Digital Commons Network^™

Statutory Interpretation After Hively: Where Will The Seventh Circuit Go?, Douglas O. Smith

Accounting Faculty Research and Publications

Fifty years ago, when Title VII was passed, no one thought that sexual orientation discrimination was unlawful sex discrimination. The Seventh Circuit’s decision to re-interpret Title VII challenges traditional approaches to statutory interpretation that should put Seventh Circuit litigants on notice of future uncertainty.

Due Process Abroad, Nathan S. Chapman

Northwestern University Law Review

Defining the scope of the Constitution’s application outside U.S. territory is more important than ever. In February, the Supreme Court heard oral argument about whether the Constitution applies when a U.S. officer shoots a Mexican teenager across the border. At the same time, federal courts across the country scrambled to evaluate the constitutionality of an Executive Order that, among other things, deprived immigrants of their right to reenter the United States. Yet the extraterritorial reach of the Due Process Clause—the broadest constitutional limit on the government’s authority to deprive persons of “life, liberty, or property”—remains obscure.

Up to now, scholars …

Role Of Cannabinoid Receptor Type 2 (Cb2) In Late Stage Atherosclerosis, Makenzie Fulmer

Electronic Theses and Dissertations

Atherosclerosis is a chronic inflammatory disorder of medium and large vessels. Immune signaling and dyslipidemia are two of several processes which influence lesion development in atherosclerosis. Cannabinoids, such as those found in marijuana, exert their effects through two cannabinoid receptors, CB1 and CB2. Recent studies using CB2 knockout mice and CB2-selective ligands have shed light on a protective role of CB2 in early stages of atherosclerosis. However, the role of CB2 in advanced stages of atherosclerosis remains unclear. To determine if CB2 plays a role in advanced atherosclerotic lesion composition and progression, we investigated the effects of systemic CB2 gene …

Impact Of Natural Blind Spot Location On Perimetry., Mengyu Wang, Lucy Q. Shen, Michael V. Boland, Sarah R. Wellik, Carlos Gustavo De Moraes, Jonathan S. Myers, Peter J. Bex, Tobias Elze

Wills Eye Hospital Papers

We study the spatial distribution of natural blind spot location (NBSL) and its impact on perimetry. Pattern deviation (PD) values of 11,449 reliable visual fields (VFs) that are defined as clinically unaffected based on summary indices were extracted from 11,449 glaucoma patients. We modeled NBSL distribution using a two-dimensional non-linear regression approach and correlated NBSL with spherical equivalent (SE). Additionally, we compared PD values of groups with longer and shorter distances than median, and larger and smaller angles than median between NBSL and fixation. Mean and standard deviation of horizontal and vertical NBSL were 14.33° ± 1.37° and -2.06° ± …

Trends In It Human Resourses And End-Users Involved In It Applications, Vipin K. Agrawal, Vijay K. Agrawal, Srivatsa Seshadri, A. Ross Taylor

Journal of International Technology and Information Management

The Bureau of Labor Statistics projected the demand for information technology (IT) human resources to increase by 13.26 percent between 2014 and 2024. In this survey research, the IT professionals estimated a growth of 34.16 percent in IT human resources over a period of five years from the year 2016. The goal of this survey study was to try to understand the discrepancy in the estimates for IT human Resources requirements by developing a theory-driven model to evaluate the impact of growth in IT outsourcing/offshoring, cloud-computing, end-users-computing, IT applications, and usage of commercial-off-the-shelf/ERP on the need for IT human resources.

Contraction Intensity And Sex Differences In Knee-Extensor Fatigability, Paul Ansdell, Kevin Thomas, Glyn Howatson, Sandra K. Hunter, Stuart Goodall

Exercise Science Faculty Research and Publications

Females are less fatigable than males during isometric contractions across various muscles and intensities. However, sex differences in knee-extensor fatigability remain relatively unexplored. Purpose: To determine the sex difference in performance fatigability for intermittent, isometric contractions of the knee-extensor muscles. Methods: Eighteen participants (10 males, 8 females) performed intermittent, isometric, knee-extensor contractions at 30% of their maximal voluntary force (MVC) for 30 min and in a separate session at 50% MVC until task-failure. During both fatiguing protocols a MVC was performed every 60 s and electromyography (EMG) was recorded during all contractions. Results: At task completion males had a larger …

Voluntary Activation And Variability During Maximal Dynamic Contractions With Aging, Vianney Rozand, Jonathon W. Senefeld, Hamidollah Hassanlouei, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Whether reduced supraspinal activation contributes to age-related reductions in maximal torque during dynamic contractions is not known. The purpose was to determine whether there are age differences in voluntary activation and its variability when assessed with stimulation at the motor cortex and the muscle during maximal isometric, concentric, and eccentric contractions. Thirty young (23.6 ± 4.1 years) and 31 old (69.0 ± 5.2 years) adults performed maximal isometric, shortening (concentric) and lengthening (eccentric) contractions with the elbow flexor muscles. Maximal isometric contractions were performed at 90° elbow flexion and dynamic contractions at a velocity of 60°/s. Voluntary activation was assessed …

Measurement Of Peptoid Concentration Using Uv Spectroscopy, Katie Holland

Chemical Engineering Undergraduate Honors Theses

The goal of this research is to establish a relationship between ultraviolet adsorption and peptiod concentration to be used to determine the concentration of an unknown peptoid sample. This will allow for the measurement of concentration differences of peptoid samples before and after incubation with membrane surfaces. Samples were prepared nine know concentrations and diluted 50 fold. The UV absorbances of each sample was measured using a UV spectrophotometer at wavelengths from 200 to 450 nanometers. This process was repeated, and the maximum absorbance of each replicate was averaged to yield an absorbance value for each concentration of peptoid. …

A Risk-Based Method For Estimating The Carbon Sequestration Budget For A Mixed Hardwood Forest, Erin Cooper

Chemical Engineering Undergraduate Honors Theses

Carbon Dioxide (CO₂) levels in the atmosphere have risen from approximately 310 ppm in the 1950’s to over 400 ppm as of 2015. This rise in CO₂ has likely resulted in the observed warming trend of the earth’s atmosphere in the same time frame, causing significant concern in the scientific community. Several mitigation strategies have arisen to combat the upward trend of CO₂ emissions in recent decades, among them being carbon sequestration- the process of capturing CO₂ from the atmosphere and holding it for an extended period of time. This study used the U.S. Forest …

Coupling K-12 Music Education With Science, Technology, Engineering And Math (Stem) Curricula: Implementation Of A Stemusic Outreach Program, Mallory Maestri

Civil Engineering Undergraduate Honors Theses

Many studies have investigated the effects of music on evoking human emotions and diverse types of brain responses. One study by Juslin and Vastfjall indicates that hearing music can stimulate brain stem reflexes, create emotional contagion, recall episodic memories and provoke visual imagery. Due to the influence music has on human brain waves, researchers have been studying the effect of music on enhancing the spatial abilities of young students. Science, Technology, Engineering and Math (STEM) professions rely heavily on spatial skills. Research on the connection of music with spatial skills proposes that when the brain processes rhythm a “mental rotation” …

Training Personal Information To Children Diagnosed With Autism Spectrum Disorder, Diana C. Carlos

Theses and Dissertations

For many children diagnosed with Autism Spectrum Disorder, learning emergency information such as their parents’ names, contact information, or important health information may be useful in case of elopement, getting lost, or abduction. In the present study, I evaluated the use of video self-modeling (VSM) to facilitate acquisition of personal information in comparison to echoic prompts using a parallel treatments design with children with ASD. Components of the intervention included: a test, followed by the prompt (e.g., echoic or VSM) for no response given or for an incorrect response. The use of VSM involves the learner viewing a video of …

Habituation And Dishabituation In The Olfactory Bulb: From Neural Responses To Behavior, Mary Cameron Ogg

Theses and Dissertations (ETD)

Habituation and dishabituation modulate the neural resources and behavioral significance allocated to incoming stimuli across the sensory systems. The purpose of the research presented in this dissertation was to characterize these processes in the mouse olfactory bulb (OB) and to determine if OB acetylcholine (ACh) has a role in physiological and behavioral olfactory dishabituation. Calcium imaging was used to determine the timecourse and magnitude of habituation in different parts of the OB during and after a prolonged odor presentation. Widefield imaging of the dendritic, or glomerular, response of OB output cells demonstrated that prolonged odor input habituates glomerular responses during …

Assessing Neuronal Synchrony And Brain Function Through Local Field Potential And Spike Analysis, Samuel Stuart Mcafee

Theses and Dissertations (ETD)

Studies of neuronal network oscillations and rhythmic neuronal synchronization have led to a number of important insights in recent years, giving us a better understanding of the temporal organization of neuronal activity related to essential brain functions like sensory processing and cognition. Important principles and theories have emerged from these findings, including the communication through coherence hypothesis, which proposes that synchronous oscillations render neuronal communication effective, selective, and precise. The implications of such a theory may be universal for brain function, as the determinants of neuronal communication inextricably shape the neuronal representation of information in the brain. However, the study …

Revealing A Non-Canonical Role Of Anti-Apoptotic Mcl-1 In Early Embryonic Development, Xue Yang

Theses and Dissertations (ETD)

MCL-1, a well-known pro-survival BCL-2 family member, is indispensable for the survival of various cellular lineages and is also among the most frequently amplified genes in a variety of human malignancies. Gene ablation studies previously revealed that Mcl-1 deficiency leads to embryonic lethality around E3.5 during peri-implantation stage. Strikingly, the study did not detect any increase in apoptotic cells of the blastocyst, indicating a function of MCL-1 beyond regulating apoptosis. Our previous studies revealed an unrecognized role of MCL-1 in promoting mitochondrial physiology, which is independent of its classical anti-apoptotic function and requires being imported into the mitochondrial matrix. In …

Pitx3null Mutant (Striatal Dopamine-Deficient) Mice Have Exaggerated Spiny Projection Neuron Responses To L-Dopa And D1 Agonism And Lack Baseline Striatonigral Spiking, Ben Sagot

Theses and Dissertations (ETD)

L-3,4 dihidroxyphenylalanine (l-DOPA) strongly stimulates motor activity in parkinsonian patients and animal models of Parkinson's disease. Severe striatal dopamine (DA) loss characterizes Parkinson's disease and its animal models. Given the canonical rate model of Parkinson's Disease pathophysiology based on differences in DA pharmacology manifesting as electrophysiological differences in striatal projection neuron (SPN) spike rates, SPNs should increase spiking during the motor response to l-DOPA. In fact, stimulating specific subsets of these neurons to spike in freely-moving wild type and parkinsonian animals causes or inhibits motor activity as predicted. However, pharmacological effects of DA deficiency, let alone those of DA replacement, …

“They All Write About Some Woman In Their Poetry”: The Heroines Of Ulysses And As I Lay Dying, Elizabeth O'Malley

Senior Honors Theses

No abstract provided.

Russian Foreign Policy And National Identity, Monica Hanson-Green

Senior Honors Theses

National identity provides the interpretive framework through which foreign policy makers understand their role in the world and the actions of other states, and can also be utilized as a tool to mobilize public support behind foreign policy maneuvers. Foreign policy in turn is both shaped by constructions of national identity, and often used to forge and substantiate the narratives of national identity which best serve the regime’s domestic interests. This thesis will seek to establish the mutually constitutive relationship between national identity and foreign policy through an analysis of the interaction of these elements in the Russian Federation under …

Fatty Acid Concentration And Phase Transitions Modulate Aβ Aggregation Pathways, Pratip Rana, Dexter N. Dean, Edward D. Steen, Ashuwin Vaidya, Vijayaraghavan Rangachari, Preetam Ghosh

Department of Mathematics Faculty Scholarship and Creative Works

Aggregation of amyloid β (Aβ) peptides is a significant event that underpins Alzheimer disease (AD) pathology. Aβ aggregates, especially the low-molecular weight oligomers, are the primary toxic agents in AD and hence, there is increasing interest in understanding their formation and behavior. Aggregation is a nucleation-dependent process in which the pre-nucleation events are dominated by Aβ homotypic interactions. Dynamic flux and stochasticity during pre-nucleation renders the reactions susceptible to perturbations by other molecules. In this context, we investigate the heterotypic interactions between Aβ and fatty acids (FAs) by two independent tool-sets such as reduced order modelling (ROM) and ensemble kinetic …

Towards Green Building: Energy Efficient Roof System For Buildings, Dhruv Sangal

Theses and Dissertations

The present work focusses on investigating the thermal performance of different energy efficient roof systems for buildings for different climates. Buildings constitutes about 40 percent of total energy consumed by United States, and previous research shows that 20 percent of the building cooling load comes through ceiling of a building. Thus, it is important to analyze different energy efficient roof systems which can help in reducing building cooling and heating load. The present study focusses on three technologies – green roof, radiant barriers and photovoltaics. To analyze the performance of these systems, a detailed energy based mathematical model were developed …

Parents: Active Partners In The Educational Achievement Of Their Children, Michael O'Neill, Shane Lavery, Anne Coffey

eJournal of Catholic Education in Australasia

Parents exercise a significant influence on student achievement and psychosocial functioning within the school environment. However, the best way to involve parents as active partners in the education of their children is not always evident. This article explores the perceptions of parents and their role in the academic achievement of students in nine high performing Catholic secondary schools in Western Australia. Initially, the review of literature focuses on three constructs: relational trust, parental involvement and policy documents for Catholic schools. Data collection involved a series of focus group interviews in which parents were invited to reflect not only on their …

Additive Manufacturing Techniques And Their Biomedical Applications, Yujing Liu, Wei Wang, Laichang Zhang

Research outputs 2014 to 2021

Additive manufacturing (AM), also known as three-dimensional (3D) printing, is gaining increasing attention in medical fields, especially in dental and implant areas. Because AM technologies have many advantages in comparison with traditional technologies, such as the ability to manufacture patient-specific complex components, high material utilization, support of tissue growth, and a unique customized service for individual patients, AM is considered to have a large potential market in medical fields. This brief review presents the recent progress of 3D-printed ­biomedical materials for bone applications, mainly for metallic materials, including multifunctional alloys with high strength and low Young’s modulus, shape memory alloys, …

To Group Or Not To Group? Good Practice For Housing Male Laboratory Mice, S Kappel, P Hawkins, M Mendl

School of Biological and Marine Sciences

It is widely recommended to group-house male laboratory mice because they are ‘social animals’, but male mice do not naturally share territories and aggression can be a serious welfare problem. Even without aggression, not all animals within a group will be in a state of positive welfare. Rather, many male mice may be negatively affected by the stress of repeated social defeat and subordination, raising concerns about welfare and also research validity. However, individual housing may not be an appropriate solution, given the welfare implications associated with no social contact. An essential question is whether it is in the best …

What Do Work Value Differentiation And Profile Elevation Predict?, Jinhao Chi

Master's Theses

Using a sample of 251 college students, it was found that 1) when differentiation (D) of work values was calculated using three indices, high-low D, Iachan D, and variance D, only Iachan D positively related to indecision but high-low D and variance D did not, 2) none of the three indices of D related to career maturity, 3) work values profile elevation (PE) positively related to extraversion, openness, and negatively related to depressive symptoms and career indecision but was unrelated to career certainty and neuroticism and 4) work values PE moderated the relationship between Iachan D and career indecision. The …

2017-2021 Nasig Strategic Plan

NASIG Newsletter

No abstract provided.

Call For Applicants For Nasig 2018 Grants, Awards, And Scholarships

NASIG Newsletter

No abstract provided.

Profile Of Shannon (Regan) Keller, Chair Of The Digitial Preservation Task Force, Christian Burris

NASIG Newsletter

No abstract provided.

Investigation And Engineering Of Polyketide Biosynthetic Pathways, Lei Sun

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This research is focused on investigation and engineering of natural product biosynthetic pathways for efficient production of pharmaceutically important molecules or generation of new bioactive molecules for drug development.

Natural products are an important source of therapeutics, such as chromomycin (anti-cancer), emodin (anti-inflammatory and anti-tumor) and sprolaxine (anti-Helicobacter pylori). Metabolic engineering of natural product biosynthetic pathways shows its promise for creating and producing valuable compounds with chemical diversity for drug discovery. One goal of this research is to create highly efficient strains to biosynthesize valuable natural products. The engineered Streptomyces roseiscleroticus strain constructed in this work showed higher …

Community Wildfire Planning And Design: A Review And Evaluation Of Current Policies And Practices In The Western United States, Carlene C. Klein

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Wildland fire is an important and complex issue, particularly in the fire-prone ecosystems of the Western United States. At the same time that the number of catastrophic wildland fires is increasing across the United States, more people are moving in to wildland areas growing the interface between urban and wildlands. Managing wildfire in the Western United States is becoming increasingly more complex and costly as growth and development continues to push the edge of municipalities into undeveloped wildlands. Communities in this wildland urban interface are exacerbating the problem of wildfire in the West.

With more people living in wildfire prone …

Experimental And Simplified Analytical Investigation Of Full Scale Sandwich Panel Walls, Salam Adil. Al-Rubaye

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Concrete sandwich wall panels have been used for decades in the precast concrete construction industry because of their thermal efficiency. To achieve full or partial-composite action in concrete sandwich panel walls, the engineer must obtain a percent composite action from a connector manufacturer, making some engineers uncomfortable. Engineers are dependent upon the recommendations given by the connector manufacturers to establish their designs. This project tested six full scale sandwich panel walls to evaluate the percent composite action of various connectors and compare the results to those provided by the composite connector manufacturers.

This project aimed to validate current procedures using …

Novel Statistical Models For Quantitative Shape-Gene Association Selection, Xiaotian Dai

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Other research reported that genetic mechanism plays a major role in the development process of biological shapes. The primary goal of this dissertation is to develop novel statistical models to investigate the quantitative relationships between biological shapes and genetic variants. However, these problems can be extremely challenging to traditional statistical models for a number of reasons: 1) the biological phenotypes cannot be effectively represented by single-valued traits, while traditional regression only handles one dependent variable; 2) in real-life genetic data, the number of candidate genes to be investigated is extremely large, and the signal-to-noise ratio of candidate genes is expected …