Digital Commons Network^™

The 9th Conference On Metal Toxicity And Carcinogenesis: The Conference Overview, James T. F. Wise, Lei Wang, Zhuo Zhang, Xianglin Shi

Pharmacology and Nutritional Sciences Faculty Publications

Heavy metals, such as arsenic, chromium, cadmium, nickel, mercury, and uranium are known to cause many human diseases and health complications after occupational or environmental exposure. Consequently, metals are environmental health concerns. This manuscript is an overview of the 9th Conference on Metal Toxicity and Carcinogenesis held in October 2016 in Lexington, Kentucky. Since 2000, this biennial meeting brings together experts in the field to discuss current and prospective research in an effort to advance research pertaining to metal toxicity and carcinogenesis. In this review we summarize the major topics discussed and provide insight regarding current research in the field …

Um Disaster Mental Health Expert Offers Advice For Hurricane Survivors, Sarah Sapp

University of Mississippi News

Department of Social Work offers tips to those affected by recent storms

September 15, 2017, The Dakota Student

The Dakota Student

No abstract provided.

Gucy2c Signaling Opposes The Acute Radiation-Induced Gi Syndrome., Peng Li, Evan Wuthrick, Jeff A. Rappaport, Crystal Kraft, Jieru E. Lin, Glen Marszalowicz, Adam E. Snook, Tingting Zhan, Terry M. Hyslop, Scott A. Waldman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

High doses of ionizing radiation induce acute damage to epithelial cells of the gastrointestinal (GI) tract, mediating toxicities restricting the therapeutic efficacy of radiation in cancer and morbidity and mortality in nuclear disasters. No approved prophylaxis or therapy exists for these toxicities, in part reflecting an incomplete understanding of mechanisms contributing to the acute radiation-induced GI syndrome (RIGS). Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. Here, we reveal a role for the GUCY2C paracrine axis in compensatory mechanisms opposing RIGS. …

Posttranscriptional Regulation Of Parg Mrna By Hur Facilitates Dna Repair And Resistance To Parp Inhibitors, Saswati N. Chand, Mahsa Zarei, M. J. Schiewer, Akshay R. Sanan, Carmella Romeo, Shruti Lal, Joseph A. Cozzitorto, Avinoam Nevler, Laura Scolaro, Eric R. Londin, Wei Jiang, Nicole Meisner-Kober, Michael J. Pishvaian, Karen E. Knudsen, Charles Yeo, John M Pascal, Jordan M. Winter, Jonathan R. Brody

Department of Surgery Faculty Papers

The majority of pancreatic ductal adenocarcinomas (PDAC) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer growth and progression. Here, we show that CRISPR-Cas9–mediated silencing of the HuR locus increases the relative sensitivity of PDAC cells to PARP inhibitors (PARPi). PDAC cells treated with PARPi stimulated translocation of HuR from the nucleus to the cytoplasm, specifically promoting stabilization of a new target, poly (ADP-ribose) glycohydrolase (PARG) mRNA, by binding a unique sequence embedded in its 3⁰ untranslated region. HuR-dependent upregulation of PARG expression facilitated DNA repair via hydrolysis of polyADP-ribose on related repair proteins. Accordingly, strategies to …

Health Promotion And Nursing In Cuba, Debra Pettit Whisenant, Alice L. March

Biennial Convention (CONV)

The purpose is to provide information regarding the organization and functioning of the Cuban health care system. We will examine how nurses are educated and practice. We will discuss our preconceived ideas about health care in Cuba and how those were altered by an actual visit to the country.

September 15, 2017, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Climate Controls Over The Net Carbon Uptake Period And Amplitude Of Net Ecosystem Production In Temperate And Boreal Ecosystems, Zheng Fu, Paul C. Stoy, Yiqi Luo, Jiquan Chen, Jian Sun, Leonardo Montagnani, Georg Wohlfahrt, Abdullah F. Rahman, Serge Rambal, Christian Bernhofer

School of Earth, Environmental, & Marine Sciences Faculty Publications

Highlights

• The start of net C uptake was determined by spring temperature in DBF and EF.

• Summer precipitation determined NEPmax anomalies in DBF and GRA.

• Climate controls annual NEP variability by regulating CUP and NEPmax.

Abstract

The seasonal and interannual variability of the terrestrial carbon cycle is regulated by the interactions of climate and ecosystem function. However, the key factors and processes determining the interannual variability of net ecosystem productivity (NEP) in different biomes are far from clear. Here, we quantified yearly anomalies of seasonal and annual NEP, net carbon uptake period (CUP), and the maximum daily NEP (NEPmax) …

Evidence For The Early Onset Of The Ipswichian Thermal Optimum: Palaeoecology Of Last Interglacial Deposits At Whittlesey, Eastern England, H Langford, S Boreham, Rm Briant, Gr Coope, Et Al

School of Geography, Earth and Environmental Sciences

Fossiliferous deposits infilling a channel at Whittlesey, eastern England, are dated by amino acid racemization to the Last Interglacial, and pollen analysis indicates deposition in Ipswichian biozones Ip Ib and Ip IIb. Multidisciplinary palaeoenvironmental analyses of these deposits provide a rare insight into Ip Ib subzone conditions. Specifically, the Ip Ib deposits contain exotic thermophiles Naias minor, Belgrandia marginata, Bembidion elongatum, Pelochares versicolor, Caccobius schreberi, Onthophagus massai and Emys orbicularis, usually associated with Ip IIb. Combined palaeotemperature reconstructions based on beetle, ostracod and vertebrate assemblages of the Ip Ib deposits indicate that summers (mean July range +19 to +22°C) were …

Seeds From Fresh Conventional Tomatoes Germinate Faster Than Dried Or Organic Seeds, Christopher G. Brown, Kautz Evan, Cameron Kilpatrick, Mary Vu, Mallory Weaver

Georgia Journal of Science

Conventionally-grown and organically-grown tomato seeds sourced from both fresh tomatoes and store-bought packages were germinated for seven days to evaluate the effect of seed source on germination rates. Seeds from fresh Roma tomatoes were prepared by allowing them to ferment in their own pulp for 24 hours, while commercially packaged dry seeds did not require any preparation. Once prepared, the seeds were spaced evenly on wet paper towels and stored in resealable plastic bags in groups of 10 for a total sample size of 100 seeds in each of four treatments. The number of germinated seeds and the length of …

Permanent Draft Genome Sequence Of Photorhabdus Temperata Strain Hm, An Entomopathogenic Bacterium Isolated From Nematodes, Shimaa M. Ghazal, Erik Swanson, Stephen Simpson, Krystalynne Morris, Feseha Abebe-Akele, W. Kelley Thomas, Kamal M. Khalil, Louis S. Tisa

Molecular, Cellular & Biomedical Sciences

Photorhabdus temperata strain Hm is an entomopathogenic bacterium that forms a symbiotic association with Heterorhabditis nematodes. Here, we report a 5.0-Mbp draft genome sequence for P. temperata strain Hm with a G+C content of 44.1% and containing 4,226 candidate protein-encoding genes.

Brief Of Amicus Curiae Fred T. Korematsu Center For Law And Equality In Support Of Appellant, Fred T. Korematsu Center For Law And Equality, Attorneys For Amicus Curiae

Fred T. Korematsu Center for Law and Equality

State of Washington v. Lares-Storms

Weyand Receives Federal Grant To Study Gonorrhea Infection, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Setonian, September 14, 2017, Seton Hall University

2017

No abstract provided.

1017-September-14-Acl Fall Classes, University Marketing And Communication, East Tennessee State University

ETSU News

No abstract provided.

1017-September-14-Sydney Ross, University Marketing And Communication, East Tennessee State University

ETSU News

No abstract provided.

Hawks' Herald -- Sep. 14, 2017, Roger Williams University

Hawk's Herald

No abstract provided.

Exploring Biological Heterogeneity And Its Consequences At Tissue And Cellular Scales Through Mathematical And Computational Modeling, Romica Kerketta

Biomedical Sciences ETDs

This dissertation explores the effects of heterogeneity across different biological scales in cancer as well as normal cells. At the tissue scale, we investigated the variability present in the tumor microenvironment and its effect on patient chemotherapeutic outcomes using a mathematical model of drug transport. We found that parameters such as tumor blood perfusion and radius of blood vessel had an impact on the tumor cytotoxicity. This indicated that the physical microenvironment of the tumor is an important regulator of the tumor response to chemotherapy. At the cellular scale, we investigated the heterogeneity present on the membrane landscape of ErbB2 …

A Good Quality Of Death, Phyllis Shacter

Seattle Journal for Social Justice

No abstract provided.

Prevention Of Renal Apob Retention Is Protective Against Diabetic Nephropathy: Role Of Tgf-Β Inhibition, Patricia G. Wilson, Joel C. Thompson, Meghan S. Yoder, Richard Charnigo, Lisa R. Tannock

Internal Medicine Faculty Publications

Animal studies demonstrate that hyperlipidemia and renal lipid accumulation contribute to the pathogenesis of diabetic nephropathy (DN). We previously demonstrated that renal lipoproteins colocalize with biglycan, a renal proteoglycan. The purpose of this study was to determine whether prevention of renal lipid (apoB) accumulation attenuates DN. Biglycan-deficient and biglycan wild-type Ldlr^−/− mice were made diabetic via streptozotocin and fed a high cholesterol diet. As biglycan deficiency is associated with elevated transforming growth factor-β (TGF-β), in some experiments mice were injected with either the TGF-β-neutralizing antibody, 1D11, or with 13C4, an irrelevant control antibody. Biglycan deficiency had no significant effect …

Biologically Inspired Network (Bionet) Authentication Using Logical And Pathological Rf-Dna Credential Pairs, Tyrone A.L. Lewis Sr.

Theses and Dissertations

The command and control (C2) of shared space resources are vulnerable to logical credential forgery and impersonation attacks among standardized and interoperable wireless radio frequency (RF) networks. Threats could come from trusted operators (insiders) or from external sources (outsiders). An attacker may gain unauthorized network access and illegally cross into C2 boundaries when conventional network authentication fails. This research proposes an integrated trust management system that uses both application-layer and physical-layer trust markers to authenticate users and their communication sources. In essence, the results from physical-layer RF-DNA fingerprinting techniques are used to improve application-level trust schemes based on command patterns, …

Characterization Of Jet Fuel Combustion Emissions During A C-130 Aeromedical Evacuation Engines Running Onload, Michelle L. Page

Theses and Dissertations

The purpose of this research was to characterize jet fuel combustion emissions (JFCE) in an occupational setting. Prior research demonstrated that aircraft emit hazardous species, especially at engine start-up and ground idle. Complaints of eye, nose, and throat irritation from occupational exposures near aircraft exist. In this study JFCE were tested during an aeromedical evacuation engines running patient onload (ERO) on a C-130 Hercules at the 179^th Airlift Wing, Mansfield-Lahm Air National Guard. Ultrafine particles, VOC, formaldehyde, carbon monoxide (CO), sulfuric acid, and metals were sampled simultaneously in approximate crew and patient breathing zones. Testing methods were portable condensation …

The Bg News September 14, 2017, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. September 14, 2017. Volume 97-Issue 9.

Illustrating, Quantifying, And Correcting For Bias In Post-Hoc Analysis Of Gene-Based Rare Variant Tests Of Association, Kelsey E. Grinde, Jaron Arbet, Alden Green, Michael O'Connell, Alessandra Valcarcel, Jason Westra, Nathan L. Tintle

Faculty Work Comprehensive List

To date, gene-based rare variant testing approaches have focused on aggregating information across sets of variants to maximize statistical power in identifying genes showing significant association with diseases. Beyond identifying genes that are associated with diseases, the identification of causal variant(s) in those genes and estimation of their effect is crucial for planning replication studies and characterizing the genetic architecture of the locus. However, we illustrate that straightforward single-marker association statistics can suffer from substantial bias introduced by conditioning on gene-based test significance, due to the phenomenon often referred to as “winner's curse.” We illustrate the ramifications of this bias …

Strategic Landscape, 2050: Preparing The U.S. Military For New Era Dynamics, Roman Muzalevsky Mr.

Books, Monographs & Collaborative Studies

A series of megatrends will present a major challenge to the United States in the coming decades, exposing it to crises and opportunities on the battlefield and in the market. The U.S. military should stand ready to harness these dynamics to retain its edge in an operational environment marked by increased complexity, speed, and intensity of global developments.

Does Breastfeeding Shape Food Preferences? Links To Obesity, Alison K. Ventura

Kinesiology and Public Health

The first 2 years of life have been recognized as a critical window for obesity prevention efforts. This period is characterized by rapid growth and development and, in a relatively short period of time, a child transitions from a purely milk-based diet to a more varied solid-food diet. Much learning about food and eating occurs during this critical window, and it is well-documented that early feeding and dietary exposures predict later food preferences, eating behaviors, and dietary patterns. The focus of this review will be on the earliest feeding experiences - breast- and formula-feeding - and the unique role of …

Is It All Relative? Relative Pitch And L2 Lexical Tone Perception/Tone Language Comprehension By Adult Tone And Non-Tone Language Speakers, Sloane C. Von Wertz

Dissertations, Theses, and Capstone Projects

Languages generally use musical pitch variation of the voice as part of their sound systems (Maddieson, 2011)—pitch variations that can be somewhat reminiscent of music. Music ability and/or training may influence language processing (e.g., Bidelman et al, 2011; Delogue et al, 2010). In particular, studies have concluded that there may be a relationship between absolute pitch and tone language acquisition (e.g., Lee, Lee, and Shi, 2011; Tillmann et al., 2011; Pfordresher and Brown, 2009). Other research has shown that fundamental frequency (F0) and F0 slope are crucial elements upon which native tone language speakers rely in tone perception (Guion and …

The Chicken Or The Egg? Adaptation To Desiccation And Salinity Tolerance In A Lineage Of Water Beetles, Susana Pallarés, Paula Arribas, David T. Bilton, Andrés Millán, Josefa Velasco, Ignacio Ribera

School of Biological and Marine Sciences

No abstract provided.

Exploring Botnet Evolution Via Multidimensional Models And Visualisation, William Dash, Matthew J. Craven

School of Engineering, Computing and Mathematics

A botnet is a program designed to perform a specific task using multiple computers connected in a network. In this paper we will focus on botnets being used to distribute malicious programs. In the real world, botnets have been shown to exhibit more aggressive and sophisticated behaviour than traditional malware. Botnets are used to infect computer networks and hence their success depends on the properties of the networks. We observe the behaviour of mathematical models used to describe botnets when botnet parameters are varied to understand if such variation is beneficial to their spread. We also introduce novel models for …

Modified Inertial Mass From Information Loss, Me Mcculloch, J Giné

School of Biological and Marine Sciences

A modification of inertia (called MiHsC or quantized inertia) has been proposed that assumes that inertia is caused by Unruh radiation, and that this radiation is made inhomogeneous in space by either Rindler horizons caused by acceleration or the distant Hubble horizon. The former predicts the standard inertial mass, and the latter predicts galaxy rotation without dark matter and cosmic acceleration without dark energy. It is proposed here that this model can be derived in an alternative way by assuming that the sum of mass (M), energy (E) and the information content of horizons (I) is conserved (EMI) so that …