Digital Commons Network^™

The Application Of Small Molecule Inhibitors Of Ngr1 And Lpa1 Towards The Goal Of Neuroregeneration In The Central Nervous System, Hiam Naiditch

Yale Medicine Thesis Digital Library

Disorders affecting the CNS are significantly disabling and often carry a poor prognosis of functional recovery. Pharmacotherapies that promote functional improvement via neuroregeneration have proven to be an elusive goal. Factors intrinsic to the neuronal microenvironment, particularly myelin-associated proteins such as Nogo-A, MAG, and OMgp, have been shown to be important in inhibiting such regeneration through neuronal NgR1. Additionally, LPA signaling through LPA1 has also shown to be important in inhibiting neuroregeneration through mechanisms that are currently being researched.

It has been previously shown that application of a NgR1 decoy receptor (AA-NgR(310)ecto-Fc) increases sprouting below the site of the lesion …

Longitudinal Assessment Of Blood Brain Barrier Disruption In Primary Hiv Infection And Effect Of Cart Therapy, Elham Rahimy

Yale Medicine Thesis Digital Library

Abnormal blood brain barrier (BBB) permeability has been implicated in the neuropathogenesis of chronic HIV infection. As neurocognitive impairment can persist despite effective combination antiretroviral therapy (cART), it is possible that irreversible central nervous system (CNS) processes are initiated in early infection, before cART is typically initiated. We analyzed the natural history of BBB permeability in primary HIV infection (PHI), and the effects of cART initiated during this period. CSF:Serum albumin quotient (QAlb), a marker of BBB permeability, was measured in longitudinal observational studies of PHI. We analyzed trajectories of QAlb pre- and post-cART using mixed-effects models, and associations between …

Prioritizing Primary Prevention Strategies For Cardiovascular Disease At The Clinic Population Level, Giulio Cesare Rottaro Castejon

Yale Medicine Thesis Digital Library

Cardiovascular Disease remains the number one cause of mortality in the United States with atherosclerotic cardiovascular disease (ASCVD) being a major component. Lifestyle interventions remain the first line treatment for the prevention of ASCVD, and clinic- based interventions effectively improve rates of healthy lifestyle choices. However, these programs require additional resources and there is currently no guidance for clinic directors to understand what lifestyle intervention(s) have the highest value for their unique population. We propose a novel application of the 10-year ASCVD risk calculator to a clinic patient cohort, thereby acting as a tool for providers and administrators to develop …

A Synoptic Review Of The Eocene (Ypresian) Cartilaginous Fishes (Chondrichthyes: Holocephali, Elasmobranchii) Of The Bolca Konservat-Lagerstätte, Italy, Giuseppe Marramà, Giorgio Carnevale, Andrea Engelbrecht, Kerin M. Claeson, Roberto Zorzin, Mariagabriella Fornasiero, Jürgen Kriwet

PCOM Scholarly Works

Here, we review and discuss the records and taxonomy of the Ypresian (Eocene) chondrichthyans from the famous Bolca Konservat-Lagerstätte in northeastern Italy. Despite the outstanding diversity and the numerous studies focusing on the actinopterygian faunas from Pesciara and Monte Postale, the current knowledge about the systematics, taxonomy and phylogenetic relationships of the cartilaginous fishes from these Eocene sites remains elusive and largely inadequate. The celebrated Eocene Bolca Lagerstätte has yielded several exquisitely preserved articulated remains of chondrichthyan fishes in which delicate structures and soft tissues are preserved, as well as isolated teeth. The cartilaginous fish assemblage of Bolca comprises at …

A New Species Of The Neopterygian Fish Enchodus From The Duwi Formation, Campanian, Late Cretaceous, Western Desert, Central Egypt, W L. Holloway, Kerin M. Claeson, H M. Sallam, S El-Sayed, M Kora, J Jw Sertich, P M. O'Connor

PCOM Scholarly Works

The neopterygian fish Enchodus was a widespread, speciose genus consisting of approximately 30 recognized species that were temporally distributed from the late Early Cretaceous through the Paleocene. Many Enchodus specimens are fragmentary cranial remains or isolated dental elements, as is the case for previously reported occurrences in Egypt. Here, we present the most complete specimen of Enchodus recovered from the Late Cretaceous of northeast Africa. The specimen was collected from the upper Campanian Duwi Formation, near the village of Tineida (Dakhla Oasis, Western Desert, Egypt). The new species, Enchodus tineidae sp. nov., consists of right and left dentaries, a partial …

Perceptions Of The Strong Survivors Staff Members And Their Experience In The Program, Marie Bongiorno

Research Papers

No abstract provided.

Social Media Coverage Of Women’S Sports: A Case Study Of Ncaa Division I Conferences’ Facebook Pages., Incheol Jang

Research Papers

No abstract provided.

Student-Athletes' Perceptions Of Athletic Trainers, Richard W. Brainerd Iii

Research Papers

The purpose of this study is to look at the perceptions student-athletes at Southern Illinois University have about their athletic trainers. Data was collected from 86 student-athletes at a NCAA Division I, mid-major university. The participants were administered an 11-question perception questionnaire. The perceptions scores of student-athletes with a full-time athletic trainer were compared to student-athletes with a graduate assistant athletic trainer. The results showed that both groups had a high mean perception score with no significant difference. The mean perception score for all 86 student-athletes was 28.14 (SD = 2.49) out of a total score of 33. Student-athletes …

Tweet Along: Analyzing The Relationship Between Social Media And Television Ratings, Christian Holt

Research Papers

Television ratings affect everything from advertising rates to the time a show is scheduled, and ultimately, its success. In recent years, rating methods have been updated not only to include live viewings, but also viewers who record and stream shows on the Internet. This is the result of living in a digital age. The pressure put on those who create television shows to get high ratings is even more intense, and viewers now expect a level of interaction from actors, writers and television staff on social media. This study examines the importance of the relationship between social media presence and …

The College County: Analyzing Economic Development, Jacob Rr Williams

Research Papers

No abstract provided.

Critical Communication Pedagogy And Its Relationship To Time, Labor, And Capitalism, Yvet Youssef

Research Papers

As a GTA working in a critically oriented Communication Studies department at Southern Illinois University, Carbondale, I am encouraged to be(come) an instructor whose teaching methods are steeped in the principles of critical pedagogy. One of the most inhibiting things I have come across as I have made attempts to uphold such principles of critical pedagogy is the issue of time.

This research report is about the problematic tension of trying to uphold a critical pedagogy in a system – a capitalist system – in which time is hard to come by. How can we perform an ethic of …

The Anticancer Effects Of The Different Analogs Of Cysteine Deleted Tachyplesin On A549 Lung Cancer Cells, Nathan Riley Hendrickson

Master's Theses and Doctoral Dissertations

It has been previously shown that cysteine-deleted tachyplesin (CDT) and its many analogs display antibacterial effects. However, little has been said about its possible anticancer effects and which analogs serve as the best inhibitors of the growing cancer cells. This research focused on CDT and four of its analogs: All D-CDT, Reverse DCDT, Reverse CDT, and Serine-Control CDT. MTT assays against the A549 adenocarcinoma lung cancer cell line showed All D-CDT to be the most effective analog in preventing cancer cell growth. Hyaluronidase and apoptosis assays were performed to better understand the mechanism by which the All D-CDT is preventing …

Contributors To Processing Speed Deficit In Old Age: A Focus On History Of Obesity And Medical Conditions, Melissa E. Pulcini

Master's Theses and Doctoral Dissertations

Obesity has been associated with impairment in most cognitive domains, but the nature of this relationship is unclear. Most studies have examined the relationship between cognitive impairment and current obesity and/or history of obesity-related medical conditions. However, a number of “lower-level” obesity factors (e.g., increased adipokines, low grade inflammation, chronic mild hypoventilation) are present even among the otherwise healthy obese population, and it is possible that many of these factors have differential impact on cognition according to magnitude and duration of exposure. Knowledge of a person’s weight history, which may serve as a proxy for a number of lower-level obesity …

Waldensian Tour Book, Kathleen Demsky

All Books

No abstract provided.

Applying User Experience (Ux) Design In Interior Space For Art, Science Museums, And Learning Environments, Zainab Al-Hajji

Master's Theses and Doctoral Dissertations

This research study explores the role of user experience (UX) and user interface (UI) in educational spaces: museums, science centers, galleries, libraries, and classrooms. This study examines the effects of enhancing displays in learning spaces and focuses on users’ interactions and experiences. This project observes the effectiveness of learning modes and styles applied in different museums and focuses on the users’ experiences in an educational environment, which was measured through student users’ impressions, behaviors, and performance. It was hypothesized that students would retain more information through the experience. The concepts covered included using UX/UI on websites and small devices. Results …

The Worship Experience We Long For: The How Of Worship, S. Joseph Kidder

Faculty Publications

Have you ever longed for meaningful worship? In the previous article of this series, we discovered that God’s identity as the powerful and good God is the reason—the why—of worship. Now that we know the why behind our worship, it’s time to answer the question of how. Amidst all our discussions of worship, we often center on the style of worship. The intent of this article is to describe how to behave in a worshipful way, whether in a personal or corporate setting, given insights gleaned from Psalm 100.

Searching The Scriptures: Andrews University Seminary Emerging Scholars Pay Tribute To Their Professors, Slavisa Milodar Jankovic

All Books

The purpose of this project is simple. In writing these essays each author wishes to offer a tangible expression of appreciation and gratitude to those professors who have invested their time in teaching them the value of studying Scripture. Each one of the professors represented has greatly influenced the authors’ understanding of the Biblical text, and for this they are forever indebted to them. This festschrift recognizes the scholarship of the following professors: Drs. Richard M. Davidson, Jiří Moskala, Roy Gane, Ranko Stefanović, Paul Gregor, and Thomas Shepherd.

The Long Journey Of Joshua Louis Hicks: A Voice From The Texas Working Class, Kyle Wilkison

East Texas Historical Journal

No abstract provided.

Aberdeen, Scotland; Gilded Age Labor; & The Reconstruction Of The Texas Capitol, Carolyn White

East Texas Historical Journal

No abstract provided.

Ethj Vol-55 No-2

East Texas Historical Journal

No abstract provided.

Lender Discrimination, Black Churches, And Bankruptcy, Pamela Foohey

Scholarly Works

Based on my original empirical research, in this Article, I expose a disparity between the demographics of the roughly 650 religious congregations that have filed for chapter 11 bankruptcy during part of the last decade and congregations nationwide. Churches with predominately black membership — Black Churches — appeared in chapter 11 more than three times as often as they appear among churches across the country. A conservative estimate of the percentage of Black Churches among religious congregation chapter 11 debtors is 60%. The likely percentage is upward of 75%. Black Churches account for 21% of congregations nationwide.

Why are Black …

Calling On The Cfpb For Help: Telling Stories And Consumer Protection, Pamela Foohey

Scholarly Works

Since it began operating in 2011, the Consumer Financial Protection Bureau (CFPB) has handled more than a million complaints regarding consumer financial product and services. Beginning in June 2015, the CFPB began publishing consumers’ narratives submitted with their complaints. This Article analyses a random sample of 5,000 of these narratives to assess how people engage with the complaint mechanism in light of the CFPB’s role in processing complaints. I find that people predominately use the complaint function for two distinct purposes: to express their anger and frustration about companies’ practices, or to express sadness and fear about how companies’ practices …

In Pursuit Of Good & Gold: Data Observations Of Employee Ownership & Impact Investment, Christopher Greczy, Jessica S. Jeffers, David K. Musto, Anne M. Tucker

Scholarly Works

A startup’s path to self-sustaining profitability is risky and hard, and most do not make it. Venture capital (VC) investors try to improve these odds with contractual terms that focus and sharpen employees’ incentives to pursue gold. If the employees and investors expect the startup to balance the goal of profitability with another goal—the goal of good—the risks are likely to both grow and multiply. They grow to the extent that profits are threatened, and they multiply to the extent that balancing competing goals adds a dimension to the incentive problem. In this Article, we explore contracting terms specific to …

Judging Immigration Equity: Deportation And Proportionality In The Supreme Court, Jason A. Cade

Scholarly Works

Though it has not directly said so, the United States Supreme Court cares about proportionality in the deportation system. Or at least it thinks someone in the system should be considering the justifiability of removal decisions. As this Article demonstrates, the Court’s jurisprudence across a range of substantive and procedural challenges over the last fifteen years increases or preserves structural opportunities for equitable balancing at multiple levels in the deportation process. Notably, the Court has endorsed decision makers’ consideration of the normative justifiability of deportation even where noncitizens have a criminal history or lack a formal path to lawful status. …

Tribute To Sam Davis: A Georgia Perspective, Ronald L. Carlson

Scholarly Works

Sam Davis had a twenty-seven year history at Georgia, commencing in 1970. After a distinguished record as a student at the University of Mississippi School of Law, he joined the Georgia law faculty. Sam moved through the academic ranks, ultimately becoming Allen Post Professor of Law. Along the way he served, at various times, as Assistant Dean, as Associate Dean, and he was for a time the University's Associate Vice President for Academic Affairs. In 1997 he took over as Dean at the University of Mississippi School of Law. This article comments on his life and professional career, with some …

Judicial Federalism In The European Union, Michael Wells

Scholarly Works

This article compares European Union judicial federalism with the American version. Its thesis is that the European Union’s long-term goal of political integration probably cannot be achieved without strengthening its rudimentary judicial institutions. On the one hand, the EU is a federal system in which judicial power is divided between EU courts, of which there are only three, and the well-entrenched and longstanding member state court systems. On the other hand, both the preamble and Article 1 of the Treaty of Europe state that an aim of the European Union is “creating an ever closer union among the peoples of …

Dictation And Delegation In Securities Regulation, Usha Rodrigues

Scholarly Works

When Congress undertakes major financial reform, either it dictates the precise contours of the law itself or it delegates the bulk of the rulemaking to an administrative agency. This choice has critical consequences. Making the law self-executing in federal legislation is swift, not subject to administrative tinkering, and less vulnerable than rulemaking to judicial second-guessing. Agency action is, in contrast, deliberate, subject to ongoing bureaucratic fiddling and more vulnerable than statutes to judicial challenge.

This Article offers the first empirical analysis of the extent of congressional delegation in securities law from 1970 to the present day, examining nine pieces of …

How The Supreme Court Derailed Formal Rulemaking, Kent H. Barnett

Scholarly Works

Based on archival research, this Essay explores the untold story of how the Supreme Court in the 1970s largely ended “formal” trial-like rulemaking by federal agencies in two railway cases. In the first, nearly forgotten decision, United States v. Allegheny-Ludlum Steel Corp., the Court held sua sponte that an agency was not required to use formal rulemaking, despite its significant historical provenance. That unpersuasive decision all but decided the second, better-known decision, United States v. Florida East Coast Railway, the following term. In response to both decisions, agencies abandoned formal rulemaking—one of only four broad categories of agency action—and policymakers …

A Politics-Reinforcing Political Question Doctrine, Harlan G. Cohen

Scholarly Works

The modern political question doctrine has long been criticized for shielding the political branches from proper judicial scrutiny and allowing the courts to abdicate their responsibilities. Critics of the doctrine thus cheered when the Supreme Court, in Zivotofsky I, announced a narrowing of the doctrine. Their joy though may have been short-lived. Almost immediately, Zivotofsky II demonstrated the dark side of judicial review of the separation of powers between Congress and the President: deciding separations of powers cases may permanently cut one of the political branches out of certain debates. Judicial scrutiny in a particular case could eliminate political scrutiny …

Droit De Suite, Copyright’S First Sale Doctrine And Preemption Of State Law, David E. Shipley

Scholarly Works

The primary focus of this article is whether California’s forty-year old droit de suite statute; the California Resale Royalty Act (CRRA), is subject to federal preemption under the Copyright Act. This issue is now being litigated in the Ninth Circuit, and this article concludes that the CRRA is preempted under section 301(a) of the Copyright Act and under the Supremacy Clause because it at odds with copyright’s well-established first sale doctrine.

The basic idea of droit de suite is that each time an artist’s work is resold by a dealer or auction house, the artist is entitled to a royalty, …