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2017

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Skeletal Blast Trauma: An Application Of Clinical Literature And Current Methods In Forensic Anthropology To Known Blast Trauma Casualties, Petra Banks Dec 2017

Skeletal Blast Trauma: An Application Of Clinical Literature And Current Methods In Forensic Anthropology To Known Blast Trauma Casualties, Petra Banks

Theses and Dissertations

In order to examine the feasibility of assessing blast event conditions from bone and to distinguish blast trauma from aircraft crash trauma, this study attempts to determine if the observations made in clinical research are mirrored in skeletal remains of individuals who died in blast events. Research was conducted by assessing the frequency of different forms of trauma and their comparison to aircraft crash trauma, the directionality of trauma, and open-air versus enclosed blast trauma. Data consisted of historic and forensic anthropology reports of individuals who died from blast events and aircraft crashes from the Defense POW/MIA Accounting Agency (DPAA). …

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Spatiotemporal Variation In Space Use By Eastern Wild Turkeys In Mississippi, Ryo Ogawa Dec 2017

Spatiotemporal Variation In Space Use By Eastern Wild Turkeys In Mississippi, Ryo Ogawa

Theses and Dissertations

Spatiotemporal variation in animal space use is critical for understanding how individual animals respond to changes in resource availability across space and time. My study was aimed to: 1) determine functional responses of habitat selection by eastern wild turkeys (Meleagris gallopavo silvestris) across 7 study sites in Mississippi; and 2) determine the effect of temporal vegetation variation on order-II habitat selection by wild turkeys over 12 years. I developed resource selection functions using radio telemetry location data. Individual-specific coefficients of order-III habitat selection for forest were related inversely to forest availability in meta-regressions. Yearly coefficients of order-II habitat selection for …

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Vista Deficiency Attenuates Antibody-Induced Arthritis And Alters Macrophage Gene Expression In Response To Simulated Immune Complexes, Sabrina Ceeraz, Susan K. Eszterhas, Petra Sergent, David A. Armstrong, Alix Ashare, Thomas Broughton, Li Wang, Dov Pechenick, Christopher M. Burns, Randolph J. Noelle, Matthew P. Vincenti, Roy A. Fava Dec 2017

Vista Deficiency Attenuates Antibody-Induced Arthritis And Alters Macrophage Gene Expression In Response To Simulated Immune Complexes, Sabrina Ceeraz, Susan K. Eszterhas, Petra Sergent, David A. Armstrong, Alix Ashare, Thomas Broughton, Li Wang, Dov Pechenick, Christopher M. Burns, Randolph J. Noelle, Matthew P. Vincenti, Roy A. Fava

Dartmouth Scholarship

In addition to activated T cells, the immune checkpoint inhibitor “V domain-containing Ig suppressor of T-cell activation” (VISTA) is expressed by myeloid cell types, including macrophages and neutrophils. The importance of VISTA expression by myeloid cells to antibody-induced arthritis and its potential for relevance in human disease was evaluated. Methods: VISTA was immunolocalized in normal and arthritic human synovial tissue sections and synovial tissue lysates were subjected to western blot analysis. The collagen antibody-induced arthritis model (CAIA) was performed with DBA/1 J mice treated with antibodies against VISTA and with VISTA-deficient mice (V-KO). Total mRNA from arthritic joints, spleens, and …

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The Cosm Aggregate, Georgia Southern University Dec 2017

The Cosm Aggregate, Georgia Southern University

College of Science & Mathematics: News & Publications (2012-2022)

No abstract provided.

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Gender And Domain Differences In College Students’ Responses To Success And Failure, Elizabeth K. Lawner Dec 2017

Gender And Domain Differences In College Students’ Responses To Success And Failure, Elizabeth K. Lawner

Doctoral Dissertations

Four studies examined perceptions of STEM and non-STEM college courses, gender and domain differences in responses to success and failure, and whether interventions to make failure seem normative could ameliorate negative responses to failure, particularly among women. Study 1 found that college students perceive STEM courses as more difficult than non-STEM courses, and believe that introductory STEM courses are used to remove students from those fields. Moreover, the difference in perceptions of STEM and non-STEM courses was larger for women. Study 2 piloted a novel task that was used in Studies 3 and 4. These studies did not support the …

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A Correlation Study On Soil Selenium Content And Diabetes Mellitus In Contiguous United States, Yang-Chih Tsao Dec 2017

A Correlation Study On Soil Selenium Content And Diabetes Mellitus In Contiguous United States, Yang-Chih Tsao

Theses and Dissertations

Selenium, the essential trace element, is well known as its antioxidant function, antiviral properties, and its anti-inflammatory function to human health. The relationships between selenium status and diabetes mellitus have been widely studied, but the consistency of results is lacking. This study used diagnosed diabetes incidence from year 2004 to 2012 and soil selenium content by counties within 48 contiguous states in the U.S. with Generalized Linear Mixed Model- R-Side as the major statistical method to determine whether there is a significant correlation or not. Results showed that the diagnosed diabetes population had been increased from 2004 to 2012 for …

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Biodiversity Of Larval And Adult Dragonflies And Damselflies (Odonata) Of Interdunal Wetlands At Saugatuck Harbor Natural Area, Devon Volz Dec 2017

Biodiversity Of Larval And Adult Dragonflies And Damselflies (Odonata) Of Interdunal Wetlands At Saugatuck Harbor Natural Area, Devon Volz

Honors Theses

The effects of climate change on insects in the United States have yet to be fully understood. Research on the insect populations of Lake Michigan’s interdunal wetlands has been particularly limited. As these vibrant habitats are already at risk of destruction due to increased development, it is vital to have a working knowledge of the species that are living in the habitat. However, to date, there have been no studies on assemblages of interdunal wetlands in Michigan. Examining community compositions is critical to understanding the ecological problems that could occur in the future. This study is the first to look …

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Establishing The Structure Function Relationship Of Polypyridyl Ruthenium And Berenil-Type Compounds In The Formation Of Complexes With B-Dna And/Or G-Quadruplex Dna, Clinton Gregory Mikek Dec 2017

Establishing The Structure Function Relationship Of Polypyridyl Ruthenium And Berenil-Type Compounds In The Formation Of Complexes With B-Dna And/Or G-Quadruplex Dna, Clinton Gregory Mikek

Theses and Dissertations

Cancer results from the accumulation of genetic mutations in a normal cell that ultimately result in the expression (or overexpression) of oncogenes. The design of drugs having high affinity for specific DNA sequences or structural motifs is vital to gaining a better understanding of gene expression and to the development of new cancer treatments that are based on turning off oncogene expression. This dissertation presents studies of the binding of two ligand families, Berenil (DMZ), and ruthenium polypyridyl complexes (RPCs), to B-DNA and G-quadruplex (G4) DNA. The structureunction relationships for the interaction of these ligand families with DNA were probed …

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Regulation Of Stomata Opening In The Crassulacean Acid Metabolism Plant Kalanchoe Laxiflora, Anoud Abdulmalik Albader Dec 2017

Regulation Of Stomata Opening In The Crassulacean Acid Metabolism Plant Kalanchoe Laxiflora, Anoud Abdulmalik Albader

Theses and Dissertations

Stomata are small pores that are located on the surface of epidermal leaves, and they can regulate the uptake of CO2 and prevent water lose by opening and closing the pores. Stomata of plants can be regulated by external condition such as CO2, biotic and abiotic stresses and internal factors. CAM (crassulacean acid metabolism) plants adapt to hot and dry environments by closing stomata during the day and opening stomata during the cool night. However, it is still unclear how CAM plants open their stomata during the night and close them during the day. In this study, a number of …

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Management Practices For Corn Producers Implementing Early Planting As A Production Strategy, Matthew W. Hock Dec 2017

Management Practices For Corn Producers Implementing Early Planting As A Production Strategy, Matthew W. Hock

Theses and Dissertations

Producers choosing to implement an early corn planting management strategy often experience several yield limiting biotic and abiotic factors. Field variability, flooding, sub-optimal soil temperatures which leads to poor nutrient uptake, delayed emergence and reduced root growth can limit grain production. Three separate experiments were conducted to address some of the negative effects associated with early corn planting. Experiment 1 evaluated flooding effects on several morpho-physiological traits including root system architecture during early crop development. Hybrids (DKC 6208, Pioneer 1197) were flooded at planting (V0) and growth stages V1, V2, V3 for 0, 6, 12, 24, 48, 96 hours. Plants …

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Role Of Rap1a In Age/Rage-Mediated Signaling In Type Ii Diabetes Mellitus, Jia Zhao Dec 2017

Role Of Rap1a In Age/Rage-Mediated Signaling In Type Ii Diabetes Mellitus, Jia Zhao

Theses and Dissertations

Type II diabetes mellitus (TIIDM) causes multiple complications under chronic hyperglycemia. Long term persistent exposure to elevated glucose conditions is considered one of the major factors for diabetic complications. Pathologically, mechanical and biochemical stimuli will induce a signaling cascade in cardiac fibroblasts, which causes myocardial fibrosis and leading to ventricular stiffness. Non-enzymatically, high levels of glucose can react with long-lived proteins, such as collagen to form advanced glycation end-products (AGEs). AGEs have been shown to be associated with many of the diabetic cardiovascular complications due to their interaction with the receptor for AGE (RAGE). AGE/RAGE activation stimulates the secretion of …

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Sperm Genetic And Epigenetic Mechanisms Regulating Male Fertility, Naseer Ahmad Kutchy Dec 2017

Sperm Genetic And Epigenetic Mechanisms Regulating Male Fertility, Naseer Ahmad Kutchy

Theses and Dissertations

Male fertility, ability to fertilize and activate the egg and support early embryo development, is crucial for mammalian reproduction and development. Testis specific histone 2B (TH2B) of sperm, protamines (PRM1/2), and posttranslational modifications of histone 3 (H3K27me3 and H3k27ac) are involved in spermatogenesis and male fertility. However, molecular and cellular mechanisms by which TH2B regulates histone to protamine replacement is poorly defined. Immunocytochemistry, western blotting, flow cytometry, computer-assisted sperm analysis (CASA) and bioinformatic approaches were applied to analyze sperm from Holstein bulls with different in vivo fertility. Results from the immunocytochemistry experiments showed that while TH2B and H3K27me3 were localized …

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The Application And Exploration Of The City Biodiversity Index Through A Case Study Of The City Of Starkville, Mississippi, Leslie Rhea Moma Dec 2017

The Application And Exploration Of The City Biodiversity Index Through A Case Study Of The City Of Starkville, Mississippi, Leslie Rhea Moma

Theses and Dissertations

During the 21st century, more people will reside in cities than in rural areas for the first time in human history. As cities expand to accommodate their growing population, pressure is mounting on local biodiversity and the ecosystems they support. This prompted the U.N. Convention on Biological Diversity - in collaboration with the City of Singapore - to develop a biodiversity index specifically for cities. In 2014, the final draft of the City Biodiversity Index was released. Twenty-three indicators comprise three categories that assess: native biodiversity, ecosystem services, and municipal support for local biodiversity. A case-study was designed for Starkville, …

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Imaging Calcium Carbonate Crystallization In Association With Organic Compounds, Maurice Philip Testa Dec 2017

Imaging Calcium Carbonate Crystallization In Association With Organic Compounds, Maurice Philip Testa

Theses and Dissertations

The objective of this study is to better understand the relationship between organic compounds and carbonate mineral growth in different natural environments by imaging the interface between organic compounds and carbonate precipitates in ancient and modern rocks, and laboratory experiments. Three separate projects were designed to document the organic/carbonate mineral interface through imagery. 1) Images of the interfaces between organic components and initial mineral precipitates were investigated in a deteriorating microbial mat from Vermelha, Brazil that was taken from the site in 2006. As the mat deteriorated the amount of calcification increased. A section of the transitional section between living …

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Impacts Of Immigration Policy Changes On Employment Of Foreign Born Doctorate Recipients, Jun Cheng Dec 2017

Impacts Of Immigration Policy Changes On Employment Of Foreign Born Doctorate Recipients, Jun Cheng

Theses and Dissertations

The H-1B visa program was initiated in 1990 to temporarily hire highly-skilled foreign workers. The H-1B visa program has changed several times since its initiation. One of the most important changes occurred in 2001 when the 21st Century Act exempted individuals employed by institutions of higher education and nonprofit and government research organizations from the H-1B visa cap increasing the number of visas available for foreign high-skilled immigrants. To analyze the impact of policy changes affecting the H-1B program on highly-skilled workers, we study the behavior of foreign-born Ph.D. students who graduated from institutions in the United States over the …

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Finite Element Study On The Influence Of Bone-Implant Interface Condition On Femoral Fracture After Cementless Total Hip Replacement, Caleb Onuh Yenusah Dec 2017

Finite Element Study On The Influence Of Bone-Implant Interface Condition On Femoral Fracture After Cementless Total Hip Replacement, Caleb Onuh Yenusah

Theses and Dissertations

Finite element analysis was performed on an implanted femur, using loads of daily living activities, performed by total hip replacement patients. A probabilistic bone fatigue failure model was utilized to analysis the risk of post-operative femoral fracture in different patient groups, depending on bone fatigue strength for young and elderly patients, and activity levels for normal and active patients. Different bone-implant interface conditions were considered: after surgery, osseointegrated, fibrous tissue covering, and loose. For young patients, the probability of failure is less than 4% for all cases. While in elderly patients, high of 28.2% and 57.9% are reported for normal …

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Formulation Of Whey Protein Stabilized Multilayered Microemulsion And Nanoemulsion Systems With Hyperoxidative Curcumin, Soma Mukherjee Dec 2017

Formulation Of Whey Protein Stabilized Multilayered Microemulsion And Nanoemulsion Systems With Hyperoxidative Curcumin, Soma Mukherjee

Theses and Dissertations

A primary emulsion with whey protein isolate (WPI) and hexanoic acid was prepared, and chitosan (Ch) (0.01%, 0.02%, and 0.03%) was added to evaluate its impact on particle size distribution of the emulsion. NaCl (0, 20, 40, and 80 mM) was added to increase ionic interactions to stabilize the multilayer emulsion. Lecithin (0.5%, 1%, 2%, 3 %, w/v) was mixed with the primary emulsion in order to form a multilayer, and casein hydrolysate (CH) was used to stabilize the tertiary emulsion system without the use of NaCl for 28 d at 4 °C. Stable O/W nanoemulsions were generated for use …

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Genomics And Molecular Approaches To Delineate Pathogenesis Of Aeromonas Hydrophila, Aeromonas Veronii, And Edwardsiella Piscicida Infections In Fish, Hasan Cihad Tekedar Dec 2017

Genomics And Molecular Approaches To Delineate Pathogenesis Of Aeromonas Hydrophila, Aeromonas Veronii, And Edwardsiella Piscicida Infections In Fish, Hasan Cihad Tekedar

Theses and Dissertations

The U.S. aquaculture industry has become well established in the last three decades, and channel catfish aquaculture is the most significant component of this industry. Virulent Aeromonas hydrophila has been a serious disease problem since 2009 in the U.S. catfish aquaculture, and Aeromonas veronii and Edwardsiella piscicida are emerging pathogens of catfish. Therefore, this study aims to address fundamental questions on virulence mechanisms of these three fish pathogens, which I expect to support the development of control measures for preventing these diseases. In this study, E. piscicida and virulent Aeromonas hydrophila (vAh) genomes were sequenced, and comparative analyses were conducted …

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Ecology And Conservation Of Bird Assemblages In Native And Afforested Environments In The Northern Campos Grasslands Of Uruguay, Juan Andrés Martínez Lanfranco Dec 2017

Ecology And Conservation Of Bird Assemblages In Native And Afforested Environments In The Northern Campos Grasslands Of Uruguay, Juan Andrés Martínez Lanfranco

Theses and Dissertations

Commercial forestry has expanded across the Rio de la Plata Grasslands (RPG) of South America in recent decades. I conducted a resource-use based study on bird communities during the 2013-2014 austral breeding season in northern Uruguay. I assessed relationships between habitat types and bird abundance as a function of vegetation structure. To compare avian responses to treatments, I included native environments, pine and eucalyptus plantations of different ages and thinning regimes. I detected differences in species richness and composition and species-specific responses in abundance along structural gradients sampled. Although poorer in species than native habitat types, tree plantations were extensively …

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An Oral History & Literary Review Of Edward Blake Jr.: Exploring The Evidence Of A Principled Practice, Hans Curtis Herrmann Dec 2017

An Oral History & Literary Review Of Edward Blake Jr.: Exploring The Evidence Of A Principled Practice, Hans Curtis Herrmann

Theses and Dissertations

This thesis is a study of oral histories and literary records covering the professional development and works of Edward Blake Jr., ASLA, (1947-2010). The study considers Blake’s design principles via newly collected oral histories and a review of his literary record within the continuum of landscape architecture history from 1970 to 2010. Additionally, the study explores Blake’s position within the ecological design community to establish his status as a possible founding voice of ecologically focused landscape architecture practice in the Coastal Plains Region of the southeastern United States. The primary sources include a newly developed oral history collection with questionnaire-based …

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Characterization Of Type Vi Secretion System In Edwardsiella Ictaluri, Safak Kalindamar Dec 2017

Characterization Of Type Vi Secretion System In Edwardsiella Ictaluri, Safak Kalindamar

Theses and Dissertations

Edwardsiella ictaluri causes enteric septicemia of catfish (ESC), which is one of the most important bacterial diseases causing significant economic losses in the US catfish industry. Understanding the virulence mechanisms of E. ictaluri plays a vital role to develop preventives, such as vaccines for the disease. Therefore, further research is necessary to discover the new virulence mechanisms of this pathogen. The long-term goal of our group is to determine the mechanism of E. ictaluri pathogenesis and to develop effective live attenuated vaccines against ESC. The overall goal of this project is to understand the role of Type 6 secretion system …

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Listeria Monocytogenes Response To Sublethal Sodium Hypochlorite Induced Oxidative Stress On Its Biofilm Forming Ability And Antibiotic Resistance, Mohit Bansal Dec 2017

Listeria Monocytogenes Response To Sublethal Sodium Hypochlorite Induced Oxidative Stress On Its Biofilm Forming Ability And Antibiotic Resistance, Mohit Bansal

Theses and Dissertations

Listeria monocytogenes response to oxidative stress by sublethal sodium hypochlorite was investigated in this study. Continuous exposure of sublethal chlorine influenced biofilm formation and stress adaptation (homologous and heterologous) in L. monocytogenes. The biofilm forming ability of oxidative stress adapted and control cells were investigated on polystyrene surface at 22°C and 37°C. The oxidative stress adapted cells were found to form less biofilm in the presence of chlorine (p < 0.10) when compared to non-treated control cells at both the temperatures. In addition, the biofilm forming ability of L. monocytogenes was reduced significantly at higher sublethal chlorine concentrations (p < 0.10). In conclusion, oxidative stress adapted L. monocytogenes has developed tolerance to chlorine and some of the antibiotics. However, oxidative stress those cells did demonstrate an antibiofilm effect. This demonstrates that oxidative stress reduces L. monocytogenes biofilm formation but can also increase antibiotic resistance.

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The Characterization Of Zebrafish Natural Killer Cells And Their Role In Immunological Memory, Preeti Judith Muire Dec 2017

The Characterization Of Zebrafish Natural Killer Cells And Their Role In Immunological Memory, Preeti Judith Muire

Theses and Dissertations

Rag1-/- mutant zebrafish lack lymphocytes and were used to study the basis of acquired protective immunity in the absence of lymphocytes to the intracellular bacterium Edwardsiella ictaluri. This study morphologically identified and quantified lymphocyte like cells (LLCs) present in the liver, kidney and spleen of these fish. LLCs included Natural Killer (NK) cells and non-specific cytotoxic cells (NCCs) and were discriminated by size, and by the presence of cytoplasmic granules. The antibodies anti-NITR9, anti-NCCRP-1 (5C6) and anti-MPEG-1 were used to evaluate these cell populations by flow cytometry. Gene expression profiles in these tissues were evaluated after the Rag1-/- mutants were …

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The Defense Response Of Glycine Max To Heterodera Glycines And Macrophomina Phaseolina, Bisho Ram Lawaju Dec 2017

The Defense Response Of Glycine Max To Heterodera Glycines And Macrophomina Phaseolina, Bisho Ram Lawaju

Theses and Dissertations

The understanding of plant defense response in plant-pathogen interaction provides useful information to combat the disease. Soybean cyst nematode (SCN), Heterodera glycines, and charcoal rot causing fungus, Macrophomina phaseolina, are major pathogens of soybean, Glycine max, and infestation with SCN has found to aggravate the fungal disease severity. The gene expression analysis in resistant and susceptible interactions between H. glycines and G. max has identified some candidate resistance genes and signaling pathways but they are yet to be fully characterized. This dissertation aims to characterize one such gene, Conserved Oligomeric Golgi (COG) complex. The COG complex is important in structural …

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The Effect Of Controlling Temperature And Relative Humidity On Tyrophagus Putrescentiae (Schrank) (Sarcoptiformes: Acaridae) Infestations On Dry Cured Hams Treated In Food Grade Ingredient Infused Nets, Jasmine Deneen Hendrix Dec 2017

The Effect Of Controlling Temperature And Relative Humidity On Tyrophagus Putrescentiae (Schrank) (Sarcoptiformes: Acaridae) Infestations On Dry Cured Hams Treated In Food Grade Ingredient Infused Nets, Jasmine Deneen Hendrix

Theses and Dissertations

Since methyl bromide is an ozone depleting substance, there is a significant need to find effective alternative compounds to control mite infestations on dry cured hams. Therefore, the objective of this study was to determine the most effective relative humidity and/or temperature to minimize mite reproduction and mold growth on dry cured hams in untreated and food grade ingredient infused nets. Mites on ham slices in untreated nets were reduced from the initial inoculum level of 50 mites per ham slice when exposed to 85% RH at 24, 28, and 32°C. Results indicated that hams should be stored at 85% …

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Wastewater Remediation Using Modified Biochars, Griffin Allen Burk Dec 2017

Wastewater Remediation Using Modified Biochars, Griffin Allen Burk

Theses and Dissertations

Water polluted by metals and phosphates can be hazardous to both the environment and human health. The aim of this study was used to improve understanding of the adsorption properties of low-cost, green adsorbents for removal of pollutants from aqueous solution. Biochar was used as an adsorbent, which was produced from the gasification of pine wood waste and the fast pyrolysis of Douglas fir. Biochar is a bio-renewable product that can easily be modified, and the cost is lower compared to other adsorbents like activated carbon. The gasifier produced biochar was modified by coating the biochar surface with chitosan. Douglas …

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Effect Of Water Temperature, Angling Time, And Dissolved Oxygen Concentration On The Survival Of Angled And Tournament-Handled Largemouth Bass, Kevin Randy Keretz Dec 2017

Effect Of Water Temperature, Angling Time, And Dissolved Oxygen Concentration On The Survival Of Angled And Tournament-Handled Largemouth Bass, Kevin Randy Keretz

Theses and Dissertations

Largemouth Bass Micropterus salmoides is the most sought after species by recreational anglers in the United States. Survival of angled and tournament-handled Largemouth Bass is related to numerous factors; however, the independent effects of water temperature, angling time, and live well dissolved oxygen concentration on survival have not been measured. Survival was evaluated in simulated catch and release and tournament trials over the range of temperatures encountered by Largemouth Bass anglers (17-33°C) while also testing independent effects of angling time, live well temperature, and live well dissolved oxygen treatments. Caught-and-released Largemouth Bass experienced 100% survival at temperatures ≤33°C after 1 …

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An Application Of Roger Ulrich's Methods: Designing A Healing Garden For African American Women Living In Low-Income Public Housing, Juriel Annishia Rogers Dec 2017

An Application Of Roger Ulrich's Methods: Designing A Healing Garden For African American Women Living In Low-Income Public Housing, Juriel Annishia Rogers

Theses and Dissertations

The purpose of this preference study is to identify the effects that the presence of a healing garden may have, on the perceived stress of African American women living in in low-income public housing. Literature states that women who live in public housing experience higher rates of malnutrition, fatigue, susceptibility to infection, and premature death (Adler et al., 1994; Whelch and Kneipp, 2005). Few of these studies address healing gardens as solutions. The explanation of behavior while visiting a healing garden in this study will help to identify particular aspects of gardens that are perceived as therapeutic. This research compared …

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Effects Of Leukoreduction And Storage On Erythrocyte Phosphatidylserine Expression And Eicosanoid Concentrations In Units Of Canine Packed Red Blood Cells, Samantha Muro Dec 2017

Effects Of Leukoreduction And Storage On Erythrocyte Phosphatidylserine Expression And Eicosanoid Concentrations In Units Of Canine Packed Red Blood Cells, Samantha Muro

Theses and Dissertations

Storage of canine packed red blood cells (pRBCs) can increase erythrocyte phosphatidylserine (PS) expression and eicosanoid concentrations. The objective of this study was to determine the effects of leukoreduction on erythrocyte PS expression and eicosanoid concentrations in stored units of canine pRBCs. Units of whole blood were leukoreduced (LR) or non-leukoreduced (non-LR), and stored (10 and 21 days) as pRBCs. Samples were collected at donation, and before and after a simulated transfusion. PS expression was measured by flow cytometry, and concentrations of arachidonic acid (AA), prostaglandin F2α (PGF2α), prostaglandin E2 (PGE2), prostaglandin D2 (PGD2), thromboxane B2 (TXB2), 6-keto-prostaglandin F1α (6-keto-PGF1α) …

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Efficacy Of Novel Pyridinium Oximes In Preventing Neural Damage, Charles Andrew Leach Dec 2017

Efficacy Of Novel Pyridinium Oximes In Preventing Neural Damage, Charles Andrew Leach

Theses and Dissertations

Organophosphates are neurotoxic compounds that inhibit acetylcholinesterase producing excess cholinergic stimulation. This produces various toxic signs including excitotoxic neuronal damage. Oximes can be used as a treatment for organophosphate poisoning by reactivating inhibited acetylcholinesterase. Traditional oximes do not penetrate the blood-brain barrier, limiting protection of the central nervous system. Novel, brain-penetrating oximes have the potential to protect the brain from organophosphate induced damage. Adult male rats were used to examine the ability of model organophosphates to produce neuropathology and the ability of novel oximes to prevent this damage. Additionally, adult male rats were used to examine changes in gene expression …

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