Digital Commons Network^™

Whole Tumor Rna-Sequencing And Deconvolution Reveal A Clinically-Prognostic Pten/Pi3k-Regulated Glioma Transcriptional Signature, Yuan Pan, Erin C. Bush, Joseph A. Toonen, Yu Ma, Anne C. Solga, Peter A. Sims, David H. Gutmann

Open Access Publications

The concept that solid tumors are maintained by a productive interplay between neoplastic and non-neoplastic elements has gained traction with the demonstration that stromal fibroblasts and immune system cells dictate cancer development and progression. While less studied, brain tumor (glioma) biology is likewise influenced by non-neoplastic immune system cells (macrophages and microglia) which interact with neoplastic glioma cells to create a unique physiological state (glioma ecosystem) distinct from that found in the normal tissue. To explore this neoplastic ground state, we leveraged several preclinical mouse models of neurofibromatosis type 1 (NF1) optic glioma, a low-grade astrocytoma whose formation and maintenance …

Pengaruh Dosis Silika Terhadap Karakter Fisiologı Dan Hasil Tanaman Padi (Oryza Sativa L.) Kultivar Lokal Poso (Kultıvar 36-Super Dan Tagolu), Wan Priando Tampoma, Tati Nurmala, Meddy Rachmadi

Jurnal Kultivasi

Padi (Oryza sativa L.) merupakan salah satu jenis tanaman yang memegang peran penting di Indonesia dalam memenuhi kebutuhan pangan. Tanaman padi kultivar lokal merupakan salah satu jenis padi yang memiliki poduktivitas rendah. Pemberian silika pada pertanaman padi dapat membantu mengoptimalkan pertumbuhan dan hasil tanaman padi. Tujuan penelitian ini adalah untuk mengetahui pengaruh silika terhadap karakter agronomi kultivar lokal Poso. Rancangan percobaan yang digunakan dalam penelitian ini adalah menggunakan Rancangan Petak Terbagi (RPT). Faktor pertama sebagai petak utama terdiri dua taraf perlakuan yaitu K1 (Kultivar 36-Super) dan K2 (Kultivar Tagolu). Sedangkan faktor ke dua sebagai anak petak terdiri atas 4 taraf …

Respons Pertumbuhan Dan Hasil Benih Kentang G0 Di Dataran Medium Terhadap Waktu Dan Cara Aplikasi Paklobutrazol, Nuzula Suci Azima, Anne Nuraini, Sumadi, Jajang Sauman Hamdani

Jurnal Kultivasi

Aplikasi paklobutrazol pada penanaman kentang di dataran medium dapat mengurangi sintesis giberelin yang menyebabkan penurunan hasil kentang. Efektifitas paklobutrazol tidak hanya dipengaruhi oleh konsentrasi, tetapi juga waktu dan cara aplikasinya. Tujuan penelitian ini adalah untuk memperoleh waktu dan cara aplikasi paklobutrazol yang memberikan pengaruh paling baik dalam meningkatkan hasil benih kentang G0 di dataran medium. Rancangan penelitian menggunakan Rancangan Acak Kelompok (RAK) Faktorial dengan 3 ulangan. Perlakuannya terdiri dari waktu aplikasi paklobutrazol yaitu 28, 35 dan 42 HST (Hari Setelah Tanam) dan cara aplikasi paklobutrazol yaitu disemprot ke daun, disiram ke media tanam dan kombinasi antara penyemprotan ke daun dan …

An Exploration Of Rhythm Perception In African Penguins (Spheniscus Demersus), Irene A. Fobe

Theses

Rhythmic properties in penguin vocalizations may be unique to individuals. Rhythm perception is a cognitive ability previously thought to be exclusive to vocal-learning species who have the neurological complexities required to mimic conspecific and heterospecific vocalizations. Discovering rhythm perception in penguins would provide insight on penguins’ ability to recognize kin using auditory cues, and discount theories constraining rhythm perception to vocal-learning animals. The goal of this study was to learn if African penguins (Spheniscus demersus) could perceive changes in rhythm using a habituation-dishabituation paradigm. Subjects were 32-38 African penguins housed at the Seneca Park Zoo in Rochester, NY. Penguins were …

Exploring Gria2 Sequence Variations Using Virtual Reality, Jimmy Fan Zhang

Theses

The effective visualization and presentation of biological data is of critical importance to research scientists. The increasing rate at which experiments generate data has only exacerbated the problem. While bioinformatics datasets continue to increase in size and complexity, the shift to adopt new user interface (UI) paradigms has historically lagged. Consequently, a major bottleneck for analysis of next-generation sequencing data is the continued use of UIs primarily inspired from the 1990’s through the early 2000’s. This paper presents the novel use of virtual reality (VR) as a medium for visualizing genomic, transcriptomic and proteomic data. Using the Gria2 (GluR2 or …

Crying And Attachment Style: The Role Of Romantic Relationships, Katherine L. Fiori, Jessica Buthmann, Christy A. Denckla

Journal of Social, Behavioral, and Health Sciences

Crying is an attachment behavior that functions to elicit support from others (Nelson, 1998); the context in which the crying occurs is important in understanding whether it is adaptive or maladaptive (Hendriks & Vingerhoets, 2006). However, very little research has examined whether and how attachment style is associated with adult crying, and if this association might vary by an individual’s relationship status. Using a sample of 305 first-year college students and a series of hierarchical regressions, we examined the moderating effect of relationship status on the associations between attachment style (measured using the Revised Experiences in Close Relationships Scale; Fraley, …

Effect Of Cayratia Trifolia L (Domin) Extract On Reduced Expression Of Matrix Metalloproteinase-9 (Mmp–9) And Vascular Endothelial Growth Factor –A (Vegf-A) In White Rats With Breast Cancer, Devi Cynthia Dewi, I Ketut Sudiana

Folia Medica Indonesiana

The number of cancer cases in every year has increased. One effort in reducing breast cancer cases is by using anti-angiogenesis which could prevent the growth and metastasis of cancer cells. Xxx the process of angiogenesis and metastasis in cancer cells are associated with the expression of Matrixmetalloproteinase- 9 (MMP-9) and Vascular Endothelial Growth Factor (VEGF). To reduce metastasis in cancer cells, it can be performed by giving plant extracts Cayratiatrifolia L (Domin), containing the active compound Resveratrol, delphinidin/malvidin and Quercetin. The content of the chemical compound of these herbs has immunomodulatory effects, which could potentially prevent angiopoitin, FGF and …

Neurogenic Modulation By Neurokinin-1 Receptor Antagonist, Cp-96,345 To Inhibit Rheumatoid Arthritis Development In Adjuvant Induced Arthritis Rat Model, Yuyun Wirasasmita, Mahardian Rahmadi, Imam Susilo, Junaidi Khotib

Folia Medica Indonesiana

Rheumatoid arthritis (RA) is a chronic form of persistent inflammation. Meanwhile, Substance P is the most associated neuropeptide in neurogenic inflammation and hyperalgesia commonly found in chronic pain. Substance P act by binding to neurokinin-1 receptor. The present study was conducted to evaluate the effect of neurokinin-1 receptor antagonist (CP-96,345) on Adjuvant Induced Arthritis rat model, induced by Complete Freund's Adjuvant (CFA). The objective is to attenuate neurogenic inflammation which in turn will increase the latency time of hyperalgesia response, decreases neurokinin-1 receptor expression, and inhibits the development of RA in AIA rat model. Rats were intra-articularly injected with CFA …

Review Article: Does Intra-Arterial Heparin Flushing (Iahf) Can Actually Increase Manual Muscle Test (Mmt) Score In Chronic Ischemic Stroke Patients?, Moh Hasan Machfoed, Mohammad Kurniawan, Fritz Sumantri Usman

Folia Medica Indonesiana

Stroke is still a major health problem in the world. Ischemic stroke accounts for 87% of all acute stroke occurrences. In 2013, the American Heart Association (AHA)/American Stroke Association (ASA), published a Guideline for the Early Management of Patients with Acute Ischemic Stroke. The managements consist of the use of recombinant tissue plasminogen activator (rtPA), endovascular treatment, etc. Unlike acute ischemic stroke, until now, no guidelines have been provided about the management of chronic ischemic stroke that approved universally. The result of the study with the title of "Intra Arterial Heparin Flushing Increases Manual Muscle Test – Medical Research Councils …

Cubesat Active Thermal Control Via Microvascular Carbon Fiber Channel Radiator, Alexander Ghosh, Devin Bunce, Dawn Haken, Stephen Vrkljan, Tiago Silva, Grant Berland, Elwodd Agasid, David Mayer, Jeffery Feller, Patrick Haddox, James J. Cockrell

Small Satellite Conference

Small spacecraft rarely have space for any thermal control subsystems and often must perform operations in “burst” mode as a result. The few spacecraft who do have control rely on low-complexity thermal control systems which conduct heat to the bus structure and then radiate the heat away. These simplistic techniques are sufficient for low power missions in Low Earth Orbit (LEO) but are not capable of dumping the heat produced in new mission profiles that are in development. This is due to small spacecraft incorporating increasingly advanced subsystems which have difficult thermal control requirements such as propulsion systems or high-power …

The Tampon Tax: Sales Tax, Menstrual Hygiene Products, And Necessity Exemptions, Jennifer Bennett

The Business, Entrepreneurship & Tax Law Review

Women in the United States face many economic obstacles that their male counterparts do not. Many of these obstacles – including the wage gap, economic issues related to childbearing, and implicit bias in the workplace, among others – are the result of multiple political, social, and cultural factors, making them hard to eliminate. The tampon tax is comparatively simple to take on: if state legislatures decide to remove it, women will no longer have to pay it. The term “tampon tax” refers to how the majority of states impose a general sales tax on tampons, pads, reusable menstrual cups, and …

Hemiscorpius Shahii Sp. N. From Iran (Scorpiones: Hemiscorpiidae), František Kovařík, Shahrokh Navidpour, Michael E. Soleglad

Euscorpius

Hemiscorpius shahii sp. n. from Iran, Hormozgan Province, is described and compared with other species of Hemiscorpius genus. The new species is characterized mainly by total length of 84 (female) to 110.7 (male) mm and unique trichobothrial pattern of pedipalp patella. The number of external trichobothria on patella is 17–18 (5 eb, 4 esb, 2–3 em, 3 est, 3 et); the number of ventral trichobothria on patella is 14–16. This distinguishes H. shahii sp. n. from all other species of genus Hemiscorpius, which have 3 or 10–12 ventral trichobothria on patella, one or …

Personal Identity, Austin Baker

JCCC Honors Journal

What is the definition of what it means to be a person, what it means to be a human, and the differentiation between the two? Through deductive and inductive reasoning, the argument is made that there is only one universal person who is identical inside all of us and that it is actually our human qualities which make us unique. Similarities and differences are highlighted between the author’s person and the established philosophical views of personhood, including Buddhist, David Hume, Cartesian and Hindu philosophies on personal identity. The author suggests that the nature of human hood and the nature of …

Syncing Up: Autism And Communication, Katrell Westbrook

JCCC Honors Journal

According to CNN.com, 1 in 68 Americans is diagnosed with Autism currently. Autism is a range of conditions characterized by challenges with social skills, repetitive behaviors, speech and nonverbal communication, as well as by unique strengths and differences. (A. S. Editors, what is Autism) These difficulties in communication as aforementioned, is what the research found, is meant to highlight the advantages and tools needed to develop an inclusive and comprehensive social environment between those who are Autistic and their Neurotypical peers.

Informing and building awareness of what Autism is, how to communicate with Autistic individuals, and what methods professionals have …

Inactivation Of The Major Hemolysin Gene Influences Expression Of The Nonribosomal Peptide Synthetase Gene Swra In The Insect Pathogen Serratia Sp. Strain Scbi, Lauren M. Petersen, Kaitlyn Lacourse, Tim A. Schoner, Helge Bode, Louis S. Tisa

Molecular, Cellular & Biomedical Sciences

Hemolysins are important virulence factors for many bacterial pathogens, including Serratia marcescens. The role of the major hemolysin gene in the insect pathogen Serratia sp. SCBI was investigated using both forward and reverse genetics approaches. Introduction of the major hemolysin gene into Escherichia coli resulted in a gain of both virulence and hemolytic activity. Inactivation of this hemolysin in Serratia sp. SCBI resulted in loss of hemolysis, but did not attenuate insecticidal activity. Unexpectedly, inactivation of the hemolysin gene in Serratia sp. SCBI resulted in significantly increased motility as well as increased antimicrobial activity. qRT-PCR analysis of mutants with a …

Metrology Of Dna Arrays By Super-Resolution Microscopy, Christopher M. Green, Kelly Schutt, Noah Morris, Reza M. Zadegan, William L. Hughes, Wan Kuang, Elton Graugnard

Materials Science and Engineering Faculty Publications and Presentations

Recent results in the assembly of DNA into structures and arrays with nanoscale features and patterns have opened the possibility of using DNA for sub-10 nm lithographic patterning of semiconductor devices. Super-resolution microscopy is being actively developed for DNA-based imaging and is compatible with inline optical metrology techniques for high volume manufacturing. Here, we combine DNA tile assembly with state-dependent super-resolution microscopy to introduce crystal-PAINT as a novel approach for metrology of DNA arrays. Using this approach, we demonstrate optical imaging and characterization of DNA arrays revealing grain boundaries and the temperature dependence of array quality. For finite arrays, analysis …

Forms Of Science Capital Mobilized In Adolescents’ Engineering Projects, Amy Wilson-Lopez, Christina M. Sias, Allen Smithee, Indhira María Hasbún

Teacher Education and Leadership Faculty Publications

The purpose of this multiple case study was to identify the forms of science capital that six groups of adolescents mobilized toward the realization of their self-selected engineering projects during after-school meetings. Research participants were high school students who self-identified as Hispanic, Latina, or Latino; who had received English as a Second Language (ESL) services; and whose parents or guardians had immigrated to the United States and held working class jobs. The research team used categories from Bourdieusian theories of capital to identify the forms of science capital mobilized by the participants. Data sources included transcripts from monthly interviews and …

Cic Meeting Minutes, Georgia Southern University Consolidation Implementation Committee

Armstrong State & Georgia Southern Consolidation: Implementation Committee (Archived)

These are the meeting minnutes from the Georgia Southern University and Armstrong State University Consolidation Implementation Meeting.

The Influence Of Socialization On The Acculturation Of Vietnamese American Adolescents, Nicole Citerella

CUP Ed.D. Dissertations

Acculturation is the process of cultural change (Berry, Phinney, Sam, & Vedder, 2010). The influence of socialization on acculturation using Berry’s (1980) theory of acculturation was examined. According to Berry’s (1980) theory the process of acculturation includes maintenance of the heritage culture and contact participation in the host culture. Information was collected from an examination of individual interviews of nine adolescent, first-, second-, or third-generation Vietnamese American participants, ages 12–14, from two public middle schools in the United States. An analysis of the data produced four themes under maintenance of the heritage culture: religious influence, cultural awareness, family experience, and …

Polymer Nanoassemblies With Hydrophobic Pendant Groups In The Core Induce False Positive Sirna Transfection In Luciferase Reporter Assays, Steven Rheiner, Derek Alexander Reichel, Piotr G. Rychahou, Tadahide Izumi, Hsin-Sheng Yang, Younsoo Bae

Pharmaceutical Sciences Faculty Publications

Poly(ethylene glycol)-conjugated polyethylenimine (PEG-PEI) is a widely studied cationic polymer used to develop non-viral vectors for siRNA therapy of genetic disorders including cancer. Cell lines stably expressing luciferase reporter protein typically evaluate the transfection efficacy of siRNA/PEG-PEI complexes, however recent findings revealed that PEG-PEI can reduce luciferase expression independent of siRNA. This study elucidates a cause of the false positive effect in luciferase assays by using polymer nanoassemblies (PNAs) made from PEG, PEI, poly-(L-lysine) (PLL), palmitate (PAL), and deoxycholate (DOC): PEG-PEI (2P), PEG-PEI-PAL (3P), PEG-PLL (2P′), PEG-PLL-PAL (3P′), and PEG-PEI-DOC (2PD). In vitro transfection and western blot assays of luciferase …

Cic Meeting Consent Agenda, Georgia Southern University Consolidation Implementation Committee

Armstrong State & Georgia Southern Consolidation: Implementation Committee (Archived)

This is the consent agenda for the Georgia Southern University and Armstrong State University Consolidation Implementation Meeting.

Evaluation Framework For Effective Hiv/Public Health Programming In Nigeria, Saheed Ottun

Capstone Collection

Evaluation is a buzzword in the field of development. How can one ensure the incorporation of effective monitoring and assessment framework in HIV/AIDS and public health programming that will impact positively on the reproductive health of young adults in Nigeria? In most public corporations in Nigeria, there is hardly any conscious effort on the part of the government to conduct either process evaluation or impact assessment on various government projects and policy, especially on HIV/public health programming. This course-linked capstone thematically illustrated the current state of the problem by providing in-depth analysis of the degree of HIV impact on the …

The Effect Of An Increase In Lead In The Water System On Fertility And Birth Outcomes: The Case Of Flint, Michigan, Daniel Grossman, David J.G. Slusky

Economics Faculty Working Papers Series

Flint changed its public water source in April 2014, increasing lead exposure. The effects of lead in water on fertility and birth outcomes are not well established. Exploiting variation in the timing of births we find fertility rates decreased by 12%, fetal death rates increased by 58% (a selection effect from a culling of the least healthy fetuses), and overall health at birth decreased (from scarring), compared to other cities in Michigan. Given recent efforts to establish a registry of residents exposed, these results suggests women who miscarried, had a stillbirth or had a newborn with health complications should register.

Assessing The Influence Of Temporal Autocorrelations On The Population Dynamics Of A Disturbance Specialist Plant Population In A Random Environment, Eric A. Eager, Diana Pilson, Helen M. Alexander, Brigitte Tenhumberg

School of Biological Sciences: Faculty Publications

Biological populations are strongly influenced by random variations in their environment, which are often autocorrelated in time. For disturbance specialist plant populations, the frequency and intensity of environmental stochasticity (via disturbances) can drive the qualitative nature of their population dynamics. In this article, we extended our earlier model to explore the effect of temporally autocorrelated disturbances on population persistence. In our earlier work, we only assumed disturbances were independent and identically distributed in time. We proved that the plant seed bank population converges in distribution, and we showed that the mean and variance in seed bank population size were both …

Developmental Trauma Disorder & Effective Therapeutic Interventions, Ellena C. Rosenthal

University Honors Theses

In 2005 The Complex Trauma Task force, which is part of the National Child Traumatic Stress Network, constructed diagnostic criteria for a new diagnosis: Developmental Trauma Disorder (DTD). DTD serves as a more precise, accurate, and specific diagnosis for children and adolescents who’ve experienced multiple exposures to one or more developmentally adverse interpersonal traumas, which affect multiple areas of functioning and cause extreme interruptions in developmental processes throughout the course of one’s life. A diagnosis of DTD describes the immense impairments and distress that characterize individuals living with developmental trauma, and provides clinicians a foundation and trauma-informed framework for working …

A Life Course Examination Of The Physical Environmental Determinants Of Physical Activity Behaviour: A “Determinants Of Diet And Physical Activity” (Dedipac) Umbrella Systematic Literature Review, Angela Carlin, Camille Perchoux, Anna Puggina, Katina Aleksovska, Christoph Buck, Con Burns, Greet Cardon, Simon Chantal, Donatella Ciarapica, Giancarlo Condello, Tara Coppinger, Cristina Cortis, Sara D’Haese, Marieke De Craemer, Andrea Di Blasio, Sylvia Hansen, Licia Iacoviello, Johann Issartel, Pascal Izzicupo, Lina Jaeschke, Martina Kanning, Aileen Kennedy, Jeroen Lakerveld, Fiona Chun Man Ling, Agnes Luzak, Giorgio Napolitano, Julie Anne Nazare, Tobias Pischon, Angela Polito, Alessandra Sannella, Holger Schulz, Rhoda Sohun

Publications

Background: Participation in regular physical activity is associated with a multitude of health benefits across the life course. However, many people fail to meet PA recommendations. Despite a plethora of studies, the evidence regarding the environmental (physical) determinants of physical activity remains inconclusive. Objective: To identify the physical environmental determinants that influence PA across the life course. Methods: An online systematic literature search was conducted using MEDLINE, ISI Web of Science, Scopus and SPORTDiscus. The search was limited to studies published in English (January 2004 to April 2016). Only systematic literature reviews (SLRs) and meta-analyses (MAs) of observational studies, that …

Interview With Eric Jensen: Enriching Mindsets For Teachers Of Students In Poverty, Dan W. Rea

National Youth Advocacy & Resilience Journal

In this interview, Eric Jensen, an internationally recognized speaker and writer on student poverty and brain-based learning, discusses how the educational mindsets and practical strategies from his latest two books, Poor Students, Rich Teaching: Mindsets for Change (2016) and Poor Students, Richer Teaching: Mindsets for Change (2017), can enrich the learning of students in poverty. Some of the new mindsets include how to enrich classroom relationships, student achievement, student engagement, and school climate for student success.

Trade-Offs: The Production Of Sustainability In Households, Kirstin Marie Elizabeth Munro

Dissertations and Theses

Over the past half-century, environmental problems have become increasingly serious and seemingly intractable, and a careless, clueless, or contemptuous consumer is often portrayed as the root cause of this environmental decline. This study takes a different approach to evaluating the demand for resources by households, assessing possible pro-environmental paths forward through a study of highly ecologically-conscious households. By modeling "green" households as producers of sustainability rather than consumers of environmental products, the sustainability work that takes place in households is brought into focus. An investigation of household sustainability production makes possible the evaluation of the trade-offs inherent in these pro-environmental …

Layers Of Estrangement: Social-Emotional And Educational Implications Of Homelessness On K–12 Students, Rajni Shankar-Brown

National Youth Advocacy & Resilience Journal

This qualitative case study examines and illuminates the social-emotional and educational experiences of children ages 5 to 18 residing in an urban, family emergency housing shelter located in the Southeastern region of the United States. Data were collected and triangulated through participant observations, semi-structured interviews, and document analysis. Findings revealed deep educational estrangement and adverse impacts on the social-emotional development of children and youth experiencing homelessness. The study suggests an urgent need to provide high-quality educational preparation to public school administrators and teachers working with children living in poverty and experiencing homelessness in the U.S. With persistent and rising child …

Guided Imagery: A Technique To Benefit Youth At Risk, Lisa M. Skeens

National Youth Advocacy & Resilience Journal

Guided imagery is a valuable intervention strategy that can benefit children who are at risk for social, academic, and mental health problems. Guided imagery is a technique that employs imagination, emotions, and a spectrum of bodily senses (Naparstek, 1994). This particular technique can be applied in community and academic settings to help enhance self-efficacy and mental health functioning for youth at risk. The need to implement creative interventions for youth can be overlooked by the chaos of poverty and social problems in vulnerable communities. Many schools and community agencies carry the burden of managing daily crises with few resources. This …