Digital Commons Network^™

Efficacy And Safety Of Abatacept, A T-Cell Modulator, In A Randomised, Double-Blind, Placebo-Controlled, Phase Iii Study In Psoriatic Arthritis, Philip Mease, Alice Gottlieb, D Van Der Heijde, O Fitzgerald, A Johnsen, M Nys, S Banerjee, D Gladman

NYMC Faculty Publications

OBJECTIVES: To assess the efficacy and safety of abatacept, a selective T-cell costimulation modulator, in a phase III study in psoriatic arthritis (PsA). METHODS: This study randomised patients (1:1) with active PsA (~60% with prior exposure to a tumour necrosis factor inhibitor) to blinded weekly subcutaneous abatacept 125 mg (n=213) or placebo (n=211) for 24 weeks, followed by open-label subcutaneous abatacept. Patients without >/=20% improvement in joint counts at week 16 were switched to open-label abatacept. The primary end point was the proportion of patients with >/=20% improvement in the American College of Rheumatology (ACR20) criteria at week 24. RESULTS: …

The Link Between Foster Youth And Teachers Using Empowerment: Do Trusting Relationships Improve Outcomes?, Rosio Hernandez

Electronic Theses, Projects, and Dissertations

This study presents findings on elementary teacher’s relationship with foster youth, whether teachers are able to use an empowerment approach to build trust and improve outcomes. This study was quantitative and measured the key variables through a descriptive design. Specifically using Qualtrics which tested the key variables of empowerment, trust, and improved outcomes. Also, Qualtrics described the findings through bar graphs and the researcher interpreted this through univariate statistics specifically. Significant findings were found towards teachers making a positive impact on foster youth.

Anti-Staphylococcal Activity Of Variovorax Paradoxus Eps, Patricia Holt-Torres

Electronic Theses, Projects, and Dissertations

Variovorax paradoxus EPS is a gram-negative rod isolated from the sunflower rhizosphere at CSUSB. Preliminary research has shown that Variovorax paradoxus EPS has anti-staphylococcal activity in liquid and solid co-culture. Anti-staphylococcal activity of Wild type and V. paradoxus EPS 𝚫4519 on 0.5% YE agar with embedded S. aureus AH1710 supports the idea that a soluble molecule is responsible for this activity, as the agar acted as a physical barrier between V. paradoxus EPS and S. aureus colonies. Preliminary genetic analysis of V. paradoxus EPS identified three loci that suitable candidates for the synthesis of a potential anti-staphylococcal small molecule. …

The Role Of Efferent Reduction Of Cochlear Compression In The Detection Of Tones In Noise, Shaum Bhagat, Anusha Yellamsetty

Faculty Publications

Stimulation of medial olivocochlear (MOC) efferent neurons reduces basilar membrane (BM) sensitivity and increases the slope of BM input-output (I/O) functions in animal models. Decreased compression of I/O functions associated with activation of MOC efferent neurons may assist in extending the neural response to the tone above that of noise, leading to an improvement in masked thresholds. To evaluate this hypothesis, the distortion-product otoacoustic emission (DPOAE) I/O function, a proxy measure of BM compression, was examined in conditions with presentation of contralateral noise. DPOAE I/O functions were measured at f2 frequencies of 1000 and 2000 Hz in 16 normal-hearing adults. …

Statistical Models For Single Molecule Localization Microscopy, Ahmed Elmokadem

Doctoral Dissertations

Single-molecule localization microscopy (SMLM) has revolutionized the field of cell biology. It allowed scientists to break the Abbe diffraction limit for fluorescence microscopy and got it closer to the electron microscopy resolution but still it faced some serious challenges. Two of the most important of these are the sample drift and the measurement noise problems that result in lower resolution images. Both of these problems are generally unavoidable where the sample drift is a natural mechanical phenomenon that occurs during the long time of image acquisition required for SMLM (Geisler et al. 2012) while the measurement noise, which arises from …

Greder Wins Starkey Award For Service, University Communications

News and Events (Discontinued Series)

No abstract provided.

Song Rhythm Development In Zebra Finches, Julia Hyland Bruno

Dissertations, Theses, and Capstone Projects

This dissertation investigates song-rhythm learning in songbirds. Songbirds have been studied extensively in mechanistic investigations into the sensorimotor underpinnings of the cultural transmission of learned vocalizations. While several studies identified forebrain song-system neurons that generate rhythmic song patterns, we know little about how song rhythms are learned. The first part of the dissertation describes methods for detecting and analyzing birdsong rhythm patterns, and demonstrates their utility for identifying the role of song rhythms in social interactions. Results suggest that rhythm plasticity in zebra finch song may provide a potential vehicle for communication. Controlled song-learning experiments further found that developing zebra …

The Fight For Legal Recognition Of Same-Sex Parenting Rights In The United States, Nancy Tresil

Dissertations, Theses, and Capstone Projects

This thesis focuses on how same sex couples within the United States claim specific parenting rights and to what extent can law promote social change. Since certain beliefs, values, and behaviors are accepted by some cultural groups or organizations in a society, many same sex couples believe that they should obtain an equal amount of legal entitlement instead of being limited or restricted from certain rights. The theoretical approach incorporates the concepts of legal consciousness and the importance of legal recognition. Legal consciousness is a form of legal awareness and empowerment of people involving issues in regards to the law. …

Parental Influence On Second Generation Chinese-American Youth’S Career Choice And Development, Yingli Huang

Dissertations, Theses, and Capstone Projects

A large body of literature supports the claim that the role of parents in shaping Asian-American youth's career development is significant (Leong & Serafica, 1995; Leong & Hardin, 2002; Yuan, 2012; Sandhu, 2017; Qin, 2011). When considering the family impact on Asian-Americans’ vocational choices, researchers should examine the phenomena through culturally specific lens so that variables that are more cultural relevant are captured. This is a pilot study with the goal to provide a preliminary understanding of the ways in which first-generation Chinese immigrant parents influence the choice and development of a career to their second-generation young adult children. In …

Labeling Histories: Mental Disability In American Schooling, Kylah Torre

Dissertations, Theses, and Capstone Projects

The purpose of the study is to examine the effect that dominant cultural schemas (norms) had on the educational outcomes and identity formation of students with mental disabilities. Through an examination of histories of psychology and public schooling in the United States, as well as oral history interviews with 7 participants, the research investigates how these cultural schemas have shifted over time and what role students with mental disabilities have played in reproducing or resisting schemas which marked them as deficient. Sewell’s (1992) theory of structure and agency, Disability Studies theory, and theories of labeling and intersectionality are utilized to …

Stereospecific Electrophilic Fluorination Of Alkylcarbastannatrane Reagents, Xinghua Ma

Dissertations, Theses, and Capstone Projects

The introduction of fluorine atoms into organic molecules significantly changes their physical, chemical, and biological properties. Fluorinated organic compounds are used as pharmaceuticals, agrochemicals, materials, and tracers for positron emission tomography (PET). For example, the site-specific fluorination of drugs can block sites of phase I metabolism by cytochrome P450 enzymes as well as improve target-binding affinities. In view of the unique features of fluorine-containing compounds, there has been increasing interest in the development of novel methods for the synthesis of fluorinated molecules, especially the site-specific monofluorination of complex molecules. Herein, we present the enantiospecific conversion of chiral secondary alkylcarbastannatranes into …

Comparison Of Proteomic Profiles Of The Venoms Of Two Of The 'Big Four' Snakes Of India, The Indian Cobra (Naja Naja) Andthe Common Krait (Bungarus Caeruleus), And Analyses Of Their Toxins, Manisha Choudhury, Ryan J.R. Mccleary, Manish Kesherwani, R. Manjunatha Kini, Devadasan Velmurugan

Biology Faculty Publications

Snake venoms are mixtures of biologically-active proteins and peptides, and several studies have described the characteristics of some of these toxins. However, complete proteomic profiling of the venoms of many snake species has not yet been done. The Indian cobra (Naja naja) and common krait (Bungarus caeruleus) are elapid snake species that are among the ‘Big Four’ responsible for the majority of human snake envenomation cases in India. As understanding the composition and complexity of venoms is necessary for successful treatment of envenomation in humans, we utilized three different proteomic profiling approaches to characterize these venoms: i) one-dimensional SDS-PAGE coupled …

The Nuclear And Mitochondrial Genomes Of The Facultatively Eusocial Orchid Bee Euglossa Dilemma, Philipp Brand, Nicholas Saleh, Hailin Pan, Cai Li, Karen M. Kapheim, Santiago R. Ramírez

Biology Faculty Publications

Bees provide indispensable pollination services to both agricultural crops and wild plant populations, and several species of bees have become important models for the study of learning and memory, plant–insect interactions, and social behavior. Orchid bees (Apidae: Euglossini) are especially important to the fields of pollination ecology, evolution, and species conservation. Here we report the nuclear and mitochondrial genome sequences of the orchid bee Euglossa dilemma Bembé & Eltz. E. dilemma was selected because it is widely distributed, highly abundant, and it was recently naturalized in the southeastern United States. We provide a high-quality assembly of the 3.3 Gb genome, …

Issue 13

The Synapse: Intercollegiate science magazine

No abstract provided.

Impact Of Habitat Degradation On Species Diversity And Nest Abundance Of Five African Stingless Bee Species In A Tropical Rainforest Of Kenya, Nkoba Kiatoko, Suresh Kumar Raina, Frank Van Langevelde

All Peer-Reviewed Publications

Natural habitat degradation often involves the reduction or disappearance of bee species. In Africa, stingless bees are hunted for honey, which is used as food, for medicinal purposes, and for traditional rituals. Severe habitat degradation due to human settlement is hypothesized to have a negative impact on the species diversity of the African stingless bee species. In this paper, we assess the impact of habitat degradation on the diversity of five stingless bee species across different habitats in the tropical rainforest of Kenya (indigenous forest, mixed indigenous forest) and its neighbouring landscape (grassland, village) in western Kenya. The species fauna, …

Readiness For Antimicrobial Resistance (Amr) Surveillance In Pakistan; A Model For Laboratory Strengthening, Dania Khalid Saeed, Rumina Hasan, Mahwish Naim, Afia Zafar, Erum Khan, Kauser Jabeen, Seema Irfan, Imran Ahmed Haq, Mohammad Zeeshan, Zabin Wajidali, Joveria Farooqi, Sadia Shakoor, Abdul Chagla, Jason Rao

Department of Pathology and Laboratory Medicine

Background: Limited capacity of laboratories for antimicrobial susceptibility testing (AST) presents a critical diagnostic bottleneck in resource limited countries. This paper aims to identify such gaps and to explore whether laboratory networks could contribute towards improving AST in low resource settings.
Methods: A self-assessment tool to assess antimicrobial susceptibility testing capacity was administered as a pre-workshop activity to participants from 30 microbiology laboratories in 3 cities in Pakistan. Data from public and private laboratories was analyzed and capacity of each scored in percentage terms. Laboratories from Karachi were invited to join a support network. A cohort of five laboratories that …

Readiness For Antimicrobial Resistance (Amr) Surveillance In Pakistan; A Model For Laboratory Strengthening, Dania Khalid Saeed, Rumina Hasan, Mahwish Naim, Afia Zafar, Erum Khan, Kauser Jabeen, Seema Irfan, Imran Ahmed Haq, Mohammad Zeeshan, Zabin Wajidali, Joveria Farooqi, Sadia Shakoor, Abdul Chagla, Jason Rao

Department of Pathology and Laboratory Medicine

Background: Limited capacity of laboratories for antimicrobial susceptibility testing (AST) presents a critical diagnostic bottleneck in resource limited countries. This paper aims to identify such gaps and to explore whether laboratory networks could contribute towards improving AST in low resource settings.
Methods: A self-assessment tool to assess antimicrobial susceptibility testing capacity was administered as a pre-workshop activity to participants from 30 microbiology laboratories in 3 cities in Pakistan. Data from public and private laboratories was analyzed and capacity of each scored in percentage terms. Laboratories from Karachi were invited to join a support network. A cohort of five laboratories that …

On Copyright And Scientific Theory, Thomas M. Byron

Santa Clara High Technology Law Journal

On Copyright and Scientific Theory

Smoking, Adhd, And Problematic Video Game Use: A Structural Modeling Approach, Hyo Jin Lee

Loma Linda University Electronic Theses, Dissertations & Projects

Problematic video game use (PVGU), or addiction-like use of video games, is associated with negative physical and mental health problems as well as problems in social and occupational functioning. Possible contributors to PVGU include frequency of play, cigarette smoking, and ADHD. The aim of the current study was to explore the relationships among PVGU, cigarette smoking, ADHD, and frequency of play simultaneously using a structural modeling approach. Secondary data analysis was conducted on 2,801 video game users (Mage = 22.43 years, SDage = 4.7; 93% male) who completed an online survey comprising measures of PVGU, ADHD symptomatology, smoking behavior, and …

The Role Of Temporal Distraction On Short-Term Memory And Delayed Recognition, Susanna Luu

Loma Linda University Electronic Theses, Dissertations & Projects

Memory is a complex process that requires the translation of information from an external sensory experience into an internal representation. Once information has been translated into memory, there is little agreement regarding the cognitive structure of memory storage and maintenance. Baddeley (1966) developed a model based on a multi-storage structure which suggested that as information entered through the sensory system, it was relayed by a cognitive control center and placed into storage units based on information type (i.e. auditory, visual, etc.). Baddeley’s (1966) multi-store memory model hypothesized that content translated into memory by two phases: short-term and long-term memory. More …

Galaxy Rotations From Quantised Inertia And Visible Matter Only, Me Mcculloch

School of Biological and Marine Sciences

It is shown here that a model for inertial mass, called quantised inertia, or MiHsC (Modified inertia by a Hubble-scale Casimir effect) predicts the rotational acceleration of the 153 good quality galaxies in the SPARC dataset (2016 AJ 152 157), with a large range of scales and mass, from just their visible baryonic matter, the speed of light and the co-moving diameter of the observable universe. No dark matter is needed. The performance of quantised inertia is comparable to that of MoND, yet it needs no adjustable parameter. As a further critical test, quantised inertia uniquely predicts a specific increase …

Demonstrating The Applicability Of Robust Decision Making (Rdm) To Conservation Decision-Making Under Uncertain Future Climate: Pilot Study Using The Northern Pygmy Salamander (Desmognathus Organi)., C Parmesan

School of Biological and Marine Sciences

Climate change challenges conservation planners in making decisions about habitat site selection and augmentation. This pilot study explores the use of Robust Decision Making (RDM), a decision analytic approach employed in water and coastal management, for conservation decision-making. It employs the RDM approach to design a theoretical decision experiment that compares the differences in performance between stylized static and adaptive land purchase strategies that notionally aim to protect additional habitat for Desmognathus organi, a salamander in the south central Appalachians, under uncertain future climate conditions. The static strategy purchases a specific parcel of land in the present, whereas the adaptive …

Cyber-Empathic Design: A Data-Driven Framework For Product Design, Dipanjan Ghosh, Andrew Olewnik, Kemper Lewis, Junghan Kim, Arun Lakshaman

Research Collection Lee Kong Chian School Of Business

A critical task in product design is mapping information from consumer to design space. Currently, this process largely depends on designers identifying and mapping psychological and consumer level factors to engineered attributes. In this way, current methodologies lack provision to test a designer's cognitive reasoning and could introduce bias when mapping from consumer to design space. In addition, current dominant frameworks do not include user-product interaction data in design decision making, nor do they assist designers in understanding why a consumer has a particular perception about a product. This paper proposes a framework-cyber-empathic (CE) design-where user-product interaction data are acquired …

Community Engagement Through An Environmental Studies Lens, Jane T. Costlow

All Faculty Scholarship

Situated within a state strongly identified with pristine nature, our central Maine campus provides a fabulous "laboratory" for both environmental science and civic engagement. To take full advantage of this fortunate situation, Bates College's Environmental Studies (ES) program includes community civic engagement in many, if not all, of our classes and major requirements. Questions about community, diversity, and civic life help our students grapple with the complexity of environmental challenges, pushing them to consider the many kinds of knowledge essential to addressing problems at both local and more global scales. We strongly believe that a liberal arts environmental education can …

From Microscope To Management: The Critical Value Of Plankton Taxonomy To Marine Policy And Biodiversity Conservation, Abigail Mcquatters-Gollop, David G. Johns, Eileen Bresnan, Jennifer Skinner, Isabelle Rombouts, Rowena Stern, Anaïs Aubert, Marie Johansen, Jacob Bedford, Antony Knights

School of Biological and Marine Sciences

Taxonomic information provides a crucial understanding of the most basic component of biodiversity – which organisms are present in a region or ecosystem. Taxonomy, however, is a discipline in decline, at times perceived as ‘obsolete’ due to technical advances in science, and with fewer trained taxonomists and analysts emerging each year to replace the previous generation as it retires. Simultaneously, increasing focus is turned towards sustainable management of the marine environment using an ecosystem approach, and towards conserving biodiversity, key species, and habitats. Sensitive indicators derived from taxonomic data are instrumental to the successful delivery of these efforts. At the …

Amlexanox Enhances Premature Termination Codon Read-Through In Col7a1 And Expression Of Full Length Type Vii Collagen: Potential Therapy For Recessive Dystrophic Epidermolysis Bullosa., Velina S. Atanasova, Qiujie Jiang, Marco Prisco, Christina Gruber, Josefina Piñón Hofbauer, Mei Chen, Cristina Has, Leena Bruckner-Tuderman, John A. Mcgrath, Jouni Uitto, Andrew P. South

Department of Dermatology and Cutaneous Biology Faculty Papers

Recessive dystrophic epidermolysis bullosa (RDEB) is a rare monogenic blistering disorder caused by the lack of functional type VII collagen, leading to skin fragility and subsequent trauma-induced separation of the epidermis from the underlying dermis. A total of 46% of patients with RDEB harbor at least one premature termination codon (PTC) mutation in COL7A1, and previous studies have shown that aminoglycosides are able to overcome RDEB PTC mutations by inducing "read-through" and incorporation of an amino acid at the PTC site. However, aminoglycoside toxicity will likely prevent widespread clinical application. Here the FDA-approved drug amlexanox was tested for its ability …

An Open Letter To Prof. Eduardo Echeverria, Roy A. Clouser

Pro Rege

Editor's Note: Dr. Roy Clouser's letter is a response to Dr. Eduardo Echeverria's article in Pro Rege, vol. 45, no. 1, September 2016.

Consolidation Review Committee, Bob Jackson

Faculty Senate: Index

No abstract provided.

2484: Establishment Of The Tennessee-Sickle Cell Disease Network As A Mechanism For Engaging A Rare Disease Population In Patient Centered Outcomes Research, Tilicia Mayo-Gamble, Velma Mcbride Murry, Michael R. Debaun

Health Policy & Community Health: Faculty Publications

OBJECTIVES/SPECIFIC AIMS: Despite the high prevalence of individuals diagnosed with sickle cell disease (SCD) in Tennessee, comprehensive care and education for patients with SCD is not as widely available as healthcare services for individuals managing other chronic illnesses. We aimed to engage SCD stakeholders in patient-centered outcomes research (PCOR) as a mechanism for advancing care and translational research for this rare disease population. METHODS/STUDY POPULATION: Through a partnership with the Sickle Cell Foundation of Tennessee, we implemented Community Health Ambassadors to systematically engage patient partners with SCD and their caregivers, aged 18–50 from rural and urban communities throughout Tennessee, in …

University Honors Program Newsletter, Honors College, Georgia Southern University

Honors College: News & Publications (2008-2020)

• Honors Art Receives a Standing Ovation
• Competition in the Community
• Honors in Action: Summer Research