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The Reform Of Drug Patent System In Thailand, Wanna Sriviriyanupap

The Thai Journal of Pharmaceutical Sciences

Drug patent system has a direct impact on the health care cost and the access of the drugs of people. Previously, the drug patent system in Thailand encounters the problems both efficiency and quality of patent approval. This study aims to analyze the pr.

Effects Of The Standardized Extract Of Centella Asiatica Eca233 On Hepatic Phase Ii Drug-Metabolizing Enzymes In Rats, Pitchayapa Seeka, Nuansri Niwattisaiwong, Mayuree H. Tantisira, Songpol Chevapat, Kridsada Anuntawuttikul, Khemchat Apipalakul, Somsong Lawanprasert

The Thai Journal of Pharmaceutical Sciences

The standardized extract of C. asiatica ECa233 (ECa 233) was shown to possess neuroprotective and wound healing effects. The purpose of this study was to investigate effects ECa 233 on the activities of phase II drug metabolizing enzymes including UDP-gl.

Application Of Ion-Pair Complexation Reaction For The Spectrophotometric Determination Of Clarithromycin In Pharmaceutical Formulations, Sameer A. M. Abdulrahman

The Thai Journal of Pharmaceutical Sciences

Two simple, rapid, sensitive, selective and extraction-free spectrophotometric methods have been developed for the determination of clarithromycin (CLR) both in pure form and in pharmaceutical formulations. The developed methods are based on ion-pair com.

High-Performance Thin-Layer Chromatography Analysis Of (E)-4-(3?,4?-Dimethoxyphenyl)But-3-En-1-Ol (Compound D) In Zingiber Cassumunar Roxb Rhizome Extract: An Application On Genetic Differentiation, Prasan Tangyuenyongwatana, Piyarat Parinyapong Chareonsap, Wandee Gritsanapan

The Thai Journal of Pharmaceutical Sciences

Objectives: This study focused on developing high performance thin-layer chromatography (HPTLC) quantitative analysis method for compound D, a major anti-inflammatory compound in Zingiber cassumunar extract. In addition, the amplified fragment length pol.

Hepatoprotective And Hepatoregenerative Therapeutic Effects Of Polyherbal Medicine Heparmin Tm On Rattus Norvegicus Wistar With Liver Fibrosis, Diana Lyrawati, Amalia Ghassani Muslimah, Dewi Laksmita, Dian Indrawati Santoso, Erlien Lindawati Poernomo, Karina Larasati, Lina Zahrotus Sajidah, Oktavia Rahayu Adianingsih, Rosida Dewi Agusningtyas, Mudjiwijono Handaru Eko, Bogi Pratomo Wibowo

The Thai Journal of Pharmaceutical Sciences

Chronic injury severely impairs liver regeneration through excess inflammation, scarring and epithelial abnormalities, since injured cells may shift response from pro-regeneration into pro-fibrosis which leads to cirrhosis and total liver failure. An Ind.

Fp-17-03 Median Age At First Divorce, 2015, Lydia R. Anderson

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Fp-17-04 Trends In Births To Single And Cohabiting Mothers, 1980-2014, Huijing Wu

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Fp-17-07 Generational Differences During Young Adulthood: Families And Households Of Baby Boomers And Millennials, Lydia R. Anderson

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Fp-17-10 Women's Experiences Of Unintended Childbearing, Karen Benjamin Guzzo

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Fp-17-11 Nonmarital Sex By Age 25: Generational Differences Between Baby Boomers And Millennials, Paul Hemez

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Fp-17-25 Marriage Rate In The U.S. Geographic Variation, 2016, Paul Hemez

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Fp-17-23 Characteristics Of Early Marriages, Kasey J. Eickmeyer, Paul Hemez

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Fp-17-22 Crossover In The Median Age At First Marriage And First Birth: Thirty-Five Years Of Change, Kasey J. Eickmeyer, Krista K. Payne, Susan L. Brown, Wendy D. Manning

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Development Of A Health Care Systems Curriculum., Zachary Pruitt, Rahul Mhaskar, Bryan G. Kane Md, Robert D. Barraco Md, Mph, Deborah J Dewaay, Alexander M. Rosenau Do, Kristin A. Bresnan Md, Marna R. Greenberg Do, Mph, Facep

Department of Emergency Medicine

Background: There is currently no gold standard for delivery of systems-based practice in medical education, and it is challenging to incorporate into medical education. Health systems competence requires physicians to understand patient care within the broader health care system and is vital to improving the quality of care clinicians provide. We describe a health systems curriculum that utilizes problem-based learning across 4 years of systems-based practice medical education at a single institution.

Methods: This case study describes the application of a problem-based learning approach to system-based practice medical education. A series of behavioral statements, called entrustable professional activities, was created …

Individual And Institutional Level Factors That Influence Hiv Testing And Counseling Utilization During Antenatal Care In Nigeria, Modupeoluwa O. Durojaiye

All ETDs from UAB

Of the estimated 150,000 new HIV infections in children in 2015, 122,000 occurred in sub-Saharan Africa (SSA), with Nigeria accounting for a third of all cases. Most of these infections were acquired via mother-to-child transmission (MTCT). HIV testing and counseling, a critical first step in the prevention of MTCT (PMTCT), can ensure that HIV-positive women access services that can reduce HIV transmission risk. Incorporating HIV testing and counseling into antenatal care (ANC) is an integral component of the World Health Organization (WHO) strategies. This dissertation aims to understand factors that influence HIV testing and counseling during ANC. It is comprised …

Publc Hospital Conversions: A Question Of Social Capital?, Antionette Smith Epps

All ETDs from UAB

ABSTRACT Between 1975 and 2015, the number of public hospitals decreased by 43%, from 1761 to 1003. Public hospitals have undergone changes in ownership status, structural and/or governance conversions and closures. Reasons for these changes are varied and numerous, however, many studies identify financial difficulties as a major reason that decision-makers consider an ownership change. Some public hospitals persist despite exhibiting financial issues. Therefore, there may be other factors contributing to the persistence of some public hospitals. This paper examines the potential role of social capital or community engagement and cohesion as a factor in determining if a public hospital …

Home Healthcare And Performance: Development And Application Of A Typology For Home Health Agencies, Ronique Nechelle Evans

All ETDs from UAB

This three-paper dissertation sought to examine the existence of strategic groups in the home health industry, the application of Porter’s generic strategies (cost leader, differentiator, “stuck-in-the-middle” and both cost leader/differentiator) in identifying these groups, and the association of group membership with agency performance. The findings of this study will provide researchers and managers with a highlight of the current strategic makeup of the home health industry and its relationship with quality and financial performance. The results of this dissertation provide some evidence that strategic groups do exist in the home health industry and can be described along the basis of …

Playing God: Sub-Creation, Rules, And Role-Playing Games, George Simeon Evans

All ETDs from UAB

Role-playing games can allow for extreme creative freedom where world building is concerned. In this sense, they inherit much of their structure from Tolkien’s idea of sub-creation. However, along with this creative freedom, RPGs contain rote rules and restrictions that must be followed. This paradox creates an intrinsic tension that players are forced to deal with. Rather than casting off restrictions, or punishing players that do not submit, gamers need to understand the purpose and necessity of rules, and be empathetic towards other players when they have difficulty following the dictates of a gaming manual. If these principles are followed, …

The Effectiveness Of Clinical Integration: The Relationship Between Evidence-Based Clinical Processes, In-Network Utilization And Clinical, Service And Efficiency Outcomes, Patrick D. Falvey

All ETDs from UAB

THE EFFECTIVENESS OF CLINICAL INTEGRATION: THE RELATIONSHIP BETWEEN EVIDENCE-BASED CLINICAL PROCESSES, IN-NETWORK UTILIZATION AND CLINICAL, SERVICE AND EFFICIENCY OUTCOMES PATRICK D. FALVEY EXECUTIVE DOCTORAL PROGRAM – SCHOOL OF HEALTH PROFESSIONS ABSTRACT The evolving U.S. health care system continues to steer healthcare organizations and integrated healthcare delivery networks (IDNs) to function as population health networks and ACOs. Policymakers, payers, health care leaders and consumer groups are advocating that IDNs clinically integrate processes and structures under the assumption that they will improve the clinical outcomes for a population, reduce the health care spend, and enhance the patient experience. Relatively little research has …

Role Of Calmodulin In Death Receptor 5-Mediated Apoptosis In Breast Cancer, Romone Markel Fancy

All ETDs from UAB

Drug resistant estrogen receptor positive (ER-positive) and triple-negative (TN) breast cancers, are prolific breast cancers with poor clinical outcome. TRA-8 is a death receptor-5 (DR5) specific agonistic antibody with tumoricidal activity in vitro and in vivo, without inducing normal hepatocyte apoptosis. ER-positive and TN breast cancers have a range of sensitivity to TRA-8 mediated cytotoxicity. TRA-8 activation of DR5 leads to DR5 oligomerization that is critical for formation of the death inducing signaling complex (DISC) at the death domain of DR5 and initiation of apoptotic signaling. Calmodulin (CaM) is overexpressed in breast cancer and is involved in regulating breast cancer …

Identification And Exploration Of The Information Needs And Information-Seeking Behaviors Of Medical-Surgical Nurses During Patient Care, Carrie Lee Gardner

All ETDs from UAB

Errors during the course of clinical practice are common and can lead to adverse events in hospitalized patients. Insufficient information and lack of clinician knowledge can serve as major contributing factors to the incidence of errors that occur during patient care. Nurses at the bedside need immediate access to patient specific information, at the point of care, and in an easily accessible format. There is a need for better understanding of the information needs and information-seeking behaviors of medical-surgical nurses. The purpose of this mixed-methods study was to explore the information-seeking behaviors of nurses when delivering patient care on medical-surgical …

Immunoregulation During Acute And Chronic Exposure To Aspergillus Fumigatus, Jaleesa M. Garth

All ETDs from UAB

A. fumigatus is one of the most common fungal isolates with clinical disorders ranging from mild to severe. The development of Aspergillus-induced allergic and invasive fungal infections is a major health concern in several patient populations. IL-1 family members have been shown to play critical roles in host defense against A. fumigatus. IL-33, an IL-1 family member widely study in allergic and inflammatory diseases, was induced upon acute exposure to A. fumigatus. IL-33 receptor knockout mice, (Il1rl1-/-), demonstrated lower lung fungal burden in the presence of enhanced IL-1α, IL-1β, IL-6, IL-17A, IL-22, and PGE2 production. Administration of IL-33 to normal …

Neuroanatomical Correlates Of Antisocial Traits In Adolescent Males, Emma Sartin Goodman

All ETDs from UAB

Prior research suggests that antisocial traits and behaviors often found in psychopathy are also present during childhood and adolescence. Thus, understanding the neurobiology of children and adolescents who are displaying early-signs of antisocial behavior can enhance the pace of diagnosis, allow for earlier and more effective intervention, and allow for researchers to record the developmental trajectory of these traits more accurately. This project used magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) to examine the neuroanatomy of gray and white matter in 25 adolescent males, which were further analyzed using a regression model and the Youth Psychopathic Traits Inventory …

Non-Markovian Investigation Of An Autonomous Quantum Heat Engine, Ketan Goyal Goyal

All ETDs from UAB

A systematic study of a quantum heat engine is presented in this thesis. In particular, we study heat conduction through a two-two level composite system, which is then connected to a photon cavity to extract work, forming an autonomous quantum heat engine. The question as to what extent quantum effects such as quantum coherence and correlations impact thermodynamic properties of such a system is addressed. The investigated heat engine has been previously studied using the popular Born-Markovian quantum master equation under weak internal coupling approximation. However, we show that the used approach is quite limited in addressing such problems as …

Reducing Acute Cardiovascular Hospitalizations With A Weight Management Program (Reach), Laura A. Graham

All ETDs from UAB

Reducing cardiovascular (CVD) risk factors such as obesity through lifestyle and behavioral interventions like weight management programs should result in better cardiovascular health. However, there is conflicting evidence on the effectiveness of these interventions in reducing long-term CVD outcomes such as acute myocardial infarction or stroke. This reflects an important gap in our understanding about factors affecting recruitment and engagement in these programs and how these factors relate to improvement in long-term cardiovascular health. To address this gap, we will use a retrospective study with up to 11 years of follow up data from the nation’s largest health care system-associated …

The Effects Of 6 Weeks Of High Intensity Interval Training Vs. Moderate Intensity Training On Cardiometabolic Health Markers And Mitochondrial Function In Individuals With Spinal Cord Injury, Kyle Gary Graham

All ETDs from UAB

Background: Individuals with SCI fail to meet the recommended exercise guidelines due to limited time, resources, and structural or architectural limitations (e.g., accessibility of facilities and knowledgeable instructors). Therefore, a time efficient and effective exercise program is needed to reverse chronic metabolic conditions and improve health quality in individuals with SCI. A growing body of evidence from our group and others has demonstrated the potential for low volume high-intensity interval training (HIIT) to provide comparable or superior improvements in cardiometabolic health outcomes in able-bodied individuals compared to continuous moderate intensity training (MIT) that requires 60-80% greater time commitment. Purpose: To …

Evaluating The Genotype Phenotype Correlations In Cleidocranial Dysplasia, Stephen Lamar Greene

All ETDs from UAB

Cleidocranial dysplasia (CCD, OMIM 119600) is a rare (1 in 1,000,000) human autosomal dominant skeletal disorder with unique craniofacial and dental features caused by mutations the gene coding for transcription factor RUNX2. RUNX2 is a key master regulator of osteoblast differentiation, chondrocyte maturation and tooth formation. CCD is commonly diagnosed based on bone defects with ~90% of cases presenting with supernumerary teeth or a “third dentition”. Mouse Runx2 null models (Runx2+/-), although having similar CCD skeletal defects, do not mimic the human dental phenotype of supernumerary teeth. Instead, Runx2-/- mouse have arrested tooth formation at the cap stage. Furthermore, based …

Transcriptional Dysregulation In Interneurons Causes Altered Modulation Of Hippocampal Synaptic Transmission And Circuit Function By The Dopamine System, Lillian J. Brady

All ETDs from UAB

Genetic deletion of the transcriptional coactivator PGC-1α leads to transcriptional dysregulation in interneurons, and transcriptional dysregulation in interneurons lead to changes in hippocampal synaptic transmission and circuit function. Hippocampal circuit activity and synaptic transmission alterations have implications for symptoms of cognitive impairment in neurological disorders like schizophrenia. Modulation of dopamine receptor activity through pharmacologic application of haloperidol and the specific dopamine D4 receptor antagonist L-745,870 in PGC-1α-/- mice leads to altered effects on inhibitory/excitatory synaptic transmission balance, circuit function, and innate hippocampal dependent nesting behavior. These are key aspects underlying hippocampus dependent cognitive impairment. Specifically, bath application of haloperidol restores …

Fabrication, Structure, And Transport Properties Of Alumina Nanofiber-Based Materials, William Anthony Brayer

All ETDs from UAB

One of the most promising nano-materials is nanofibrous alumina (Al2O3) but current production methods are too slow and too inconsistent for applications outside of laboratory proof of concepts. Alumina structures were fabricated from aluminum nitrate/polyvinylpyrrolidone precursor nanofibers prepared using a novel free-surface alternating current (AC) electrospinning method. Precursor fibers were generated at the rates up to 6.4 g/h and collected as 100–300 m thick sheets suitable for direct conversion into the nanofibrous alumina structures. A computational model of the surrounding electric field was constructed to compare to experimental observations. The effects of process conditions and annealing temperature on the nanofiber …

Strategies Early Childhood Elementary Teachers Use In Order To Provide A Welcoming Environment For Student Who They Perceive To Be Lgbtq Or Exhibit Stereotypical Characteristics, Felecia Brooks-Jones

All ETDs from UAB

STRATEGIES EARLY CHILDHOOD TEACHERS USE IN ORDER TO PROVIDE A WELCOMING CLASSROOM ENVIRONMENT FOR STUDENTS WHO THEY PERCEIVE TO BE LGBTQ OR EXHIBIT STEREOTYPICAL CHARACTERISTICS FELECIA BROOKS-JONES EARLY CHILDHOOD EDUCATION ABSTRACT People who identify as Lesbian, gay, bisexual, transgender, and queer/questioning are becoming more socially accepted today than they were before. Laws have been passed to give same-sex couples equal rights as heterosexual couples. However, they are not always treated the same, especially here in the southeast, which is known as the Bible Belt. There is minimal research or literature in the field of education concerning early elementary LGBTQ students, …