Digital Commons Network^™

Revisiting Neutrophil Responses To Toll-Like Receptor 4 : Influence Of Ligand Structures And Cellular Environments., Shuvasree Sengupta

Electronic Theses and Dissertations

Neutrophils respond to bacterial LPS through Toll-like receptor 4 (TLR4), which activates or potentiates immune defensive functions and prolongs cell survival. Activation of TLR4 signaling in neutrophils is beneficial for effective clearance of LPS-bearing Gram-negative bacteria, but may also drive aberrant inflammation if not stringently regulated. The regulatory processes by which neutrophil functions are calibrated to respond appropriately to different LPS-bearing bacteria are incompletely understood. Described here are investigations that reveal an unexpected sensitivity of TLR4 in neutrophils to small changes in LPS structure typical of various Gram-negative bacteria, including those that are dangerously virulent (Escherichia coli and Salmonella …

Algorithms For Automated Assignment Of Solution-State And Solid-State Protein Nmr Spectra., Andrey Smelter

Electronic Theses and Dissertations

Protein nuclear magnetic resonance spectroscopy (Protein NMR) is an invaluable analytical technique for studying protein structure, function, and dynamics. There are two major types of NMR spectroscopy that are used for investigation of protein structure – solution-state and solid-state NMR. Solution-based NMR spectroscopy is typically applied to proteins of small and medium size that are soluble in water. Solid-state NMR spectroscopy is amenable for proteins that are insoluble in water. In the vast majority NMR-based protein studies, the first step after experiment optimization is the assignment of protein resonances via the association of chemical shift values to specific atoms in …

Articulating The New Normal(S) : Mental Disability, Medical Discourse, And Rhetorical Action., Andrew Wesley Holladay

Electronic Theses and Dissertations

“Articulating the New Normal(s): Mental Disability, Medical Discourse, and Rhetorical Action” studies the writing of people diagnosed with autism and post- traumatic stress disorder within online discussion boards related to mental health and outlines their unique rhetorical strategies for interacting with biomedical ideologies of psychiatry and activist discourses. The opening chapter situates this dissertation in relation to previous scholarship in Rhetoric, Disability Studies, and other fields. I also provide a summary of the set of mixed methods I use to gather and analyze my data, including rhetorical analysis, corpus analysis, and qualitative interviews. In Chapter 2, “Medical Terminology and Discourse …

Cumulative Trauma, Emotion Reactivity And Salivary Cytokine Response Following Acute Stress Among Healthy Women., Yvette Z. Szabo

Electronic Theses and Dissertations

This study furthers understanding of how trauma exposure may be connected to the development and maintenance of poor health by focusing on cytokines, tightly regulated proteins of the immune system. Cytokine responses to acute stress have been associated with the onset of poorer mental health in physically healthy women. The present study examined how two factors recently associated with cytokine reactivity –cumulative trauma and emotion reactivity– are associated with salivary cytokine reactivity among healthy women. Seventy-one women, screened to be physically and mentally healthy, completed a laboratory acute stress paradigm and self-report measures of state emotion and trauma exposure. Participants …

Advances In Tumor-Targeted Therapy Using Nanomedicine., Divya Karukonda

Electronic Theses and Dissertations

Despite continuous improvement and significant progress made in diagnostic and therapeutic approaches for cancer, it is still the leading cause of death worldwide. Although conventional chemotherapy has made significant advances in improving patient survival the indiscriminate destruction of normal cells leads to severe side effects and poor clinical outcomes. Thus, there is a need for effective delivery of drugs to the tumor site avoiding normal tissues to reduce toxicity in the rest of the body. For this reason, a novel multidisciplinary field called Nanotechnology has evolved in recent years and advances in this field have contributed to the development of …

Prevention And Treatment Of Familial Adenomatous Polyposis And Colorectal Cancer By Bilberry-Derived Anthocyanidins., Ashley M. Mudd

Electronic Theses and Dissertations

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths within the United States. Familial adenomatous polyposis (FAP) is an inherited disorder which if left untreated will develop into colon cancer. The family of plant-derived compounds, anthocyanins, show significant therapeutic potential against a variety of diseases, however, they are limited by their instability and poor bioavailability. The goal of my Master’s research project was to determine whether anthocyanidins (non-glycosylated anthocyanins) are more effective than the native anthocyanins, and whether exosomal formulation of anthocyanidins (ExoAnthos) can enhance therapeutic potency compared with free Anthos against both FAP and CRC. The antiproliferative …

American Muslim Men And Stigma : The Use Of Religious Communities As Mechanisms For Stigma Management., Jack R. Allen Iii

Electronic Theses and Dissertations

The experiences of American Muslim men deserve further study because they are relevant to current civil rights discussions, especially in a social-political climate that is growing increasingly hostile toward the Islamic world. Despite acknowledging the significant impact of gender, relatively little research has focused exclusively on masculine Muslim experiences of stigmatization. This research addresses the experiences of religiously practicing Muslim men and addresses the following questions: How do Muslim men experience stigma in their communities? What experience do these men have with religious institutions? And finally, how do these experiences with religious institutions inform how these individuals manage stigma? Using …

Optimal Control-Based Inverse Determination Of Electrode Distribution For Electroosmotic Micromixer, Yuan Li, Yongbo Deng, Zhenyu Liu, Teng Zhou, Yihui Wu, Shizhi Qian

Mechanical & Aerospace Engineering Faculty Publications

This paper presents an optimal control-based inverse method used to determine the distribution of the electrodes for the electroosmotic micromixers with external driven flow from the inlet. Based on the optimal control method, one Dirichlet boundary control problem is constructed to inversely find the optimal distribution of the electrodes on the sidewalls of electroosmotic micromixers and achieve the acceptable mixing performance. After solving the boundary control problem, results are also provided to demonstrate the effectiveness of the proposed method; the step-shaped distribution of the external electric potential imposed on the sidewalls is obtained, and the electrodes with an interlaced arrangement …

Safety And Freedom: Let’S Get It Together, Hiram E. Chodosh, Matthew Bibbens, Nyree Gray, Dianna Graves

Journal of Legal Education

No abstract provided.

Book Review Of Elizabeth Cady Stanton And The Feminist Foundations Of Family Law By Tracy A. Thomas, Paula A. Monopoli

Journal of Legal Education

No abstract provided.

Increasing Diversity By A New Master’S Degree In Legal Principles, Joni Hersch

Journal of Legal Education

No abstract provided.

An Economic Analysis Of A Total Allowable Catch-Individual Transferable Quota System In A Developing Country Heterogeneous Fishery: An Application To The Digha Fishery In West Bengal, India, Nadeeka Weerasekara

Department of Agricultural Economics: Dissertations, Theses, and Student Research

This thesis contributes to the literature of economics of small-scale fishery communities and fishery management in developing nations. In the first section we review literature on state of the fishery resource and the livelihoods in the globe and performance of fishery management systems in developing and developed countries. Second section discusses the results of an empirical study on the economics of subsistence fishers in Digha-Shankarpur in Eastern India. Results of the empirical study shows by-catch by the trawlers leads to the depletion of target fish stock of the subsistence fishers. Underutilization of the capacity by the subsistence fishers due to …

Conservation Biological Control Of Western Bean Cutworm: Molecular Gut Content Analysis Of Arthropod Predators, Feeding Trials For Key Predators And Agricultural Surveys For Integrated Pest Management, Westen Ray Archibald

Department of Entomology: Dissertations, Theses, and Student Research

Western bean cutworm (WBC), Striacosta albicosta, is a major pest of corn in western Nebraska. In 1999, its range expanded into much of North America causing damage from Nebraska to Canada and Mexico. WBC periodically causes kernel damage as severe as 15 bu/ac for one larva/plant. Control for WBC relies on Bt corn hybrids with Vip3A and Cry1F traits and insecticides. There has been a 5.2-fold decrease in efficacy of Cry1F for WBC. Concerns over management tactics may be creating space for conservation biological control to become part of a WBC integrated pest management (IPM) program. Objective 1, used …

Evaluation Of Host Plant Resistance Against Sunflower Moth, Homoeosoma Electellum(Hulst), In Cultivated Sunflower In Western Nebraska, Dawn M. Sikora

Department of Entomology: Dissertations, Theses, and Student Research

Sunflower moth, Homoeosoma electellum, is a serious pest of oilseed and confection sunflowers. In this study, we determine efficacy of resistance against this pest. Thirty commercial hybrids, inbreds, and varieties of sunflowers were tested in replicated field and laboratory studies. Trait efficacy is determined by pericarp strength by means of physical compression tests and damage to achenes. Initial sunflower entries were planted May 2014 and data collection began in early August 2014. A second season was planted June 2015, with sampling beginning late August the same year.

In 2014, oilseed varieties showed a strength average of 2.71 ± 0.11 N …

Mapping The Ecology Of Information: Hierarchical Habitat Selection By Nebraska Pheasant Hunters, Lyndsie Wszola

School of Natural Resources: Dissertations, Theses, and Student Research

Hunting regulations are assumed to moderate the effects of hunting consistently across a game population. A growing body of evidence suggests that hunter effort varies temporally and spatially, and that variation in effort at multiple spatial scales can affect game populations in unexpected ways. We set out to determine the causes of variation in hunting effort among ring-necked pheasant (Phasianus colchicus) hunters at four spatial scales: among regions within the state of Nebraska, among sites within a given region, among access points at a given site, and among habitat patches within a site. At each scale, pheasant hunters used direct …

Understanding Cigarette Butt Littering Behavior On Public Beaches: A Case Study Of Jekyll Island, Georgia, Maranda R. Miller

School of Natural Resources: Dissertations, Theses, and Student Research

The world’s natural environment is degrading, and human behavior is a leading cause. Therefore, in order to address environmental problems it is important to understand the factors driving environmentally degrading behaviors and subsequently design behavioral interventions to alter undesirable behaviors.

One environmental issue of particular concern is toxins leeching from trash. Specifically, cigarette butts are of concern due to their prevalence in the environment. Cigarette butt discarding behavior is affected by personal attributes, but data regarding which personal attributes and how these affect discarding behavior is lacking. This thesis seeks to understand cigarette butt disposal on public beaches by exploring …

Soil Ecosystem Service Tradeoffs And Social–Ecological Resilience In The North Central Great Plains, Hannah E. Birge

School of Natural Resources: Dissertations, Theses, and Student Research

Humans seek to improve their wellbeing by altering ecological processes to maximize the output of specific ecosystem services, which often leave the system vulnerable to unintended and undesirable side effects. Ecosystem services emerge from complex interactions among ecological structures and processes occurring at multiple scales. The degree to which an ecosystem maintains a predictable range of structures and processes in the face of disturbance can be described as its resilience. The 1930s Dust Bowl of the North American Great Plains is an example of a system reconfiguration and loss of resilience that was ultimately driven by human optimization for a …

Assessment Of The Campus Food Environment Using Components Of The Healthy Campus Environmental Audit, Candace Sorden

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

The objective was to assess whether the food environment at the University of Nebraska-Lincoln (UNL) campuses supports healthy eating behaviors using components of the Healthy Campus Environmental Audit (vending, dining, and convenience store audits). Secondary aims were to compare the UNL food environment to other college campuses and explore whether there are existing health promotion and obesity prevention initiatives, programs, pledges and/or policies at UNL.

Research team members accessed a secure online website to review training materials prepared by Syracuse University. Evaluators did audit practice trials to meet inter-rater reliability score standards (>80%). audits were conducted at designated sites …

Enantioselective Γ- And Δ -Borylation Of Unsaturated Carbonyl Derivatives: Synthesis, Mechanistic Insights, And Applications, Gia L. Hoang

Department of Chemistry: Dissertations, Theses, and Student Research

Chiral boronic esters are valuable synthetic intermediates widely used in a variety of stereospecific transformations. Transition metal-catalyzed asymmetric hydroboration (CAHB) of alkenes is among the most popular methods for their preparation. Enantioselective hydroboration of activated alkenes (i.e., vinyl arene derivatives or conjugated carbonyl compounds) have been extensively studied by many research groups. We, on the other hand, are interested in enantioselective hydroboration of unactivated alkenes utilizing coordinating functional groups (e.g., carbonyl derivatives) to give functionalized, chiral boronic esters. While conjugate addition and C–H activation methodologies provide efficient alternatives to CAHB for enantioselective beta-borylation of carbonyl compounds, direct gamma- and delta-borylations …

Examining Drinking Motivation, Resiliency, And Alcohol Use Among American Indian And Caucasian College Students, Emily Sargent

Theses and Dissertations

While previous research has suggested American Indians (AI) experience higher levels of alcohol use and related consequences than Caucasians (CA), recent research has demonstrated that AI may actually be drinking at the same or lower rates than CA. AI college students may choose to consume alcohol for different reasons than CA students, referred to as drinking motivation. Resiliency (i.e., experiencing positive outcomes regardless of serious threats) may be one factor that moderates the relationship between specific drinking motives and alcohol use. The current study examined alcohol use, drinking motivation, and resiliency among University of North Dakota (UND) AI (n = …

Theory And Applications Of Absorbing Guided-Mode Resonant Devices In Sensing, Communications, And Display, Alexander Leighton Fannin

Electrical Engineering Dissertations - Archive

Guided-mode resonant (GMR) technology is incorporated into lossy dielectric materials to assist in the absorption of incident light for various applications. Varying topologies and methodologies are explored. A series of devices taking advantage of narrow band, coherent interferometry is found to work as a serviceable coherent perfect absorber (CPA) whereby the total transmittance through the device is tunable based upon the relative phase of two or more beams. The differing beams are shown to be exciting the same mode in the device enabling the interferometric function. A similar, active topology for use in electronically interrogable interfacing is explored. Multiple hybrid …

Glazing Performance In The Patient Care Setting, Adam A. Rose

All Theses

Windows can have positive effects on hospital staff and patient health and well-being. Proper window design can also significantly benefit hospital energy conservation, consequentially reducing environmental impact. However, often the glazing and fenestration design of the hospital envelope can be heavily impacted by building components like structural and mechanical systems. The location of these building components at the exterior wall can lead to a reduction of glazing area, increase the use of electric lighting, and limit the potential benefits that glazing design can provide to occupants. The health benefits of glazing for building occupants have been well documented. Natural daylight …

Controlling Recombinant Escherichia Coli Cultures To The Boundary Of Oxidative And Overflow Metabolism (Boom) For Robust Efficient Growth, Shahin Gharakozlou Lashkari

All Theses

In the last three decades, biopharmaceuticals such as human growth hormone have been used to treat many diseases from HIV/AIDS to different types of cancer. Controlling the growth of recombinant cells, such as Escherichia coli (E. coli), is essential for productivity and efficiency of biopharmaceutical manufacturing. The cell growth can be controlled by regulating feed rate as the limiting factor. Hence, a robust and efficient feed controller – that only uses common industrial sensors – is desired. In this thesis, a controller is presented which can set the appropriate feed rate based on the metabolic state of E. coli. A …

Rod Library Newsletter: Notes For The Stalled, V10n1, August 2017, University Of Northern Iowa. Rod Library.

Rod Library newsletter: Notes for the Stalled

Contents:

--Library Services Desk
--Creatures of Pointillism
--Bash in the Stacks
--One Search Expanded

Identity Through Clothing: Argentinian Vs. American Women, Magali Farfan

Apparel Merchandising and Product Development Undergraduate Honors Theses

According to Roach-Higgins, Eicher, and Johnson (1995), “individuals acquire identity through social, physical, and biological settings” (pg.12). When acquiring identity, culture plays a vital role. Because of numerous influences on identity, a conflict exists for those who identify with more than one culture. This study focuses specifically on the problems of women who identify both as Argentinian and American. The purpose of this creative project was to create an outfit that could be worn by an Argentinian/American woman in the presence of family and friends, regardless of culture, and not feel that she is disregarding societal norms of either culture. …

Single-Limb Landing Biomechanics Are Altered And Patellar Tendinopathy Related Pain Is Reduced With Acute Infrapatellar Strap Application, Adam B. Rosen, Jupil Ko, Cathleen N. Brown

Health and Kinesiology Faculty Publications

Background

Patellar tendinopathy, a common condition of the knee, is often treated with patellar tendon straps to control pain during dynamic activity. Little is known regarding their effect on pain, landing kinematics and kinetics with their application. The purpose of this study was to determine if patellar tendon straps influenced pain, kinematics at landing and ground reaction forces in individuals with patellar tendinopathy versus healthy controls.

Methods

Thirty participants with patellar tendinopathy and 30 controls participated. They completed single-limb landings with and without patellar tendon straps while pain, three-dimensional kinematics and vertical ground reaction forces were measured. A multivariate …

Nrg Oncology-Radiation Therapy Oncology Group Study 1014: 1-Year Toxicity Report From A Phase 2 Study Of Repeat Breast-Preserving Surgery And 3-Dimensional Conformal Partial-Breast Reirradiation For In-Breast Recurrence., Douglas W. Arthur, Kathryn A. Winter, Henry M. Kuerer, Bruce G. Haffty, Laurie W. Cuttino, Dorin A. Todor, Nicole L. Simone, Shelly B. Hayes, Wendy A. Woodward, Beryl Mccormick, Randi J. Cohen, Walter M. Sahijdak, Daniel J. Canaday, Doris R. Brown, Adam D. Currey, Christine M. Fisher, Reshma Jagsi, Julia White

Department of Radiation Oncology Faculty Papers

PURPOSE: To determine the associated toxicity, tolerance, and safety of partial-breast reirradiation.

METHODS AND MATERIALS: Eligibility criteria included in-breast recurrence occurring >1 year after whole-breast irradiation, <3 >cm, unifocal, and resected with negative margins. Partial-breast reirradiation was targeted to the surgical cavity plus 1.5 cm; a prescription dose of 45 Gy in 1.5 Gy twice daily for 30 treatments was used. The primary objective was to evaluate the rate of grade ≥3 treatment-related skin, fibrosis, and/or breast pain adverse events (AEs), occurring ≤1 year from re-treatment completion. A rate of ≥13% for these AEs in a cohort of 55 patients was …

Atmospheric Microbial Community Sampling System For Varying Altitude Collection, Kenneth David Domingue

Masters Theses

The study of airborne microbial communities in the vertical atmosphere is an area of research in which very little data has been collected and analyzed. Developing a vehicle to house biological sampling equipment that collects, and mitigates contamination is required by a team of biology researchers to perform sampling of atmospheric microbial communities. This study uses a sampler box that is attached to aerostatic vehicles: zero pressure balloons and tethered balloon/kite structures. Zero pressure balloons are used for sampling at altitudes above 150 m above sea level, and tethered balloon/kite structures are used for sampling at 30 m and 150 …

Math Department Newsletter, 2017, University Of Dayton. Department Of Mathematics

Department of Mathematics Newsletters

No abstract provided.

Geochemical Fractionation, Speciation, And Bioavailability Of Heavy Metals In Stream Sediments In Aurora, Mo, Miles Pearson

Graduate Theses/Dissertations

Stream sediments from Chat Creek in Aurora, MO, part of the former Tristate Mining District, were digested via a sequential extraction procedure modeled after the Tessier method. Prior sampling had shown elevated levels of zinc, lead, and cadmium in sediments located near former chat piles. Metals in sediments were divided into four geochemical fractions: 1) easily exchangeable, 2) carbonate-bound, 3) iron-manganese oxides-bound, and 4) organic matter-bound. The distribution of the metals within these fractions can help predict the bioavailability and speciation of said metals. The majority of metals were contained in the third and to a lesser extent the fourth …