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2017

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Effects Of Plant Extracts On Melanin Biosynthesis And Melanogenetic Gene Expression In B16f10 Melanoma Cells, Moragot Chatatikun Jan 2017

Effects Of Plant Extracts On Melanin Biosynthesis And Melanogenetic Gene Expression In B16f10 Melanoma Cells, Moragot Chatatikun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Ultraviolet radiation from sunlight is a significant environmental factor in skin damage and can induce hyperpigmentation disorder and aesthetic problem. Development of novel whitening phytochemical compounds from natural products has been become trends recently. The purpose of this study was to find some plant extracts that reduce melanin synthesis and melanogenetic gene expression in alpha-MSH-induced B16F10 mouse melanoma cells. To screen total phenolics and flavonoids, antioxidant activity, and anti-mushroom tyrosinase activity, we used 13 plants which were extracted with petroleum ether, dichloromethane and ethanol solvents, subsequently. We found that total phenolic content of 13 plants extracts was found in the …

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Role Of Progesterone Receptor A And B Isoforms In Lung Neuroendocrine Tumors, Teeranut Asavasupreechar Jan 2017

Role Of Progesterone Receptor A And B Isoforms In Lung Neuroendocrine Tumors, Teeranut Asavasupreechar

Chulalongkorn University Theses and Dissertations (Chula ETD)

Lung neuroendocrine tumors (NETs) incidences are increasing in recent years. Women with lung NETs have significantly better survival rates as compared to men suggesting the involvement of sex steroids and their receptors in the progression of lung NETs. Recent data suggested that progesterone receptor (PR) may play a role in the survival of lung NET patients. PR exists as two major isoforms, PRA and PRB. How expression of PR isoforms affects proliferation of lung NETs and patient's survival is not known. To determine the role of PR isoforms in lung NETs, we constructed H727 lung NET cell models expressing PRB …

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Protein Profiling Analysis Of Platelets In Hypercoagulable State Of Β-Thalassemia/Hbe Patients, Puangpaka Chanpeng Jan 2017

Protein Profiling Analysis Of Platelets In Hypercoagulable State Of Β-Thalassemia/Hbe Patients, Puangpaka Chanpeng

Chulalongkorn University Theses and Dissertations (Chula ETD)

β-thalassemia/HbE is an inherited hemolytic anemia caused by defect in β-globin synthesis resulting in accumulation of excess α-globin chains in red blood cells. A hypercogulable state leading to high risk of thromboembolic event is one of the most common complications observed in this disease, particularly in patients with splenectomy. Previous studies suggested that increased platelet activation and coagulation factors in β-thalassemia/HbE intermediate patients promote the hypercoagulable state. However, the hypercoagulable state as well as the molecular mechanism regarding this pathogenesis in β-thalassemia/HbE is not yet well understood. This study aimed to identify proteins related to platelet activation and to hypercoagulable …

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Comparison Between Digital Image Analysis And Visual Assessment Of Immunohistochemical Her2 Expression In Breast Cancer, Morten Ragn Jakobsen Jan 2017

Comparison Between Digital Image Analysis And Visual Assessment Of Immunohistochemical Her2 Expression In Breast Cancer, Morten Ragn Jakobsen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Assessment of HER2 status is considered standard of care in the histopathologic workup of breast cancer and conveys prognostic and predictive information used to guide treatment decisions. The assessment is often carried out in a two-step approach where immunohistochemical expression of HER2 protein is first evaluated by conventional microscopy and equivocal cases are further analyzed by in-situ hybridization techniques to assess gene amplification status. Methods: In this study we compared conventional manual assessment of immunohistochemical HER2 expression with digital image analysis (DIA) and consensus manual assessment by a panel of three pathologists. From our archive we retrieved sections of …

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Histopathologic Difference Between Sinonasal Mucosa And Polyp Tissue For Diagnosing Eosinophilic Chronic Rhinosinusitis, Wanrawee Thaitrakool Jan 2017

Histopathologic Difference Between Sinonasal Mucosa And Polyp Tissue For Diagnosing Eosinophilic Chronic Rhinosinusitis, Wanrawee Thaitrakool

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aims to assess the appropriate site for diagnosing eosinophilic chronic rhinosinusitis (ECRS) by histopathology. Patients with chronic rhinosinusitis with polyps (CRSwNP) were enrolled. Specimens were collected from polyp apex, polyp pedicle, polyp scraping and ethmoid mucosa. Number of tissue eosinophil of the four samples was assessed with intrapersonal comparison for diagnosing ECRS. Correlations with clinical characteristics of ECRS were assessed for each site. Results showed that thirty patients with CRSwNP were enrolled. Polyp apex, polyp pedicle and ethmoid mucosa gave similar results for diagnosing ECRS in 16 patients (53.3%). Median tissue eosinophil was greater in polyp apex (84, …

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Using Sound To Describe Scenes With Still And Moving Obstacles, Kawin Metsiritrakul Jan 2017

Using Sound To Describe Scenes With Still And Moving Obstacles, Kawin Metsiritrakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

The information human get from sight and hearing sense are similar. With these correlations, there are many works that take this idea to describe the spatial information with sound. The previous works only described the nearest obstacle with the direction and distance information to sound. To let the user clearly understand the spatial information in the scene, we aim to develop the describing solution from spatial information to auditory information including direction, distance, boundary and speed info with the multiple obstacle descriptions. The participants took the experiment by controlling the character and avoiding the obstacles in the different scenarios to …

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Developing An Area Classification System From Mobile Phone Usage Data, Naruethai Thongphasook Jan 2017

Developing An Area Classification System From Mobile Phone Usage Data, Naruethai Thongphasook

Chulalongkorn University Theses and Dissertations (Chula ETD)

Since human activities are vary by time and place, there have been many attempts to extract social behavior in spatial studies which included area use in the city. This information helps gaining advantages in city and facilities planning. Nowadays, many people carry mobile phone with them for communication purpose. This motivates us to analyze mobile phone usage in different area types. This thesis proposes method of an analysis for area use classification from mobile phone usage pattern. CDR data was used to define mobile phone usage pattern by hour from 1:00 to 24:00 and day of week from Monday to …

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Automatic 3d Hair Model From Small Set Of Images, Nuttapon Vanakittistien Jan 2017

Automatic 3d Hair Model From Small Set Of Images, Nuttapon Vanakittistien

Chulalongkorn University Theses and Dissertations (Chula ETD)

We present a system for creating hair model that matches a user's hairstyle from images. The model consists of guide hair strands and can be used in a real-time hair simulator. Our goal differs from most previous work which aims to create realistic high resolution hair for off-line applications or create mesh of the exterior of the hair volume for image manipulation. Our primary aim is for user to be able to put his/her hairstyle into game or other real-time applications. By taking photos in 8 views of the user's head using a smart phone camera and segmenting images with …

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Random Field Optimization Using Local Label Hierarchy, Sangsan Leelhapantu Jan 2017

Random Field Optimization Using Local Label Hierarchy, Sangsan Leelhapantu

Chulalongkorn University Theses and Dissertations (Chula ETD)

Random field formulation has proven to be a powerful framework for solving various computer vision tasks, specifically those involving assigning labels to image pixels or superpixels subjected to spatial relationships and visual contexts, due to the ability to intuitively incorporate global and local information. Unfortunately, solving these problems can be impractical when large number of variables and possible labels are present as the computational complexity grows fast with the problem size. In this thesis, we propose a speedup scheme for random field optimization using local label hierarchy. We focus on problems in which the label space has a natural ordering …

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Efficient And Robust Grasp Planning Based On Independent Contact Region And Caging, Teesit Makapunyo Jan 2017

Efficient And Robust Grasp Planning Based On Independent Contact Region And Caging, Teesit Makapunyo

Chulalongkorn University Theses and Dissertations (Chula ETD)

A conventional way to find a proper grasp to grab and hold any object is to measure its stability which usually is based on physical constraint called force-closure. This execution works well from the theoretical point of view but often fails on an actual robot due to many reasons such as intrinsic errors in robot's system and a disparity between real and simulated physics. Several research works introduced methods to alleviate those issues and increase the success rate of grasping for a real robot. Caging and Independent Contact Region are ones of them. In this work, we investigate a method …

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Mesh-Based Multi-View Normal Integration With Energy Minimization Using Surface Reflectance Properties, Wichayut Eaksarayut Jan 2017

Mesh-Based Multi-View Normal Integration With Energy Minimization Using Surface Reflectance Properties, Wichayut Eaksarayut

Chulalongkorn University Theses and Dissertations (Chula ETD)

We propose a technique to reconstruct a general 3D object using surface reflectance information from multiple viewpoints. Our core optimization framework uses multi-view normal integration, which can recovers water-tight surface of the object iteratively in a coarse to fine manner. The integration requires normal vector field from multiple viewpoints, which we can derive from surface reflectance. We then handle the topological changes if self-intersection occurs from the optimization. We also employ the idea of multi-resolution and weighted data heuristic which helps dealing with noisy data and improves both accuracy and optimization time. Our experiment shows that the framework is able …

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Prediction Model Of Water Quality In Chaophraya River Using Artificial Neural Network, Weeris Treeratanajaru Jan 2017

Prediction Model Of Water Quality In Chaophraya River Using Artificial Neural Network, Weeris Treeratanajaru

Chulalongkorn University Theses and Dissertations (Chula ETD)

No abstract provided.

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Enhancing Captcha Using Eye Movement, Apichai Siripitakchai Jan 2017

Enhancing Captcha Using Eye Movement, Apichai Siripitakchai

Chulalongkorn University Theses and Dissertations (Chula ETD)

CAPTCHA is a method designed to prevent automatic registration and access. It can distinguish between real human and automated program (BOT). CAPTCHA connects to a server and then starts human verification process. The user must answer a question correctly or follow an instruction in order to get access to the system. However, there are some problems occurred to users. For example, the verification text is too distorted that even real humans do not understand or the effectiveness of preventing an automated computer program is doubted. From these reasons, researchers are still developing CAPTCHA to make it better and more effective. …

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High Capacity Image Steganography Tolerating Image Compression, Eittipat Kraichingrith Jan 2017

High Capacity Image Steganography Tolerating Image Compression, Eittipat Kraichingrith

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nowadays, data privacy becomes more important. Most of the existing data protection schemes based on cryptography cannot hide the existence of secret data. Thus, a steganography approach plays an important role to handle this problem. Image steganography can be categorized into two methods which are baesd on spatial domain and transform domain. Methods using spatial domain have high embedding capacity but they are not robust to image compression. On the other hand, methods using transform domain usually work with image compression but have low embedding capacity. In recent image steganography research, many transform domain methods are based on JPEG format …

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Biological-Like Memory Allocation Scheme Simulation, Gasydech Lergchinnaboot Jan 2017

Biological-Like Memory Allocation Scheme Simulation, Gasydech Lergchinnaboot

Chulalongkorn University Theses and Dissertations (Chula ETD)

When Gordon Moore observed the number of transistor increasing pattern while memory bandwidth could not catch up with processing unit performance, this diverging rate kept stretching out to create what eventually transpired to be “Memory Wall.” This consequence becomes a major performance bottleneck. Many bottleneck elimination approaches have been attempted. They incorporate considerable overhead and high complexity. This research proposes a novel memory allocation scheme that employs biological behavioral principles of the living creatures. At the principal construct of their life form lives the cells having limited resources, yet passively operates with little overhead. The proposed method imitates this unicellular …

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Discovery Of Relation Between Listeria And Other Bacterial Contamination Using Classification Refinement Technique, Napas Jeamchotpatanakul Jan 2017

Discovery Of Relation Between Listeria And Other Bacterial Contamination Using Classification Refinement Technique, Napas Jeamchotpatanakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

People often use chicken to prepare their diary meal which creates a great demand for food producers and exporters in Thai food industry. Thailand is ranked fourth in chicken exporters in the world. Standards on chicken meat regulations differ from country to country. One commonality remains: controlling the bacteria that can affect human life, particularly pregnant women and the unborn. One of the important bacteria is called Listeria which receives high attention for the industry to prevent their contamination in chicken. A microbiological test is usually conducted to analyze the data from industry. However, the microbiological test is incapable of …

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Diagnosis Of Heart Disease Using Mixed Classifier, Sarawut Meesri Jan 2017

Diagnosis Of Heart Disease Using Mixed Classifier, Sarawut Meesri

Chulalongkorn University Theses and Dissertations (Chula ETD)

At present, there are many studies related to the use of medical information, in order to assist in the analysis and diagnosis of the patients. In the field of computer science, there are methods to assist in analysis and diagnosis of the various diseases using the data mining techniques. Data mining is a popular technique used for analyzing a large number of data, to find the relationship of the hidden information in those data and applied for the benefits of the organization. Classification technique based on the supervised learning is one of the data mining techniques, which divides the dataset …

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Energy Aware Scheduling For Heterogeneous Mobile Task Computing, Vittayasak Rujivorakul Jan 2017

Energy Aware Scheduling For Heterogeneous Mobile Task Computing, Vittayasak Rujivorakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

The problem of scheduling a set of dependent tasks from a user mobile device to several servers in communication cells while the user is moving along these cell in various speed is studied in this thesis. The challenging issue is the execution speed of each server and the speed of user's movement are not compatible. This leads to the difficulty of assigning and finishing the subset of scheduled dependent tasks to each server within the limitation of execution time during passing a cell. Another concern involved this study is the constraints on the length of makespan in terms of minimum …

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Development Of In Situ Gel For Artificial Saliva And Satisfaction Study, Rawi Tishyadhigama Jan 2017

Development Of In Situ Gel For Artificial Saliva And Satisfaction Study, Rawi Tishyadhigama

Chulalongkorn University Theses and Dissertations (Chula ETD)

Xerostomia, the subjective complaint about the dry mouth, may lead to the difficulty in daily living including speaking, swallowing, taste acuity and sleeping. Patients are often advised to drink water or chew ice to moisturize the oral cavity and also recommended to use stimulant or saliva substitute, such as sour candies, chewing gum and artificial saliva. In Thailand, there is no artificial saliva products available in the market and this makes it difficult to access the artificial saliva. Hence, artificial saliva have been developed in the form of solution in many hospitals to dispense for xerostomia patients in the hospitals. …

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Development Of An Instructional Model Integrating Webquest Learning Approach And Reflective Practice To Enhance English Critical Reading Ability Of Undergraduate Students In Cambodia, Chanchhaya Chhouk Jan 2017

Development Of An Instructional Model Integrating Webquest Learning Approach And Reflective Practice To Enhance English Critical Reading Ability Of Undergraduate Students In Cambodia, Chanchhaya Chhouk

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purposes of this study were 1) to develop an instructional model integrating WebQuest Learning Approach and Reflective Practice to enhance English critical reading ability of undergraduate students, 2) to investigate the effectiveness of the instructional, and 3) to investigate undergraduate students' English critical reading ability development learning with the instructional model. The research and development processes were divided into four phases: 1) studying of the significance of the problem and learning approaches, 2) developing of the instructional model integrating WebQuest Learning Approach and Reflective Practice, 3) Studying the effectiveness of the instructional model integrating WebQuest Learning Approach and Reflective …

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Socioeconomic Determinants Of Happiness Of The Elderly In Bhutan, Tashi Duba Jan 2017

Socioeconomic Determinants Of Happiness Of The Elderly In Bhutan, Tashi Duba

Chulalongkorn University Theses and Dissertations (Chula ETD)

Elderly in Bhutan are rising steadily as a proportion of total population. In 2015, population older than 60 constituted about 7.3% of the total population compared to 6.9% in 2010. By 2030, the elderly population is estimated to reach 10.1% of total population. Along with growing numbers of elderly in Bhutan and rapid socioeconomic transformations, the individual-level of happiness decreases with age, the lowest being among the elderly (the Gross National Happiness Index surveys of 2010 and 2015 and Bhutan Living Standard Survey 2012). Nevertheless, there is limited literature exploring factors that are associated with happiness of the elderly. This …

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Land Use And Land Cover Change Of Chanthaburi Watershed Following 1999, 2006 And 2013 Floods, Chuti Chatewutthiprapa Jan 2017

Land Use And Land Cover Change Of Chanthaburi Watershed Following 1999, 2006 And 2013 Floods, Chuti Chatewutthiprapa

Chulalongkorn University Theses and Dissertations (Chula ETD)

The application of remote sensing (RS) and Geographic Information System (GIS) has become an effective tool and widely used in monitoring the environment on the earth surface. In this study, Landsat imageries were used as a data to deal with the assessment of land use and land cover changes (LULC) before and after the 3-year floods in 1999, 2006 and 2013. The images were classified by supervised classification process and it can be identified as 9 classes consisting of paddy field, field crop, para rubber, orchard, aquacultural land, forest land, mangrove forest, urban and built-up area, and water bodies. The …

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Geochemistry Of Petroleum Potential Source Rock In Tak Fa Formation, Phetchabun Province, Supawich Fuengfu Jan 2017

Geochemistry Of Petroleum Potential Source Rock In Tak Fa Formation, Phetchabun Province, Supawich Fuengfu

Chulalongkorn University Theses and Dissertations (Chula ETD)

Since 1962, petroleum exploration was begun in Khorat Plateau until now (2018). Nam Phong and Sin Phu Horm are two onshore petroleum commercial fields. Gas and condensate have been accumulated in Permian carbonate Pha Nok Khao Formation. Upper Carboniferous - Upper Permian in Saraburi Group was predicted to a petroleum source rock beneath the Khorat Plateau. This study analyses potential source rock in Khao Khwang Platform of Tak Fa Formation as Middle Permian sedimentary rock by nine outcrop samples from Bueng Sam Phan, Chon Daen and Nong Phai areas, Phetchabun province. Petroleum geochemistry methods are used to determine petroleum potential …

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Tobacco Use, Health Care Utilization, Household Expenditure And Smoking Cessation In China, Changle Li Jan 2017

Tobacco Use, Health Care Utilization, Household Expenditure And Smoking Cessation In China, Changle Li

Chulalongkorn University Theses and Dissertations (Chula ETD)

This dissertation studied the tobacco use impact of on health care utilization, household expenditure, and self-rated health among rural residents in rural China. The 2010-2014 China Family Panel Studies data were employed here. Moreover, this study also conducted the randomized controlled trial and analyzed the cost-effectiveness smoking cessation intervention among college-aged smokers in Inner Mongolia, China. The main findings showed: (1) Current and former smokers use more outpatient care than non-smokers. Moreover, former smokers use more inpatient care than non-smokers in rural China. (2) Long-term quitters decreased the probability of using inpatient care compared with recent and moderate-term quitters in …

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Regional Development Models With Clean Coal Power Plants, Christoph Casimir Odermatt Jan 2017

Regional Development Models With Clean Coal Power Plants, Christoph Casimir Odermatt

Chulalongkorn University Theses and Dissertations (Chula ETD)

This thesis examines clean coal technology to be used in Thailand in three studies. The economic impacts on the economic structure of southern Thailand are forecasted with the input-output method. Further, the relative levelized costs of clean coal energy relative to its amount of carbon equivalent emissions are compared to other technologies and their carbon equivalent emissions in order to compute a carbon certificate price. Lastly, the costs of the solar subsidy on the end consumer is calculated in different scenarios. The results suggest that there may be slight changes in the economic structure in southern Thailand with increases in …

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Asset Pricing And Network Topology, Harnchai Eng-Uthaiwat Jan 2017

Asset Pricing And Network Topology, Harnchai Eng-Uthaiwat

Chulalongkorn University Theses and Dissertations (Chula ETD)

This dissertation provides new empirical evidence for the relationship between network structure and asset returns in US, international markets, and Thailand. Previous studies find that a network of return correlations provides the meaningful economic taxonomy of the equity market. This finding makes the network structure a suitable channel through which an idiosyncratic shock propagates. This network feature can eliminate or amplify the idiosyncratic shock on the system-wide level. Therefore, the diversifying argument of the capital asset pricing models is not always true as the idiosyncratic shock becomes more significant when interacting with the network measures. Based on this idiosyncratic shock …

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Economic Policy Uncertainty And Carry Trade Strategy, Tiranan Sanguanjeen Jan 2017

Economic Policy Uncertainty And Carry Trade Strategy, Tiranan Sanguanjeen

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study provides a comprehensive analysis of the impact of economic policy uncertainty on carry trade. Based on 24 countries (both emerging and developed markets) during the past 17 years, the paper considers five strategies of carry trade investment (i.e. positive carry, carry to risk, yield slope, policy change and valuation), three methods of portfolio constructions (equal weight, risk parity and mean variance optimization), and four types of economic policy uncertainties (US, Japan, EU and Global). Based on vector autoregressive model, it is found that US and Japan economic policy uncertainties have most impact on carry trade return. However, direction …

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Optimal Sizing, Siting, And Scheduling Of Bess For Mitigatingvoltage Problem In Distribution Utilities With Highpenetration Of Pv Rooftops, Anh Thi Nguyen Jan 2017

Optimal Sizing, Siting, And Scheduling Of Bess For Mitigatingvoltage Problem In Distribution Utilities With Highpenetration Of Pv Rooftops, Anh Thi Nguyen

Chulalongkorn University Theses and Dissertations (Chula ETD)

For ambition of reducing CO2 emission and reliance on fossil fuels, solar power generation has been received special supports and deployed rapidly in many distribution networks. However, with a high presence of solar power generation, power grid control is no longer simple as conventional one due to natural variation of solar power and large space dispersion of solar power systems. The negative impacts comprise power system stability, electric power quality involving frequency and voltage criteria and other potential issues. Among these impacts, voltage problem is most obvious. Many solutions have been proposed to solve the voltage problem whereas battery energy …

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A Ubiquitous Mooc Instructional Design Model Based On Cognitive Dissonance For Enhancing Higher Education Students' Cross-Cultural Competence, Boonrat Plangsorn Jan 2017

A Ubiquitous Mooc Instructional Design Model Based On Cognitive Dissonance For Enhancing Higher Education Students' Cross-Cultural Competence, Boonrat Plangsorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

The research objectives of this study were (1) to study undergraduate students' opinions in designing a ubiquitous MOOC, (2) to develop a ubiquitous MOOC instructional design model based on cognitive dissonance for enhancing higher education student's cross-cultural competence (U-MOOC model), and (3) to study the effects of a ubiquitous MOOC instructional design model based on cognitive dissonance for enhancing higher education student's cross-cultural competence. This study used the research and development research methodology divided into three phases: survey research, U-MOOC model development, and experimental research. The samples of survey phase were 410 undergraduate students recruited from eight government universities. The …

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A Revisit To Impulse Breakdown Voltage Of Standard Air Gaps, Chhoum Vathana Chhom Jan 2017

A Revisit To Impulse Breakdown Voltage Of Standard Air Gaps, Chhoum Vathana Chhom

Chulalongkorn University Theses and Dissertations (Chula ETD)

By its simplicity, sphere gaps method for the measuring of peak voltage is preferred to be used as standard for calibration purposes. The limits of accuracy of the standard sphere-gaps depends on the ratio of the gap spacing S to the sphere diameter D, as follows. For AC, switching and lightning impulse voltage, S ≤0.5D, uncertainty is ±3%, but for gap spacing 0.75D > S > 0.5D, the uncertainty is larger than ±3%. However, the U50% disruptive discharge of some standard spheres at the same gap spacing showed the different value from each other. The significant case occurred between 5cm and 10cm …

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