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Therapeutic And Immunological Interventions In Primary Biliary Cholangitis: From Mouse Models To Humans, Atsushi Tanaka, Patrick S.C. Leung, Howard A. Young, M. Eric Gershwin

United States Public Health Resources

Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease that predominantly affects women in their fifth and sixth decades. The diagnostic hallmarks of PBC are detection of anti-mitochondrial antibodies (AMAs) and chronic non-suppurative destructive cholangitis (CNSDC) of small- and medium-sized intrahepatic bile ducts in liver histological examination [1, 2]. A significant amount of data suggests that immunological activity against small biliary epithelial cells (BECs), found histologically as portal inflammation, leads to clinical disease. In PBC, as with other autoimmune diseases, both genetic and environmental factors contribute to the development of pathology [3–8]. The first-line therapy of PBC is ursodeoxycholic …

Copd National Action Plan

United States Natonal Institutes of Health: Materials

The COPD National Action Plan is the first-ever blueprint for a multi-faceted, unified fight against the disease. Developed at the request of Congress.

Annual Report 2017 - 2018, Houston Academy Of Medicine - Texas Medical Center Library

Annual Reports: 1943 - Present

This file contains the Annual Report for the library from 2017-2018.

The Other Cheek, Stacia M. Fleegal

Nelle (literary magazine)

p. 84

Genomic Differences Between Nasal Staphylococcus Aureus From Hog Slaughterhouse Workers And Their Communities., Yaqi You, Li Song, Bareng A S Nonyane, Lance B Price, Ellen K Silbergeld

Environmental and Occupational Health Faculty Publications

New human pathogens can emerge from the livestock-human interface and spread into human populations through many pathways including livestock products. Occupational contact with livestock is a risk factor for exposure to those pathogens and may cause further spreading of those pathogens in the community. The current study used whole genome sequencing to explore nasal Staphylococcus aureus obtained from hog slaughterhouse workers and their community members, all of whom resided in a livestock-dense region in rural North Carolina. Sequence data were analyzed for lineage distribution, pathogenicity-related genomic features, and mobile genetic elements. We observed evidence of nasal S. aureus differences between …

The Last Brandy, Angela Ball

Birmingham Poetry Review

p. 75

Where It Begins, Jay Udall

Birmingham Poetry Review

pp. 190-191

I Heard The Buzzards Shrill, Laura Neal

Birmingham Poetry Review

p. 147

Soupbone Madrigal, Lisa Russ Spaar

Birmingham Poetry Review

p. 180

Why It Worked: Participants' Insights Into An Mhealth Antiretroviral Therapy Adherence Intervention In China., Lora L Sabin, Lauren Mansfield, Mary Bachman Desilva, Taryn Vian, Zhong Li, Xie Wubin, Allen L Gifford, Yiyao Barnoon, Christopher J Gill

Global Health Faculty Publications

Background: Few Antiretroviral Therapy (ART) adherence trials investigate the reasons for intervention success or failure among HIV-positive individuals.

Objectives: To conduct qualitative research to explore the reasons for effectiveness of a 6-month mHealth (mobile health) trial that improved adherence among ART patients in China. The intervention utilized Wireless Pill Containers (WPCs) to provide, real-time SMS reminders, WPC-generated adherence reports, and report-informed counseling.

Methods: We conducted in-depth interviews with 20 intervention-arm participants immediately following the trial. Sampling was purposeful to ensure inclusion of participants with varied adherence histories. Questions covered adherence barriers and facilitators, and intervention experiences. We analyzed data in …

Antiretroviral Therapy Interruptions: Impact On Hiv Treatment And Transmission., Gueorgui Dubrocq, Natella Rakhmanina

Pediatrics Faculty Publications

Introduction: Successful management of pediatric and adult human immunodeficiency virus (HIV) disease includes lifelong administration of antiretroviral therapy (ART). The need for the continuous use of antiretroviral drugs throughout the life course poses a challenge to children, adolescents, and adults living with HIV and their caregivers. Historically, treatment interruptions have been viewed as a negative therapeutic strategy. Recently, however, treatment interruptions or treatment reduction strategies have become a focus of investigations as innovative approaches to the long-term management of HIV disease. Current challenges with treatment interruptions include identifying an appropriate timeframe for length of interruptions and identifying HIV patient populations …

Among Patients With Endometriosis, Does The Use Of Serum Biomarkers, Versus Laparoscopic Surgery For Diagnosis And Staging Of The Disease Decrease The Incidence Of Disease Related Negative Outcomes, Ellyn C. Hexum

Theses and Graduate Projects

Objective: To determine the ability and efficacy of non-invasive serum biomarker testing as a replacement for laparoscopic surgery in the diagnosis and staging of endometriosis to decrease the incidence of negative disease outcomes, leading to improvement in the accuracy of diagnoses and patient tailored treatment protocols.

Background: Endometriosis is a debilitating inflammatory disease of the reproductive tract. Currently, the gold standard for the diagnosis and staging of endometriosis is exploratory laparoscopic surgery. The use of surgery as the source of achieving a definitive diagnosis holds the potential to increase the incidence of negative disease outcomes. Because of this, the use …

Nobody Likes Flies, Zachary Mattson

Theses and Graduate Projects

Leishmaniasis is a protozoan disease that is common in tropical areas of the globe. Around the world this disease is transmitted from different hosts by various sand-fly species. The most prevalent countries for any type of leishmaniasis are Brazil, India, and Ethiopia. There are three presentations of the disease seen around the world: visceral, mucosal, and cutaneous. Overall cutaneous leishmaniasis is a disease that can be disfiguring and disrupting to individuals across the world. Though it may be difficult to access information for those in rural communities in Central America it is important for providers to provide information in an …

Are Platelet Rich Plasma Injections A Better Choice Compared To Glucocorticoid Injections For The Treatment Of Rotator Cuff Tendinopathy In Adult Patients?, Sawyer Lange

Theses and Graduate Projects

An estimated 16 to 34 percent of the general population will experience shoulder pain at some point in their life. Rotator cuff tendinopathy makes up a large portion of that percentage. Platelet rich plasma (PRP) is an autologous blood product that has supraphsyiologic levels of growth factors and cytokines that have the potential to expedite the tendon healing process. This literature review will look at the current science surrounding PRP and look at studies comparing its efficacy to the commonly used corticosteroid injection.

Do Non-Steroidal Anti-Inflammatory Drugs Increase The Risk For Non- Or Mal-Union Following Acute Fracture? A Literature Review, Bryan Moritz

Theses and Graduate Projects

NSAID medications are among the most commonly used analgesic medications world wide, and it was estimated in 2010 (updated 2015 data is expected to be published next year) that about 29 million adults in the United States regularly used NSAID medications at least three times per week for more than three months. Fracture healing has been shown to be dependent on the inflammatory cascade. NSAID medication use appears to have a mechanistic in-vivo and in-vitro animal risk for the development of non- and mal-union following fracture. However, human data is lacking to support total avoidance of this analgesic option for …

Therapeutic Hypothermia For Neonatal Hypoxic Ischemic Encephalopathy: Effects On Neurodevelopmental Outcomes, Claire Rustad

Theses and Graduate Projects

Therapeutic hypothermia is a standardized protocol in the management of term- or near- term neonates who have suffered asphyxia in the perinatal period. Birth asphyxia, if sustained, may develop into a more serious condition known as hypoxic ischemic encephalopathy (HIE). Depending on severity, HIE is associated with adverse cognitive and neurodevelopmental outcomes, yet through various physiological mechanisms, hypothermia sustained for a 72-hour period has been shown to attenuate, or even prevent, permanent brain damage by decreasing cerebral energy demands. Unfortunately, cognitive and neurodevelopmental outcomes are difficult to prognosticate before or after completion of hypothermia protocol, but existing standards and technology …

Exploring The Lives Of Retired Nurses Using The Lens Of Legacy, Verliss L. Keller-Miller

Theses and Graduate Projects

Legacy can be viewed as a summary of life. Legacy develops over a lifetime and changes and grows as one ages. How do retired nurses view their legacy? This paper looks at a select group of five female retired nurses and how each views her legacy at this time in life. Each was a professional nurse, and each is fully retired. Imogene King’s Goal Attainment Theory discusses the concepts of self and role. Through individual conversations, each retired nurse shares her life story of self and the roles she held during her working years. Literature yields little information about this …

Acute Post-Operative Pain Management: Preventing Overuse Of Opioids, Alison Hirsch

Theses and Graduate Projects

Background: Surgical pain management with opioids is common. The use of multimodal analgesia has been proposed in order to provide opioid-sparing regimens and improve pain control post-operatively. Inadequate control of surgical pain can lead to development of chronic pain. Furthermore, studies have linked acute surgical opioid use to increased risk of long-term use. Long-term opioid use has undesirable, life-altering consequences, including physical dependence and addiction which may lead to overdose or death. Use of a variety of medications in the operative setting can lead to synergistic or additive effects on pain control, thus decreasing post-operative opioid consumption.

Methods: A literature …

The Future Of 5-Fluorouracil Treatment Of Colorectal Cancer: Translating A Better Understanding Into Improved Patient Care, Nathan Smits

Theses and Graduate Projects

5-fluorouracil (5-FU) is a pyrimidine analog that has been successfully employed in anticancer therapy for over forty years. Over the past several decades, researchers have characterized its cellular and clinical pharmacology and uncovered multiple mechanisms of action, which include the inhibition of thymidylate synthase (TS) and incorporation of its metabolites into DNA and RNA. The purpose of this quantitative systemic review was to summarize and evaluate what is known of these mechanisms to determine which are of most significance in the anticancer effects of 5-FU in metastatic colorectal cancer (mCRC) patients. A literature search of peer-reviewed articles dating back to …

Global Health And Societal Impacts Of Schistosomiasis, William Ryan

Theses and Graduate Projects

Schistosomiasis, a parasitic infection, is classified as a Neglected Tropical Disease (NTD). While there are many NTDs that impact poor people across the world, schistosomiasis is one of the most prevalent. Currently 200 million people worldwide are infected with schistosomiasis and 800 million more are at risk for infection. Like other NTDs, this infection is preventable and treatable. Mass drug administration of the anti-parasitic drug praziquantel (the only drug available to treat schistosomiasis) is currently the main method of control. Although, China has recently demonstrated success by employing strategies that involve controlling the infection in the livestock population. Epidemiological surveys …

Increased Antibiotic Resistance Of Escherichia Coli In Nicaragua: Potential Causes And Future Implications, Ryan S. Paukert

Theses and Graduate Projects

Since 1987, no new structural class of antibiotic has been introduced into human medicine. Aside from the absence of a new structural class of antibiotics, there has been a startlingly low number of new antibiotics approved since 1987. With the lack of new antibiotics, finding current antibiotics that are effective is becoming an alarming challenge due to the worldwide emergence of antibiotic resistance. Antibiotic-resistant bacteria presents a major threat to public health because they reduce the effectiveness of antibiotic treatment leading to increased morbidity, mortality, and healthcare expenditure. Without treatment for common infections, like uropathogenic Escherichia coli (UPEC), resistant infections …

Best Practices And Challenges To Composting In A Restaurant Setting, Christopher Jon Audette

Theses and Graduate Projects

Composting and organic waste reduction has been an important topic in recent years. The large volume of food waste that is generated and sent to landfills is of growing concern for municipalities as they struggle to handle ever increasing waste. Though recycling efforts of glass, paper and metal materials has become more common, the addition of composting organic waste on a large scale is still relatively not established. Composting in restaurants is a growing component to reducing the amount of organic waste that ends up in landfills due to the high volume of waste that they generate. The creation of …

Washington University Magazine, Fall/Winter 2018-2019

Washington University Magazine

No abstract provided.

Washington University Magazine, Spring 2018

Washington University Magazine

No abstract provided.

The Role Of Piay In Elementary School: The Perceptions Of Students, Aaron Skjerseth

Theses and Graduate Projects

This study is a look into students' views surrounding play and its place in the elementary classroom. The study was qualitative in nature and focused wholly on student interviews and their viewpoints and opinions on the subject. From these interviews, four broad themes were established. These themes revealed that students found play to be crucial in developing and maintaining friendships, destressing throughout the day, keeping up focus during lessons, and finally, there needs to be more play in schools. These themes suggest play should be taken more seriously in the classroom, as students view it to be crucial in several …

The Use Of Offensive Language By Middle School Students In The Special Education Classroom: Student And Staff Perspectives, Matthew Francis Hillis Byrnes

Theses and Graduate Projects

Students'use of offensive language often leads to behavioral problems, such as fights, that impede learning in the classroom environment. Through comparing and contrasting the perspectives of students and staff in a program for middle school students with emotional and/or behavioral disorders, this research seeks to understand why students use offensive language. Both students and staffwere interviewed. The students were sixth and eighth graders who spend 60-100% of their time in school in a special education classroom. The staff who were interviewed include special education teachers, an educational assistant, a teacher in the mainstream program, and a school psychologist. All of …

Just Like Us: Elizabeth Kendall’S Imperfect Quest For Equality, Kate Rose

Journal of Feminist Scholarship

This essay analyzes United States academic Elizabeth Kendall’s 1913 travelogue A Wayfarer in China through the lenses of gender and criticism of imperialism. In China, Kendall sought to transcend social norms while reflecting empathetically, though sometimes contradictorily, on the lives of the people she encountered. In her travelogue, Kendall is exploring China’s wild areas but also the metaphysical, untamed space beyond conventions in a quest for gender equality and cultural autonomy. She also defends Chinese immigrants in the US at a time of overwhelming anti-Asian prejudice.

2018 Intersession Catalog, Illinois Mathematics And Science Academy

Intersession Catalogs

No abstract provided.

Tinctorial Cartographies: Plant, Dye & Place, Anna Heywood-Jones

Textile Society of America: Symposium Proceedings

We live in a plant-dominated biosphere, and yet the relevance and meaning of vegetal life, beyond its contribution to human existence, is rarely considered. This way of thinking has led us to see nature as external to ourselves, as “other,” as that mysterious realm beyond the human sphere of being. As in visual culture, plant life possesses signifiers and coded meanings in its contextual configurations. Botanical literacy offers insight into environmental, sociocultural, and historical narratives of place, as the forests and herbaceous margins of our communities speak of complex past, a parallel history of survival and adaptation. Plants and textiles, …

Radical Access: Textiles And Museums, Michele Hardy, Joanne Schmidt

Textile Society of America: Symposium Proceedings

This presentation discusses recent initiatives at Glenbow and Nickle Galleries that endeavor to provide new, radical levels of access to textile collections as a means to build community and affect creativity. While locking textiles away in environmentally controlled rooms and minimizing handling are useful methods for preservation, they are less effective in building vibrant communities or creating future relevance form museum collections. This paper, building on Hemming’s post-colonial textile theory, as well as Onciul’s theories on decolonizing engagement, challenge the apparent dichotomy between access and preservation. It argues that preservation without radical access, without shared community meaning making, without respecting …