil, Hongzhen Hu, Durga P. Mohapatra

Open Access Publications

No abstract provided.

Go to article

Caveolin-1 Regulates Lipid Droplet Metabolism In Endothelial Cells Via Autocrine Prostacyclin–Stimulated, Camp-Mediated Lipolysis, Andrew Kuo, Monica Y. Lee, Kui Yang, Richard W. Gross, William C. Sessa Jan 2018

Caveolin-1 Regulates Lipid Droplet Metabolism In Endothelial Cells Via Autocrine Prostacyclin–Stimulated, Camp-Mediated Lipolysis, Andrew Kuo, Monica Y. Lee, Kui Yang, Richard W. Gross, William C. Sessa

Open Access Publications

No abstract provided.

Go to article

Perilipin 5 And Liver Fatty Acid Binding Protein Function To Restore Quiescence In Mouse Hepatic Stellate Cells, Jianguo Lin, Shizhong Zheng, Alan D. Attie, Mark P. Keller, David A. Bernlohr, William S. Blaner, Elizabeth P. Newberry, Nicholas O. Davidson, Anping Chen Jan 2018

Perilipin 5 And Liver Fatty Acid Binding Protein Function To Restore Quiescence In Mouse Hepatic Stellate Cells, Jianguo Lin, Shizhong Zheng, Alan D. Attie, Mark P. Keller, David A. Bernlohr, William S. Blaner, Elizabeth P. Newberry, Nicholas O. Davidson, Anping Chen

Open Access Publications

No abstract provided.

Go to article

Diagnosis Of Lvad Thrombus Using A High-Avidity Fibrin-Specific 99mtc Probe, Grace Cui, Walter J. Akers, Michael J. Scott, Michael Nassif, John S. Allen, Anne H. Schmieder, Krishna S. Paranandi, Akinobu Itoh, Dmitry D. Beyder, Samuel Achilefu, Gregory A. Ewald Jan 2018

Diagnosis Of Lvad Thrombus Using A High-Avidity Fibrin-Specific 99mtc Probe, Grace Cui, Walter J. Akers, Michael J. Scott, Michael Nassif, John S. Allen, Anne H. Schmieder, Krishna S. Paranandi, Akinobu Itoh, Dmitry D. Beyder, Samuel Achilefu, Gregory A. Ewald

Open Access Publications

No abstract provided.

Go to article

Iron Overload Accelerates The Progression Of Diabetic Retinopathy In Association With Increased Retinal Renin Expression, Kapil Chaudhary, Wanwisa Promsote, Sudha Ananth, Rajalakshmi Veeranan-Karmegam, Amany Tawfik, Pachiappan Arjunan, Pamela Martin, Sylvia B. Smith, Muthusamy Thangaraju, Oleg Kisselev, Vadivel Ganapathy, Jaya P. Gnana-Prakasam Jan 2018

Iron Overload Accelerates The Progression Of Diabetic Retinopathy In Association With Increased Retinal Renin Expression, Kapil Chaudhary, Wanwisa Promsote, Sudha Ananth, Rajalakshmi Veeranan-Karmegam, Amany Tawfik, Pachiappan Arjunan, Pamela Martin, Sylvia B. Smith, Muthusamy Thangaraju, Oleg Kisselev, Vadivel Ganapathy, Jaya P. Gnana-Prakasam

Open Access Publications

No abstract provided.

Go to article

Multi-Radial Lbp Features As A Tool For Rapid Glomerular Detection And Assessment In Whole Slide Histopathology Images, Olivier Simon, Rabi Yacoub, Sanjay Jain, John E. Tomaszewski, Pinaki Sarder Jan 2018

Multi-Radial Lbp Features As A Tool For Rapid Glomerular Detection And Assessment In Whole Slide Histopathology Images, Olivier Simon, Rabi Yacoub, Sanjay Jain, John E. Tomaszewski, Pinaki Sarder

Open Access Publications

No abstract provided.

Go to article

An Accord Of Nuclear Receptor Expression In M. Tuberculosis Infected Macrophages And Dendritic Cells, Ankita Saini, Sahil Mahajan, Nancy Ahuja, Ella Bhagyaraj, Rashi Kalra, Ashok Kumar Janmeja, Pawan Gupta Jan 2018

An Accord Of Nuclear Receptor Expression In M. Tuberculosis Infected Macrophages And Dendritic Cells, Ankita Saini, Sahil Mahajan, Nancy Ahuja, Ella Bhagyaraj, Rashi Kalra, Ashok Kumar Janmeja, Pawan Gupta

Open Access Publications

No abstract provided.

Go to article

No Evidence That Carotenoid Pigments Boost Either Immune Or Antioxidant Defenses In A Songbird, Rebecca E. Koch, Andreas N. Kavazis, Dennis Hasselquist, Wendy R. Hood, Yufeng Zhang, Matthew B. Toomey, Geoffrey E. Hill Jan 2018

No Evidence That Carotenoid Pigments Boost Either Immune Or Antioxidant Defenses In A Songbird, Rebecca E. Koch, Andreas N. Kavazis, Dennis Hasselquist, Wendy R. Hood, Yufeng Zhang, Matthew B. Toomey, Geoffrey E. Hill

Open Access Publications

No abstract provided.

Go to article

Mtor Signaling In Skeletal Development And Disease, Jianquan Chen, Fanxin Long Jan 2018

Mtor Signaling In Skeletal Development And Disease, Jianquan Chen, Fanxin Long

Open Access Publications

No abstract provided.

Go to article

First Prev Next Last