Digital Commons Network^™

Sample Size Calculations And Normalization Methods For Rna-Seq Data., Xiaohong Li

Electronic Theses and Dissertations

High-throughput RNA sequencing (RNA-seq) has become the preferred choice for transcriptomics and gene expression studies. With the rapid growth of RNA-seq applications, sample size calculation methods for RNA-seq experiment design and data normalization methods for DEG analysis are important issues to be explored and discussed. The underlying theme of this dissertation is to develop novel sample size calculation methods in RNA-seq experiment design using test statistics. I have also proposed two novel normalization methods for analysis of RNA-seq data. In chapter one, I present the test statistical methods including Wald’s test, log-transformed Wald’s test and likelihood ratio test statistics for …

Culturally Relevant Teachers : A Critical Beacon In The Educational Standards Movement., Angela Pleasant

Electronic Theses and Dissertations

The purpose of this study was to describe culturally relevant teachers’ beliefs and teaching practices as they implement the Reading CCSS. It was hypothesized that by exploring the beliefs and practices of teachers who practice a culturally relevant pedagogy, this research could provide evidence of the specific and identifiable practices that demonstrated high expectations, culturally competency, and critical consciousness. This research could provide evidence of effective strategies, which could be used to impact the literacy achievement of students of color while the teacher implements the Reading Common Core State Standards or any standards movement that follows. A qualitative case study …

Southern Veils : The Sisters Of Loretto In Early National Kentucky., Hannah O'Daniel

Electronic Theses and Dissertations

This thesis analyzes the experiences of Roman Catholic women who joined the Sisters of Loretto, a community of women religious in rural Washington and Nelson Counties, Kentucky, between the 1790s and 1826. It argues that the Sisters of Loretto used faith to interpret and respond to unfolding events in the early nation. The women sought to combat moral slippage and restore providential favor in the face of local Catholic institutional instability, global Protestant evangelical movements, war and economic crisis, and a tuberculosis outbreak. The Lorettines faced financial, social, and cultural pressures—including an economic depression, a culture that celebrated family formation …

The Knowledge Economy : Increasing Human Capital On The U.S. I-65 Corridor., Brandon S. Mcreynolds

Electronic Theses and Dissertations

In economics, the term growth often refers to the increase in economic activity between two points in time. Within the context of the United States of America, the language of growth has permeated beyond just economics and into other societal institutions due to spillover. As a result, growth is not just an economic term but rather a part of the culture of capitalism which impacts every area of society. The dissertation using growth machine theory and the global cities literature examines how in the knowledge economy, cities play a growing role in mediating the supply and demand for …

Pcb-Associated Steatohepatitis And The Role Of Nuclear Receptors., Heather Brooke Clair

Electronic Theses and Dissertations

Metabolic diseases, including fatty liver disease, hyperglycemia, and obesity, result when body systems responsible for managing allostasis (dynamic homeostasis across systems) are pressured beyond their collective compensatory reserve. Nutritional excess contributes to this state, the capacity of which is limited by genetic variation, and failure of one system will gradually lead to pathological overload in the others. Agents which act directly on the communication machinery linking these connected systems can also change the point at which allostatic load becomes allostatic overload. Environmental exposure to polychlorinated biphenyls (PCBs), a class of persistent organic pollutant, is associated with a specific form of …

Numerical Investigation Of Drop Impingement On Dry And Wet Surfaces., Yisen Guo

Electronic Theses and Dissertations

In-flight icing due to supercooled large droplets (SLDs) imposes great danger on aviation safety. Because of the large size, SLDs have different characteristics than typical cloud droplets that most icing encounters involve. As a result, SLDs more likely hit the wing surface and move into areas not protected by de-icing devices to form ice, which can lead to loss of lift, increase in drag, altered controllability, and eventually stall and loss of control of the aircraft. The phenomenon of droplet splashing is considered as the most important aspect of the SLD icing accretion problem. Although previous studies have established splashing …

Emotion Socialization And Families Of Children With And Without Adhd., Danielle M. Walerius

Electronic Theses and Dissertations

Emotional competence (EC) represents several distinct emotional skills found to be strongly associated with children’s socioemotional outcomes. EC is thought to develop through a process known as emotion socialization (ES), whereby children’s emotions and emotion-based behaviors are socialized through interactions with parents and/or other primary figures. The present study examined ES across families of children with and without ADHD in order to clarify the role ES plays in the development of EC in typically developing (TD) children versus children more prone to EC impairments due to intrapersonal characteristics (e.g., inattention, disinhibition, etc.). Forty-eight children 5 to 8-years-old (23 with ADHD, …

Heterogenization Of Complexes With Redox Active Ligands For Hydrogen Evolution Reaction., Wuyu Zhang

Electronic Theses and Dissertations

Hydrogen fuel is a promising future energy carrier with many applications. Thermodynamically, 1.23 V is needed for the water electrolysis, which is a clean method to generate hydrogen gas. In practice excess potential is required, which is called overpotential, due to kinetic barriers. Catalysts to reduce the overpotential for the hydrogen evolution reaction (HER) include many homogeneous catalysts and heterogeneous catalysts. Heterogenization of homogeneous catalysts on electrode surfaces is an ideal way to study a catalyst by combining homogeneous and heterogeneous study together. In this dissertation, several characterization techniques have been employed, include cyclic voltammetry, linear sweep voltammetry, electrochemical impedance …

Norton Commons, Clifton, And Social Equity : A Neighborhood, Inter-Neighborhood, And Regional Comparison Of New Urbanism And “Old” Urbanism., Aaron J. Stephenson

Electronic Theses and Dissertations

This dissertation examines two paradigms aimed at restoring urban vitality-- grassroots neighborhood revitalization and New Urbanism. New Urbanism is comprised of progressive goals, but unfortunately the relevant literature suggests that these goals have not been achieved. As such, this study focuses upon the degree to which each of these paradigms, New Urbanism and grassroots revitalization, may impact social equity on a spatial level. This dissertation explores this through a comprehensive micro-level comparison of two neighborhoods in Louisville, Kentucky- Clifton and Norton Commons. Clifton is an activist urban neighborhood that has been revitalized in recent decades, to become one of Louisville’s …

Lgbtq+ Nondiscrimination Laws In Kentucky., Christopher M Wales

Electronic Theses and Dissertations

This thesis explores the political and demographic obstacles facing the Fairness movement in Kentucky in regards to local employment protection ordinances for LGBTQ+ persons (Fairness Ordinances). Using case studies on recent Fairness debates in Berea and Bowling Green, this thesis explores the concern some Kentuckians have about LGBTQ+ nondiscrimination ordinances in their communities. From these cases studies, it can be concluded that many of the concerns espoused by opponents of Fairness are simple scare tactics with no evidence supporting their claims. This thesis then utilizes a logistical regression to uncover what demographic characteristics increase the odds of a municipality possessing …

The Relationship Between Positive Behavioral Interventions And Supports In Elementary Schools And Mathematics Achievement., Robert Larry Taylor

Electronic Theses and Dissertations

This causal-comparative study examined the relationship between Positive Behavioral Interventions and Supports (PBIS) and academic achievement in elementary school mathematics. Research has shown that PBIS may help establish a positive school climate, which supports the conditions for effective teaching and learning (Bradshaw, Koth, Bevans, Ialongo, & Leaf, 2008; Horner, Sugai, & Vincent, 2005; Hoy, Tarter, & Bliss, 1990). Accordingly, this study examined variables of particular interest, which were mathematical performance, including mathematical performance by male academic achievement, female academic achievement, and socioeconomic status, based on PBIS implementationThe data used were school-level, 5th grade mathematics achievement scores. Elementary schools, which participated …

Farmscapes : Picturing Land Transformation In Nineteenth-Century America., Eileen L Yanoviak

Electronic Theses and Dissertations

This dissertation examines American farmstead imagery of the nineteenth-century and how those images reflect the environmental history of the North. In this study, images of farms illustrate, through the landscape, the transition from subsistence farming to agribusiness that fundamentally changed American life and the land over the century. By comparing the actual ecological and economic conditions of the farm and farmer to the images depicted by artists, it is possible to see both representations of change and the persistence of the agrarian myth in spite of dramatically different realities. This study focuses on the process of change in the American …

Metabolic Regulation Of Myocardial Adaptation To Exercise., Andrew Alan Gibb

Electronic Theses and Dissertations

While the benefits of exercise affect several organs, a significant adaptive response occurs within the heart. Exercise promotes cardiac growth, increases angiogenesis, and enhances cardiac function and these adaptations are associated with a cardioprotective phenotype. Additionally, extensive evidence shows that exercise dynamically regulates myocardial metabolism. This can be attributed to both changes in hormonal stimulation, increases in bioenergetic demand, and the bioavailability of circulating substrates. However, it is unclear whether these changes in metabolism contribute to physiologic cardiac growth. We reason that exercise-induced changes in metabolism are required to balance the catabolic and anabolic reactions needed for growth. Specifically, we …

Modeling Effective Work Groups And Teams : An Assessment Of The Inclusion Of Social Value Orientation., Gary Daniel Jones

Electronic Theses and Dissertations

The purpose of this study is to examine research on effective work groups in terms of measurable input characteristics and relevant collective outputs. Antecedents and consequences of group processes are explored; models of work groups and teams are examined and assessed in light of subsequent research. Additionally, social value orientation – a behavioral trait known to predictably influence interpersonal outcomes – is introduced as a concept that is also relevant to group work. A revised model that includes social value orientation as a predictive factor for group productivity is presented and tested. This empirical study is a correlative, quantitative investigation …

Applicability Of Zipper Merge Versus Early Merge In Kentucky Work Zones, Erin Lammers-Staats, Jerry G. Pigman, Brian K. Howell, Adam J. Kirk

Kentucky Transportation Center Research Report

In an effort to improve work zone safety and streamline traffic flows, a number of state transportation agencies (STAs) have experimented with the zipper merge. The zipper merge differs from a conventional, or early, merge in that vehicles do not merge into the lane that remains open immediately after being notified of a lane closure. Rather, vehicles continue to occupy all lanes until they reach the taper, at which point — and directed by signage — vehicles take turns merging into the open lane, creating a zipper pattern. At the request of the Kentucky Transportation Cabinet (KYTC), Kentucky Transportation Center …

Fiscal Year 2017 Fhwa-536 Report For The Kentucky Transportation Cabinet, Steven Douglas Kreis, Candice Y. Wallace, Bryan Gibson, Sarah M. Mccormack

Kentucky Transportation Center Research Report

The Federal Highway Administration (FHWA) requires state transportation agencies to submit a biennial report on local highway finances. The purpose of these reports is to provide FHWA with the data it needs to capture the financing of highway activities at the local level. Based on this information, it can identify trends in revenue, expenditures, investments, and program development, and in turn make decisions about future investments. The report, FHWA-536, asks agencies to report on four areas of local highway finance: 1) disposition of highway-user revenues; 2) revenues used for roads and streets identified by source and funding type; 3) road …

Dynamic Mechanical Properties And Microstructure Of Graphene Oxide Nanosheets Reinforced Cement Composites, Wujian Long, Jingjie Wei, Hongyan Ma, Feng Xing

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

This paper presents an experimental investigation on the effect of uniformly dispersed graphene oxide (GO) nanosheets on dynamic mechanical properties of cement based composites prepared with recycled fine aggregate (RFA). Three different amounts of GO, 0.05%, 0.10%, and 0.20% in mass of cement, were used in the experiments. The visual inspections of GO nanosheets were also carried out after ultrasonication by transmission electron microscope (TEM) atomic force microscope (AFM), and Raman to characterize the dispersion effect of graphite oxide. Dynamic mechanical analyzer test showed that the maximum increased amount of loss factor and storage modulus, energy absorption was 125%, 53%, …

Amplification Of Earthquake Ground Motions In Washington, Dc, And Implications For Hazard Assessments In Central And Eastern North America, Thomas L. Pratt, J. Wright Horton Jr., Jessica Munoz, Susan E. Hough, Martin C. Chapman, C. Guney Olgun

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The extent of damage in Washington, DC, from the 2011 M_W 5.8 Mineral, VA, earthquake was surprising for an epicenter 130 km away; U.S. Geological Survey “Did-You-Feel-It” reports suggest that Atlantic Coastal Plain and other unconsolidated sediments amplified ground motions in the city. We measure this amplification relative to bedrock sites using earthquake signals recorded on a temporary seismometer array. The spectral ratios show strong amplification in the 0.7 to 4 Hz frequency range for sites on sediments. This range overlaps with resonant frequencies of buildings in the city as inferred from their heights, suggesting amplification at frequencies to …

Low-Cost Wearable Head-Up Display For Flight General Aviation, Pavan K. Chinta

Doctoral Dissertations and Master's Theses

A low-cost wearable Commercial-off-The-Shelf (COTS) Augmented Reality (AR) Head-Up Display (HUD) system is designed, successfully reduced to practice, and flight tested. The system is developed based on the need for a technology that improves loss-of-control (LOC) safety in the General Aviation (GA) sector. The accuracy of the flight-path based system is determined to be within a degree of the truth source. The repeatability of the data from the COTS system is excellent. A complementary filter is proposed for air data flow angles and successfully flight tested for straight and level flight, dynamic maneuvering, and atmospheric turbulence, provided that a reasonably …

Mechanical And Electrical Characterization Of Carbon Fiber/Bucky Paper/Zinc Oxide Hybrid Composites, Suma Ayyagari

Doctoral Dissertations and Master's Theses

The quest for multifunctional carbon fiber reinforced composites (CFRPs) expedited the use of several nano reinforcements such as zinc oxide nanorods (ZnO) and carbon nanotubes (CNTs). Zinc oxide is semi-conductor with good piezoelectric and pyroelectric properties. These properties could be transmitted to CFRPs when a nanophase of ZnO is embedded within CFRPs. In lieu of ZnO nanorods, Bucky paper comprising mat of multiwall-carbon nanotubes (MWCNTs) could be sandwiched in-between laminae to construct a functionally graded composite with elevated electrical and thermal conductivities. In this study, a low temperature ( 90_C) hydrothermal synthesis method was utilized to grow ZnO nanorods on …

Computational Investigation Of The Biomechanics Of Babywearing In Regards To Developmental Dysplasia Of The Hip, Gaurav Girish

Doctoral Dissertations and Master's Theses

Developmental Dysplasia of the Hip (DDH) is a congenital condition where an infant’s hip socket is either loose or otherwise unstable. DDH causes a joint instability where the femoral head is not properly situated inside the acetabulum. Etiology of the condition is in part congenital and developmental, with a difference of DDH prevalence between ethnicities. Incidence of DDH is also in some part dependent on cultural practices and activities of the mother and child. The exact nature of this cultural incidence is not clearly understood. A computational approach is hypothesized to identify the impact of babywearing position on the healthy …

Development Of A Remotely-Piloted Vehicle Platform To Support Implementation, Verification, And Validation Of Pilot Control Systems, Sean O’Toole

Doctoral Dissertations and Master's Theses

This thesis presents the development of a research test bed and the use of a set of metrics for evaluating handling qualities with pilot in the loop configuration. The main objective of this study is to provide software and hardware tools to support performance evaluation of control systems designed to compensate for Pilot Induced Oscillations (PIOs). A remotely-piloted vehicle presented in this thesis consists of an RC aircraft modified to be flown from a ground station cockpit. The unmanned aerial system has a high-speed on-board processing system capable of simulating different conditions during flight such as injecting actuator failures and …

A Study On The Control, Dynamics, And Hardware Of Micro Aerial Biomimetic Flapping Wing Vehicles, Siara Hunt

Doctoral Dissertations and Master's Theses

Biological flight encapsulates 400 million years of evolutionary ingenuity and thus is the most efficient way to fly. If an engineering pursuit is not adhering to biomimetic inspiration, then it is probably not the most efficient design. An aircraft that is inspired by bird or other biological modes of flight is called an ornithopter and is the original design of the first airplanes. Flapping wings hold much engineering promise with the potential to produce lift and thrust simultaneously. In this research, modeling and simulation of a flapping wing vehicle is generated. The purpose of this research is to develop a …

The Plays Of Kalidasa: Treading The Line Between Constraint And Freedom, Sukanya Chakrabarti

Faculty Research, Scholarly, and Creative Activity

The world of Kalidasa is defined by transgression at many levels. The possibilities of his dramatic world are vast and each level interacts with the other only because of the transgressive power of love and memory, and sometimes,even of forgetfulness. I argue that Kalidasa’s plays transcend, rather than establish, the conflicts between love and duty. I establish that the diverse and, often disjunctive, worlds seem to be in conversation in Kalidasa’s unifying dramatic realm –in this realm, while everything seems possible, everything possible can be made impossible because of the disruptive power of memory or forgetfulness.

The Problem Of Illusion In The Phenomenology Of Claude Romano, Joseph Cutolo

Student Theses and Dissertations

The phenomenology of Claude Romano constructs a strict distinction between perceptions and illusions. This distinction is so strict that the former excludes the latter completely. Putting this distinction into play is not a local decision about our experiences and the structures of our experiences. This decision brings with it metaphysical, ontological, and phenomenological frameworks to ground it. In what follows I attempt to draw out the consequences of Romano’s decisions about our experience, and to study the philosophical frameworks that underlie his decisions. In doing so, I reconnect his phenomenology with a wider terminology of phenomenology, in order to study …

Multiscale Mechanistic Approach To Enhance Pool Boiling Performance For High Heat Flux Applications, Arvind Jaikumar

Theses

The advent of cloud computing and the complex packaging architecture of next generation electronic devices drives methods for advanced thermal management solutions. Convection based single-phase cooling systems are inefficient due to their large pressure drops, fluid temperature differences and costs, and are incapable of meeting the cooling requirements in the high power density components and systems. Alternatively, phase-change cooling techniques are attractive due to their ability to remove large amounts of heat while maintaining uniform fluid temperatures. Pool boiling heat transfer mechanism centers on the nucleation, growth and departure of a bubble from the heat transfer surface in a stagnant …

Better Fit: A Conceptual Solution For Seamless Exercise Experience, Hongwei Huang

Theses

The development of fitness technology has changed the way we exercise over time, and each technology has allowed people to exercise independently in various ways, such as wearable devices, fitness apps, game consoles, and even social media. The consequence is that more people get used to exercising solely with their digital device and get motivated from virtual communities rather than in a real environment. However, the research shows there can be even more benefit for people by exercising with others in a physical space.

The thesis utilizes UX design methodologies to develop a seamless-workout experience that enables a user to …

Resilient Housing Design For Tsunami Prone Andaman And Nicobar Islands In India, Sabyasachi Das

Theses

Human settlement along coastal areas has grown dramatically over the last two decades. Unfortunately, coastal areas are prone to natural disasters caused by climate change and tectonic shifts underwater in the adjacent water bodies, resulting in loss of life and property. Tsunami is a form of natural disaster which occurs because of earthquakes under oceans and seas creating large waves which flood or wash out any coastal cities or islands located in the area impacted.

In 2004 the Indian Ocean Tsunami had an enormous impact on the coastal cities in Southeast Asia causing loss of thousands of lives and making …

Deer: Creating A Realistic 3d Animal Using Photogrammetry, Karie Carita

Theses

Creating a 3D animal using the process of photogrammetry can bring more realism to a user’s game experience.

In the 3D world, there are various ways for creating animals in video games. Specifically, quadrupeds are known to be very challenging. Since technology is evolving every day, there are always newer ways of creating video game assets. It is challenging to have complex model details and also have smooth real-time rendering in a game engine.

Photogrammetry can capture exact details of a real world animal and incorporate them into a 3D asset. The purpose for using this process is to create …

Revitalization Of Controversial Sites In Downtown Banda Aceh, Ria Purnama

Theses

As issues pertaining to environmental, economic and cultural sustainability continue to persist throughout the world, the manner in which abandoned sites and properties are treated can be a means of revitalizing important resources, while simultaneously preserving cultural identities. For this reason, this research intend to offer ways to approach these problems by posing a central question: “How the abandoned spaces with specific issues be revitalized in relation to the continuity of cultural identity and place familiarity by providing the functions along with criteria and parameters that comply with the context, regulations, and culture?

In this case, specific sites located in …